Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects

Metabolism: Clinical and Experimental

Volumn 45, Issue 8, 1996, Pages 947-950

  Phillips, D I W ^a   Caddy, S ^b   Ilic, V ^b   Fielding, B A ^b   Frayn, K M ^b   Borthwick, A C ^b   Taylor, R ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE; INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; DISEASE PREDISPOSITION; ENZYME ACTIVATION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE UTILIZATION; GLYCOGEN METABOLISM; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MUSCLE BIOPSY; MUSCLE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SKELETAL MUSCLE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0029787329     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90260-7     Document Type: Article

References (24)

1. Oscai LB, Essig DA, Palmer WK: Lipase regulation of muscle triglyceride hydrolysis. J Appl Physiol 69:1571-1577, 1990
2. Storlein LH, Jenkins AB, Chisholm DJ, et al: Influence of dietary fat composition on development of insulin resistance in rats: Relationship to muscle triglyceride and ω-3 fatty acids in muscle phospholipid. Diabetes 40:280-289, 1991
3. Falholt K, Jenson I, Lindkaer Jensen S, et al: Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients. Diabetic Med 5:27-31, 1988
4. Randle PJ, Priestman DA, Mistry SC, et al: Glucose fatty acid interactions and the regulation of glucose disposal. J Cell Biochem 558:1-11, 1994
5. Phillips DIW, Barker DJP, Hales CN, et al: Thinness at birth and insulin resistance in adult life. Diabetologia 37:150-154, 1994
6. Phipps K, Barker DJP, Hales CN, et al: Fetal growth and impaired glucose tolerance in men and women. Diabetologia 36:225-228, 1993
7. Hirst S, Phillips DIW, Vines SK, et al: Reproducibility of the short insulin tolerance test. Diabetic Med 10:839-842, 1993
8. Durnin JVGA, Wormsley J: Body fat assessed from total body density and its estimation from skinfold thickness: Measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32:77-97, 1974
9. Sobey WJ, Beer SF, Carrington CA, et al: Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. Biochem J 260:535-541, 1989
10. Shimizu S: Enzymatic determination of serum free fatty acids: A colorimetric method. Anal Biochem 107:193-198, 1980
11. Folch J, Lees M, Sloane Stanley GH: A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509, 1957
12. Lowry OH, Rosebrough NJ, Farr AL, et al: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951
13. Humphreys SM, Fisher RM, Frayn KN: Micro-method for measurement of sub-nanomole amounts of triacylglycerol. Ann Clin Biochem 27:597-598, 1990
14. Frayn KN, Maycock PF: Skeletal muscle triglyceride in the rat: Methods for sampling and measurement, and studies of biological variability. J Lipid Res 21:139-144, 1980
15. Lillie RD, Ashburn LL: Supersaturated solutions of fat stains in dilute isopropanyl for demonstration of acute fatty degenerations not shown by Herxheimer technique. Arch Pathol 36:432-435, 1943
16. 14C-glucose. Anal Biochem 25:486-499, 1968
17. Barker DJP, Godfrey KM, Osmond C, et al: The relation of fetal length, ponderal index, and head circumference to blood pressure and the risk of hypertension in adult life. Paediatr Perinat Epidemiol 6:35-44, 1992
18. Gorski J: Muscle triglyceride metabolism during exercise. Can J Physiol Pharmacol 70:123-131, 1992
19. Felber J-P, Ferrannini E, Golay A, et al: Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes. Diabetes 36:1341-1350, 1987
20. Randle PJ, Garland PB, Hales CN, et al: The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785-789, 1963
21. Bonora E, Moghetti P, Zancanaro C, et al: Estimates of in vivo insulin action in man: Comparison of insulin tolerance tests with euglycemic and hyperglycemic clamp studies. J Clin Endocrinol Metab 68:374-378, 1989
22. Akinmokum A, Selby PL, Ramaiya K, et al: The short insulin tolerance test for determination of insulin sensitivity: A comparison with the euglycaemic clamp. Diabetic Med 9:432-437, 1992
23. Gelding SV, Robinson S, Lowe S, et al: Validation of the low dose short insulin tolerance test for evaluation of insulin sensitivity. Clin Endocrinol (Oxf) 40:611-615, 1994
24. Simoneau J-A, Colberg SR, Thaete FL, et al: Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J 9:273-278, 1995