SCOPUS 정보 검색 플랫폼

Angewandte Chemie - International Edition

Volumn 42, Issue 24, 2003, Pages 2718-2736

Application and limitations of x-ray crystallographic data in structure-based ligand and drug design

(3) Davis, Andrew M a Teague, Simon J a Kleywegt, Gerard J b

a ASTRAZENECA (United Kingdom)

b UPPSALA UNIVERSITY (Sweden)

Author keywords

Drug design; Protein models; Protein structures; X ray crystallography

Indexed keywords

COMPLEXATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; X RAY CRYSTALLOGRAPHY;

LIGANDS;

DRUG PRODUCTS;

1 (3 AMINO 5 INDAZOLYL) 4,7 DIBENZYL 3 BUTYL 2,3,4,5,6,7 HEXAHYDRO 5,6 DIHYDROXY 2H 1,3 DIAZEPIN 2 ONE; 1,3 BIS(3 AMINOBENZYL) 4,7 DIBENZYL 2,3,4,5,6,7 HEXAHYDRO 5,6 DIHYDROXY 1H 1,3 DIAZEPIN 2 ONE; 4 CYANO N [3 [(CYCLOPROPYL)(5,6,7,8,9,10 HEXAHYDRO 4 HYDROXY 2 OXO 2H CYCLOOCTA[B]PYRAN 3 YL)METHYL]PHENYL]BENZENESULFONAMIDE; 4,7 DIBENZYL 2,3,4,5,6,7 HEXAHYDRO 5,6 DIHYDROXY 1,3 BIS[4 (HYDROXYMETHYL)BENZYL] 2H 1,3 DIAZEPIN 2 ONE; A 70450; ACETAZOLAMIDE; AMPRENAVIR; CARBONATE DEHYDRATASE INHIBITOR; DIURETIC AGENT; DMP 850; DORZOLAMIDE; FATTY ACID BINDING PROTEIN; INDINAVIR; LIGAND; LOPINAVIR; LY 315920; OLEIC ACID; OSELTAMIVIR; PHENPROCOUMON; PHOSPHOLIPASE A2 INHIBITOR; PIPERAZINE DERIVATIVE; PROTEIN; PROTEINASE INHIBITOR; RENIN INHIBITOR; RITONAVIR; SAQUINAVIR; SIALIDASE INHIBITOR; TIPRANAVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZANAMIVIR;

ALGORITHM; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG METABOLISM; DRUG SOLUBILITY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING TECHNOLOGY; MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REVIEW; STRUCTURE BASED DESIGN; TECHNOLOGY; X RAY CRYSTALLOGRAPHY;

CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; DRUG DESIGN; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE;

EID: 0038336897 PISSN: 14337851 EISSN: None Source Type: Journal
DOI: 10.1002/anie.200200539 Document Type: Review

Times cited : (351)

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