Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: Implications for the design of antifungal agents

Protein Science

Volumn 5, Issue 4, 1996, Pages 640-652

  Abad Zapatero, Cele ^a   Goldman, Robert ^a   Muchmore, Steven W ^a   Hutchins, Charles ^a   Stewart, Kent ^a   Navaza, Jorge ^b   Payne, Candia D ^c   Ray, Thomas L ^c  

^a ABBOTT LABORATORIES   (United States)

^b Laboratoire de Physique   (France)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

antifungal drug design; antifungal targets; aspartic proteinases; C. albicans; rational drug design

Indexed keywords

A 70450; ANTIFUNGAL AGENT; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CARBOXY TERMINAL SEQUENCE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEINASE INHIBITION; STRUCTURE ANALYSIS;

EID: 0029935527     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560050408     Document Type: Article

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