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Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1441, Issue 2-3, 1999, Pages 223-228

Structure-based design of a new class of anti-inflammatory drugs: Secretory phospholipase A2 inhibitors, SPI

(2) Mihelich, Edward D a Schevitz, Richard W a

a ELI LILLY AND COMPANY (United States)

Author keywords

Secretory phospholipase A2 inhibitor; Structure based design

Indexed keywords

3 (3 ACETAMIDO 1 BENZYL 3 ETHYLINDOLYL 5 OXY)PROPANE; [[3 (AMINOOXOACETYL) 2 ETHYL 1 (PHENYLMETHYL) 1H INDOL 4 YL]OXY]ACETATE; ANTIINFLAMMATORY AGENT; INDOLE DERIVATIVE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; UNCLASSIFIED DRUG;

DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; GENE OVEREXPRESSION; INFLAMMATION; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ACETIC ACIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDOLES; MICE; MICE, TRANSGENIC; MOLECULAR STRUCTURE; PHOSPHOLIPASES A;

EID: 0032701132 PISSN: 13881981 EISSN: None Source Type: Journal
DOI: 10.1016/S1388-1981(99)00157-2 Document Type: Review

Times cited : (56)

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