Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking

Chemistry and Biology

Volumn 8, Issue 5, 2001, Pages 445-457

  Anderson, Amy C ^a,b   O'Neil, Robert H ^a,b   Surti, Toral S ^a   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Dartmouth College   (United States)

Author keywords

Crystal structure; Docking; Ligand design; Protein flexibility; Thymidylate synthase

Indexed keywords

ALGORITHM; CELL ANCHORAGE; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME CONFORMATION; ENZYME INDUCTION; ENZYME KINETICS; ENZYME MODIFICATION; LIGAND BINDING; LIGAND; PLASTICITY; PROTEIN TARGETING; THYMIDYLATE SYNTHASE;

ALGORITHMS; AMINO ACID MOTIFS; BINDING SITES; CRYSTALLOGRAPHY; DEOXYURACIL NUCLEOTIDES; DRUG DESIGN; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; LIGANDS; MEMBRANE PROTEINS; PLIABILITY; PNEUMOCYSTIS; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; THYMIDYLATE SYNTHASE;

PNEUMOCYSTIS CARINII;

EID: 0034996721     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00023-0     Document Type: Article

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