-
1
-
-
0030811307
-
Cyclic HIV protease inhibitors capable of displacing the active site structural water molecule
-
De Lucca, G.V., Erickson-Viitanen, S., Lam, P.Y.S. (1997). Cyclic HIV protease inhibitors capable of displacing the active site structural water molecule. Drug Discovery Today 2, 6-18.
-
(1997)
Drug Discovery Today
, vol.2
, pp. 6-18
-
-
De Lucca, G.V.1
Erickson-Viitanen, S.2
Lam, P.Y.S.3
-
2
-
-
0031054725
-
Recent developments in HIV protease inhibitor research
-
Chrusciel, R.A., Romines, K.R. (1997). Recent developments in HIV protease inhibitor research. Expert Opin. Ther. Pat. 7, 111-121.
-
(1997)
Expert Opin. Ther. Pat.
, vol.7
, pp. 111-121
-
-
Chrusciel, R.A.1
Romines, K.R.2
-
3
-
-
0005241362
-
Active human immunodeficiency virus protease is required for viral infectivity
-
Kohl, N.E., et.al., & Sigal, I.S. (1988). Active human immunodeficiency virus protease is required for viral infectivity. Proc. Natl Acad. Sci. USA 85, 4686-4690.
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 4686-4690
-
-
Kohl, N.E.1
Sigal, I.S.2
-
4
-
-
0024334170
-
Role of human immunodeficiency virus type 1 -specific protease in core protein maturation and viral infectivity
-
Peng, C., et al., & Chang, N.T. (1989). Role of human immunodeficiency virus type 1 -specific protease in core protein maturation and viral infectivity. J. Virol. 63, 2550-2556.
-
(1989)
J. Virol.
, vol.63
, pp. 2550-2556
-
-
Peng, C.1
Chang, N.T.2
-
6
-
-
0028057975
-
Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors
-
Lam, P.Y.S., et al., & Erickson-Viitanen, S. (1994). Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors. Science 263, 380-384.
-
(1994)
Science
, vol.263
, pp. 380-384
-
-
Lam, P.Y.S.1
Erickson-Viitanen, S.2
-
7
-
-
9544235162
-
Cyclic HIV protease inhibitors: Synthesis, conformational analysis, P2/P2′ structure-activity relationship, and molecular recognition of cyclic ureas
-
Lam, P.Y.S., et al., & Hodge, C.N. (1996). Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2′ structure-activity relationship, and molecular recognition of cyclic ureas. J. Med. Chem. 39, 3514-3525.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 3514-3525
-
-
Lam, P.Y.S.1
Hodge, C.N.2
-
8
-
-
0030113025
-
DMP 450: An orally bioavailable cyclic urea inhibitor of the HIV protease
-
Hodge, C.N., et al., & Erickson-Viitanen, S. (1996). DMP 450: an orally bioavailable cyclic urea inhibitor of the HIV protease. Chem. Biol. 3, 301-314.
-
(1996)
Chem. Biol.
, vol.3
, pp. 301-314
-
-
Hodge, C.N.1
Erickson-Viitanen, S.2
-
9
-
-
0028235440
-
-
Bacheler, L.T., Paul, M., Jadhav, P.K., Otto, M., Stone, B. & Miller, J. (1994). Antiviral Chem. Chemother. 5, 111.
-
(1994)
Antiviral Chem. Chemother.
, vol.5
, pp. 111
-
-
Bacheler, L.T.1
Paul, M.2
Jadhav, P.K.3
Otto, M.4
Stone, B.5
Miller, J.6
-
10
-
-
0021798968
-
Protein binding of propisomide
-
Zini, R., Barre, J., Defer, G., Jeanniot, J.P., Houin, G., Tillement, J.P. (1985). Protein binding of propisomide. J. Pharm. Sci. 74, 530-533.
-
(1985)
J. Pharm. Sci.
, vol.74
, pp. 530-533
-
-
Zini, R.1
Barre, J.2
Defer, G.3
Jeanniot, J.P.4
Houin, G.5
Tillement, J.P.6
-
11
-
-
0028949539
-
Multiple mutations in the human immunodeficiency virus protease gene are responsible for decreased susceptibility to protease inhibitors
-
King, R.W. et al., & Otto, M.J. (1995). Multiple mutations in the human immunodeficiency virus protease gene are responsible for decreased susceptibility to protease inhibitors. Antiviral Chem. Chemother. 6, 80-88.
-
(1995)
Antiviral Chem. Chemother.
, vol.6
, pp. 80-88
-
-
King, R.W.1
Otto, M.J.2
-
12
-
-
0030591865
-
Potent cyclic urea HIV protease inhibitors with benzofused heterocycles as P2/P2′ groups. Bioorg
-
Rodgers, J.D., et al., & Chang, C.-H. (1996). Potent cyclic urea HIV protease inhibitors with benzofused heterocycles as P2/P2′ groups. Bioorg. Med. Chem. Lett. 6, 2919-2924.
-
(1996)
Med. Chem. Lett.
, vol.6
, pp. 2919-2924
-
-
Rodgers, J.D.1
Chang, C.-H.2
-
13
-
-
0032492679
-
Potent cyclic urea HIV protease inhibitors with 3-aminoindazole P2/P2′ groups
-
Rodgers, J.D., et al., & Chang, C.-H. (1998). Potent cyclic urea HIV protease inhibitors with 3-aminoindazole P2/P2′ groups. Bioorg. Med. Chem. Lett. 8, 715.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 715
-
-
Rodgers, J.D.1
Chang, C.-H.2
-
14
-
-
0031022510
-
Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV
-
Jadhav, P.K., et al., & Bacheler, L.T. (1997). Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV. J. Med. Chem. 40, 181-191.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 181-191
-
-
Jadhav, P.K.1
Bacheler, L.T.2
-
15
-
-
0030063923
-
Stereoselective synthesis of HIV-1 protease inhibitor DMP 323
-
Pierce, M., et al., & Emmett, G.C. (1996). Stereoselective synthesis of HIV-1 protease inhibitor DMP 323. J. Org. Chem. 61, 444-450.
-
(1996)
J. Org. Chem.
, vol.61
, pp. 444-450
-
-
Pierce, M.1
Emmett, G.C.2
-
16
-
-
0028260973
-
Potency and selectivity of inhibition of human immunodeficiency virus protease by a small nonpeptide cyclic urea, DMP 323
-
Erickson-Viitanen, S., et al., & Meek, J.L. (1994). Potency and selectivity of inhibition of human immunodeficiency virus protease by a small nonpeptide cyclic urea, DMP 323. Antimicro. Agents Chemo. 38, 1628-1634.
-
(1994)
Antimicro. Agents Chemo.
, vol.38
, pp. 1628-1634
-
-
Erickson-Viitanen, S.1
Meek, J.L.2
-
17
-
-
0028988566
-
Limited sequence diversity of the HIV type 1 protease gene from clinical isolates and in vitro susceptibility to HIV protease inhibitors
-
Winslow, D.L., et al., & Otto, M.J. (1995). Limited sequence diversity of the HIV type 1 protease gene from clinical isolates and in vitro susceptibility to HIV protease inhibitors. AIDS Res. Hum. Retroviruses 11, 107-113.
-
(1995)
AIDS Res. Hum. Retroviruses
, vol.11
, pp. 107-113
-
-
Winslow, D.L.1
Otto, M.J.2
-
18
-
-
0028877042
-
Weak binding of VX-478 to human plasma proteins and implications for anti-human immunodeficiency virus therapy
-
Livingston, D.J., et al., & Painter, G.R. (1995), Weak binding of VX-478 to human plasma proteins and implications for anti-human immunodeficiency virus therapy. J. Infect. Dis. 172, 1238-1245.
-
(1995)
J. Infect. Dis.
, vol.172
, pp. 1238-1245
-
-
Livingston, D.J.1
Painter, G.R.2
-
19
-
-
84959844240
-
Drug binding and apparent volume of distribution
-
Tillement, J.P. & Lindendlaub, E., eds., Schatauer, Stuggart
-
Houin, G. (1995). Drug binding and apparent volume of distribution. In Protein Binding and Drug Transport (Tillement, J.P. & Lindendlaub, E., eds.), p213-226, Schatauer, Stuggart.
-
(1995)
Protein Binding and Drug Transport
, pp. 213-226
-
-
Houin, G.1
-
20
-
-
0028874048
-
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
-
Ho, D.D, et al., & Markowitz, M. (1995). Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123-126.
-
(1995)
Nature
, vol.373
, pp. 123-126
-
-
Ho, D.D.1
Markowitz, M.2
-
21
-
-
0028811974
-
Viral dynamics in human immunodeficiency virus type 1 infection
-
Wei, X., et al., & Shaw, G.M. (1995). Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373, 117-122.
-
(1995)
Nature
, vol.373
, pp. 117-122
-
-
Wei, X.1
Shaw, G.M.2
-
22
-
-
0028949539
-
Multiple mutations in the human immunodeficiency virus protease gene are responsible for decreased susceptibility to protease inhibitors
-
King, R.W. et al., & Otto, M.J. (1995). Multiple mutations in the human immunodeficiency virus protease gene are responsible for decreased susceptibility to protease inhibitors. Antiviral Chem. Chemother. 6, 80-88.
-
(1995)
Antiviral Chem. Chemother.
, vol.6
, pp. 80-88
-
-
King, R.W.1
Otto, M.J.2
-
23
-
-
0028943992
-
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
-
Condra J.H., et al., & Emini, E.A. (1995), In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 374, 569-571.
-
(1995)
Nature
, vol.374
, pp. 569-571
-
-
Condra, J.H.1
Emini, E.A.2
-
24
-
-
0003204589
-
Long term follow-up of combination protease inhibitor therapy with nelfinavir and saquinavir (soft gel) in HIV infection
-
Feb. 1-5, 1998, Chicago, Il., Abstract 394c
-
Kravcik, S. et al., & Cameron, D.W. (1998). Long term follow-up of combination protease inhibitor therapy with nelfinavir and saquinavir (soft gel) in HIV infection. 5th Conference on Retroviruses and Opportunistic Infections, Feb. 1-5, 1998, Chicago, Il., Abstract 394c.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Kravcik, S.1
Cameron, D.W.2
-
25
-
-
85030341622
-
Influence of Gag sequences on the replicative capatcity of HIV-1 protease mutants
-
July 3-6, Whistler, Canada, Abstract 19
-
Anton, E.D. et al., & Bacheler, L.T. (1996). Influence of Gag sequences on the replicative capatcity of HIV-1 protease mutants. Fifth Workshop on HIV Drug Resistance, July 3-6, Whistler, Canada, Abstract 19.
-
(1996)
Fifth Workshop on HIV Drug Resistance
-
-
Anton, E.D.1
Bacheler, L.T.2
-
26
-
-
0029869305
-
Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors
-
Rose, R.E. et al., & Lin, P.F. (1996). Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors. Proc. Natl Acad. Sci. USA 93, 1648-1653.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 1648-1653
-
-
Rose, R.E.1
Lin, P.F.2
-
27
-
-
0028222149
-
L735,524: An orally bioavailable human immunodeficiency virus type 1 protease inhibitor
-
Vacca, J.P., et al., & Huff, J.R. (1994). L735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor. Proc. Natl Acad. Sci. USA 91, 4096-4100.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 4096-4100
-
-
Vacca, J.P.1
Huff, J.R.2
-
28
-
-
0028968902
-
ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans
-
Kempf, D.J., et al., & Norbeck D.W. (1995). ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc. Natl Acad. Sci. USA 92, 2484-2488.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 2484-2488
-
-
Kempf, D.J.1
Norbeck, D.W.2
-
29
-
-
0029614884
-
Drug resistant patterns of saquinavir and other HIV protease inhibitors
-
Roberts, N.A. (1995). Drug resistant patterns of saquinavir and other HIV protease inhibitors. AIDS 9, S27-S32.
-
(1995)
AIDS
, vol.9
-
-
Roberts, N.A.1
-
30
-
-
0030032764
-
Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of the HIV type 1 protease
-
Shetty, B.V., Kosa, M.B., Khalil, D.A. & Webber, S. (1996). Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of the HIV type 1 protease. Antimicrobial Agents and Chemo. 40, 110-114.
-
(1996)
Antimicrobial Agents and Chemo.
, vol.40
, pp. 110-114
-
-
Shetty, B.V.1
Kosa, M.B.2
Khalil, D.A.3
Webber, S.4
|