De novo design, discovery and development of cyclic urea HIV protease inhibitors

Drugs of the Future

Volumn 23, Issue 9, 1998, Pages 987-994

  De Lucca, G V ^a   Lam, P Y S ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,7 DIBENZYL 2,3,4,5,6,7 HEXAHYDRO 5,6 DIHYDROXY 1,3 BIS[4 (HYDROXYMETHYL)BENZYL] 2H 1,3 DIAZEPIN 2 ONE; ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; MACROGOL 400; MOZENAVIR; PROPYLENE GLYCOL; UREA DERIVATIVE; WATER;

AREA UNDER THE CURVE; CLINICAL TRIAL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROGEN BOND; LIPOPHILICITY; MOLECULAR WEIGHT; NONHUMAN; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0032465924     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1998.023.09.473829     Document Type: Review

References (30)