Cluster analysis of consensus water sites in thrombin and trypsin shows conservation between serine proteases and contributions to ligand specificity

Protein Science

Volumn 7, Issue 10, 1998, Pages 2054-2064

  Sanschagrin, Paul C ^a   Kuhn, Leslie A ^a  

^a Michigan State University   (United States)

Author keywords

Binding site characterization; Conserved water sites; Drug design; Hydration; Water mediated ligand recognition

Indexed keywords

APROTININ; LIGAND; SERINE PROTEINASE; THROMBIN; TRYPSIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CLUSTER ANALYSIS; CRYSTAL; DRUG DESIGN; HYDRATION; HYDROGEN BOND; HYDROPHILICITY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE;

BOVINAE;

EID: 0031762253     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560071002     Document Type: Article

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