Expression of the p53 and Maspin protein in primary prostate cancer: Correlation with clinical features

International Journal of Cancer

Volumn 95, Issue 5, 2001, Pages 337-342

  Machtens, Stefan ^a   Serth, Jürgen ^a   Bokemeyer, Carsten ^b   Bathke, Wolfgang ^a   Minssen, Antje ^a   Kollmannsberger, Christian ^b   Hartmann, Jörg ^b   Knüchel, Ruth ^c   Kondo, Masahiko ^a,d   Jonas, Udo ^a   Kuczyk, Markus ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Maspin protein expression; p53 dependent Maspin regulation; Prognostic significance; Prostate cancer

Indexed keywords

MASPIN; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; FOLLOW UP; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; PROSTATECTOMY; PROTEIN EXPRESSION; REGULATORY MECHANISM; TREATMENT OUTCOME; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; AGE FACTORS; AGED; ANALYSIS OF VARIANCE; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROSTATECTOMY; PROSTATIC NEOPLASMS; PROTEIN BIOSYNTHESIS; PROTEINS; SERPINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035922097     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20010920)95:5<337::AID-IJC1059>3.0.CO;2-1     Document Type: Article

References (13)

1. Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3
2. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells
3. Maspin is an angiogenesis inhibitor
4. Transactivation through Ets and Apl transcription sites determines the expression of the tumor-suppressing gene maspin
5. Molecular biology of prostate cancer
6. Production, purification and characterisation of recombinant maspin protein
7. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells
8. Expression of maspin in prostate cells is regulated by a positive Ets element and a negative hormonal responsive element site recognized by androgen receptor
9. The prognostic value of p53 for long-term and recurrence-free survival following radical prostatectomy
10. mMaspin: The mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility
11. The myoepithelial defense: A host defense against cancer
12. Sensitive detection of circulating breast cancer cells by reverse-transcriptase polymerase chain reaction of maspin gene
13. Rat and human maspins: Structures, metastatic suppressor activity and mutation in prostate cancer cells