Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice

Cancer Research

Volumn 58, Issue 6, 1998, Pages 1253-1259

  Mangues, Ramon ^a,c   Corral, Teresa ^a   Kohl, Nancy E ^b   Symmans, W Fraser ^a   Lu, Suying ^a   Malumbres, Marcos ^a   Gibbs, Jackson B ^b   Oliff, Allen ^b   Pellicer, Angel ^a,d  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^d NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; ANTINEOPLASTIC AGENT; MEVINOLIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST TUMOR; CANCER INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; LYMPHATIC SYSTEM TUMOR; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PROCESSING; TRANSGENIC MOUSE;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; FARNESYLTRANSTRANSFERASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; LYMPHOMA; MAMMARY NEOPLASMS, EXPERIMENTAL; METHIONINE; MICE; MICE, TRANSGENIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 0032521211     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. DeFeo, D., Gonda, M. A., Young, H. A., Chang, E. H., and Lowy, D. R. Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus. Proc. Natl. Acad. Sci. USA, 78: 3328-3332, 1981.
2. Tabin, C. J., Bradley, S. M., Bargmenn, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., and Chang, E. H. Mechanism of activation of a human oncogene. Nature (Lond.), 300: 143-147, 1982.
3. Shih, C., and Weinberg, R. A. Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell, 29: 161-169, 1982.
4. Nras expression. EMBO J., 5: 2617-2621, 1986.
5. George, D. L., Glick, B., Trusko, S., and Freeman, N. Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line. Proc. Natl. Acad. Sci. USA, 83: 1651-1655, 1986.
6. Sinn, E., Muller, W., Pattengale, P., Tepler, I., Wallace, R., and Leder, P. Coexpression of MMTV/v-H-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell, 49: 465-475, 1987.
7. Mangues, R., Seidman, I., Gordon, J. W., and Pellicer, A. Overexpression of the N-ras proto-oncogene, not somatic mutational activation, associated with malignant tumors in transgenic mice. Oncogene, 7: 2073-2076, 1992.
8. Schafer, W. R., Kim, R., Sterne, R. E., Thorner, J., Kim, S. H., and Rine, J. Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science (Washington DC), 254: 379-385, 1989.
9. Hancock, J. F., Magee, A. I., Childs, J. E., and Marshall, C. J. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell, 57: 1167-1177, 1989.
10. Cox, A. D., and Der, C. J. Protein prenylation: more than just glue? Curr. Opin. Cell Biol., 4: 1008-1016, 1992.
11. Kohl, N. E., Mosser, S. D., deSolms, S. J., Giuliani, E. A., Pompliano, D. L., Graham, S. L., Smith, R. L., Scolnick, E. M., Oliff, A., and Gibbs, J. B. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science (Washington DC), 260: 1934-1937, 1993.
12. Sepp-Lorenzino, L., Ma, Z., Rands, E., Kohl, N. E., Gibbs, J. B., Oliff, A., and Rosen, N. A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res., 55: 5302-5309, 1995.
13. James, G. L., Goldstein, J. L., Brown, M. S., Rawson, T. E., Somers, T. C., McDowell, R. S., Crowley, C. W., Lucas, B. K., Levinson, A. D., and Masters, J. C. Benzodiazepine peptidomimetics: potent inhibitors of ras farnesylation in animal cells. Science (Washington DC), 260: 1937-1942, 1993.
14. Prendergast, G. C., Davide, J. P., deSolms, S. J., Giuliani, E. A., Graham, S. L., Gibbs, J. B., Oliff, A., and Kohl, N. E. Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol. Cell. Biol., 14: 4193-4202, 1994.
15. Kohl, N. E., Wilson, F. R., Mosser, S. D., Giuliani, E. A., deSolms, S. J., Conner, M. W., Anthony, N. J., Holtz, W. J., Gomez, R. P., Lee, T. J., Smith, R. L., Graham, S. L., Hartman, G. D., Gibbs, J. B., and Oliff, A. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc. Natl. Acad. Sci. USA, 91: 9141-9145, 1994.
16. Kohl, N. E., Omer, C. A., Conner, M. W., Anthony, N. J., Davide, J. P., deSolms, S. J., Giuliani, E. A., Gomez, R. P., Graham, S. L., Hamilton, K., Handt, L. K., Hartman, G. D., Koblan, K. S., Kral, A. M., Miller, P. J., Mosse, S. D., O'Neill, T. J., Rands, E., Schaner, M. D., Gibbs, J. B., and Oliff, A. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat. Med., 1: 792-797, 1995.
17. N oncogene. Oncogene, 5: 1491-1497, 1990.
18. Mangues, R., Symmans, W. F., Lu, S., Schwartz, S., and Pellicer, A. Activated N-ras oncogene, and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis. Oncogene, 13: 1053-1063, 1996.
19. Bos, J. L. Ras oncogenes in human cancer: a review. Cancer Res., 49: 4682-4689, 1989.
20. Whyte, D. B., Kirschmeier, P., Hockenberry, T. N., Nunez-Oliva, I., James, L., Catino, J. J., Bishop, W. R., and Pai, J-K. K-and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J. Biol. Chem., 272: 14459-14464, 1997.
21. Rowell, C. A., Kowalczyk, J. J., Lewis, M. D., and Garcia, A. M. Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo. J. Biol. Chem., 272: 14093-14097, 1997.
22. Nagasu, T., Yoshimatsu, K., Rowell, C., Lewis, M. D., and Garcia, A. M. Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res., 55: 5310-5314, 1995.