-
1
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos, J.L., ras oncogenes in human cancer: a review. Cancer Res., 49, 4682-4689 (1989).
-
(1989)
Cancer Res.
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
2
-
-
0000081175
-
Post-translational modification of the Ha-ras oncogene protein: Evidence for a third class of protein carboxymethyltransferases
-
CLARKE, S., VOGEL, J.P., DESCHENES, R.J. and STOCK, J., Post-translational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxymethyltransferases. Proc. nat. Acad. Sci. (Wash.), 85, 4643-4647 (1988).
-
(1988)
Proc. Nat. Acad. Sci. (Wash.)
, vol.85
, pp. 4643-4647
-
-
Clarke, S.1
Vogel, J.P.2
Deschenes, R.J.3
Stock, J.4
-
3
-
-
0027998986
-
The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation
-
Cox, A.D., GARCIA, A.M., WESTWICK, J.K., KOWALCZYK, J.J., LEWIS, M.D., BRENNER, D.A. and DER, C.J., The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J. biol. Chem., 269, 19203-19206 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 19203-19206
-
-
Cox, A.D.1
Garcia, A.M.2
Westwick, J.K.3
Kowalczyk, J.J.4
Lewis, M.D.5
Brenner, D.A.6
Der, C.J.7
-
4
-
-
0029091930
-
The farnesyl-protein-transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21 -ras but does not affect their function or localization
-
DALTON, M.B., FANTLE, K.S., BECHTOLD, H.A., DEMAIO, L., EVANS, R.M., KRYSTOSEK, A. and SINENSKY, M., The farnesyl-protein-transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21 -ras but does not affect their function or localization. Cancer Res., 55, 3295-3304 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 3295-3304
-
-
Dalton, M.B.1
Fantle, K.S.2
Bechtold, H.A.3
Demaio, L.4
Evans, R.M.5
Krystosek, A.6
Sinensky, M.7
-
5
-
-
0027320616
-
Peptidomimetic inhibitors of ras farnesylation and function in whole cells
-
GARCIA, A.M., ROWELL, C. ACKERMANN, K., KOWALCZYK, J.J. and LEWIS, M.D., Peptidomimetic inhibitors of ras farnesylation and function in whole cells. J. biol. Chem., 268, 18415-18418 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 18415-18418
-
-
Garcia, A.M.1
Rowell, C.2
Ackermann, K.3
Kowalczyk, J.J.4
Lewis, M.D.5
-
6
-
-
0028331587
-
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
-
GIBBS, J.B., OLIFF, A. and KOHL, N.E., Farnesyltransferase inhibitors: ras research yields a potential cancer therapeutic. Cell, 77, 175-178 (1994).
-
(1994)
Cell
, vol.77
, pp. 175-178
-
-
Gibbs, J.B.1
Oliff, A.2
Kohl, N.E.3
-
7
-
-
0026040193
-
Non-farnesylated tetrapeptides inhibitors of protein farnesyltransferase
-
GOLDSTEIN, J.L., BROWN, M.S., STRADLEY, S.J., REISS, Y. and GIERASCH, L.M., Non-farnesylated tetrapeptides inhibitors of protein farnesyltransferase. J. biol. Chem., 266, 15575-15578 (1991).
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 15575-15578
-
-
Goldstein, J.L.1
Brown, M.S.2
Stradley, S.J.3
Reiss, Y.4
Gierasch, L.M.5
-
8
-
-
0028276488
-
Relative steady-state expression of the different post-translational products of p21H-ras from normal rat tissue. A 2D-Western-immunoblot study
-
GULBIS, B. and GALAND, P., Relative steady-state expression of the different post-translational products of p21H-ras from normal rat tissue. A 2D-Western-immunoblot study. Life Sci., 54, 1747-1756 (1994).
-
(1994)
Life Sci.
, vol.54
, pp. 1747-1756
-
-
Gulbis, B.1
Galand, P.2
-
9
-
-
0024465343
-
Posttranslational processing of p21 ras is two-step and involves carboxylation and carboxy-terminal proteolysis
-
GUTTIEREZ, L., MAGEE, A., MARSHALL, C. and HANCOCK, J., Posttranslational processing of p21 ras is two-step and involves carboxylation and carboxy-terminal proteolysis. EMBO J., 8, 1093-1098 (1989).
-
(1989)
EMBO J.
, vol.8
, pp. 1093-1098
-
-
Guttierez, L.1
Magee, A.2
Marshall, C.3
Hancock, J.4
-
10
-
-
0026037624
-
A CAAX or a CAAL motif and a second signal are sufficient for plasma-membrane targeting of ras proteins
-
HANCOCK, J.F., CADWALLADER, K., PATERSON, H. and MARSHALL, C.J., A CAAX or a CAAL motif and a second signal are sufficient for plasma-membrane targeting of ras proteins. EMBO J., 10, 1093-1098 (1991).
-
(1991)
EMBO J.
, vol.10
, pp. 1093-1098
-
-
Hancock, J.F.1
Cadwallader, K.2
Paterson, H.3
Marshall, C.J.4
-
11
-
-
0027409561
-
Identification of ras farnesyltansferase inhibitors by microbial screening
-
HARA, M., KAZUHITO, A., AKINAGA, S., OKABE, M., NAKANO, R.G., WOOD, D., UH, M. and TAMANOI, F., Identification of ras farnesyltansferase inhibitors by microbial screening. Proc. nat. Acad. Sci. (Wash.), 90, 2281-2285 (1993).
-
(1993)
Proc. Nat. Acad. Sci. (Wash.)
, vol.90
, pp. 2281-2285
-
-
Hara, M.1
Kazuhito, A.2
Akinaga, S.3
Okabe, M.4
Nakano, R.G.5
Wood, D.6
Uh, M.7
Tamanoi, F.8
-
12
-
-
0029877708
-
Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl: Protein transferase inhibitor
-
ITO, T., KAWATA, S., TAMURA, S., IGURA, T., NAGASE, T., MIYAGAWA, J., YAMAZAKI, E., ISHIGURO, H. and MATSUZAWA, Y., Suppression of human pancreatic cancer growth in BALB/c nude mice by manumycin, a farnesyl: protein transferase inhibitor. Jap. J. Cancer Res., 87, 113-116 (1996).
-
(1996)
Jap. J. Cancer Res.
, vol.87
, pp. 113-116
-
-
Ito, T.1
Kawata, S.2
Tamura, S.3
Igura, T.4
Nagase, T.5
Miyagawa, J.6
Yamazaki, E.7
Ishiguro, H.8
Matsuzawa, Y.9
-
13
-
-
0027323459
-
Benzodiazepine peptidomimetics: Potent inhibitors of ras farnesylation in animal cells
-
JAMES, G.L., GOLDSTEIN, J.L., BROWN, M.S., RAWSON, T.E., SOHERS, T.C., MCDOWELL, R.S., CROWLEY, C.W., LUCAS, B.K., LEVINSON, A.D. and MARSTERS, J.C., Benzodiazepine peptidomimetics: potent inhibitors of ras farnesylation in animal cells. Science, 260, 1937-1942 (1993).
-
(1993)
Science
, vol.260
, pp. 1937-1942
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
Rawson, T.E.4
Sohers, T.C.5
Mcdowell, R.S.6
Crowley, C.W.7
Lucas, B.K.8
Levinson, A.D.9
Marsters, J.C.10
-
14
-
-
0026747866
-
Isoprenoid addition to ras protein is the critical modification for its membrane association and transforming activity
-
KATO, K., COX, A.D., HISAKA, M.M., GRAHAM, S.M. and DER, C.J., Isoprenoid addition to ras protein is the critical modification for its membrane association and transforming activity. Proc. nat. Acad. Sci. (Wash.), 89, 6403-6407 (1992).
-
(1992)
Proc. Nat. Acad. Sci. (Wash.)
, vol.89
, pp. 6403-6407
-
-
Kato, K.1
Cox, A.D.2
Hisaka, M.M.3
Graham, S.M.4
Der, C.J.5
-
15
-
-
0027248872
-
Selective inhibition of ras-dependent transformation by a farnesyl-transferase inhibitors
-
KOHL, N.E., MOSSER, S.D., DE SOLMS, J., GIUCIANI, E.A., POMPCIANO, D.L., GRAHAM, S.L., SMITH, R.L., SCOLNICK, E.M., OLIFF, A. and GIBBS, J.B., Selective inhibition of ras-dependent transformation by a farnesyl-transferase inhibitors. Science. 260, 1934-1937 (1993).
-
(1993)
Science.
, vol.260
, pp. 1934-1937
-
-
Kohl, N.E.1
Mosser, S.D.2
De Solms, J.3
Giuciani, E.A.4
Pompciano, D.L.5
Graham, S.L.6
Smith, R.L.7
Scolnick, E.M.8
Oliff, A.9
Gibbs, J.B.10
-
16
-
-
0028892646
-
Evidence that farnesylase inhibitors suppress ras transformation by interfering with Rho activity
-
LEBOWITZ, P.F., DAVIDE, J.P. and PRENDERGAST, G.C., Evidence that farnesylase inhibitors suppress ras transformation by interfering with Rho activity. Mol. cell. Biol., 15, 6613-6622 (1995).
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 6613-6622
-
-
Lebowitz, P.F.1
Davide, J.P.2
Prendergast, G.C.3
-
17
-
-
0028973293
-
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive ras-raf complexes
-
LERNER, E.C., QIAN, Y., BLASKOVICH, M.A., FOSSUM, R.D., VOGT, A., SUN, J., COX, A.D., DER, C.J., HAMILTON, A.D. and SEBTI, S.M., Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive ras-raf complexes. J. biol. Chem., 270, 26802-26806 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26802-26806
-
-
Lerner, E.C.1
Qian, Y.2
Blaskovich, M.A.3
Fossum, R.D.4
Vogt, A.5
Sun, J.6
Cox, A.D.7
Der, C.J.8
Hamilton, A.D.9
Sebti, S.M.10
-
18
-
-
0029000897
-
Bi-substrate inhibitors of farnesyltransferase: A novel class of specific inhibitors of ras-transformed cells
-
MANNE, V. and 16 OTHERS, Bi-substrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras-transformed cells. Oncogene, 10, 1763-1773 (1995).
-
(1995)
Oncogene
, vol.10
, pp. 1763-1773
-
-
Manne, V.1
-
19
-
-
0029940817
-
Inhibition of cell growth of human hepatoma cell line (Hep G2) by a farnesyl-protein-transferase inhibitor: A preferential suppression of ras farnesylation
-
NAGASE, T., KAWATA, S., TAMURA, S., MATSUDA, Y., INUI, Y., YAMASAKI, E., ISHIGURO, H., ITO, T. and MATSUZAWA, Y., Inhibition of cell growth of human hepatoma cell line (Hep G2) by a farnesyl-protein-transferase inhibitor: a preferential suppression of ras farnesylation. Int. J. Cancer, 65, 620-626 (1996).
-
(1996)
Int. J. Cancer
, vol.65
, pp. 620-626
-
-
Nagase, T.1
Kawata, S.2
Tamura, S.3
Matsuda, Y.4
Inui, Y.5
Yamasaki, E.6
Ishiguro, H.7
Ito, T.8
Matsuzawa, Y.9
-
20
-
-
0029025272
-
Phospninyl-acid-based bi-substrate analog inhibitors of farnesyl protein transferase
-
PATEL, D.V. and 12 OTHERS, Phospninyl-acid-based bi-substrate analog inhibitors of farnesyl protein transferase. J. med. Chem., 38, 435-442 (1995).
-
(1995)
J. Med. Chem.
, vol.38
, pp. 435-442
-
-
Patel, D.V.1
-
21
-
-
0028318136
-
Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
-
PRENDERGAST, G.G., DAVIDE, J.P., DE SOLMS, S.J., GIULIANI, E., GRAHAM, S., GIBBS. J.B., OLIFF, A. and KOHL, N.E., Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol. cell. Biol., 14, 4193-4202 (1994).
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 4193-4202
-
-
Prendergast, G.G.1
Davide, J.P.2
De Solms, S.J.3
Giuliani, E.4
Graham, S.5
Gibbs, J.B.6
Oliff, A.7
Kohl, N.E.8
-
22
-
-
0027213688
-
Inhibitors of Ras farnesyltransterases
-
TAMANOI, E. Inhibitors of Ras farnesyltransterases. Trends biochem. Sci., 18, 349-353 (1993).
-
(1993)
Trends Biochem. Sci.
, vol.18
, pp. 349-353
-
-
Tamanoi, E.1
-
23
-
-
0028912593
-
A non-peptide mimetic of ras-CAAX: Selective inhibition of farnesyltransferase and ras processing
-
VOGT, A., QIAN, Y., BLASTOKOVICH, M.A., FOSSUM, R.D., HAMILTON, A.D. and SEBTI, S.M., A non-peptide mimetic of ras-CAAX: selective inhibition of farnesyltransferase and ras processing. J. biol. Chem., 270, 660-664 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 660-664
-
-
Vogt, A.1
Qian, Y.2
Blastokovich, M.A.3
Fossum, R.D.4
Hamilton, A.D.5
Sebti, S.M.6
|