Inhibition of radiation-induced nuclear factor-κB activation by an anti-Ras single-chain antibody fragment: Lack of involvement in radiosensitization

Cancer Research

Volumn 62, Issue 8, 2002, Pages 2318-2326

  Russell, Jeffery S ^a,b   Raju, Uma ^b   Gumin, Glenice J ^b   Lang, Fredrick F ^b   Wilson, Deborah R ^c   Huet, Thierry ^d   Tofilon, Philip J ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Introgen Therapeutics Inc   (United States)

^d AVANIR PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRICYANIDE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR;

ADENOVIRUS; ARTICLE; CELL KILLING; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIATION INJURY; RADIOSENSITIZATION; TRANSCRIPTION REGULATION;

DNA-BINDING PROTEINS; FIBROBLASTS; GLIOBLASTOMA; HUMANS; I-KAPPA B PROTEINS; IMMUNOGLOBULIN FRAGMENTS; MUTATION; NF-KAPPA B; PHOSPHORYLATION; RADIATION TOLERANCE; RAS PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037089516     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Increasing complexity of the Ras signaling pathway
2. The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation
3. Radioresistance induced by oncogenic transformation
4. Increased radiation resistance in transformed and nontransformed cells with elevated ras proto-oncogene expression
5. Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells
6. Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines
7. The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts
8. Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes
9. Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
10. Radiosensitization of human tumor cell lines induced by the adenovirus-mediated expression of an anti-Ras single-chain antibody fragment
11. Intracellular single chain Fv antibody inhibits Ras activity in T-cell antigen receptor stimulated Jurkat cells
12. Intracellular expression of anti-p21ras single chain Fv fragments inhibits meiotic maturation of Xenopus oocytes
13. Intracellular expression of an antibody fragment-neutralizing p21 ras promotes tumor regression
14. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase
15. Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation
16. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
17. Enhanced radiosensitivity by inhibition of nuclear factor κB activation in human malignant glioma cells
18. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras
19. Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells
20. Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms
21. Inhibition of the transcription factor nuclear factor-κB by adenoviral-mediated expression of IκBαM results in tumor cell death
22. Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-κB: Requirement of Ras/mitogen-activated protein kinases in the activation of NF-κB by oxidants
23. Expression of a dominant-negative mutant of p21(ras) inhibits induction of nitric oxide synthase and activation of nuclear factor-κB in primary astrocytes
24. 2with sulfhydryl groups in HL-60 cells: Zinc-metallothionein and other sites
25. Forman. H. J. Transmembrane redox signaling activates NF-κB in macrophages
26. Control of IκBα proteolysis by site-specific, signal-induced phosphorylation
27. Recombinant IκB kinases α and β are direct kinases of IκBα
28. Proliferation of human malignant astrocytomas is dependent on Ras activation
29. Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras
30. Hypoxic activation of nuclear factor-κB is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2)
31. NF-κB is a target of AKT in anti-apoptotic PDGF signalling
32. Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IκB kinase signalsome activation and IκB proteolysis
33. Understanding Ras, “it ain’t over ’til it’s over”
34. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
35. Separation of oxidant-initiated and redox-regulated steps in the NF-κB signal transduction pathway
36. A redox-triggered ras-effector interaction. Recruitment of phosphatidylinositol 3′-kinase to Ras by redox stress
37. Ras, superoxide and signal transduction
38. Phosphorylation meets ubiquitination: The control of NF-κB activity
39. Role of the IκB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells
40. Ionizing radiation induces expression and binding activity of the nuclear factor κB
41. Induction of nuclear factor κB after low-dose ionizing radiation involves a reactive oxygen intermediate signaling pathway
42. A role for nuclear factor κB in the antiapoptotic function of insulin
43. Insulin-like growth factor-1-mediated neuroprotection against oxidative stress is associated with activation of nuclear factor κB
44. Roles of nuclear factor κB in neuronal survival and plasticity
45. Inhibition of NF-κB, clonogenicity, and radiosensitivity of human cancer cells
46. IKKα controls formation of the epidermis independently of NF-κB
47. Regulation of β-catenin function by the IκB kinases