Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects

Oncogene

Volumn 18, Issue 52, 1999, Pages 7514-7526

  Feldkamp, Matthias M ^a,b   Lau, Nelson ^a   Guha, Abhijit ^a,b,c,d  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Astrocytoma; Farnesyl transferase inhibitor; FTI; Glioma; L 744,832; Ras

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANOSINE TRIPHOSPHATE; PROTEIN BAK; PROTEIN BAX; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P21; PROTEIN TYROSINE KINASE;

ANGIOGENESIS; APOPTOSIS; ARTICLE; ASTROCYTOMA CELL; CANCER GRADING; CELL CYCLE PARAMETERS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSTASIS; GENE MUTATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033539952     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203105     Document Type: Article

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