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Volumn 21, Issue 1, 2000, Pages 113-116

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN;

EID: 0033959438     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.1.113     Document Type: Article
Times cited : (45)

References (33)
  • 1
    • 0028097472 scopus 로고
    • Pharmaceutical research in molecular oncology
    • Gibbs, J.B. and Oliff, A. (1994) Pharmaceutical research in molecular oncology. Cell, 79, 193-198.
    • (1994) Cell , vol.79 , pp. 193-198
    • Gibbs, J.B.1    Oliff, A.2
  • 2
    • 0024376173 scopus 로고
    • ras oncogenes in human cancer: A review
    • Bos, J.L. (1989) ras oncogenes in human cancer: a review. Cancer Res., 49, 4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 5
    • 0023262990 scopus 로고
    • Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
    • Forrester, K., Almoguera, C., Han, K., Grizzle, W.E. and Perucho, M. (1987) Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature, 327, 298-303.
    • (1987) Nature , vol.327 , pp. 298-303
    • Forrester, K.1    Almoguera, C.2    Han, K.3    Grizzle, W.E.4    Perucho, M.5
  • 6
    • 0026680448 scopus 로고
    • Clinical significance of ras oncogene activation in human lung cancer
    • Rodenhuis, S. and Slebos, R.J.C. (1992) Clinical significance of ras oncogene activation in human lung cancer. Cancer Res., 52, 2665s-2669s.
    • (1992) Cancer Res. , vol.52
    • Rodenhuis, S.1    Slebos, R.J.C.2
  • 7
    • 0024406286 scopus 로고
    • All ras proteins are polyisoprenylated but only some are palmitoylated
    • Hancock, J.F., Magee, A.I., Childs, J.E. and Marshall, C.J. (1989) All ras proteins are polyisoprenylated but only some are palmitoylated. Cell, 57, 1167-1177.
    • (1989) Cell , vol.57 , pp. 1167-1177
    • Hancock, J.F.1    Magee, A.I.2    Childs, J.E.3    Marshall, C.J.4
  • 9
    • 0025883047 scopus 로고
    • Dominant inhibitory ras mutants selectively inhibit the activity of either cellular or oncogenic ras
    • Stacey, D.W., Feig, L.A. and Gibbs, G.B. (1991) Dominant inhibitory ras mutants selectively inhibit the activity of either cellular or oncogenic ras. Mol. Cell. Biol., 11, 4053-4064.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 4053-4064
    • Stacey, D.W.1    Feig, L.A.2    Gibbs, G.B.3
  • 11
    • 0026747866 scopus 로고
    • Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
    • Kato, K., Cox, A.D., Hisaka, M.M., Graham, S.M., Buss, J.E. and Der, C.J. (1992) Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc. Natl Acad. Sci. USA, 89, 6403-6407.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 6403-6407
    • Kato, K.1    Cox, A.D.2    Hisaka, M.M.3    Graham, S.M.4    Buss, J.E.5    Der, C.J.6
  • 14
    • 0029135061 scopus 로고
    • Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells
    • James, G.L., Brown, M.S. and Goldstein, J.L. (1995) Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells. Methods Enzymol., 255, 38-46.
    • (1995) Methods Enzymol. , vol.255 , pp. 38-46
    • James, G.L.1    Brown, M.S.2    Goldstein, J.L.3
  • 15
    • 0027213688 scopus 로고
    • Inhibitors of Ras farnesyltransferases
    • Tamanoi, F. (1993) Inhibitors of Ras farnesyltransferases. Trends Biochem. Sci., 18, 349-353.
    • (1993) Trends Biochem. Sci. , vol.18 , pp. 349-353
    • Tamanoi, F.1
  • 16
    • 0028912593 scopus 로고
    • A non-peptide mimetic of Ras-CAAX: Selective inhibition of farnesyltransferase and Ras processing
    • Vogt, A., Qian, Y., Blaskovich, M.A., Fossum, R.D., Hamilton, A.D. and Sebti, S.M. (1995) A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing. J. Biol. Chem., 270, 660-664.
    • (1995) J. Biol. Chem. , vol.270 , pp. 660-664
    • Vogt, A.1    Qian, Y.2    Blaskovich, M.A.3    Fossum, R.D.4    Hamilton, A.D.5    Sebti, S.M.6
  • 17
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesyl:Protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
    • Sepp-Lorenzino, L., Ma, Z., Rands, E., Kohl, N.E., Gibbs, J.B., Oliff, A. and Rosen, N. (1995) A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res., 55, 5302-5309.
    • (1995) Cancer Res. , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3    Kohl, N.E.4    Gibbs, J.B.5    Oliff, A.6    Rosen, N.7
  • 18
    • 0028973293 scopus 로고
    • Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cyloplasmic accumulation of inactive Ras-Raf complexes
    • Lerner, E.C., Qian, Y., Blaskovich, M.A., Fossum, R.D., Vogt, A., Sun, J., Cox, A.D., Der, C.J., Hamilton, A.D. and Sebti, S.M. (1995) Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cyloplasmic accumulation of inactive Ras-Raf complexes. J. Biol. Chem., 270, 26802-26806.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26802-26806
    • Lerner, E.C.1    Qian, Y.2    Blaskovich, M.A.3    Fossum, R.D.4    Vogt, A.5    Sun, J.6    Cox, A.D.7    Der, C.J.8    Hamilton, A.D.9    Sebti, S.M.10
  • 19
    • 0028810275 scopus 로고
    • Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor
    • Lerner, E.C., Qian, Y., Hamilton, A.D. and Sebti, S.M. (1995) Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J. Biol. Chem., 270, 26770-26773.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26770-26773
    • Lerner, E.C.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 20
    • 0029023145 scopus 로고
    • Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion
    • Sun, J., Qian, Y. Hamilton, A.D. and Sebti, S.M. (1995) Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. Cancer Res., 55, 4243-4247.
    • (1995) Cancer Res. , vol.55 , pp. 4243-4247
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 21
    • 0032546264 scopus 로고    scopus 로고
    • Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
    • Sun, J., Qian, Y., Hamilton, A.D. and Sebti, S.M. (1998) Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts. Oncogene, 16, 1467-1473.
    • (1998) Oncogene , vol.16 , pp. 1467-1473
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 22
    • 0024437222 scopus 로고
    • Relationship between formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines
    • Belinsky, S.A., Devereux, T.R., Maronpot, R.R., Stoner, G.D. and Anderson, M.W. (1989) Relationship between formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines. Cancer Res., 49, 5305-5311.
    • (1989) Cancer Res. , vol.49 , pp. 5305-5311
    • Belinsky, S.A.1    Devereux, T.R.2    Maronpot, R.R.3    Stoner, G.D.4    Anderson, M.W.5
  • 23
    • 0028362117 scopus 로고
    • Modulation of azoxymethane induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis
    • Singh, J., Kulkarni, N., Kelloff, G. and Reddy, B.S. (1994) Modulation of azoxymethane induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis. Carcinogenesis, 15, 1317-1323.
    • (1994) Carcinogenesis , vol.15 , pp. 1317-1323
    • Singh, J.1    Kulkarni, N.2    Kelloff, G.3    Reddy, B.S.4
  • 24
    • 0030999105 scopus 로고    scopus 로고
    • Tissue-specific expression of the K-ras allele from the A/J parent in (A/J×TSG-p53) F1 mice
    • Matzinger, S.A., Chen, B., Wang, Y. Crist, K.A., Stoner, G.D., Kelloff, G.J., Lubet, R.A. and You, M. (1997) Tissue-specific expression of the K-ras allele from the A/J parent in (A/J×TSG-p53) F1 mice. Gene, 188, 261-269.
    • (1997) Gene , vol.188 , pp. 261-269
    • Matzinger, S.A.1    Chen, B.2    Wang, Y.3    Crist, K.A.4    Stoner, G.D.5    Kelloff, G.J.6    Lubet, R.A.7    You, M.8
  • 25
    • 0024592908 scopus 로고
    • Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells
    • Tindall, K. and Stankowski, L. (1989) Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells. Mutat. Res., 220, 241-253.
    • (1989) Mutat. Res. , vol.220 , pp. 241-253
    • Tindall, K.1    Stankowski, L.2
  • 26
    • 0028787221 scopus 로고
    • CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza2′deoxycytidine
    • Otterson, G.A., Khleif, S.N., Chen, W., Coxon, A.B. and Kaye, F.J. (1995) CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza2′deoxycytidine. Oncogene, 11, 1211-1216.
    • (1995) Oncogene , vol.11 , pp. 1211-1216
    • Otterson, G.A.1    Khleif, S.N.2    Chen, W.3    Coxon, A.B.4    Kaye, F.J.5
  • 27
    • 0028001112 scopus 로고
    • Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors
    • Herzog, C.R., Wiseman, R.W. and You, M. (1994) Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors. Cancer Res., 54, 4007-4010.
    • (1994) Cancer Res. , vol.54 , pp. 4007-4010
    • Herzog, C.R.1    Wiseman, R.W.2    You, M.3
  • 28
    • 0029150669 scopus 로고
    • Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
    • Kohl, N.E., Omer, C.A., Conner, M.W. et al. (1995) Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nature Med., 1, 792-797.
    • (1995) Nature Med. , vol.1 , pp. 792-797
    • Kohl, N.E.1    Omer, C.A.2    Conner, M.W.3
  • 29
    • 0028958919 scopus 로고
    • Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
    • James, G.L., Goldstein, J.L. and Brown, M.S. (1995) Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. J. Biol. Chem., 270, 6221-6226.
    • (1995) J. Biol. Chem. , vol.270 , pp. 6221-6226
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 30
    • 0030968859 scopus 로고    scopus 로고
    • Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo
    • Rowell, C.A., Kowalczyk, J.J., Lewis, M.D. and Garcia, A.M. (1997) Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo. J. Biol. Chem., 272, 14093-14097.
    • (1997) J. Biol. Chem. , vol.272 , pp. 14093-14097
    • Rowell, C.A.1    Kowalczyk, J.J.2    Lewis, M.D.3    Garcia, A.M.4
  • 31
    • 0030952552 scopus 로고    scopus 로고
    • Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and geranylgeranyltransferase I inhibitor in human tumor cell lines
    • Lerner, E.C., Zhang, T.-T., Knowles, D.B., Qian, Y., Hamilton, A.D. and Sebti, S.M. (1997) Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and geranylgeranyltransferase I inhibitor in human tumor cell lines. Oncogene, 15, 1283-1288.
    • (1997) Oncogene , vol.15 , pp. 1283-1288
    • Lerner, E.C.1    Zhang, T.-T.2    Knowles, D.B.3    Qian, Y.4    Hamilton, A.D.5    Sebti, S.M.6
  • 32
    • 0030943198 scopus 로고    scopus 로고
    • Characterization of Ha-ras, N-ras, Ki-Ras4A and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I
    • Zhang, F.L., Kirschmeier, P., Carr, D., James, L., Bond, R.W., Wang, L., Patton, R., Windsor, W.T., Syto, R., Zhang, R. and Bishop, W.R. (1997) Characterization of Ha-ras, N-ras, Ki-Ras4A and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I. J. Biol. Chem., 272, 10232-10239.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10232-10239
    • Zhang, F.L.1    Kirschmeier, P.2    Carr, D.3    James, L.4    Bond, R.W.5    Wang, L.6    Patton, R.7    Windsor, W.T.8    Syto, R.9    Zhang, R.10    Bishop, W.R.11
  • 33
    • 0030749458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
    • Cox, A.D. and Der, C.J. (1997) Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras? Biochim. Biophys Acta, 1333, F51-F71.
    • (1997) Biochim. Biophys Acta , vol.1333
    • Cox, A.D.1    Der, C.J.2


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