TLR-induced negative regulatory circuits: Role of suppressor of cytokine signaling (SOCS) proteins in innate immunity

Vaccine

Volumn 21, Issue SUPPL. 2, 2003, Pages

  Heeg, Klaus ^a   Dalpke, Alexander ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

SOCS; Suppressor of cytokine signaling; Toll like receptors

Indexed keywords

ALPHA INTERFERON; ANTIGEN; BETA INTERFERON; CILIARY NEUROTROPHIC FACTOR; CYTOKINE; ERYTHROPOIETIN; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH HORMONE; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 9; JANUS KINASE; LEPTIN; LEUKEMIA INHIBITORY FACTOR; LYMPHOCYTE ANTIGEN RECEPTOR; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PATHOGEN ASSOCIATED MOLECULAR PATTERN RECEPTOR; PROLACTIN; REGULATOR PROTEIN; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; THROMBOPOIETIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; IMMUNOREGULATION; MACROPHAGE ACTIVATION; MICROBIAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 0037650188     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(03)00202-0     Document Type: Review

References (62)

1. Medzhitov R., Janeway C.A. Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9:1997;4-9.
2. Kopp E.B., Medzhitov R. The Toll-receptor family and control of innate immunity. Curr. Opin. Immunol. 11:1999;13-18.
3. Medzhitov R., Janeway C. Jr. The Toll receptor family and microbial recognition. Trends Microbiol. 8(10):2000;452-456.
4. Hayashi F., Smith K.D., Ozinsky A.et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 410(6832):2001;1099-1103.
5. Underhill D.M., Ozinsky A. Toll-like receptors: key mediators of microbe detection. Curr. Opin. Immunol. 14:2002;103-110.
6. Dalpke A., Heeg K. Signal Integration following TLR Triggering. Crit. Rev. Immunol. 22(3):2002;217-250.
7. Freudenberg M.A., Salomao R., Sing A., Mitov I., Galanos C. Reconciling the concepts of endotoxin sensitization and tolerance. Prog. Clin. Biol. Res. 397:1998;261-268.
8. Lehner M.D., Morath S., Michelsen K.S., Schumann R.R., Hartung T. Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators. J. Immunol. 166(8):2001;5161-5167.
9. Biron C.A. Interferons alpha and beta as immune regulators - a new look. Immunity. 14(6):2001;661-664.
10. Sun S, Sprent J. Role of type I interferons in T cell activation induced by CpG DNA. Curr Top Microbiol Immunol 2002;247:107-17.
11. Balasubramanian V., Nguyen L.T., Balasubramanian S.V., Ramanathan M. Interferon-γ-inhibitory oligodeoxynucleotides alter the conformation of interferon-γ Mol. Pharmacol. 53(5):1998;926-932.
12. Horng T., Medzhitov R. Drosophila MyD88 is an adapter in the Toll signaling pathway. Proc. Natl. Acad. Sci. USA. 98(22):2001;12654-12658.
13. Yamamoto M., Sato S., Hemmi H.et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 420(6913):2002;324-329.
14. Horng T., Barton G.M., Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2(9):2001;835-841.
15. Fitzgerald K.A., Palsson-McDermott E.M., Bowie A.G.et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 413:2001;78-83.
16. Medzhitov R., Preston-Hurlburt P., Kopp E.et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell. 2:1998;253-258.
17. Muzio M., Natoli G., Saccani S., Levrero M., Mantovani A. The human Toll signaling pathway: divergence of nuclear factor kappa B and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J. Exp. Med. 187:1998;2097-2101.
18. Kawai T., Takeuchi O., Fujita T.et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167(10):2001;5887-5894.
19. Kisseleva T., Bhattacharya S., Braunstein J., Schindler C.W. Signaling through the JAK/STAT pathway. Gene. 285(1-2):2002;1-24.
20. O'Shea J.J., Gadina M., Schreiber R.D. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell. 109:2002;S121-S131.
21. Yasukawa H., Sasaki A., Yoshimura A. Negative regulation of cytokine signaling pathways. Annu. Rev. Immunol. 18:2000;143-164.
22. Myers M.P., Andersen J.N., Cheng A.et al. TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J. Biol. Chem. 276(51):2001;47771-47774.
23. Irie-Sasaki J., Sasaki T., Matsumoto W.et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 409(6818):2001;349-354.
24. Shuai K. Modulation of STAT signaling by STAT-interacting proteins. Oncogene. 19(21):2000;2638-2644.
25. Endo T.A., Masuhara M., Yokouchi M.et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature. 387:1997;921-924.
26. Naka T., Narazaki M., Hirata M.et al. Structure and function of a new STAT-induced STAT inhibitor. Nature. 387:1997;924-929.
27. Starr R., Willson T.A., Viney E.M.et al. A family of cytokine-inducible inhibitors of signalling. Nature. 387:1997;917-921.
28. Hilton D.J., Richardson R.T., Alexander W.S.et al. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA. 95:1998;114-119.
29. Nicholson S.E., Willson T.A., Farley A.et al. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL- 6 signal transduction. EMBO J. 18:1999;375-385.
30. Yasukawa H., Sasaki A., Yoshimura A. Negative regulation of cytokine signaling pathways. Annu. Rev. Immunol. 18:2000;143-164.
31. Matsumoto A., Masuhara M., Mitsui K.et al. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood. 89(9):1997;3148-3154.
32. Naka T., Tsutsui H., Fujimoto M.et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo. Immunity. 14(5):2001;535-545.
33. Auernhammer C.J., Bousquet C., Melmed S. Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc. Natl. Acad. Sci. USA. 96:1999;6964-6969.
34. Gregorieff A., Pyronnet S., Sonenberg N., Veillette A. Regulation of suppressor of cytokine signalling-1 (SOCS-1) expression by translational repression. J. Biol. Chem. 275(28):2000;21596-21604.
35. Schluter G., Boinska D., Nieman-Seyde S.C. Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frame. Biochem. Biophys. Res. Commun. 268(2):2000;255-261.
36. Yasukawa H., Misawa H., Sakamoto H.et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18:1999;1309-1320.
37. Sasaki A., Yasukawa H., Suzuki A.et al. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells. 4(6):1999;339-351.
38. Nicholson S.E., De Souza D., Fabri L.J.et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. USA. 97(12):2000;6493-6498.
39. Sasaki A., Yasukawa H., Shouda T., Kitamura T., Dikic I., Yoshimura A. CIS3/SOCS3 suppresses erythropoietin signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 275(38):2000;29338-29347.
40. Bjorbak C., Lavery H.J., Bates S.H.et al. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275(51):2000;40649-40657.
41. Schmitz J., Weissenbach M., Haan S., Heinrich P.C., Schaper F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem. 275(17):2000;12848-12856.
42. Hansen J.A., Lindberg K., Hilton D.J., Nielsen J.H., Billestrup N. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins. Mol. Endocrinol. 13(11):1999;1832-1843.
43. Cacalano N.A., Sanden D., Johnston J.A. Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras. Nat. Cell Biol. 3(5):2001;460-465.
44. Cohney S.J., Sanden D., Cacalano N.A.et al. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell Biol. 19:1999;4980-4988.
45. Zhang J.G., Farley A., Nicholson S.E.et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA. 96:1999;2071-2076.
46. Verdier F., Chretien S., Muller O.et al. Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein. J. Biol. Chem. 273(43):1998;28185-28190.
47. Starr R., Metcalf D., Elefanty A.G.et al. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1m. Proc. Natl. Acad. Sci. USA. 95:1998;14395-14399.
48. Naka T., Matsumoto T., Narazaki M.et al. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc. Natl. Acad. Sci. USA. 95:1998;15577-15582.
49. Marine J.C., Topham D.J., McKay C.et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell. 98:1999;609-616.
50. Alexander W.S., Starr R., Fenner J.E.et al. SOCS1 is a critical inhibitor of interferon γ signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell. 98:1999;597-608.
51. Metcalf D., Greenhalgh C.J., Viney E.et al. Gigantism in mice lacking suppressor of cytokine signalling-2. Nature. 405(6790):2000;1069-1073.
52. Marine J.C., McKay C., Wang D.et al. SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell. 98(5):1999;617-627.
53. Matsumoto A., Seki Y., Kubo M.et al. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Mol. Cell Biol. 19(9):1999;6396-6407.
54. Boisclair Y.R., Wang J., Shi J., Hurst K.R., Ooi G.T. Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1â on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells. J. Biol. Chem. 275(6):2000;3841-3847.
55. Dalpke A., Opper S., Zimmermann S., Heeg K. Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol. 166(12):2001;7082-7089.
56. Stoiber D., Kovarik P., Cohney S., Johnston J.A., Steinlein P., Decker T. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ J. Immunol. 163:1999;2640-2647.
57. Bode J.G., Ludwig S., Freitas C.A.et al. The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription. Biol. Chem. 382(10):2001;1447-1453.
58. Bode J.G., Nimmesgern A., Schmitz J.et al. LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages. FEBS Lett. 463:1999;365-370.
59. Crespo A., Filla M.B., Russell S.W., Murphy W.J. Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-α/β Biochem. J. 349(Pt 1):2000;99-104.
60. Stoiber D., Stockinger S., Steinlein P., Kovarik J., Decker T. Listeria monocytogenes modulates macrophage cytokine responses through STAT serine phosphorylation and the induction of suppressor of cytokine signaling 3. J. Immunol. 166(1):2001;466-472.
61. Kinjyo I., Hanada T., Inagaki-Ohara K.et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity. 17(5):2002;583-591.
62. Nakagawa R., Naka T., Tsutsui H.et al. SOCS-1 participates in negative regulation of LPS responses. Immunity. 17(5):2002;677-687.