The Toll receptor family and microbial recognition

Trends in Microbiology

Volumn 8, Issue 10, 2000, Pages 452-456

  Medzhitov, Ruslan ^a   Janeway Jr , Charles ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; RECEPTOR; SIGNAL PEPTIDE;

AMINO ACID COMPOSITION; BACTERIAL INFECTION; COMPLEMENT ACTIVATION; DROSOPHILA; EVOLUTION; HOST RESISTANCE; HUMAN; IMMUNE SYSTEM; LIGAND BINDING; MAMMAL CELL; NONHUMAN; PATTERN RECOGNITION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; REVIEW;

ANIMAL; BACTERIA; DROSOPHILA; HUMAN; IMMUNITY, NATURAL; INFECTION; MEMBRANE GLYCOPROTEINS; MICE; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0034307339     PISSN: 0966842X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-842X(00)01845-X     Document Type: Review

References (46)

1. Approaching the asymptote? Evolution and revolution in immunology
2. Phylogenetic perspectives in innate immunity
3. The instructive role of innate immunity in the acquired immune response
4. Innate immunity: impact on the adaptive immune response
5. The collectins in innate immunity
6. The mannose receptor is a pattern recognition receptor involved in host defense
7. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
8. Drosophila Toll and IL-1 receptor
9. A conserved signaling pathway: the Drosophila toll-dorsal pathway
10. Antimicrobial peptide defense in Drosophila
11. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
12. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
13. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
14. Regulated nuclear import of Rel proteins in the Drosophila immune response
15. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
16. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
17. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
18. The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
19. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
20. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
21. TRAF6 is a signal transducer for interleukin-1
22. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
23. The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling
24. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
25. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
26. Cutting edge: cells that carry a null allele for toll-like receptor 2 are capable of responding to endotoxin
27. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
28. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
29. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
30. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the LPS gene product
31. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
32. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
33. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
34. Activation of human monocytic cells by Borrelia burgdorferi and Treponema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins
35. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
36. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
37. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
38. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2
39. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
40. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
41. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
42. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors
43. Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
44. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
45. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
46. Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation