Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

Nature Cell Biology

Volumn 3, Issue 5, 2001, Pages 460-465

  Cacalano, Nicholas A ^a   Sanden, David ^a   Johnston, James A ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR; ERYTHROPOIETIN; GROWTH FACTOR; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN INHIBITOR; PROTEIN P120; RAS PROTEIN; STAT PROTEIN; TYROSINE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; MUTANT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STIMULATION;

3T3 CELLS; AMINO ACID MOTIFS; ANIMALS; BLOTTING, WESTERN; CELL DIVISION; CELL LINE; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; ERYTHROPOIETIN; HUMANS; INTERLEUKIN-2; MICE; MILK PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; P120 GTPASE ACTIVATING PROTEIN; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RAS PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; STAT5 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; THYMIDINE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TYROSINE;

EID: 0035006109     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35074525     Document Type: Article

References (24)

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3. A new protein containing an SH2 domain that inhibits JAKkinases
4. Twenty proteins containing a C-terminal SOCS box form five structural classes
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16. SH2 domains recognize specific phosphopeptide sequences
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