The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription

Biological Chemistry

Volumn 382, Issue 10, 2001, Pages 1447-1453

  Bode, J G ^a   Ludwig, S ^a   Correia Freitas, C A ^a   Schaper, F ^a   Ruhl, M ^a   Melmed, S ^a   Heinrich, P C ^a   Haussinger D ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Cytokines; Genes regulation; Inflammation; Signal transduction

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA 2 MACROGLOBULIN; BINDING PROTEIN; CYTOKINE; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME ACTIVATION; GENE CONSTRUCT; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARCINOMA, HEPATOCELLULAR; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; INTERLEUKIN-6; MAP KINASE KINASE 6; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS (GENETICS); PROTEINS; PYRIDINES; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0035168326     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2001.178     Document Type: Article

References (30)

1. Inhibition of IL-6 and IL-10 signaling and STAT activation by inflammatory and stress pathways
2. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
3. Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector
4. Autoregulation of pituitary corticotroph SOCS-3 expression: Characterization of the murine SOCS-3 promoter
5. The biological effects of interleukin-6
6. The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway
7. The mitogen-activated protein (MAP) kinase p38 and its upstream activator MAP kinase kinase 6 are involved in the activation of signal transducer and activator of transcription by hyperosmolarity
8. LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
9. A new protein containing an SH2 domain that inhibits JAK kinases
10. Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter
11. Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
12. Interleukin-6-type cytokine signaling through the gp130/Jak/STAT pathway
13. Negative regulators of cytokine signal transduction
14. raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580
15. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
16. 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways
17. The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway
18. Structure and function of a new STAT-induced STAT inhibitor
19. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
20. Activation of SHP2 via the IL-6 signal transducing receptor protein gp130 requires JAK1 and limits acute-phase protein expression
21. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
22. A family of cytokine-inducible inhibitors of signalling
23. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma
24. gp130 and the interleukin-6 family of cytokines
25. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
26. Soluble human interleukin-6 receptor. Expression in insect cells, purification and characterization
27. Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level
28. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
29. Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3