Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

Genes to Cells

Volumn 4, Issue 6, 1999, Pages 339-351

  Sasaki, Atsuo ^a   Yasukawa, Hideo ^a   Suzuki, Asuka ^a   Kamizono, Shintaro ^a   Syoda, Takanori ^a   Kinjyo, Ichiko ^a   Sasaki, Mika ^a   Johnston, James A ^b   Yoshimura, Akihiko ^a  

^a KURUME UNIVERSITY   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ENZYME ACTIVATION; HUMANS; JANUS KINASE 2; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION FACTORS;

EID: 0032803530     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1999.00263.x     Document Type: Article

References (27)

1. Adams, T.E., Hansen, J.A., Starr, R., Nicola, N.A., Hilton, D.J. & Billestrup, N. (1998) Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273, 1285-1287.
2. Becker, S., Groner, B. & Muller, C.W. (1998) Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 394, 145-151.
3. Bjorbaek, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E. & Flier, J.S. (1998) Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 4, 619-625.
4. Chen, X., Vinkemeier, U., Zhao, Y., Jeruzalmi, D., Darnell, J.E. Jr & Kuriyan, J. (1998) Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93, 827-839.
5. Darnell, J.E. Jr (1997) STATs & gene regulation. Science 277, 1630-1635.
6. Endo, T.A., Masuhara, M., Yokouchi, M., et al. (1997) A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387, 921-924.
7. Feng, J., Witthuhn, B.A., Matsuda, T., Kohlhuber, F., Kerr, I.M. & Ihle, J.N. (1997) Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell. Biol. 17, 2497-2501.
8. He, W., Rose, D.W., Olefsky, J.M. & Gustafson, T.A. (1998) Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains. J. Biol. Chem. 273, 6860-6867.
9. Helman, D., Sandowski, Y., Cohen, Y., et al. (1998) Cytokine-inducible SH2 protein (CIS3) and JAK2 binding protein (JAB) abolish prolactin receptor-mediated STATS signaling. FEBS Lett. 441, 287-291.
10. Hilton, D.J., Richardson, R.T., Alexander, W.S., et al. (1998) Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA 95, 114-119.
11. Ihle, J.N. (1995) Cytokine receptor signaling. Nature 377, 591-594.
12. Ihle, J.N. (1996) STATs: Signal transducers and activators of transcription. Cell 84, 331-334.
13. Kasus-Jacobi, A., Perdereau, D., Auzan, C., et al. (1998) Identification of the rat adapter Grb14 as an inhibitor of insulin actions. J. Biol. Chem. 273, 26026-26035.
14. Masuhara, M., Sakamoto, H., Matsumoto, A., et al. (1997) Cloning and characterization of Nnvel CIS family genes. Biochem. Biophys. Res. Commun. 239, 439-446.
15. Matsumoto, A., Masuhara, M., Mitsui, K., et al. (1997) CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STATS activation. Blood 89, 3148-3154.
16. Minamoto, S., Ikegame, K., Ueno, K., et al. (1997) Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem. Biophys. Res. Commun. 237, 79-83.
17. Naka, T., Narazaki, M., Hirata, M., et al. (1997) Structure and function of a new STAT-induced STAT inhibitor. Nature 387, 924-929.
18. Nicholson, S.E., Willson, T.A., Farley, A., et al. (1999) Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18, 375-385.
19. O'Shea, J.J. (1997) Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? Immunity 7, 1-11.
20. Sakamoto, H., Yasukawa, H., Masuhara, M., et al. (1998) A Janus kinase inhibitor, JAB, is an interferon-γ inducible gene and confers resistance to interferons. Blood 92, 1668-1676.
21. Starr, R., Metcalf, D., Elefanty, A.G., et al. (1998) Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. USA 95, 14395-14399.
22. Starr, R., Willson, T.A., Viney E.M., et al. (1997) A family of cytokine-inducible inhibitors of signalling. Nature 387, 917-921.
23. Suzuki, R., Sakamoto, H., Yasukawa, H., et al. (1998) CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in Ml leukemia cells. Oncogene 17, 2271-2278.
24. Yasukawa, H., Misawa, H., Sakamoto, H., et al. (1999) The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18, 1309-1320.
25. Yoshimura, A. (1998) The CIS/JAB family: novel negative regulators of JAK signaling pathways. Leukemia 12, 1851-1857.
26. Yoshimura, A., D'Andrea, A.D. & Lodish, H.F. (1990) Friend spleen focus forming virus glycoprotein gp55 interacts with erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism. Proc. Natl. Acad. Sci. USA 87, 4139-4143.
27. Yoshimura, A., Ohkubo, T., Kiguchi, T., et al. (1995) A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14, 2816-2826.