Interferon-γ-inhibitory oligodeoxynucleotides alter the conformation of interferon-γ

Molecular Pharmacology

Volumn 53, Issue 5, 1998, Pages 926-932

  Balasubramanian, Vandana ^a   Nguyen, Linh T ^a   Balasubramanian, Sathyamangalam V ^a   Ramanathan, Murali ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; OLIGODEOXYNUCLEOTIDE;

ARTICLE; DRUG MECHANISM; INFLAMMATION; INTERFERON PRODUCTION; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

CIRCULAR DICHROISM; EPITOPES; INTERFERON TYPE II; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN CONFORMATION; PROTEIN DENATURATION; SPECTROMETRY, FLUORESCENCE;

EID: 0031750415     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Alfa MJ and Jay FT (1988) Distinct domains of recombinant human IFN-γ responsible for anti-viral effector function. J Immunol 141:2474-2479.
2. Aloj SM, Edelhoch H, Ingham KC, Morgan FJ, Canfield RE, and Ross GT (1973) The rates of dissociation and reassociation of the subunits of human chorionic gonadotropin. Arch Biochem Biophy 159:497-504.
3. Bock LC, Griffin LC, Latham JA, Vermaas EH, and Toole JJ (1992) Selection of single-stranded DNA molecules that bind and inhibit human thrombin. Nature (Lond) 355:564-566.
4. Daubener W, Nockemann S, Gutsche M, and Hadding U (1995) Heparin inhibits the antiparasitic and immune modulatory effects of human recombinant interferon-γ. Eur J Immunol 25:688-692.
5. Douglas MS, Rix DA, Dark JH, Talbot D, and Kirby JA (1997) Examination of the mechanism by which heparin antagonizes activation of a model endothelium by interferon-γ (IFN-gamma). Clin Exp Immunol 107:578-584.
6. Ealick SE, Cook WJ, Vijay-Kumar S, Carson M, Nagabhushan TL, Trotta PP, and Bugg CE (1991) Three-dimensional structure of recombinant human interferon-γ. Science (Washington DC) 252:698-702.
7. Fasman GD (1993) Distinguishing transmembrane helices from peripheral helices by circular dichroism. Biotech Appl Biochem 18:111-138.
8. Fedoseyeva EV, Li Y, Huey B, Tam S, Hunt CA, Benichou G, and Garovoy MR (1994) Inhibition of interferon-γ-mediated immune functions by oligonucleotides. Suppression of human T cell proliferation by downregulation of IFN-gamma-induced ICAM-1 and Fc-receptor on accessory cells. Transplantation 57:606-612.
9. Gao WY, Han FS, Storm C, Egan W, and Cheng YC (1992) Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: implications for antisense technology. Mol Pharmacol 41:223-229.
10. Hogrefe HH, McPhie P, Bekisz JB, Enterline JC, Dyer D, Webb DS, Gerrard TL, and Zoon KC (1989) Amino terminus is essential to the structural integrity of recombinant human interferon-γ. J Biol Chem 264:12179-12186.
11. Jellinek D, Green LS, Bell C, and Janjic N (1994) Inhibition of receptor binding by high-affinity RNA ligands to vascular endothelial growth factor. Biochemistry 33:10450-10456.
12. Jellinek D, Lynott CK, Rifkin DB, and Janjic N (1993) High-affinity RNA ligands to basic fibroblast growth factor inhibit receptor binding. Proc Natl Acad Sci USA 90:11227-11231.
13. Lee PP, Ramanathan M, Hunt CA, and Garovoy MR (1996) An oligonucleotide blocks interferon-γ signal transduction. Transplantation 62:1297-1301.
14. Lortat-Jacob H, Baltzer F, and Grimaud JA (1996) Heparin decreases the blood clearance of interferon-γ and increases its activity by limiting the processing of its carboxyl-terminal sequence. J Biol Chem 271:16139-16143.
15. Lortat-Jacob H, Kleinman HK, and Grimaud JA (1991) High-affinity binding of interferon-γ to a basement membrane complex (matrigel). J Clin Invest 87:878-883.
16. Lortat-Jakob H and Grimaud JA (1991) Interferon-gamma C-terminal function: new working hypothesis. Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity. Cell Mol Biol 37:253-260.
17. Lortat-Jakob H and Grimaud JA (1992) Binding of interferon-gamma to heparin sulfate is restricted to the heparin-like domains and involves carboxylic-but not N-sulfated-groups. Biochim Biophys Acta 1117:126-130.
18. Macaya RF, Schultze P, Smith FW, Roe JA, and Feigon J (1993) Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution. Proc Natl Acad Sci USA 90:3745-3749.
19. Merz WE (1988) Evidence for impaired subunit interaction in chemically deglycosylated human choriogonadotropin. Biochem Biophys Res Commun 156: 1271-1278.
20. Ojwang J, Elbaggari A, Marshall HB, Jayaraman K, McGrath MS, and Rando RF (1994) Inhibition of human immunodeficiency virus type 1 activity in vitro by oligonucleotides composed entirely of guanosine and thymidine. J Acquir Immune Defic Syndr 7:560-570.
21. Padmanabhan K, Padmanabhan KP, Ferrara JD, Sadler JE, and Tulinsky A (1993) The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer. J Biol Chem 268:17651-17654.
22. Perczel A, Hollosi M, Tusnady G, and Fasman GD (1991) Convex constraint analysis: a natural deconvolution of circular dichroism curves of proteins. Protein Eng 4:669-679.
23. Perczel A, Park K, and Fasman GD (1992) Analysis of the circular dichroism spectrum of proteins using the convex constraint algorithm: a practical guide. Anal Biochem 203:83-93.
24. Ramanathan M, Lantz M, MacGregor RD, Garovoy MR, and Hunt CA (1994) Characterization of the oligodeoxynucleotide-mediated inhibition of interferon-γ-induced major histocompatibility complex class I and intercellular adhesion molecule-1. J Biol Chem 269:24564-24574.
25. Ramanathan M, Lantz M, MacGregor RD, Huey B, Tam S, Li Y, Garovoy MR, and Hunt CA (1994) Inhibition of interferon-γ-induced major histocompatibility complex class I expression by certain oligodeoxynucleotides. Transplantation 57:612-615.
26. Rando RF, Ojwang J, Elbaggari A, Reyes GR, Tinder R, McGrath MS, and Hogan ME (1995) Suppression of human immunodeficiency virus type 1 activity in vitro by oligonucleotides which form intramolecular tetrads. J Biol Chem 270:1754-1760.
27. Rider C (1993) Many cytokines and interleukins bind to glycosaminoglycans (letter). Immunol Today 14:615.
28. Schultze P, Macaya RF, and Feigon J (1994) Three-dimensional solution structure of the thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG). J Mol Biol 235: 1532-1547.
29. Seelig GF, Prosise WW, and Taremi SS (1994) Synthetic mimics of juxtaposed amino-and carboxyl-terminal peptide domains of human γ interferon block ligand binding to human γ interferon receptor. J Biol Chem 269:358-363.
30. Stein CA (1995) Does antisense exist? Nature Medicine 1:1119-1121.
31. Sylvester DM, Liu SY, and Meadows GG (1990) Augmentation of antimetastatic activity of Interferon and tumor necrosis factor by heparin. Immunopharmacol Immunotoxicol 12:161-180.
32. Tam S, Huey B, Li Y, Lui GM, Hwang DG, Lantz M, Weiss TL, Hunt CA, and Garovoy MR (1994) Suppression of interferon-γ induction of MHC class II and ICAM-1 by a 26-base oligonucleotide composed of deoxyguanosine and deoxythymidine. Transplant Immunology 2:285-292.
33. Tanaka Y, Adams DH, and Shaw S (1993) Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes. Immunol Today 14:111-115.