The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression

Blood

Volumn 95, Issue 5, 2000, Pages 1652-1655

  Anderson, Kathleen P ^a   Crable, Scott C ^a   Lingrel, Jerry B ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROID KRUPPEL LIKE FACTOR; GLOBIN; TRANSCRIPTION FACTOR GATA 1; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSFECTION; GLOBIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

EID: 0034161310     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.5.1652.005k23_1652_1655     Document Type: Article

References (38)

1. Miller IJ, Bieker JJ. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol. 1993;13:2776.
2. Anderson KP, Kern CB, Crable SC, Lingrel JB. Isolation of a gene encoding a functional zinc finger protein homologous to EKLF: identification of a new multigene family. Mol Cell Biol. 1995;15: 5957.
3. Crossley M, Whitelaw E, Perkins A, Williams G, Fujiwara Y, Orkin SH. Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol Cell Biol. 1996;16:1695.
4. Shields JM, Christy RJ, Yang VW. Identification and characterization of a gene encoding a gutenriched Kruppel-like factor expressed during growth arrest. J Biol Chem. 1996;271:20,009.
5. Garrett-Sinha LA, Eberspaecher H, Seldin MF, de Crombrugghe B. A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem. 1996;271:31,384.
6. Conkright MD, Wani MA, Anderson KP, Lingrel JB. A gene encoding an intestinal-enriched member of the Kruppel-like factor gamely expressed in intestinal epithelial cells. Nucl Acids Res. 1999;27:1263.
7. Koritschoner NP, Bocco JL, Panzetla-Dutari GM, Dumur CI, Flury A, Patrito LC. A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. J Biol Chem. 1997;272:9573.
8. Matsumoto N, Laub F, Aldabe R, et al. Cloning the cDN A for a new human zinc finger protein defines a group of closely related Kruppel-like transcription factors. J Biol Chem. 1998;273:28,229.
9. Asano H, Li XS, Stamatoyannopoulos G. FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes. Mol Cell Biol. 1999;19:3571.
10. Imataka H, Sogawa K, Yasumoto K, et al. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. EMBO J. 1992;11:3663.
11. Fautsch MP, Vrabel A, Rickard D, Subramaniam M, Spelsberg TC, Wieben ED. Characterization of the mouse TGFbeta-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts. Mamm Genome. 1998;9:838.
12. Cook T, Gebelein B, Mesa K, Mladek A, Urrutia R. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. J Biol Chem. 1998;273:25,929.
13. Imhof A, Schuierer M, Werner O, et al. Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. Mol Cell Biol. 1999;19:194.
14. Southwood CM, Downs KM, Bieker JJ. Erythroid Kruppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev Dyn. 1996;206:248.
15. Perkins AC, Sharpe AH, Orkin SH. Letal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995;375:318.
16. Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature. 1995;375:316.
17. Donze D, Townes TM, Bieker JJ. Role of erythroid Kruppel-like factor in human γ-to-β gene switching. J Biol Chem. 1995;270:1955.
18. Bieker JJ, Southwood CM. The erythroid Kruppel-like factor transactivation domain is a critical component for cell-specific inducibility of a β-globin promoter. Mol Cell Biol. 1995;15:852.
19. Wijgerde M, Gribnau J, Nuez B, Philipsen S, Grosveld F, Fraser P. The role of EKLF in human β-globin gene competition. Genes Dev. 1997;10:2894.
20. Anderson KP, Crable SC, Lingrel JB. A multi-protein complex binding to a GATA-E-box-GATA motif regulates the erythroid Kruppel-like factor (EKLF) gene. J Biol Chem, 1998;273:14,347.
21. Valge-Archer VE, Osada H, Warren A, et al. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc Natl Acad Sci U S A. 1994;91:8617
22. Osada H, Grutz G, Axelson H, Forster A, Rabbits TH. Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc Natl Acad Sci U S A. 1995;92:9585.
23. Wadman IA, Osada H, Grutz GG, et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1, and Ldb1/NL1 proteins. EMBO J. 1997;16:3145.
24. Begley CG, Green AR. The SCL gene: from case report to critical hematopoietic regulator. Blood. 1999;93:2760.
25. Vyas P, McDevitt MA, Cantor AB, Katz SG, Fujiwara Y, Orkin SH. Different sequence requirements for expression in erythroid and megakaryocylic cells within a regulatory element upstream of the GATA-1 gene. Development. 1999;126:2799.
26. Rabbitts TH. Chromosomal translocations in human cancer. Nature. 1994;372:143.
27. Baer R. TAL1, TAL2, and LYL1 : a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia. Semin Cancer Biol. 1993;4:341.
28. Boehm T, Foroni L, Kennedy M, Rabbitts TH. The rhombotin gene belongs to a class of transcriptional regulators with a potential novel protein dimerisation motif. Oncogene. 1990;5:1103.
29. Rabbitts TH, Boehm T. LIM domains. Nature. 1990;46:418.
30. Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A. 1997;94:13,707.
31. Warren AJ, Colledge WH, Carlton MBL, Evans MJ, Smith AJH, Rabbitts TH. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell. 1994;78:45.
32. Shivdasani RA, Mayer E, Orkin SH. Absence of blood formation in mice lacking the T-cell leukemia oncoprotein tal-1/SCL. Nature. 1995;373:432.
33. Robb L, Lyons I, Li R, et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995;92:7075.
34. Pevny L, Simon MC, Robertson E, et al. Erythroid differentiation in chimeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 1991;349:257-260.
35. Simon MC, Pevny L, Wiles M, Keller G, Costantini F, Orkin SH. Rescue of erythroid development in gene targeted GATA-1 mouse embryonic stem cells. Nat Genet. 1992;1:92-98.
36. Hagen B, Constantini F, Lacy E. Manipulating the Mouse Embryo. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1986.
37. Chen X, Reitman M, Bieker JJ. Chromatin structure and transcriptional control elements of the erythroid Kruppel-like factor (EKLF) gene. J Biol Chem. 1998;273:25,031.
38. Weiss MJ, Yu C, Orkin SH. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol Cell Biol. 1997;17:1642.