Active site-directed antibodies identify calpain II as an early- appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease

Brain Research

Volumn 763, Issue 2, 1997, Pages 145-158

  Grynspan, F ^a,b   Griffin, W R ^a,b   Cataldo, A ^a,b   Katayama, S ^c   Nixon, R A ^a,b  

^a Mailman Research Center   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

Alzheimer's disease; Calcium; Calcium activated neutral proteinase; Calpain antibody; Cytoskeleton; Neurofibrillary tangle

Indexed keywords

CALCIUM; CALPAIN; PROTEIN KINASE; PROTEINASE;

ALZHEIMER DISEASE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CALCIUM HOMEOSTASIS; CYTOSKELETON; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; NEUROFIBRILLARY TANGLE; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ALZHEIMER DISEASE; ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; BINDING SITES; CALPAIN; CYTOSKELETON; FEMALE; HUMANS; NERVE DEGENERATION; NEUROFIBRILLARY TANGLES; PROTEIN STRUCTURE, TERTIARY; RABBITS;

EID: 0030836467     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00384-3     Document Type: Article

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