The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 11, 1996, Pages 5472-5477

  Mourelatos, Zissimos ^a   Gonatas, Nicholas K ^a   Stieber, Anna ^a   Gurney, Mark E ^b   Dal Canto, Mauro C ^c  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b PFIZER INC   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; SUPEROXIDE DISMUTASE; ZINC;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; ARTICLE; CELL ORGANELLE; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENE MUTATION; GOLGI COMPLEX; MISSENSE MUTATION; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SPINAL CORD MOTONEURON; TRANSGENIC MOUSE;

AGING; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; GOLGI APPARATUS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MICROSCOPY, IMMUNOELECTRON; MOTOR NEURONS; MUTATION; RECOMBINANT PROTEINS; SPINAL CORD; SUPEROXIDE DISMUTASE; VACUOLES;

ANIMALIA; MUS MUSCULUS;

EID: 0029890685     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.11.5472     Document Type: Article

References (49)

1. Charcot, J.-M. (1874) Prog. Med. 2, 325-327.
2. Oppenheimer, D. R. & Esiri, M. M. (1992) in Greenfield's Neuropathology, eds. Adams J. H. and Duchen L. W. (University, New York), pp. 988-1045.
3. Hirano A., Kurland L. T. & Sayre G. F. (1967) Arch. Neurol. 16, 232-243.
4. Siddique, T., Pericak-Vance, M. A., Brooks, B. R., Roos, R. P., Hung, W.-Y., Antel, J. P., Munsat, T. L., Phillips, K., Warner, K., Speer, M., Bias, W. B., Siddique, N. A. & Roses, A. D. (1989) Neurology 39, 919-925.
5. Siddique, T., Figlewicz, D. A., Pericak-Vance, M. A., Haines, J. L., Rouleau, G., Jeffers, A. J., Sapp, P., Hung, W.-Y., Bebout, J., McKenna-Yasek, D., Deng, G., Horvitz, H. R., Gusella, J. F., Brown, R. H. & Roses, A. D. (1991) New Engl. J. Med. 324, 1381-1384.
6. Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., et al. (1993) Nature (London) 362, 59-62.
7. Crapo, J. D., Oury, T., Rabouille, C., Slot, J. W. & Chang. L.-Y. (1992) Proc. Nat. Acad. Sci. USA 89, 10405-10409.
8. Tainer, J. A., Getzoff, E. D., Beem, K. M., Richardson, J. S. & Richardson, D. C. (1982) J. Mol. Biol. 160, 181-217.
9. Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H-X., Chen, W., Zhai, P., Sufit, R. L. & Siddique, T. (1994) Science 264, 1772-1775.
10. Dal Canto, M. C. & Gurney, M. E. (1994) Am. J. Pathol. 145, 1271-1280.
11. Dal Canto, M. C. & Gurney, M. E. (1995) Brain Res. 676, 25-40.
12. Chiu, A. Y., Zhai P., Dal Canto, M. C., Peters, T. M., Kwon Y. W., Prattis S. M. & Gurney, M. E. (1995) Mol. Cell Neurosci. 6, 349-362.
13. Wong, P. C., Pardo, C. A., Borchelt, D. R., Lee, M. K., Copeland N. G., Jenkins N. A., Sisodia, S. S., Cleveland, D. W. & Price, D. L. (1995) Neuron 14, 1105-1116.
14. Mourelatos, Z., Adler, H., Hirano, A., Donnenfeld, H., Gonatas, J. O. & Gonatas, N. K. (1990) Proc. Natl. Acad. Sci. USA 87, 4393-4395.
15. Gonatas, N. K., Stieber, A., Mourelatos, Z., Chen, Y., Gonatas, J. O., Appel, S. H., Hays, A. P., Hickey, W. F. & Hauw, J.-J. (1992) Am. J. Pathol. 140, 731-737.
16. Mourelatos, Z., Yachnis, A., Rorke, L., Mikol, J. & Gonatas, N. K. (1993) Ann. Neurol. 33, 608-615.
17. Mourelatos, Z., Hirano, A., Rosenquist, A. & Gonatas, N. K. (1994) Am. J. Pathol. 144, 1288-1300.
18. Gonatas, N. K. (1994) Am. J. Pathol. 145, 751-761.
19. Gonatas, J. O., Mezitis, S. G. E., Stieber, A., Fleischer, B. & Gonatas, N. K. (1989) J. Biol. Chem. 264, 646-653.
20. Gonatas, J. O., Mourelatos, Z., Stieber, A., Lane, W. S., Brosius, J. & Gonatas, N. K.(1995) J. Cell Sci. 108, 457-467.
21. Mourelatos, Z., Gonatas, J. O., Nycum, L. M., Gonatas, N. K. & Biegel, J. A. (1995) Genomics 28, 354-355.
22. Stieber, A., Mourelatos, Z., Chen, Y.-J., Le Douarin, N. & Gonatas, N. K. (1995) Exp. Cell Res. 219, 562-570.
23. Robbins, E. & Gonatas, N. K. (1964) J. Histochem. Cytochem. 12, 704-711.
24. Turner, J. R. & Tartakoff, A. M.(1989) J. Cell Biol. 109, 2081-2088.
25. Matsumoto, S., Goto, S., Kusaka, H., Imai, T., Murakami, N., Hashizume, Y., Okazaki, H. & Hirano, A. (1993) J. Neurol. Sci. 115, 208-213.
26. Lacy, P. E., Howell, S. L., Young, D. A. & Fink, C. J. (1968) Nature (London) 219, 1177-1179.
27. Antoine, J. C., Maurice, M., Feldman, G. & Avrameas, S. (1980) J. Immunol. 125, 1939-1949.
28. Redman, C. M., Banerjee, D., Howell, K. & Palade, G. E. (1975) J. Cell Biol. 66, 42-59.
29. Farquhar, M. G. & Palade, G. (1981) J. Cell Biol. 91 (Suppl.), 77s-103s.
30. Farquhar, M. G. (1985) Annu. Rev. Cell. Biol. 1, 447-488.
31. Hammerschlag, R., Stone, G. C., Bolen, F. A., Lindsay, J. D. & Ellisman, M. H. (1982) J. Cell Biol. 93, 568-575.
32. Croul, S., Mezitis, S. G. E., Stieber, A., Chen, Y.-J., Gonatas, J. O., Goud, G. & Gonatas, N. K. (1990) J. Histochem. Cytochem. 38, 957-963.
33. Brown, W. J. & Farquhar, M. G. (1989) Methods Cell Biol. 31, 553-569.
34. Yim, M. B., Chock, P. B. & Stadman, E. R. (1990) Proc. Natl. Acad. Sci. USA 87, 5006-5010.
35. Beckman, J. S., Carson, M., Smith, C. D., Koppenol & W. H. (1993) Nature (London) 364, 584.
36. Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. & Beckman, J. S. (1992) Arch. Biochem. Biophys. 298, 431-437.
37. Karecla, P. I. & Kteis, T. E. (1992) Eur. J. Cell Biol. 57, 139-146.
38. Pavelka, M. & Ellinger, A. (1983) J. Cell Biol. 97, 737-748.
39. Misteli, T. & Warren, G. (1995) J. Cell Sci. 108, 2715-2727.
40. Johnston, P. A., Stieber, A. & Gonatas, N. K. (1994) J. Cell Sci. 107, 529-537.
41. Martinez, O., Schmidt, A., Salamero, J., Hoflack, B., Roa, M. & Goud, B. (1994) J. Cell Biol. 127, 1575-1588.
42. Miesenbock, G. & Rothman, J. E. (1995) J. Cell Biol. 129, 309-319.
43. Lippincot-Schwartz, J., Cole, N. B., Marotta. A., Conrad, P. A. & Bloom, G. S. (1995) J. Cell Biol. 128, 293-306.
44. Doms, R. W., Russ, G. & Yewdell, J. W. (1989) J. Cell Biol. 109, 893-899.
45. Lippincot-Scwartz, J., Yuan, L. C., Bonnifacino, J. S. & Klausner, R. D. (1989) Cell 56, 821-836.
46. Robbins, E. & Gonatas, N. K. (1964) J. Cell Biol. 21, 429-463.
47. Komai, K., Wang, H. S., Bauserman, S. C. & Chou, S. M. (1995) J. Neuropathol. Exp. Neurol. 54, 454 (abstr.).
48. Hirano, A. (1991) in Advances in Neurology: Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases, ed. Rowland, L. P., (Raven, New York), pp. 91-101.
49. Hirano, A. & Kato, S. (1992) in Handbook of Amyotrophic Lateral Sclerosis, ed. Smith, R. A., (Dekker, New York), pp. 183-192.