Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

Acta Neuropathologica

Volumn 96, Issue 5, 1998, Pages 445-452

  Wakabayashi, Koichi ^a   Hayashi, Shintaro ^a   Kakita, Akiyoshi ^a   Yamada, Mitsunori ^a   Toyoshima, Yasuko ^a   Yoshimoto, Makoto ^b   Takahashi, Hitoshi ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

synuclein; Lewy body; Multiple system atrophy; NACP; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; ANTIBODY; CELL PROTEIN; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; AUTOPSY; CELL INCLUSION; CELL NUCLEUS INCLUSION BODY; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOPATHOLOGY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOREACTIVITY; LEWY BODY; MAJOR CLINICAL STUDY; MOTOR NEURON DISEASE; NERVE CELL DEGENERATION; OLIGODENDROGLIA; PERIPHERAL NERVOUS SYSTEM; PICK PRESENILE DEMENTIA; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; SHY DRAGER SYNDROME; SUBSTANTIA NIGRA;

ALPHA-SYNUCLEIN; CELL AGING; HUMANS; IMMUNOHISTOCHEMISTRY; LEWY BODIES; MICROSCOPY, IMMUNOELECTRON; MULTIPLE SYSTEM ATROPHY; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NERVOUS SYSTEM DISEASES; PARKINSON DISEASE; SYNUCLEINS;

EID: 0031715399     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050918     Document Type: Article

References (55)

1. Arima K, Murayama S, Mukoyama M, Inose T (1992) Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy. 1. Neuronal cytoplasmic inclusions. Acta Neuropathol 83: 453-460
2. Baba M, Nakajo S, Tu P-H, Tomita T, Nakaya K, Lee VM-Y, Trojanowski JQ, Iwatsubo T (1998) Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 152: 879-884
3. Cairns NJ, Atkinson PF, Hanger DP, Anderton BH, Daniel SE, Lantos PL (1997) Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease. Neurosci Lett 230: 49-52
4. Churchyard A, Lees AJ (1997) The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease. Neurology 49: 1570-1576
5. Dale GE, Probst A, Luthert P, Martin J, Anderton BH, Leigh PN (1992) Relationship between Lewy bodies and pale bodies in Parkinson's disease. Acta Neuropathol 83: 525-529
6. Dickson DW, Wertkin A, Kress Y, Ksiezak-Reding H, Yen S-H (1990) Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects. Lab Invest 63: 87-99
7. Dickson DW, Ruan D, Crystal H, Mark MH, Davies P, Kress Y, Yen S-H (1991) Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology 41: 1402-1409
8. Dickson DW, Schmidt ML, Lee VM-Y, Zhao M-L, Yen S-H, Trojanowski JQ (1994) Immunoreactivity profile of hippocampal CA2/3 neurites in diffuse Lewy body disease. Acta Neuropathol 87: 269-276
9. Fearnley JM, Lees AJ (1991) Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 114: 2283-2301
10. Forno LS (1969) Concentric hyaline intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases): relationship to parkinsonism. J Am Geriatr Soc 17: 557-575
11. Hayashi S, Wakabayashi K, Ishikawa A, Nagai H, Takahashi H (1997) Autosomal dominant juvenile dystonia-parkinsonism. Brain Pathol 7: 1115
12. Hayashi Y, Kakita A, Yamada M, Egawa S, Oyanagi S, Naito H, Tsuji S, Takahashi H (1998) Hereditary dentatorubral-pallidoluysian atrophy: ubiquitinated filamentous inclusions in the cerebellar dentate nucleus neurons. Acta Neuropathol 95: 479-482
13. Hirano A, Kurland LT, Sayre GP (1967) Familial amyotrophic lateral sclerosis. A subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cells. Arch Neurol 16: 232-243
14. Irizarry MC, Growdon W, Gomez-Isla T, Newell K, George JM, Clayton DF, Hyman BT (1998) Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity. J Neuropathol Exp Neurol 57: 334-337
15. Iwai A, Yoshimoto M, Masliah E, Saitoh T (1995) Non-Aβ component of Alzheimer's disease amyloid (NAC) is amyloidogenic. Biochemistry 34: 10139-10145
16. Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, Rohan de Silva HA, Kittel A, Saitoh T (1995) The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14: 467-475
17. Jakes R, Spillantini MG, Goedert M (1994) Identification of two distinct synucleins from human brain. FEBS Lett 345: 27-32
18. Jensen PH, Hørup P, Hager H, Nielsen MS, Jacobsen L, Olesen OF, Gliemann J, Jakes R (1997) Binding of Aβ to α-and β-synucleins: identification of segments in α-synuclein/NAC precursor that bind Aβ and NAC. Biochem J 323: 539-546
19. Ji H, Liu YE, Jia T, Wang M, Liu J, Xiao G, Joseph BK, Rosen C, Shi YE (1997) Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res 57: 759-764
20. Kato S, Nakamura H (1990) Cytoplasmic argyrophilic inclusions in neurons of pontine nuclei in patients with olivopontocerebellar atrophy: immunohistochemical and ultrastructural studies. Acta Neuropathol 79: 584-594
21. Kim H, Gearing M, Mirra SS (1995) Ubiquitin-positive CA2/3 neurites in hippocampus coexist with cortical Lewy bodies. Neurology 45: 1768-1770
22. Kim J (1997) Evidence that the precursor protein of non-Aβ component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random coil. Mol Cells 7: 78-83
23. Krüger R, Kuhn W, Müller T, Woitalla D, Graeber M, Kösel S, Przuntek H, Epplen JT, Schöls L, Riess O (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat Genet 18: 106-108
24. Maroteaux L, Campanelli JT, Scheller RH (1988) Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 8: 2804-2815
25. Masliah E, Iwai A, Mallory M, Uéda K, Saitoh T (1996) Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am J Pathol 148: 201-210
26. Mizusawa H, Matsumoto S, Yen S-H, Hirano A, Rojas-Corona RR, Donnenfeld H (1989) Focal accumulation of phosphorylated neurofilaments within anterior horn cell in familial amyotrophic lateral sclerosis. Acta Neuropathol 79: 37-43
27. Murayama S, Ookawa Y, Mori H, Nakano I, Ihara Y, Kuzuhara S, Tomonaga M (1989) Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis. Acta Neuropathol 78: 143-152
28. Murayama S, Arima K, Nakazato Y, Satoh J, Oda M, Inose T (1992) Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy. 2. Oligodendroglial cytoplasmic inclusions. Acta Neuropathol 84: 32-38
29. Nakajo S, Tsukada K, Omata K, Nakamura Y, Nakaya K (1993) A new brain-specific 14-kDa protein is a phosphoprotein: its complete amino acid sequence and evidence for phosphorylation. Eur J Biochem 217: 1057-1063
30. Nakazato Y, Yamazaki H, Hirato J, Ishida Y, Yamaguchi H (1990) Oligodendroglial microtubular tangles in olivopontocerebellar atrophy. J Neuropathol Exp Neurol 49: 521-530
31. Nishiyama K, Murayama S, Shimizu J, Ohya Y, Kwak S, Asayama K, Kanazawa I (1995) Cu/Zn superoxide dismutase-like immunoreactivity is present in Lewy bodies from Parkinson disease: a light and electron microscopic immunocytochemical study. Acta Neuropathol 89: 471-474
32. Oyanagi K, Ogawa H, Nakajima T (1994) Rod-like intracytoplasmic inclusions in large neurons of the caudate nucleus: frequent appearance in myotonic dystrophy. Clin Neuropathol 13: 134-138
33. Papp MI, Lantos PL (1992) Accumulation of tubular structures in oligodendroglial and neuronal cells as the basic alteration in multiple system atrophy. J Neurol Sci 107: 172-182
34. Papp MI, Kahn JE, Lantos PL (1989) Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci 94: 79-100
35. Pollanen MS, Dickson DW, Bergeron C (1993) Pathology and biology of the Lewy body. J Neuropathol Exp Neurol 52: 183-191
36. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047
37. Spillantini MG, Schmidt ML, Lee VM-Y, Trojanowski JQ, Jakes R, Goedert M (1997) α-Synuclein in Lewy bodies. Nature 388: 839-840
38. Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 95: 6469-6473
39. Takahashi H, Oyanagi K, Ikuta F, Tanaka M, Yuasa T, Miyatake T (1993) Widespread multiple system degeneration in a patient with familial amyotrophic lateral sclerosis. J Neurol Sci 120: 15-21
40. Takahashi H, Makifuchi T, Nakano R, Sato S, Inuzuka T, Sakimura K, Mishina M, Honma Y, Tsuji S, Ikuta F (1994) Familial amyotrophic lateral sclerosis with a mutation in the Cu/Zn superoxide dismutase gene. Acta Neuropathol 88: 185-188
41. Takahashi H, Ohama E, Suzuki S, Horikawa Y, Ishikawa A, Morita T, Tsuji S, Ikuta F (1994) Familial juvenile parkinsonism: clinical and pathologic study in a family. Neurology 44: 437-441
42. Takahashi H, Iwanaga K, Egawa S, Ikuta F (1994) Ultrastructural relationship between Lewy bodies and pale bodies studied in locus ceruleus neurons of a non-parkinsonian patient. Neuropathology 14: 73-80
43. Takeda A, Arai N, Komori T, Kato S, Oda M (1997) Neuronal inclusions in the dentate fascia in patients with multiple system atrophy. Neurosci Lett 227: 157-160
44. Takeda A, Arai N, Komori T, Iseki E, Kato S, Oda M (1997) Tau immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 234: 63-66
45. Takeda A, Mallory M, Sundsmo M, Honer W, Hansen L, Masliah E (1998) Abnormal accumulation of NACP/α-synuclein in neurodegenerative disorders. Am J Pathol 152: 367-372
46. Uéda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DAC, Kondo J, Ihara Y, Saitoh T (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci USA 90: 11282-11286
47. Wakabayashi K, Takahashi H (1996) Similarities and differences among progressive supranuclear palsy, corticobasal degeneration and Pick's disease. Neuropathology 16: 262-268
48. Wakabayashi K, Takahashi H (1997) Neuropathology of autonomic nervous system in Parkinson's disease. Eur Neurol 38 [Suppl 2]: 2-7
49. Wakabayashi K, Oyanagi K, Makifuchi T, Ikuta F, Homma A, Homma Y, Horikawa Y, Tokiguchi S (1994) Corticobasal degeneration: etiopathological significance of the cytoskeletal alterations. Acta Neuropathol 87: 545-553
50. Wakabayashi K, Hansen LA, Vincent I, Mallory M, Masliah E (1997) Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease, Lewy body disease and progressive supranuclear palsy. Acta Neuropathol 93: 7-12
51. Wakabayashi K, Matsumoto K, Takayama K, Yoshimoto M, Takahashi H (1997) NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease. Neurosci Lett 239: 45-48
52. Wakabayashi K, Hayashi S, Ishikawa A, Hayashi T, Okuizumi K, Tanaka H, Tsuji S, Takahashi H (1998) Autosomal dominant diffuse Lewy body disease. Acta Neuropathol 96: 207-210
53. Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H (1998) α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 249: 180-182
54. Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT Jr (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35: 13709-13715
55. Yoshimoto M, Iwai A, Kang D, Otero DAC, Xia Y, Saitoh T (1995) NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer disease amyloid, binds Aβ and stimulates Aβ aggregation. Proc Natl Acad Sci USA 92: 9141-9145