Widespread alterations of α-synuclein in multiple system atrophy

American Journal of Pathology

Volumn 155, Issue 4, 1999, Pages 1241-1251

  Dickson, D W ^a   Liu, W K ^a   Hardy, J ^a   Farrer, M ^a   Mehta, N ^a   Uitti, R ^a   Mark, M ^b   Zimmerman, T ^b   Golbe, L ^b   Sage, J ^b   Sima, A ^c   D'Amato, C ^d   Albin, R ^d   Gilman, S ^d   Yen, S H ^d  

^a MAYO CLINIC   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; POLYCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; AUTONOMIC DYSFUNCTION; BRAIN REGION; CHEMICAL COMPOSITION; CONTROLLED STUDY; FEMALE; GLIA CELL; HUMAN; IMMUNOBLOTTING; IMMUNOREACTIVITY; MALE; PRIORITY JOURNAL; PROTEIN MODIFICATION; SHY DRAGER SYNDROME;

EID: 0032833653     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65226-1     Document Type: Article

References (34)

1. Graham JG, Oppenheimer DR: Orthostatic hypertension and nicotine insensitivity in a case of multiple system atrophy. J Neurol Neurosurg 1969, 32:28-34
2. Wenning GK, Tison F, Ben Shlomo Y, Daniel SE, Quinn NP: Multiple system atrophy: a review of 203 pathologically proven cases. Movement Disorders 1997, 12:133-147
3. Bandmann O, Sweeney MG, Daniel SE, Wenning GK, Quinn N, Marsden CD, Wood NW: Multiple-system atrophy is genetically distinct from identified inherited causes of spinocerebellar degeneration. Neurology 1997, 49:1598-1604
4. Bower JH, Maraganore DM, McDonnell SK, Rocca WA: Incidence of progressive supranuclear palsy and multiple system atrophy in Olmsted County, Minnesota, 1976 to 1990. Neurology 1997, 49:1284-1288
5. Matsuo A, Akiguchi I, Lee GC, McGeer EG, McGeer PL, Kimura J: Myelin degeneration in multiple system atrophy detected by unique antibodies. Am J Pathol 1998, 153:735-744
6. Papp MI, Kahn JE, Lantos PL: Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci 1989, 94:79-100
7. Lantos PL: The definition of multiple system atrophy: a review of recent developments. J Neuropathol Exp Neurol 1998, 57:1099-1111
8. Arima K, Murayama S, Mukoyama M, Inose T: Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy. 1. Neuronal cytoplasmic inclusions. Acta Neuropathol 1992, 83:453-460
9. Kato S, Nakamura H: Cytoplasmic argyrophilic inclusions in neurons of pontine nuclei in patients with olivopontocerebellar atrophy: immunohistochemical and ultrastructural studies. Acta Neuropathol 1990, 79:584-594
10. Horoupian DS, Dickson DW: Striatonigral degeneration, olivopontocerebellar atrophy and "atypical" Pick disease. Acta Neuropathol 1991, 81:287-295
11. Braak H, Braak E: Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia. Neuropathol Appl Neurobiol 1989, 15:13-26
12. Yamada T, McGeer PL: Oligodendroglial microtubular masses: an abnormality observed in some human neurodegenerative diseases. Neurosci Lett 1995, 120:163-166
13. Arima K, Nakamura M, Sunohara N, Ogawa M, Anno M, Izumiyama Y, Hirai S, Ikeda K: Ultrastructural characterization of the tau-immunoreactive tubules in the oligodendroglial perikarya and their inner loop processes in progressive supranuclear palsy. Acta Neuropathol 1997, 93:558-566
14. Chin SSM, Goldman JE: Glial inclusions in CNS degenerative diseases. J Neuropathol Exp Neurol 1996, 55:499-508
15. Cairns NJ, Atkinson PF, Hanger DP, Anderton BH, Daniel SE, Lantos PL: Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease. Neurosci Lett 1997, 230:49-52
16. Dickson DW, Liu W-K, Farrer M, Mehta N, Uitti R, Mark M, Zimmerman T, Golbe L, Sage J, Hardy J, Yen S-H: Glial cytoplasmic inclusions (GCI) of multiple system atrophy (MSA) contain α-synuclein (abstract). Movement Disorders 1998, 13(suppl. 2):128
17. Arima K, Ueda K, Sunohara N, Arakawa K, Hirai S, Nakamura M, Tonozuka-Uehara H, Kawai M: NACP/α-synuclein immunoreactivity in fibrillary components of neuronal, and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. Acta Neuropathol 1998, 96:439-444
18. Gai WP, Power JH, Blumbergs PC, Blessing WW: Multiple-system atrophy: a new α-synuclein disease? Lancet 1998, 352:547-548
19. Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M: Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease, and dementia with Lewy bodies. Neurosci Lett 1998, 251:205-208
20. Tu P-h, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee V M-Y: Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann Neurol 1998, 44:415-422
21. Wakabayashi K, Hayashi S, Kakita A, Yamada M, Toyoshima Y, Yoshimoto M, Takahashi H: Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy. Acta Neuropathol 1998, 96:445-452
22. Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H: Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 1998, 249:180-182
23. Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, Kittel A, Saitoh T: The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995, 14:467-475
24. Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT Jr: NACP, a protein implicated in Alzheimer's disease, and learning, is natively unfolded. Biochemistry 1996, 35:13709-13715
25. Irizarry MC, Kim T-W, McNamara M, Tanzi RE, George JM, Clayton DF, Hyman BT: Characterization of the precursor protein of the non-Aβ component of senile plaques (NACP) in the human central nervous system. J Neuropathol Exp Neurol 1996, 55:889-695
26. Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, Trojanowski JQ, Iwatsubo T: Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 1998, 152:879-884
27. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:255-272
28. Laemmli UK: Cleavage of structural protein during assembly of the head of bacteriophage T4. Nature 1970, 227:680-685
29. Takeda A, Mallory M, Sundsmo M, Honer W, Hansen L, Masliah E: Abnormal accumulation of NACP/α-synuclein in neurodegenerative disorders. Am J Pathol 1998, 152:367-372
30. Inoue M, Yagishita S, Ryo M, Hasegawa K, Amano N, Matsushita M: The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: a correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar systems. Acta Neuropathol 1997, 93:585-591
31. Castellani R: Multiple system atrophy: clues from inclusions. Am J Pathol 1998, 153:671-676
32. Dickson DW, Farrer MJ, Mehta ND, Perez-Tur J, Tiseo P, Yen S-H, Hardy J: Antibodies to non-amyloid component of plaques (NACP) specifically label Lewy bodies and Lewy neurites, but not other inclusions in neurodegenerative diseases (abstract). J Neuropathol Exp Neurol 1998, 57:516
33. Yamada T, McGeer PL: Oligodendroglial microtubular masses: an abnormality observed in some human neurodegenerative diseases. Neurosci Lett 1990, 120:163-166
34. Dickson DW, Ruan D, Crystal H, Mark MH, Davies P, Kress Y, Yen S-H: Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology 1991, 41:1402-1409