메뉴 건너뛰기




Volumn 31, Issue 1-3, 2002, Pages 61-69

TGFβ-regulated transcriptional mechanisms in cancer

Author keywords

Epithelial mesenchymal transdifferentiation; Smad; TGF ; TIEG

Indexed keywords

GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P300; RAS PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036934416     PISSN: 01694197     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (17)

References (76)
  • 1
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGFβ signaling
    • Massague J, Chen YG. Controlling TGFβ signaling. Genes Dev 2000;14:627-644.
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 4
    • 0034533657 scopus 로고    scopus 로고
    • Signaling of TGFβ family members through Smad proteins
    • Itoh S, Itoh F, Goumans MJ, et al. Signaling of TGFβ family members through Smad proteins. Eur J Biochem 2000;267:6954-6967.
    • (2000) Eur J Biochem , vol.267 , pp. 6954-6967
    • Itoh, S.1    Itoh, F.2    Goumans, M.J.3
  • 5
    • 0033377548 scopus 로고    scopus 로고
    • TGFβ and cancer
    • Reiss M. TGFβ and cancer. Microbes Infect 1999;1:1327-1347.
    • (1999) Microbes Infect , vol.1 , pp. 1327-1347
    • Reiss, M.1
  • 6
    • 0032909086 scopus 로고    scopus 로고
    • Genetic events and the role of TGFβ in epithelial tumour progression
    • Akhurst RJ, Balmain A. Genetic events and the role of TGFβ in epithelial tumour progression. J Pathol 1999;187:82-90.
    • (1999) J Pathol , vol.187 , pp. 82-90
    • Akhurst, R.J.1    Balmain, A.2
  • 7
    • 0031817391 scopus 로고    scopus 로고
    • Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion
    • Portella G, Cumming SA, Liddell J, et al. Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ 1998;9:393-404.
    • (1998) Cell Growth Differ , vol.9 , pp. 393-404
    • Portella, G.1    Cumming, S.A.2    Liddell, J.3
  • 8
    • 0027250810 scopus 로고
    • Inactivation of the type-II receptor reveals two receptor pathways for the diverse TGFβ activities
    • Chen RH, Ebner R, Derynck R. Inactivation of the type-II receptor reveals two receptor pathways for the diverse TGFβ activities. Science 1993;260:1335-1338.
    • (1993) Science , vol.260 , pp. 1335-1338
    • Chen, R.H.1    Ebner, R.2    Derynck, R.3
  • 9
    • 0035501062 scopus 로고    scopus 로고
    • TGFβ signaling in cancer - A double-edged sword
    • Akhurst RJ, Derynck R. TGFβ signaling in cancer - a double-edged sword. Trends Cell Biol 2001;11:44-51.
    • (2001) Trends Cell Biol , vol.11 , pp. 44-51
    • Akhurst, R.J.1    Derynck, R.2
  • 10
    • 0030598681 scopus 로고    scopus 로고
    • TGFβ1 inhibits the formation of benign skin tumours but enhances progression to invasive spindle cell carcinomas in transgenic mice
    • Cui W, Fowlis D, Bryson S, et al. TGFβ1 inhibits the formation of benign skin tumours but enhances progression to invasive spindle cell carcinomas in transgenic mice. Cell 1996;86:531-542.
    • (1996) Cell , vol.86 , pp. 531-542
    • Cui, W.1    Fowlis, D.2    Bryson, S.3
  • 11
    • 11944255353 scopus 로고
    • TGFβ stimulates mammary adenocarcinoma cell invasion and metastatic potential
    • Welch DR, Fabra A, Nakajima M, et al. TGFβ stimulates mammary adenocarcinoma cell invasion and metastatic potential. Proc Natl Acad Sci USA 1990;87:7678-7682.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7678-7682
    • Welch, D.R.1    Fabra, A.2    Nakajima, M.3
  • 12
    • 0035879867 scopus 로고    scopus 로고
    • TGFβ induced invasiveness of pancreatic cancer cells is mediated by MMP-2 and the urokinase plasminogen activator system
    • Ellenrieder V, Hendler SF, Ruhland C, et al. TGFβ induced invasiveness of pancreatic cancer cells is mediated by MMP-2 and the urokinase plasminogen activator system. Int J Cancer 2001;93:204-211.
    • (2001) Int J Cancer , vol.93 , pp. 204-211
    • Ellenrieder, V.1    Hendler, S.F.2    Ruhland, C.3
  • 13
    • 0034644472 scopus 로고    scopus 로고
    • TGFβ signaling in growth control, cancer, and heritable disorders
    • Massague J, Blain SW, Lo RS. TGFβ signaling in growth control, cancer, and heritable disorders. Cell 2000;103:295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 14
    • 0028856547 scopus 로고
    • Regulation of transforming growth factor beta receptors in H-ras oncogene transformed rat intestinal epithelial cells
    • Zhao J, Buick RN. Regulation of transforming growth factor beta receptors in H-ras oncogene transformed rat intestinal epithelial cells. Cancer Res 1995;55:6181-6188.
    • (1995) Cancer Res , vol.55 , pp. 6181-6188
    • Zhao, J.1    Buick, R.N.2
  • 15
    • 0035872426 scopus 로고    scopus 로고
    • TGFβ1 treatment leads to an epithelial-mesenchymal-transdifferentiation of pancreatic cancer cells requiring ERK2 activation
    • Ellenrieder V, Hendler SF, Boeck W. TGFβ1 treatment leads to an epithelial-mesenchymal-transdifferentiation of pancreatic cancer cells requiring ERK2 activation. Cancer Res 2001;61:4222-4228.
    • (2001) Cancer Res , vol.61 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3
  • 16
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-β/Smad signaling system
    • Massague J, Wotton D. Transcriptional control by the TGF-β/Smad signaling system. EMBO J 19:1745-1754.
    • EMBO J , vol.19 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 17
    • 0031438047 scopus 로고    scopus 로고
    • TGFβ signaling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Miyazono K, ten Djike P. TGFβ signaling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Djike, P.3
  • 18
    • 0030611757 scopus 로고    scopus 로고
    • Identification of Smad7, a TGFβ-inducible antagonist of TGFβ signaling
    • Nakao A, Afrakhte M, Moren A, et al. Identification of Smad7, a TGFβ-inducible antagonist of TGFβ signaling. Nature 1997;389:631-635.
    • (1997) Nature , vol.389 , pp. 631-635
    • Nakao, A.1    Afrakhte, M.2    Moren, A.3
  • 19
    • 0030765945 scopus 로고    scopus 로고
    • Smad6 inhibits signaling by the TGFβ superfamily
    • Imamura T, Takase M, Nishihara A, et al. Smad6 inhibits signaling by the TGFβ superfamily. Nature 1997;389:622-626.
    • (1997) Nature , vol.389 , pp. 622-626
    • Imamura, T.1    Takase, M.2    Nishihara, A.3
  • 20
    • 0035945639 scopus 로고    scopus 로고
    • Smads mediate signaling of the TGFbeta superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis
    • He W, Cao T, Smith DA, et al. Smads mediate signaling of the TGFbeta superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis. Oncogene 2001;20:471-483.
    • (2001) Oncogene , vol.20 , pp. 471-483
    • He, W.1    Cao, T.2    Smith, D.A.3
  • 21
    • 0033598408 scopus 로고    scopus 로고
    • The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer
    • Kleeff J, Ishiwata T, Maruyama H, et al. The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. Oncogene 1999;18:5363-5372.
    • (1999) Oncogene , vol.18 , pp. 5363-5372
    • Kleeff, J.1    Ishiwata, T.2    Maruyama, H.3
  • 22
    • 4243698239 scopus 로고    scopus 로고
    • Crossing Smads
    • Wrana JL. Crossing Smads. Sci STKE 2000;23:RE1.
    • (2000) Sci STKE , vol.23
    • Wrana, J.L.1
  • 23
    • 0033168915 scopus 로고    scopus 로고
    • Regulation of Smad signaling by protein associations and signaling crosstalk
    • Zhang Y, Derynck R. Regulation of Smad signaling by protein associations and signaling crosstalk. Trends Cell Biol 1999;9:274-279.
    • (1999) Trends Cell Biol , vol.9 , pp. 274-279
    • Zhang, Y.1    Derynck, R.2
  • 24
    • 0034788236 scopus 로고    scopus 로고
    • Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis
    • Piek E, Roberts AB. Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis. Adv Cancer Res 2001;83:1-54.
    • (2001) Adv Cancer Res , vol.83 , pp. 1-54
    • Piek, E.1    Roberts, A.B.2
  • 25
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-beta signals
    • Massague J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol 2000;1:169-178.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 169-178
    • Massague, J.1
  • 26
    • 0033835421 scopus 로고    scopus 로고
    • The importance of being K-Ras
    • Ellis CA, Clark G. The importance of being K-Ras. Cell Signal 2000;12:425-434.
    • (2000) Cell Signal , vol.12 , pp. 425-434
    • Ellis, C.A.1    Clark, G.2
  • 27
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-532.
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 28
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras
    • Kretzschmar M, Doody J, Timokhina I, et al. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev 1999;13:804-816.
    • (1999) Genes Dev , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3
  • 29
    • 0034023127 scopus 로고    scopus 로고
    • Role of Ras and MAPKs in TGFβ signaling
    • Mulder KM: Role of Ras and MAPKs in TGFβ signaling. Cytokine Growth Factor Rev 2000;11:23-35.
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 23-35
    • Mulder, K.M.1
  • 30
    • 0031059867 scopus 로고    scopus 로고
    • Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells
    • Frey RS, Mulder KM. Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells. Cancer Res 1997;57:628-633.
    • (1997) Cancer Res , vol.57 , pp. 628-633
    • Frey, R.S.1    Mulder, K.M.2
  • 31
    • 0033585086 scopus 로고    scopus 로고
    • Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells
    • Calonge MJ, Massague J. Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. J Biol Chem 1999;274:33,637-33,643.
    • (1999) J Biol Chem , vol.274 , pp. 33637-33643
    • Calonge, M.J.1    Massague, J.2
  • 33
    • 0035286516 scopus 로고    scopus 로고
    • Regulation of Smad signaling by protein kinase C
    • Yakymovych I, ten Dijke P, Heldin CH, et al. Regulation of Smad signaling by protein kinase C. FASEB J 2001;15:553-555.
    • (2001) FASEB J , vol.15 , pp. 553-555
    • Yakymovych, I.1    Ten Dijke, P.2    Heldin, C.H.3
  • 34
    • 0033601179 scopus 로고    scopus 로고
    • Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription
    • Engel ME, McDonnell MA, Law BK, et al. Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. J Biol Chem 1999;274:37,413-37,420.
    • (1999) J Biol Chem , vol.274 , pp. 37413-37420
    • Engel, M.E.1    McDonnell, M.A.2    Law, B.K.3
  • 35
    • 0033605559 scopus 로고    scopus 로고
    • MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells
    • Brown JD, DiChiara MR, Anderson KR, et al. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J Biol Chem 1999;274:8797-8805.
    • (1999) J Biol Chem , vol.274 , pp. 8797-8805
    • Brown, J.D.1    DiChiara, M.R.2    Anderson, K.R.3
  • 36
    • 0030609939 scopus 로고    scopus 로고
    • TGFβ regulation of mitogen-activated protein kinases in human breast cancer cells
    • Frey RS, Mulder KM. TGFβ regulation of mitogen-activated protein kinases in human breast cancer cells. Cancer Lett 1997;117:41-50.
    • (1997) Cancer Lett , vol.117 , pp. 41-50
    • Frey, R.S.1    Mulder, K.M.2
  • 37
    • 0029551805 scopus 로고
    • Identification of a member of the MAPKKK family as a potential mediator of TGFβ signal transduction
    • Shibuya H, Yamaguchi, Shirakabe K, et al. Identification of a member of the MAPKKK family as a potential mediator of TGFβ signal transduction. Science 1995;270:2008-2011.
    • (1995) Science , vol.270 , pp. 2008-2011
    • Shibuya, H.1    Yamaguchi2    Shirakabe, K.3
  • 38
    • 0031035582 scopus 로고    scopus 로고
    • Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling
    • Atfi A, Djelloul S, Chastre E, et al. Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling. J Biol Chem 1997;272:1429-1432.
    • (1997) J Biol Chem , vol.272 , pp. 1429-1432
    • Atfi, A.1    Djelloul, S.2    Chastre, E.3
  • 39
    • 0033578721 scopus 로고    scopus 로고
    • Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor beta induced gene expression
    • Hanafusa H, Ninomiya-Tsuji J, Masuyama N, et al. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor beta induced gene expression. J Biol Chem 1999;274:27,161-27,167.
    • (1999) J Biol Chem , vol.274 , pp. 27161-27167
    • Hanafusa, H.1    Ninomiya-Tsuji, J.2    Masuyama, N.3
  • 40
    • 0032572723 scopus 로고    scopus 로고
    • Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
    • Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 1998;394:909-913.
    • (1998) Nature , vol.394 , pp. 909-913
    • Zhang, Y.1    Feng, X.H.2    Derynck, R.3
  • 41
    • 0032499789 scopus 로고    scopus 로고
    • Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members
    • Moustakas A, Kardassis D. Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc Natl Acad Sci USA 1998;95:6733-6738.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6733-6738
    • Moustakas, A.1    Kardassis, D.2
  • 42
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner for MAD proteins in TGFbeta signaling
    • Chen X, Rubock MJ, Whitman M. A transcriptional partner for MAD proteins in TGFbeta signaling. Nature 1996;383:691-696.
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 43
    • 0033605129 scopus 로고    scopus 로고
    • Convergence of transforming growth factor beta and vitamin D signaling pathways on Smad transcriptional coactivators
    • Yanagisawa J, Yanagi Y, Masuhiro Y, et al. Convergence of transforming growth factor beta and vitamin D signaling pathways on Smad transcriptional coactivators. Science 1999;283:1317-1321.
    • (1999) Science , vol.283 , pp. 1317-1321
    • Yanagisawa, J.1    Yanagi, Y.2    Masuhiro, Y.3
  • 44
    • 0032528236 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGFβ-induced transcriptional activation
    • Feng XH, Zhang Y, Wu RY, et al. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGFβ-induced transcriptional activation. Genes Dev 1998;12:2153-2163.
    • (1998) Genes Dev , vol.12 , pp. 2153-2163
    • Feng, X.H.1    Zhang, Y.2    Wu, R.Y.3
  • 45
    • 0032527756 scopus 로고    scopus 로고
    • TGFβ-stimulated cooperation of Smad proteins with the coactivators CBP/p300
    • Janknecht R, Wells NJ, Hunter T. TGFβ-stimulated cooperation of Smad proteins with the coactivators CBP/p300. Genes Dev 1998;12:2114-2119.
    • (1998) Genes Dev , vol.12 , pp. 2114-2119
    • Janknecht, R.1    Wells, N.J.2    Hunter, T.3
  • 46
    • 0033515620 scopus 로고    scopus 로고
    • A Smad transcriptional corepressor
    • Wotton D, Lo RS, Lee S, et al. A Smad transcriptional corepressor. Cell 1999;97:29-39.
    • (1999) Cell , vol.97 , pp. 29-39
    • Wotton, D.1    Lo, R.S.2    Lee, S.3
  • 47
    • 0033595704 scopus 로고    scopus 로고
    • Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein
    • Stroschein SL, Wang W, Zhou S, et al. Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science 1999;286:771-774.
    • (1999) Science , vol.286 , pp. 771-774
    • Stroschein, S.L.1    Wang, W.2    Zhou, S.3
  • 48
    • 0035353203 scopus 로고    scopus 로고
    • The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling
    • Izutsu K, Kurokawa M, Imai Y, et al. The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling. Blood 2001;97:2815-2822.
    • (2001) Blood , vol.97 , pp. 2815-2822
    • Izutsu, K.1    Kurokawa, M.2    Imai, Y.3
  • 49
    • 0037034199 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1
    • Recio JA, Merlino G. Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1. Oncogene 2002;21:1000-1008.
    • (2002) Oncogene , vol.21 , pp. 1000-1008
    • Recio, J.A.1    Merlino, G.2
  • 50
    • 0035971496 scopus 로고    scopus 로고
    • Distinct roles of Jun:Fos and Jun:ATF dimers in oncogenesis
    • van Dam H, Castellazzi M. Distinct roles of Jun:Fos and Jun:ATF dimers in oncogenesis. Oncogene 2001;20:2453-2464.
    • (2001) Oncogene , vol.20 , pp. 2453-2464
    • Van Dam, H.1    Castellazzi, M.2
  • 51
    • 0033200361 scopus 로고    scopus 로고
    • The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
    • Luo K, Stroschein SL, Wang W, et al. The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev 1999;13:2196-2206.
    • (1999) Genes Dev , vol.13 , pp. 2196-2206
    • Luo, K.1    Stroschein, S.L.2    Wang, W.3
  • 52
    • 0032404111 scopus 로고    scopus 로고
    • Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas
    • Goggins M, Shekher M, Turnacioglu K, et al. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 1998;58:5329-5332.
    • (1998) Cancer Res , vol.58 , pp. 5329-5332
    • Goggins, M.1    Shekher, M.2    Turnacioglu, K.3
  • 53
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996;271:350-353.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3
  • 55
    • 16044369574 scopus 로고    scopus 로고
    • MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinomas
    • Eppert K, Scherer SW, Ozcelik H, et al. MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinomas. Cell 1996;86:543-552.
    • (1996) Cell , vol.86 , pp. 543-552
    • Eppert, K.1    Scherer, S.W.2    Ozcelik, H.3
  • 56
    • 0034469509 scopus 로고    scopus 로고
    • Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer
    • Donovan J, Slingerland J. Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer. Breast Cancer Res 2000;2:116-124.
    • (2000) Breast Cancer Res , vol.2 , pp. 116-124
    • Donovan, J.1    Slingerland, J.2
  • 57
    • 0034744956 scopus 로고    scopus 로고
    • TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b
    • Seoane J, Pouponnot C, Staller P, et al. TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol 2001;3:400-408.
    • (2001) Nat Cell Biol , vol.3 , pp. 400-408
    • Seoane, J.1    Pouponnot, C.2    Staller, P.3
  • 58
    • 0035011486 scopus 로고    scopus 로고
    • Integrating Myc and TGF-beta signalling in cell-cycle control
    • Amati B. Integrating Myc and TGF-beta signalling in cell-cycle control. Nat Cell Biol 2001;3:112-113.
    • (2001) Nat Cell Biol , vol.3 , pp. 112-113
    • Amati, B.1
  • 59
    • 0035970035 scopus 로고    scopus 로고
    • Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program
    • Chen CR, Kang Y, Massague J. Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program. Proc Natl Acad Sci USA 2001;98:992-999.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 992-999
    • Chen, C.R.1    Kang, Y.2    Massague, J.3
  • 60
    • 0034003075 scopus 로고    scopus 로고
    • TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth
    • Cook T, Urrutia R. TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth. Am J Physiol Gastrointest Liver Physiol 2000;278:513-521.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278 , pp. 513-521
    • Cook, T.1    Urrutia, R.2
  • 61
    • 0030610532 scopus 로고    scopus 로고
    • Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells
    • Tachibana I, Imoto M, Adjei PN, et al. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. J Clin Invest 1997;99:2365-2374.
    • (1997) J Clin Invest , vol.99 , pp. 2365-2374
    • Tachibana, I.1    Imoto, M.2    Adjei, P.N.3
  • 62
    • 0032475869 scopus 로고    scopus 로고
    • Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger encoding genes involved in the regulation of cell growth
    • Cook T, Gebelein B, Mesa K, et al. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger encoding genes involved in the regulation of cell growth. J Biol Chem 1998;273:25,929-25,936.
    • (1998) J Biol Chem , vol.273 , pp. 25929-25936
    • Cook, T.1    Gebelein, B.2    Mesa, K.3
  • 63
    • 0034866971 scopus 로고    scopus 로고
    • TGFβ-mediated signaling and transcriptional regulation in pancreatic development and cancer
    • Ellenrieder V, Fernandez-Zapico M, Urrutia R. TGFβ-mediated signaling and transcriptional regulation in pancreatic development and cancer. Curr Opin Gastroenterol 2001;17:434-440.
    • (2001) Curr Opin Gastroenterol , vol.17 , pp. 434-440
    • Ellenrieder, V.1    Fernandez-Zapico, M.2    Urrutia, R.3
  • 64
    • 0034954161 scopus 로고    scopus 로고
    • A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A
    • Zhang JS, Moncrieffe MC, Kaczynski J, et al. A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. Mol Cell Biol 2001;21:5041-5049.
    • (2001) Mol Cell Biol , vol.21 , pp. 5041-5049
    • Zhang, J.S.1    Moncrieffe, M.C.2    Kaczynski, J.3
  • 65
    • 0037093448 scopus 로고    scopus 로고
    • Signaling disrupts mSin3A binding to the Mad1-like Sin3 interacting domain of TIEG2, an Sp1-like repressor
    • Ellenrieder V, Zhang JS, Kaczynski J, et al. Signaling disrupts mSin3A binding to the Mad1-like Sin3 interacting domain of TIEG2, an Sp1-like repressor. EMBO J 2002;21:2451-2460.
    • (2002) EMBO J , vol.21 , pp. 2451-2460
    • Ellenrieder, V.1    Zhang, J.S.2    Kaczynski, J.3
  • 66
    • 0032776694 scopus 로고    scopus 로고
    • Invasion and metastasis in pancreatic cancer
    • Ellenrieder V, Adler G, Gress TM. Invasion and metastasis in pancreatic cancer. Ann Oncol 1999;4:46-50.
    • (1999) Ann Oncol , vol.4 , pp. 46-50
    • Ellenrieder, V.1    Adler, G.2    Gress, T.M.3
  • 67
    • 0032547895 scopus 로고    scopus 로고
    • TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft M, Heider KH, Beug H. TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 1998;8:1243-1252.
    • (1998) Curr Biol , vol.8 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Beug, H.3
  • 68
    • 0029662049 scopus 로고    scopus 로고
    • TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • Oft M, Peli J, Rudaz C, et al. TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 1996;10:2462-2477.
    • (1996) Genes Dev , vol.10 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3
  • 69
    • 0028603343 scopus 로고
    • TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
    • Miettinen PJ, Ebner R, Lopez AR, et al. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 1994;127:2021-2036.
    • (1994) J Cell Biol , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3
  • 70
    • 0030963513 scopus 로고    scopus 로고
    • Ki-ras mutations in exocrine pancreatic cancer: Association with clinico-pathological characteristics and with tobacco and alcohol consumption
    • PANK-ras I Project Investigators
    • Malats N, Porta M, Corominas JM, et al. Ki-ras mutations in exocrine pancreatic cancer: association with clinico-pathological characteristics and with tobacco and alcohol consumption. PANK-ras I Project Investigators. Int J Cancer 1997;17:661-667.
    • (1997) Int J Cancer , vol.17 , pp. 661-667
    • Malats, N.1    Porta, M.2    Corominas, J.M.3
  • 71
    • 0026500701 scopus 로고
    • Ki-ras oncogene activation in preinvasive pancreatic cancer
    • Lemoine NR, Jain S, Hughes CM, et al. Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology 1992;102:230-236.
    • (1992) Gastroenterology , vol.102 , pp. 230-236
    • Lemoine, N.R.1    Jain, S.2    Hughes, C.M.3
  • 72
    • 0032711157 scopus 로고    scopus 로고
    • Enhanced expression of the type II transforming growth factor-beta receptor is associated with decreased survival in human pancreatic cancer
    • Wagner M, Kleeff J, Friess H, et al. Enhanced expression of the type II transforming growth factor-beta receptor is associated with decreased survival in human pancreatic cancer. Pancreas 1999;19:370-376.
    • (1999) Pancreas , vol.19 , pp. 370-376
    • Wagner, M.1    Kleeff, J.2    Friess, H.3
  • 73
    • 0027131252 scopus 로고
    • Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival
    • Friess H, Yamanaka Y, Buchler M, et al. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology 1993;105:1846-1856.
    • (1993) Gastroenterology , vol.105 , pp. 1846-1856
    • Friess, H.1    Yamanaka, Y.2    Buchler, M.3
  • 74
    • 0032816746 scopus 로고    scopus 로고
    • Use of representational difference analysis to study the effect of TGFβ on the expression profile of a pancreatic cancer cell line
    • Geng MM, Ellenrieder V, Wallrapp C, et al. Use of representational difference analysis to study the effect of TGFβ on the expression profile of a pancreatic cancer cell line. Genes Chromosomes Cancer 1999;26:70-79.
    • (1999) Genes Chromosomes Cancer , vol.26 , pp. 70-79
    • Geng, M.M.1    Ellenrieder, V.2    Wallrapp, C.3
  • 75
    • 0037148532 scopus 로고    scopus 로고
    • Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
    • Janda E, Lehmann K, Killisch I, et al. Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol 2002;156:299-313.
    • (2002) J Cell Biol , vol.156 , pp. 299-313
    • Janda, E.1    Lehmann, K.2    Killisch, I.3
  • 76
    • 0034666839 scopus 로고    scopus 로고
    • Raf induces TGF-beta production while blocking its apoptotic but not invasive responses: A mechanism leading to increased malignancy in epithelial cells
    • Lehmann K, Janda E, Pierreux CE, et al. Raf induces TGF-beta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev 2000;14:2610-2622.
    • (2000) Genes Dev , vol.14 , pp. 2610-2622
    • Lehmann, K.1    Janda, E.2    Pierreux, C.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.