Invasion and metastasis in pancreatic cancer

Annals of Oncology

Volumn 10, Issue SUPPL. 4, 1999, Pages

  Ellenrieder, Volker ^a   Adler, G ^a   Gress, T M ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Adhesion; Angiogenesis; E cadherin; Integrin; Invasion; Metalloproteinases; Pancreatic cancer; Urokinase plasminogen activator

Indexed keywords

CADHERIN; CELL ADHESION MOLECULE; INTEGRIN; MATRIX METALLOPROTEINASE; PLASMINOGEN ACTIVATOR; PROTEINASE;

ANGIOGENESIS; BASEMENT MEMBRANE; CANCER INVASION; CELL ADHESION; CELL SURVIVAL; CONFERENCE PAPER; EXTRACELLULAR MATRIX; HUMAN; METASTASIS; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR GROWTH;

EID: 0032776694     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/10.suppl_4.S46     Document Type: Conference Paper

References (35)

1. Gold EB, Cameron JL. Chronic pancreatitis and pancreatic cancer. New Engl J Med 1993; 328: 1485-86.
2. Nicolson GL. Cancer metastasis: Tumor cell and host organ properties important in metastasis to specific secondary sites. Biochim Biophys Acta 1988; 948: 175-244.
3. Fidler IJ, Hart IR. Biologic diversity in metastatic neoplasms-origins and implications. Science 1982; 217: 998-1001.
4. Gress TM, Menke A, Bachem M et al. The role of extracellular matrix in pancreatic diseases. Digestion 1998 (in press).
5. Ebert M, Yokoyama M, Friess H et al. Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer. Int J Cancer 1995; 62: 529-35.
6. Folkman J, Klagsbrun M. Angiogenic factors. Science 1987; 235: 442-7.
7. Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation. Cell 1991; 64:327-36.
8. Pepper MS, Belin D, Montesano R et al. Transforming growth factor-beta1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cels in vitro. J Cell Biol 1990; 111: 734-55.
9. Fidler IJ, Ellis LM. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 1994; 79: 185.
10. Shimoyama S, Gansauge F, Gansauge S et al. Increased angiogenin expression in pancreatic cancer is related to cancer aggressiveness. Cancer Res 1996; 56: 2703-6.
11. Brodt P, Dedhar S. The integrins: Mediators of cell-extracellular matrix and intercellular communication. In: Pina Brodt.Cell adhesion and invasion in cancer metastasis. Springer, Heidelberg, 1996.
12. Streit M, Schmidt R, Hilgenfeld RU et al. Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors. Recent Results Cancer Res 1996; 142: 19-50.
13. Pignatelli M, Ansari TW, Gunter P et al. Loss of membranous E-cadherin expression in pancreatic cancer: Correlation with lymph node metastasis, high grade, and advanced stage. J Pathol 1994; 174(4): 243-8.
14. Frixen C, Behrens J, Sachs M. E-cadherin mediated cell-cell adhesion prevents invasiveness of human carcinoma cell lines. J Cell Biol 1991; 111: 173-85.
15. Behrens J. The role of cell adhesion molecules in cancer invasion and metastasis. Breast Cancer and Treat 1993; 24: 175-84.
16. Oyama T, Kanai Y, Ochiai A. A truncated β-catenin disrupts the interaction between E-cadherin and α-catenin: A cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res 1994; 54: 6282-7.
17. Clark EA, Brugge JS. Integrins and signal transduction pathways: The road taken. Science 1995; 268: 233-8.
18. Hall P, Coates P, Lemoine N et al. Characterization of integrin chains in normal and neoplastic human pancreas. J Pathol 1991; 165: 33-41.
19. Schwartz MA. Signaling by integrins: implications for tumorigenesis. Cancer Res 1993; 53: 1503-6.
20. Löhr M, Trautmann B, Göttler M et al. Expression and function of receptors for extracellular matrix proteins in human ductal adenocarcinomas of the pancreas. Pancreas 1996; 12: 248-59.
21. Weinel RJ, Rosendahl A, Pinschmidt E et al. The α6-integrin receptor in pancreatic carcinoma. Gastroenterology 1995; 108:523-32.
22. Vogelmann R, Kreuser E, Adler G et al. A role of integrin α6β1 for the metastatic behaviour of human pancreatic carcinoma cells. Int J Cancer 1998 (in press).
23. Rabinovitz I, Mercurio AM. The integrin a6β4 and the biology of carcinoma. Biochem Cell Biol 1996; 74: 811-21.
24. DeClerck YA, Imren S. Protease inhibitors : Role and potential therapeutic use in human cancer. Eur J Cancer 1994; 14: 2170-80.
25. Shapiro S. Matrix metalloproteinase degradation of extracellular matrix: Biological consequences. Curr Opin Cell Biol 1998; 10: 602-8.
26. Coussens LM, Werb Z. Matrix metalloproteinases and the development of cancer. Chem Biol 1996; 3: 895-904.
27. Campo E, Merino MJ et al. Evaluation of basement membrane components and the 72 kDA type IV colleganse in serous tumors of the ovary. Am J Surg Pathol 1992; 16:500-7.
28. Imren S, Kohn DB, Shimada H et al. Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion. Cancer Res 1996; 56: 2891-5.
29. Chambers AF, Matrisian LM. Changing views of the role of matrix metalloproteainases in metastasis. Natl Cancer Inst 1997; 89: 1260-70.
30. Ellenrieder V, Alber B, Lacher U et al. Expression of MT-MMP'S in pancreatic cancer and chronic pancreatitis. Gastroenterology 1998, S114: A590
31. Gress TM, Müller-Pillasch F, Lerch MM et al. Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer. Int J Cancer 1995; 62: 407-13
32. Bramhall SR. The matrix metalloproteinases and their inhibitors in pancreatic cancer. From molecular science to a clinical application. Int J Pancreatol 1997; 21: 1-12.
33. Stahl A, Muller B. Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro. Cancer Res 1994; 54: 3066-71.
34. Cantero D, Friess H, Deflorin J et al. Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma. Br J Cancer 1997; 75: 388-95.
35. Paciucci R, Vila MR, Adell T et al. Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met. Am J Pathol 1998; 153: 201-12.