Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor

EMBO Journal

Volumn 21, Issue 10, 2002, Pages 2451-2460

  Ellenrieder, Volker ^a,b   Zhang, Jin San ^a   Kaczynski, Joanna ^a   Urrutia, Raul ^a,c  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF ULM   (Germany)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

EGF; mSin3A; Repression; SID; TIEG2

Indexed keywords

EPIDERMAL GROWTH FACTOR; GENE PRODUCT; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BTEB1; PROTEIN BTEB3; PROTEIN BTEB4; PROTEIN MAD1; PROTEIN SIN3; PROTEIN TIEG1; PROTEIN TIEG2; RAS PROTEIN; SERINE; THREONINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SIN3A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE ACTIVITY; GENE FUNCTION; GENE STRUCTURE; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REPRESSOR GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL CYCLE PROTEINS; CHO CELLS; CONSENSUS SEQUENCE; CRICETINAE; GENES, REPORTER; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; PHOSPHORYLATION; PROTEIN BINDING; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSFECTION; ZINC FINGERS;

ANIMALIA;

EID: 0037093448     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.10.2451     Document Type: Article

References (26)

1. Mad1 function is regulated through elements within the carboxy terminus
2. Casein kinase II inhibits the DNA-binding activity of Max homodimers but not Myc/Max heterodimers
3. Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer
4. Identification of casein kinase II phosphorylation sites in Max: Effects on DNA-binding kinetics of Max homo- and Myc/Max heterodimers
5. Solution structure of the interacting domains of the Mad-Sin3 complex: Implications for recruitment of a chromatin-modifying complex
6. Groucho/TLE family proteins and transcriptional repression
7. TIEG proteins join the Smads as TGF-βregulated transcription factors that control pancreatic cell growth
8. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-β-inducible Spl-like zinc finger-encoding genes involved in the regulation of cell growth
9. Three conserved transcriptional repressor domains are a defining feature of the TIEG subfamily of Sp1-like zinc finger proteins
10. Regulation of nuclear localization during signaling
11. A 13-amino acid amphipathic α-helix is required for the functional interaction between the transcriptional repressor Mad1 and mSin3A
12. Sequence-specific transcriptional repression by a full length Kruppel-associated box-zinc finger protein
13. The SMRT corepressor is regulated by a MEK-1 kinase pathway: Inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export
14. Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK2 MAP kinase
15. The Sp1-like protein BTEB3 inhibits transcription via the BTE box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1
16. Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus
17. Retinoid receptors in health and disease: Co-regulators and the chromatin connection
18. Mechanism of corepressor binding and release from nuclear hormone receptors
19. Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression
20. Repression by the Mad(Mx1)-Sin3 complex
21. The CtBP family: Enigmatic and enzymatic transcriptional co-repressors
22. Identification of the Sin3-binding site in ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast
23. Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex
24. Transforming growth factor-β signal transduction in epithelial cells
25. A conserved α-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A
26. The SMRT corepressor is a target of phosphorylation by protein kinase CK2 (casein kinase II)