-
1
-
-
0027482070
-
Treatment of obesity by moderate and severe caloric restriction. Results of clinical research trials
-
Wadden TA. Treatment of obesity by moderate and severe caloric restriction. Results of clinical research trials. Ann Intern Med 1993;119:688-693
-
(1993)
Ann Intern Med
, vol.119
, pp. 688-693
-
-
Wadden, T.A.1
-
2
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-770
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
3
-
-
84958689411
-
The role of depot fat in the hypothalamic control of food intake in the rat
-
Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc (Lond) (B) 1953;140:578-592
-
(1953)
Proc R Soc (Lond) (B)
, vol.140
, pp. 578-592
-
-
Kennedy, G.C.1
-
4
-
-
0033533859
-
Body-mass index and mortality in a prospective cohort of U.S. adults
-
Calle E, Thun M, Petrelli J, et al. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 1999;341:1097-1105
-
(1999)
N Engl J Med
, vol.341
, pp. 1097-1105
-
-
Calle, E.1
Thun, M.2
Petrelli, J.3
-
6
-
-
0029073613
-
Weight-reducing effects of the plasma protein encoded by the obese gene
-
Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543-546
-
(1995)
Science
, vol.269
, pp. 543-546
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
-
7
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca P, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, P.2
Maffei, M.3
-
8
-
-
0018139377
-
Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
-
Coleman DL. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978;14:141-148
-
(1978)
Diabetologia
, vol.14
, pp. 141-148
-
-
Coleman, D.L.1
-
9
-
-
0029781055
-
Characterization of endogenous human leptin
-
Cohen SL, Halaas JL, Friedman JM, et al. Characterization of endogenous human leptin. Nature 1996;382:589
-
(1996)
Nature
, vol.382
, pp. 589
-
-
Cohen, S.L.1
Halaas, J.L.2
Friedman, J.M.3
-
10
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1(11):1155-1161
-
(1995)
Nat Med
, vol.1
, Issue.11
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
-
11
-
-
0030737953
-
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
-
Halaas JL, Boozer C, Blair-West J, et al. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci U S A 1997;94:8878-8883
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 8878-8883
-
-
Halaas, J.L.1
Boozer, C.2
Blair-West, J.3
-
12
-
-
0030297919
-
Adipogenesis and obesity: Rounding out the big picture
-
Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell 1996;87: 377-389
-
(1996)
Cell
, vol.87
, pp. 377-389
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
13
-
-
0029896530
-
Role of leptin in the neuroendocrine response to fasting
-
Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382:250-252
-
(1996)
Nature
, vol.382
, pp. 250-252
-
-
Ahima, R.S.1
Prabakaran, D.2
Mantzoros, C.3
-
14
-
-
0032572722
-
Leptin modulates the T-cell immune response and reverses starvation induced immunosuppression
-
Lord G. Leptin modulates the T-cell immune response and reverses starvation induced immunosuppression. Nature 1998;394:897-901
-
(1998)
Nature
, vol.394
, pp. 897-901
-
-
Lord, G.1
-
15
-
-
0016149002
-
Menstrual cycles: Fatness as a determinant of minimum weight for height necessary for their maintenance or onset
-
Frisch RE, McArthur JW. Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science 1974;185:949-951
-
(1974)
Science
, vol.185
, pp. 949-951
-
-
Frisch, R.E.1
McArthur, J.W.2
-
16
-
-
0031014413
-
Early onset of reproductive function in normal female mice treated with leptin
-
Chehab FF, Mounzih K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with leptin. Science 1997;275(5296):88-90
-
(1997)
Science
, vol.275
, Issue.5296
, pp. 88-90
-
-
Chehab, F.F.1
Mounzih, K.2
Lu, R.3
Lim, M.E.4
-
17
-
-
0030980198
-
A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. Rising leptin levels may signal the onset of puberty
-
Mantzoros CS, Flier JS, Rogol AD. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 1997;82(4):1066-1070
-
(1997)
J Clin Endocrinol Metab
, vol.82
, Issue.4
, pp. 1066-1070
-
-
Mantzoros, C.S.1
Flier, J.S.2
Rogol, A.D.3
-
18
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-1271
-
(1995)
Cell
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
-
19
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996;379:632-635
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
-
21
-
-
0029811162
-
Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus
-
Glaum SR, Hara M, Bindokas VT, et al. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol Pharmacol 1996;50:230-235
-
(1996)
Mol Pharmacol
, vol.50
, pp. 230-235
-
-
Glaum, S.R.1
Hara, M.2
Bindokas, V.T.3
-
22
-
-
0037178730
-
Activation of central melanocortin pathways by fenfluramine
-
Heisler LK, Cowley MA, Tecott LH, et al. Activation of central melanocortin pathways by fenfluramine. Science 2002;297:609-611
-
(2002)
Science
, vol.297
, pp. 609-611
-
-
Heisler, L.K.1
Cowley, M.A.2
Tecott, L.H.3
-
23
-
-
0032508682
-
Biologic action of leptin as an angiogenic factor
-
Sierra-Honigmann M, Nath A, Murakami C, et al. Biologic action of leptin as an angiogenic factor. Science 1998;281:1683-1686
-
(1998)
Science
, vol.281
, pp. 1683-1686
-
-
Sierra-Honigmann, M.1
Nath, A.2
Murakami, C.3
-
24
-
-
0031950686
-
OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype
-
Wang MY, Koyama K, Shimabukuro M, et al. OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. Proc Natl Acad Sci U S A 1998;95(2):714-718
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.2
, pp. 714-718
-
-
Wang, M.Y.1
Koyama, K.2
Shimabukuro, M.3
-
25
-
-
0030015417
-
Defective STAT signaling by the leptin receptor in diabetic mice
-
Ghilardi N, Ziegler S, Wiestner A, et al. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A 1996;93:6231-6235
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 6231-6235
-
-
Ghilardi, N.1
Ziegler, S.2
Wiestner, A.3
-
26
-
-
0031010408
-
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
-
Fei H, Okano HJ, Li C, et al. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A 1997;94:7001-7005
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 7001-7005
-
-
Fei, H.1
Okano, H.J.2
Li, C.3
-
28
-
-
0033305564
-
Rats with hypothalamic obesity are insensitive to central leptin injections
-
Choi SJ, Sparks R, Clay M, Dallman M. Rats with hypothalamic obesity are insensitive to central leptin injections. Endocrinology 1999;140:4426-4433
-
(1999)
Endocrinology
, vol.140
, pp. 4426-4433
-
-
Choi, S.J.1
Sparks, R.2
Clay, M.3
Dallman, M.4
-
29
-
-
0031575804
-
Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization
-
Hoggard N, Mercer JG, Rayner DV, et al. Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. Biochem Biophys Res Commun 1997;232(2):383-387
-
(1997)
Biochem Biophys Res Commun
, vol.232
, Issue.2
, pp. 383-387
-
-
Hoggard, N.1
Mercer, J.G.2
Rayner, D.V.3
-
30
-
-
0023269739
-
The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism
-
Luiten PGM, Horst GJ, Steffens AB. The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism. Prog Neurobiol 1987;28: 1-54
-
(1987)
Prog Neurobiol
, vol.28
, pp. 1-54
-
-
Luiten, P.G.M.1
Horst, G.J.2
Steffens, A.B.3
-
31
-
-
0031012588
-
The alphabet of weight control
-
Friedman JM. The alphabet of weight control. Nature 1997;385:119-120
-
(1997)
Nature
, vol.385
, pp. 119-120
-
-
Friedman, J.M.1
-
32
-
-
0029098589
-
The role of neuropeptide Y in the antiobesity action of the obese gene product
-
Stephens TW, Bashinski M, Bristow PK, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995;377:530-534
-
(1995)
Nature
, vol.377
, pp. 530-534
-
-
Stephens, T.W.1
Bashinski, M.2
Bristow, P.K.3
-
33
-
-
0029804743
-
Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
-
Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996;274(5293): 1704-1707
-
(1996)
Science
, vol.274
, Issue.5293
, pp. 1704-1707
-
-
Erickson, J.C.1
Hollopeter, G.2
Palmiter, R.D.3
-
34
-
-
0031779479
-
Cardiovascular response, feeding behavior, and locomotor activity in mice lacking the NPY Y1 receptor
-
Pedrazzini T, Seydoux J, Kustner P, et al. Cardiovascular response, feeding behavior, and locomotor activity in mice lacking the NPY Y1 receptor. Nat Med 1998;4:722-726
-
(1998)
Nat Med
, vol.4
, pp. 722-726
-
-
Pedrazzini, T.1
Seydoux, J.2
Kustner, P.3
-
36
-
-
0032861562
-
Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
-
Naveilhan P, Hassani H, Canals J, et al. Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat Med 1999;5:1188-1193
-
(1999)
Nat Med
, vol.5
, pp. 1188-1193
-
-
Naveilhan, P.1
Hassani, H.2
Canals, J.3
-
37
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997;88:131-141
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
-
38
-
-
0030614331
-
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
-
Fan W, Boston BA, Kesterson RA, et al. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997;385:165-168
-
(1997)
Nature
, vol.385
, pp. 165-168
-
-
Fan, W.1
Boston, B.A.2
Kesterson, R.A.3
-
39
-
-
0031963436
-
Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
-
Hakansson M-L, Brown H, Ghilardi N, et al. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci 1998;18:559-572
-
(1998)
J Neurosci
, vol.18
, pp. 559-572
-
-
Hakansson, M.-L.1
Brown, H.2
Ghilardi, N.3
-
40
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
Cowley M, Smart J, Rubinstein M, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001;411:480-484
-
(2001)
Nature
, vol.411
, pp. 480-484
-
-
Cowley, M.1
Smart, J.2
Rubinstein, M.3
-
41
-
-
0030764741
-
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
-
Ollmann MM, Wilson BD, Yang Y, et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997; 278:135-138
-
(1997)
Science
, vol.278
, pp. 135-138
-
-
Ollmann, M.M.1
Wilson, B.D.2
Yang, Y.3
-
42
-
-
0030893647
-
Hypothalmic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
-
Shutter JR, Graham M, Kinsey AC, et al. Hypothalmic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev 1997;11:593-602
-
(1997)
Genes Dev
, vol.11
, pp. 593-602
-
-
Shutter, J.R.1
Graham, M.2
Kinsey, A.C.3
-
43
-
-
13344279395
-
A role for melanin-concentrating hormone in the central regulation of feeding behavior
-
Qu D, Ludwig DC, Gammeltoft S, et al. A role for melanin-concentrating hormone in the central regulation of feeding behavior. Nature 1996;380:243-247
-
(1996)
Nature
, vol.380
, pp. 243-247
-
-
Qu, D.1
Ludwig, D.C.2
Gammeltoft, S.3
-
44
-
-
0032542294
-
Mice lacking melanin-concentrating hormone are hypophagic and lean
-
Shimada M, Tritos N, Lowell B, et al. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 1998;396:670-674
-
(1998)
Nature
, vol.396
, pp. 670-674
-
-
Shimada, M.1
Tritos, N.2
Lowell, B.3
-
45
-
-
0015856224
-
Cholecystokinin elicits satiety in rats with open gastric fistulas
-
Gibbs J, Young RC, Smith GP. Cholecystokinin elicits satiety in rats with open gastric fistulas. Nature 1973;245:323-325
-
(1973)
Nature
, vol.245
, pp. 323-325
-
-
Gibbs, J.1
Young, R.C.2
Smith, G.P.3
-
46
-
-
0019890231
-
Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat
-
Smith GP, Jerome C, Cushin BJ, et al. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science 1981;213:1036-1037
-
(1981)
Science
, vol.213
, pp. 1036-1037
-
-
Smith, G.P.1
Jerome, C.2
Cushin, B.J.3
-
47
-
-
0031470983
-
Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake
-
Matson CA, Wiater MF, Kuijper JL, Weigie DS. Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake. Peptides 1997;18: 1275-1278
-
(1997)
Peptides
, vol.18
, pp. 1275-1278
-
-
Matson, C.A.1
Wiater, M.F.2
Kuijper, J.L.3
Weigie, D.S.4
-
48
-
-
0032492893
-
Hypothalamic CART is a new anorectic peptide regulated by leptin
-
Kristensen P, Judge ME, Thim L, et al. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 1998;393:72-76
-
(1998)
Nature
, vol.393
, pp. 72-76
-
-
Kristensen, P.1
Judge, M.E.2
Thim, L.3
-
49
-
-
0030662465
-
Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity
-
Ohi-Hamazaki H, Watase K, Yamamoto K, et al. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. Nature 1997; 390:165-169
-
(1997)
Nature
, vol.390
, pp. 165-169
-
-
Ohi-Hamazaki, H.1
Watase, K.2
Yamamoto, K.3
-
50
-
-
0029949063
-
Leptin activation in hypothalamus
-
Woods AJ, Stock MJ. Leptin activation in hypothalamus. Nature 1996;381:745
-
(1996)
Nature
, vol.381
, pp. 745
-
-
Woods, A.J.1
Stock, M.J.2
-
51
-
-
0032489093
-
Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
-
Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998;92:573-585
-
(1998)
Cell
, vol.92
, pp. 573-585
-
-
Sakurai, T.1
Amemiya, A.2
Ishii, M.3
-
52
-
-
0033588319
-
Narcolepsy: A key role for hypocretins (orexins)
-
Siegel J. Narcolepsy: a key role for hypocretins (orexins). Cell 1999;98:409-412
-
(1999)
Cell
, vol.98
, pp. 409-412
-
-
Siegel, J.1
-
53
-
-
0024452054
-
Direct projects from the central amygdaloid nucleus to the hypothalamic paraventricular nucleus: Possible role in stress-induced adrenocorticotropin release
-
Gray TS, Carney ME, Magnuson DJ. Direct projects from the central amygdaloid nucleus to the hypothalamic paraventricular nucleus: possible role in stress-induced adrenocorticotropin release. Neuroendocrinology 1989;50:433-446
-
(1989)
Neuroendocrinology
, vol.50
, pp. 433-446
-
-
Gray, T.S.1
Carney, M.E.2
Magnuson, D.J.3
-
54
-
-
0020510357
-
Corticotropin-releasing factor immunoreactivity is widely distributed within the central nervous system of the rat: An immunohistochemical study
-
Cummings S, Elde R, Ells J, Lindall A. Corticotropin-releasing factor immunoreactivity is widely distributed within the central nervous system of the rat: an immunohistochemical study. J Neurosci 1983;3:1355-1368
-
(1983)
J Neurosci
, vol.3
, pp. 1355-1368
-
-
Cummings, S.1
Elde, R.2
Ells, J.3
Lindall, A.4
-
55
-
-
0021172033
-
Corticotropin releasing factor (CRF): Origin and course of afferent pathways to the median eminence (ME) of the rat hypothalamus
-
Merchenthaler I, Hynes M, Vigh S, et al. Corticotropin releasing factor (CRF): origin and course of afferent pathways to the median eminence (ME) of the rat hypothalamus. Neuroendocrinology 1984; 39:296-306
-
(1984)
Neuroendocrinology
, vol.39
, pp. 296-306
-
-
Merchenthaler, I.1
Hynes, M.2
Vigh, S.3
-
56
-
-
0023767089
-
Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats
-
Arase K, York D, Shimizu H, et al. Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am J Physiol 1988;255:E255-E259
-
(1988)
Am J Physiol
, vol.255
-
-
Arase, K.1
York, D.2
Shimizu, H.3
-
57
-
-
0024502612
-
Central corticotropin-releasing factor administration prevents the excessive body weight gain of genetically obese (fa/fa) rats
-
Rohner-Jeanrenaud F, Walker C-L, Greco-Perotto R, Jeanrenaud B. Central corticotropin-releasing factor administration prevents the excessive body weight gain of genetically obese (fa/fa) rats. Endocrinology 1989;124:733-739
-
(1989)
Endocrinology
, vol.124
, pp. 733-739
-
-
Rohner-Jeanrenaud, F.1
Walker, C.-L.2
Greco-Perotto, R.3
Jeanrenaud, B.4
-
58
-
-
13344280346
-
Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
-
Schwartz MW, Baskin DG, Bukowski TR, et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 1996; 45(4):531-535
-
(1996)
Diabetes
, vol.45
, Issue.4
, pp. 531-535
-
-
Schwartz, M.W.1
Baskin, D.G.2
Bukowski, T.R.3
-
59
-
-
0031054014
-
Leptin activates neurons in ventrobasal hypothalamus and brainstem
-
Elmquist JK, Ahima RS, Maratos-Flier E, et al. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 1997;138(2): 839-842
-
(1997)
Endocrinology
, vol.138
, Issue.2
, pp. 839-842
-
-
Elmquist, J.K.1
Ahima, R.S.2
Maratos-Flier, E.3
-
60
-
-
0030855190
-
Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress
-
Heiman ML, Ahima RS, Craft LS, et al. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology 1997; 138:3859-3863
-
(1997)
Endocrinology
, vol.138
, pp. 3859-3863
-
-
Heiman, M.L.1
Ahima, R.S.2
Craft, L.S.3
-
61
-
-
0026543152
-
Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene
-
Pepin MC, Pothier F, Barden N. Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene. Nature 1992;355:725-728
-
(1992)
Nature
, vol.355
, pp. 725-728
-
-
Pepin, M.C.1
Pothier, F.2
Barden, N.3
-
62
-
-
0025046510
-
Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucher rats
-
Langley SC, York DA. Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucher rats. Am J Physiol 1990;259:R539-R544
-
(1990)
Am J Physiol
, vol.259
-
-
Langley, S.C.1
York, D.A.2
-
63
-
-
0022495016
-
Effect of adrenalectomy and glucocorticoid replacement on development of obesity
-
Freedman MR, Horwitz BA, Stern JS. Effect of adrenalectomy and glucocorticoid replacement on development of obesity. Am J Physiol 1986;250: R595-R607
-
(1986)
Am J Physiol
, vol.250
-
-
Freedman, M.R.1
Horwitz, B.A.2
Stern, J.S.3
-
64
-
-
0035848818
-
Leptin-regulated endocannabinoids are involved in maintaining food intake
-
Di Marzo V, Goparaju SK, Wang L, et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 2001;410:822-825
-
(2001)
Nature
, vol.410
, pp. 822-825
-
-
Di Marzo, V.1
Goparaju, S.K.2
Wang, L.3
-
65
-
-
0035826218
-
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
-
Yamada M, Miyakawa T, Duttaroy A, et al. Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature 2001;410: 207-212
-
(2001)
Nature
, vol.410
, pp. 207-212
-
-
Yamada, M.1
Miyakawa, T.2
Duttaroy, A.3
-
66
-
-
0035843183
-
A role for ghrelin in the central regulation of feeding
-
Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-198
-
(2001)
Nature
, vol.409
, pp. 194-198
-
-
Nakazato, M.1
Murakami, N.2
Date, Y.3
-
67
-
-
0035970842
-
Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus
-
DeFalco J, Tomishima M, Liu H, et al. Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science 2001;291:2608-2613
-
(2001)
Science
, vol.291
, pp. 2608-2613
-
-
DeFalco, J.1
Tomishima, M.2
Liu, H.3
-
68
-
-
0030992071
-
A human leptin mutant induces weight gain in normal mice
-
Verploegen S, Plaetinck G, Devos R, et al. A human leptin mutant induces weight gain in normal mice. FEBS Lett 1997;405(2):237-240
-
(1997)
FEBS Lett
, vol.405
, Issue.2
, pp. 237-240
-
-
Verploegen, S.1
Plaetinck, G.2
Devos, R.3
-
69
-
-
0015949582
-
In vivo studies in obese hyperglycaemic (ob/ob) mice: Possible role of hyperinsulinaemia
-
Loten EG, Rabinovitch A, Jeanrenaud B. In vivo studies in obese hyperglycaemic (ob/ob) mice: possible role of hyperinsulinaemia. Diabetologia 1974;10:45-52
-
(1974)
Diabetologia
, vol.10
, pp. 45-52
-
-
Loten, E.G.1
Rabinovitch, A.2
Jeanrenaud, B.3
-
70
-
-
0029908857
-
Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
-
Chen G, Koyama K, Yuan X, et al. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci U S A 1996;93(25):14795-14799
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.25
, pp. 14795-14799
-
-
Chen, G.1
Koyama, K.2
Yuan, X.3
-
71
-
-
0029939065
-
Decreased food intake does not completely account for adiposity reduction after ob protein infusion
-
Levin N, Nelson C, Gurney A, et al. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci U S A 1996;93:1726-1730
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 1726-1730
-
-
Levin, N.1
Nelson, C.2
Gurney, A.3
-
72
-
-
0034655590
-
Leptin-specific patterns of gene expression in white adipose tissue
-
Soukas A, Cohen P, Socci ND, Friedman JM. Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev 2000;14(8):963-980
-
(2000)
Genes Dev
, vol.14
, Issue.8
, pp. 963-980
-
-
Soukas, A.1
Cohen, P.2
Socci, N.D.3
Friedman, J.M.4
-
73
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in ob/ob mice
-
Pelleymounter MA, Cullen MJ, Baker MD, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995;269:540-543
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
Cullen, M.J.2
Baker, M.D.3
-
74
-
-
0033037727
-
Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat
-
Chinookoswong N, Wang J, Shi Z. Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. Diabetes 1999; 48:1487-1492
-
(1999)
Diabetes
, vol.48
, pp. 1487-1492
-
-
Chinookoswong, N.1
Wang, J.2
Shi, Z.3
-
75
-
-
0033517284
-
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
-
Shimomura I, Hammer R, Ikemoto S, et al. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999; 401:73-76
-
(1999)
Nature
, vol.401
, pp. 73-76
-
-
Shimomura, I.1
Hammer, R.2
Ikemoto, S.3
-
76
-
-
0026468362
-
What if Minkowski had been ageusic? An alternative angle on diabetes
-
McGarry JD. What if Minkowski had been ageusic? An alternative angle on diabetes. Science 1992; 258:766-770
-
(1992)
Science
, vol.258
, pp. 766-770
-
-
McGarry, J.D.1
-
78
-
-
0033927667
-
Cellular mechanisms of insulin resistance
-
Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000;106:171-176
-
(2000)
J Clin Invest
, vol.106
, pp. 171-176
-
-
Shulman, G.I.1
-
79
-
-
0035912744
-
Tissue specific overexpression of lipoprotein lipase causes tissue specific insulin resistance
-
Kim J, Fillmore J, Chen Y, et al. Tissue specific overexpression of lipoprotein lipase causes tissue specific insulin resistance. Proc Natl Acad Sci U S A 2001;98:7522-7527
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 7522-7527
-
-
Kim, J.1
Fillmore, J.2
Chen, Y.3
-
80
-
-
0029885220
-
The hypothalamic leptin receptor in humans: Identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations
-
Considine RV, Considine EL, Williams CJ, et al. The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 1996;45(7):992-994
-
(1996)
Diabetes
, vol.45
, Issue.7
, pp. 992-994
-
-
Considine, R.V.1
Considine, E.L.2
Williams, C.J.3
-
81
-
-
0028793697
-
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
-
Frederich RC, Hamn A, Anderson S, et al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1995;1:1311-1314
-
(1995)
Nat Med
, vol.1
, pp. 1311-1314
-
-
Frederich, R.C.1
Hamn, A.2
Anderson, S.3
-
82
-
-
0018151024
-
The effect of westernization on native populations. Studies on a Micronesian community with a high diabetes prevalence
-
Zimmet P, Arblaster M, Thoma K. The effect of westernization on native populations. Studies on a Micronesian community with a high diabetes prevalence. Aust N Z J Med 1978;8(2):141-146
-
(1978)
Aust N Z J Med
, vol.8
, Issue.2
, pp. 141-146
-
-
Zimmet, P.1
Arblaster, M.2
Thoma, K.3
-
83
-
-
0031259837
-
Inherited non-autosomal effects on body fat in F2 mice derived from an AKR/J x SWR/J cross. Mann
-
York B, Lei K, West DB. Inherited non-autosomal effects on body fat in F2 mice derived from an AKR/J x SWR/J cross. Mann. Genome 1997;8:726-30
-
(1997)
Genome
, vol.8
, pp. 726-730
-
-
York, B.1
Lei, K.2
West, D.B.3
-
85
-
-
0031050415
-
Relatively low plasma leptin concentrations precede weight gain in Pima Indians
-
Ravussin E, Pratley RE, Maffei M, et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med 1997;3:238-240
-
(1997)
Nat Med
, vol.3
, pp. 238-240
-
-
Ravussin, E.1
Pratley, R.E.2
Maffei, M.3
-
86
-
-
0029881125
-
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
-
Schwartz MW, Peskind E, Raskind M, et al. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 1996; 2:589-593
-
(1996)
Nat Med
, vol.2
, pp. 589-593
-
-
Schwartz, M.W.1
Peskind, E.2
Raskind, M.3
-
87
-
-
0030594830
-
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
-
Caro JF, Kolaczynski JW, Nyce MR, et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996;348(9021):159-161
-
(1996)
Lancet
, vol.348
, Issue.9021
, pp. 159-161
-
-
Caro, J.F.1
Kolaczynski, J.W.2
Nyce, M.R.3
-
88
-
-
0032718072
-
CSF leptin levels after exogenous administration of recombinant methionyl human leptin
-
Fujioka K, Patane J, Lubina J, Lau D. CSF leptin levels after exogenous administration of recombinant methionyl human leptin. JAMA 1999;282: 1517-1518
-
(1999)
JAMA
, vol.282
, pp. 1517-1518
-
-
Fujioka, K.1
Patane, J.2
Lubina, J.3
Lau, D.4
-
89
-
-
0031017561
-
Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels
-
Golden PL, Maccagnan TJ, Pardridge WM. Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J Clin Invest 1997;99:14-18
-
(1997)
J Clin Invest
, vol.99
, pp. 14-18
-
-
Golden, P.L.1
Maccagnan, T.J.2
Pardridge, W.M.3
-
90
-
-
0029864416
-
Leptin enters the brain by a saturable system independent of insulin
-
Banks WA, Kastin AJ, Huang W, et al. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996;17:305-311
-
(1996)
Peptides
, vol.17
, pp. 305-311
-
-
Banks, W.A.1
Kastin, A.J.2
Huang, W.3
-
91
-
-
0032763709
-
Impaired transport of leptin across the blood-brain barrier in obesity
-
Banks W, DiPalma C, Farrell C. Impaired transport of leptin across the blood-brain barrier in obesity. Peptides 1999;20:1341-1345
-
(1999)
Peptides
, vol.20
, pp. 1341-1345
-
-
Banks, W.1
DiPalma, C.2
Farrell, C.3
-
92
-
-
0030942844
-
The leptin receptor
-
Tartaglia LA. The leptin receptor. J Biol Chem 1997;272(10):6093-6096
-
(1997)
J Biol Chem
, vol.272
, Issue.10
, pp. 6093-6096
-
-
Tartaglia, L.A.1
-
93
-
-
0031040793
-
Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
-
White DW, Kuropatwinski KK, Devos R, et al. Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J Biol Chem 1997;272: 4065-4071
-
(1997)
J Biol Chem
, vol.272
, pp. 4065-4071
-
-
White, D.W.1
Kuropatwinski, K.K.2
Devos, R.3
-
94
-
-
0031436148
-
Divergent signaling capacities of the long and short isoforms of the leptin receptor
-
Bjorbaek C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272(51):32686-32695
-
(1997)
J Biol Chem
, vol.272
, Issue.51
, pp. 32686-32695
-
-
Bjorbaek, C.1
Uotani, S.2
Da Silva, B.3
Flier, J.S.4
-
95
-
-
0029739826
-
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
-
Vaisse C, Halaas JL, Horvath CM, et al. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet 1996;14:95-97.
-
(1996)
Nat Genet
, vol.14
, pp. 95-97
-
-
Vaisse, C.1
Halaas, J.L.2
Horvath, C.M.3
-
96
-
-
0032568515
-
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with ob receptor
-
Carpenter LR, Farruggella TJ, Symes A, et la. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with ob receptor. Proc Natl Acad Sci U S A 1998;95:6061-6066
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6061-6066
-
-
Carpenter, L.R.1
Farruggella, T.J.2
Symes, A.3
-
97
-
-
0033578334
-
Leptin receptor activation of SH2 domain protein tyrosone phosphatase 2 modulates ob receptor signal transduction
-
Li C, Friedman J. Leptin receptor activation of SH2 domain protein tyrosone phosphatase 2 modulates ob receptor signal transduction. Proc Natl Acad Sci U S A 1999;96:9677-9682
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 9677-9682
-
-
Li, C.1
Friedman, J.2
-
98
-
-
0032014178
-
Identification of SOC-3 as a potential mediator of central leptin resistance
-
Bjorbaek C, Elmquist JK, Frantz JD, et al. Identification of SOC-3 as a potential mediator of central leptin resistance. Mol Cell 1998;1:619-625
-
(1998)
Mol Cell
, vol.1
, pp. 619-625
-
-
Bjorbaek, C.1
Elmquist, J.K.2
Frantz, J.D.3
-
99
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387:903-908
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
-
100
-
-
0032014836
-
A leptin missense mutation associated with hypogonadism and morbid obesity
-
Strobel A, Camoin TIL, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998;18: 213-215
-
(1998)
Nat Genet
, vol.18
, pp. 213-215
-
-
Strobel, A.1
Camoin, T.I.L.2
Ozata, M.3
Strosberg, A.D.4
-
101
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
Vaisse, C.2
Lahlou, N.3
-
102
-
-
0031668219
-
A frameshift mutation in MC4R associated with dominatly inherited human obesity
-
Yeo G, Farooqi I, Aminian S, et al. A frameshift mutation in MC4R associated with dominatly inherited human obesity. Nat Genet 1998;20:111-112
-
(1998)
Nat Genet
, vol.20
, pp. 111-112
-
-
Yeo, G.1
Farooqi, I.2
Aminian, S.3
-
103
-
-
0031017322
-
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
-
Comuzzie AG, Hixson JE, Almasy L, et al. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 1997;15:273-276
-
(1997)
Nat Genet
, vol.15
, pp. 273-276
-
-
Comuzzie, A.G.1
Hixson, J.E.2
Almasy, L.3
-
104
-
-
0031838353
-
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
-
Krude H, Biebermann H, Luck W, et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998;19:155-157
-
(1998)
Nat Genet
, vol.19
, pp. 155-157
-
-
Krude, H.1
Biebermann, H.2
Luck, W.3
-
105
-
-
0030949271
-
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
-
Jackson RS, Creemers JW, Ohagi S, et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 1997;16:303-306
-
(1997)
Nat Genet
, vol.16
, pp. 303-306
-
-
Jackson, R.S.1
Creemers, J.W.2
Ohagi, S.3
-
106
-
-
0029363329
-
Effect of degree of weight loss on health benefits
-
Blackburn G. Effect of degree of weight loss on health benefits. Obes Res 1995;3:211s-216s
-
(1995)
Obes Res
, vol.3
-
-
Blackburn, G.1
-
107
-
-
0031266130
-
Relationships between changes in body compostition and changes in cardiovascular risk factors: The SOS Intervention Study
-
Sjostrom CD, Lissner L, Sjostrom L. Relationships between changes in body compostition and changes in cardiovascular risk factors: the SOS Intervention Study. Obes Res 1997;5:519-530
-
(1997)
Obes Res
, vol.5
, pp. 519-530
-
-
Sjostrom, C.D.1
Lissner, L.2
Sjostrom, L.3
-
108
-
-
0033575993
-
Effects of recombinant leptin therapy in a child with congenital leptin deficiency
-
Farooqi I, Jebb S, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879-884
-
(1999)
N Engl J Med
, vol.341
, pp. 879-884
-
-
Farooqi, I.1
Jebb, S.2
Langmack, G.3
-
109
-
-
0032747280
-
Recombinant leptin for weight loss in obese and lean adults
-
Heymsfield S, Greenberg A, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults. JAMA 1999;282:1568-1575
-
(1999)
JAMA
, vol.282
, pp. 1568-1575
-
-
Heymsfield, S.1
Greenberg, A.2
Fujioka, K.3
-
110
-
-
0030847432
-
Acute intravenous and intracerebroventricular leptin infusion increases glucose uptake and glucose turnover by an insulin independent mechanism
-
Kamohara S, Burcelin R, Halaas JL, et al. Acute intravenous and intracerebroventricular leptin infusion increases glucose uptake and glucose turnover by an insulin independent mechanism. Nature 1997;389:374-377
-
(1997)
Nature
, vol.389
, pp. 374-377
-
-
Kamohara, S.1
Burcelin, R.2
Halaas, J.L.3
-
111
-
-
0030737573
-
Effects of leptin on insulin sensitivity in normal rats
-
Sivitz WI, Walsh SA, Morgan DA, et al. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997;138:3395-3401
-
(1997)
Endocrinology
, vol.138
, pp. 3395-3401
-
-
Sivitz, W.I.1
Walsh, S.A.2
Morgan, D.A.3
|