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Volumn 15, Issue 3, 1997, Pages 273-276

A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; LEPTIN;

EID: 0031017322     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0397-273     Document Type: Article
Times cited : (418)

References (41)
  • 1
    • 0029083859 scopus 로고
    • Increased obese mRNA expression in omental fat cells from massively obese humans
    • Hamilton, B.S., Paglia, D., Kwan, A.Y.M. & Deitel, M. Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med. 9, 953-956 (1995).
    • (1995) Nature Med. , vol.9 , pp. 953-956
    • Hamilton, B.S.1    Paglia, D.2    Kwan, A.Y.M.3    Deitel, M.4
  • 2
    • 0029050937 scopus 로고
    • Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
    • Lönnqvist, F., Arner, P., Nordfors, L. & Schalling, M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med. 1, 950-953 (1995).
    • (1995) Nature Med. , vol.1 , pp. 950-953
    • Lönnqvist, F.1    Arner, P.2    Nordfors, L.3    Schalling, M.4
  • 3
    • 0029090011 scopus 로고
    • Human obese gene expression: Adipocyte-specific expression and regional differences in the adipose tissue
    • Masuzaki, H. et al. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44, 855-858 (1995).
    • (1995) Diabetes , vol.44 , pp. 855-858
    • Masuzaki, H.1
  • 4
    • 0029974877 scopus 로고    scopus 로고
    • Adipose tissue leptin production and plasma leptin kinetics in humans
    • Klein, S., Coppack, W., Mohamed-Ali, V. & Landt, M. Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45, 984-987 (1996).
    • (1996) Diabetes , vol.45 , pp. 984-987
    • Klein, S.1    Coppack, W.2    Mohamed-Ali, V.3    Landt, M.4
  • 5
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R. & Burn, P. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546-549 (1995).
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 6
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas, J.L. et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546 (1995).
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1
  • 7
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter, M.A. et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543 (1995).
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1
  • 8
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei, M. et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med. 1, 1155-1161 (1995).
    • (1995) Nature Med. , vol.1 , pp. 1155-1161
    • Maffei, M.1
  • 9
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine, R.V. et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Eng. J. Med. 334, 292-325 (1996).
    • (1996) New Eng. J. Med. , vol.334 , pp. 292-325
    • Considine, R.V.1
  • 11
    • 0025772750 scopus 로고
    • Obesity in Mexican American subgroups: Findings from the San Antonio Heart study
    • Hazuda, H.P., Mitchell, B.D., Haffner, S.M. & Stern, M.P. Obesity in Mexican American subgroups: findings from the San Antonio Heart study. Am. J. Clin. Nutr. 53, 1529s-1534s (1991).
    • (1991) Am. J. Clin. Nutr. , vol.53
    • Hazuda, H.P.1    Mitchell, B.D.2    Haffner, S.M.3    Stern, M.P.4
  • 12
    • 0028841363 scopus 로고
    • Major gene with sex-specific effects influences fat mass in Mexican Americans
    • Comuzzie, A.G. et al. Major gene with sex-specific effects influences fat mass in Mexican Americans. Genet. Epidemiol. 12, 475-488 (1995).
    • (1995) Genet. Epidemiol. , vol.12 , pp. 475-488
    • Comuzzie, A.G.1
  • 14
    • 0025085568 scopus 로고
    • Common major gene inheritance of extreme overweight
    • Price, R.A., Ness, R. & Laskarzewski, P. Common major gene inheritance of extreme overweight. Hum. Biol. 62, 747-765 (1990).
    • (1990) Hum. Biol. , vol.62 , pp. 747-765
    • Price, R.A.1    Ness, R.2    Laskarzewski, P.3
  • 15
    • 0027496291 scopus 로고
    • Segregation analysis of fat mass and other body composition measures derived from underwater weighing
    • Rice, T., Borecki I.B., Bouchard, C. & Rao, D.C. Segregation analysis of fat mass and other body composition measures derived from underwater weighing. Am. J. Hum. Genet. 52, 967-973 (1993).
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 967-973
    • Rice, T.1    Borecki, I.B.2    Bouchard, C.3    Rao, D.C.4
  • 16
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994).
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1
  • 17
    • 0345335191 scopus 로고    scopus 로고
    • Indication for linkage of the human OB gene region with extreme obesity
    • Clemént, K. et al. Indication for linkage of the human OB gene region with extreme obesity. Diabetes 45, 687-690 (1996).
    • (1996) Diabetes , vol.45 , pp. 687-690
    • Clemént, K.1
  • 18
    • 0029938057 scopus 로고    scopus 로고
    • Extreme obesity may be linked to markers flanking the human OB gene
    • Reed, D.R. et al. Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 45, 691-694 (1996).
    • (1996) Diabetes , vol.45 , pp. 691-694
    • Reed, D.R.1
  • 19
    • 19244362737 scopus 로고    scopus 로고
    • Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7
    • Duggirala, R. et al. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. Am. J. Hum. Genet. 59, 694-703 (1996).
    • (1996) Am. J. Hum. Genet. , vol.59 , pp. 694-703
    • Duggirala, R.1
  • 20
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241-247 (1995).
    • (1995) Nature Genet. , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 21
    • 0018756428 scopus 로고
    • Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis
    • Bray, G.A. & York, D. A. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol. Rev. 59, 719-809 (1979).
    • (1979) Physiol. Rev. , vol.59 , pp. 719-809
    • Bray, G.A.1    York, D.A.2
  • 22
    • 0027503864 scopus 로고
    • Altered adrenocorticotropin and cortisol secretion in abdominal obesity: Implications for the insulin resistance syndrome
    • Hautanen, A. & Adlercreutz, H. Altered adrenocorticotropin and cortisol secretion in abdominal obesity: implications for the insulin resistance syndrome. J. Intern. Med. 234, 461-469 (1993).
    • (1993) J. Intern. Med. , vol.234 , pp. 461-469
    • Hautanen, A.1    Adlercreutz, H.2
  • 23
    • 0029021599 scopus 로고
    • Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake
    • De Vos, P., Saladin, R., Auwerx, J. & Staels, B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J. Biol. Chem. 270, 15958-15961 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 15958-15961
    • De Vos, P.1    Saladin, R.2    Auwerx, J.3    Staels, B.4
  • 24
    • 0028972884 scopus 로고
    • Dexamethasone regulates obese expression in isolated rat adipocytes
    • Murakami, T., Iida, M. & Shima, K. Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem. Biophys. Res. Comm. 214, 1260-1267 (1995).
    • (1995) Biochem. Biophys. Res. Comm. , vol.214 , pp. 1260-1267
    • Murakami, T.1    Iida, M.2    Shima, K.3
  • 25
    • 0029347069 scopus 로고
    • Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization
    • Warner, J.P., Leek, J.P., Intody, S., Markham, A.F. & Bonthron, D.T. Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization. Mammalian Genome 6, 532-536 (1995).
    • (1995) Mammalian Genome , vol.6 , pp. 532-536
    • Warner, J.P.1    Leek, J.P.2    Intody, S.3    Markham, A.F.4    Bonthron, D.T.5
  • 26
    • 0028978910 scopus 로고
    • 3-adrenergic receptor and increased capacity to gain weight in patients with morbid obesity
    • 3-adrenergic receptor and increased capacity to gain weight in patients with morbid obesity. JAMA. 333, 352-354 (1995).
    • (1995) JAMA , vol.333 , pp. 352-354
    • Clement, K.1
  • 27
    • 0025144936 scopus 로고
    • Enzyme polymorphism and clinical variability of diseases: Study of acid phosphatase locus 1 (ACP1) in obese subjects
    • Bottini, E. et al. Enzyme polymorphism and clinical variability of diseases: study of acid phosphatase locus 1 (ACP1) in obese subjects. Hum Biol. 62, 403-411 (1990).
    • (1990) Hum Biol. , vol.62 , pp. 403-411
    • Bottini, E.1
  • 28
    • 0028179074 scopus 로고
    • ApoB-100 gene EcoRI polymorphism: Relations to plasma lipoprotein changes associated with abdominal visceral obesity
    • Pouliot, M.-C. et al. ApoB-100 gene EcoRI polymorphism: Relations to plasma lipoprotein changes associated with abdominal visceral obesity. Arterioscler. Thromb. 14, 527-533 (1994).
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 527-533
    • Pouliot, M.-C.1
  • 29
    • 0024205653 scopus 로고
    • Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels, and increased risk of coronary heart disease
    • Rajput-Williams, J. et al. Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels, and increased risk of coronary heart disease. Lancet 2, 1442-1445 (1988).
    • (1988) Lancet , vol.2 , pp. 1442-1445
    • Rajput-Williams, J.1
  • 30
    • 0027448688 scopus 로고
    • DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy Indians in Singapore
    • Saha, N., Tay, J.S.H., Heng, C.K., & Humphries, S.E. DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy Indians in Singapore. Clin. Genet. 44, 113-120 (1993).
    • (1993) Clin. Genet. , vol.44 , pp. 113-120
    • Saha, N.1    Tay, J.S.H.2    Heng, C.K.3    Humphries, S.E.4
  • 31
    • 0028844493 scopus 로고
    • Plasma HDL cholesterol, triglycerides, and adiposity: A quantitative genetic test of the conjoint trait hypothesis in the San Antonio family heart study
    • Mahaney, M.C. et al. Plasma HDL cholesterol, triglycerides, and adiposity: A quantitative genetic test of the conjoint trait hypothesis in the San Antonio family heart study. Circulation 92, 3240-3248 (1995).
    • (1995) Circulation , vol.92 , pp. 3240-3248
    • Mahaney, M.C.1
  • 32
    • 0030065814 scopus 로고    scopus 로고
    • Genetic analysis of the IRS: Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures
    • Mitchell, B.D. et al. Genetic analysis of the IRS: Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures. Arterioscler. Thromb. Vasc. Biol. 16, 281-288 (1996).
    • (1996) Arterioscler. Thromb. Vasc. Biol. , vol.16 , pp. 281-288
    • Mitchell, B.D.1
  • 33
    • 0027828268 scopus 로고
    • A comparison of three methods for assessing Amerindian admixture in Mexican Americans
    • Mitchell, B.D. et al. A comparison of three methods for assessing Amerindian admixture in Mexican Americans. Ethnicity Dis. 3, 22-31 (1993).
    • (1993) Ethnicity Dis. , vol.3 , pp. 22-31
    • Mitchell, B.D.1
  • 34
    • 0029941697 scopus 로고    scopus 로고
    • Analysis of human plasma leptin by radioimmunoassay
    • Ma, Z. et al. Analysis of human plasma leptin by radioimmunoassay. Clin. Chem. J. 42, 942-946 (1996).
    • (1996) Clin. Chem. J. , vol.42 , pp. 942-946
    • Ma, Z.1
  • 35
    • 0028058128 scopus 로고
    • Robust variance-components approach for assessing genetic linkage in pedigrees
    • Amos, C.I. Robust variance-components approach for assessing genetic linkage in pedigrees. Am. J. Hum. Genet. 54, 535-543 (1994)
    • (1994) Am. J. Hum. Genet. , vol.54 , pp. 535-543
    • Amos, C.I.1
  • 36
    • 0019920786 scopus 로고
    • Extensions to multivariate normal models for pedigree analysis
    • Hopper, J.L. & Mathews, J.D. Extensions to multivariate normal models for pedigree analysis. Ann. Hum. Genet 46, 373-383 (1982).
    • (1982) Ann. Hum. Genet , vol.46 , pp. 373-383
    • Hopper, J.L.1    Mathews, J.D.2
  • 37
    • 0003958977 scopus 로고    scopus 로고
    • SOLAR: Sequential Oligogenic Linkage Analysis Routines
    • Southwest Foundation for Biomedical Research, San Antonio, Texas
    • Blangero, J. & Almasy, L.A. SOLAR: Sequential Oligogenic Linkage Analysis Routines. Population Genetics Laboratory Technical Report No. 6, Southwest Foundation for Biomedical Research, San Antonio, Texas (1996).
    • (1996) Population Genetics Laboratory Technical Report No. 6 , vol.6
    • Blangero, J.1    Almasy, L.A.2
  • 38
    • 0024190141 scopus 로고
    • Programs for pedigree analysis: Mendel, Fisher, and dGene
    • Lange, K., Weeks, D. & Boehnke, M. Programs for pedigree analysis: Mendel, Fisher, and dGene. Genet. Epidemiol. 5, 471-472 (1988).
    • (1988) Genet. Epidemiol. , vol.5 , pp. 471-472
    • Lange, K.1    Weeks, D.2    Boehnke, M.3
  • 39
    • 0029918883 scopus 로고    scopus 로고
    • Nonparametric simulation-based statistics for detecting linkage in general pedigrees
    • Davis, S., Schoeder, M., Goldin, L.R. & Weeks, D.E. Nonparametric simulation-based statistics for detecting linkage in general pedigrees. Am. J. Hum. Genet. 58, 867-880 (1996).
    • (1996) Am. J. Hum. Genet. , vol.58 , pp. 867-880
    • Davis, S.1    Schoeder, M.2    Goldin, L.R.3    Weeks, D.E.4
  • 40
    • 0028947057 scopus 로고
    • Multipoint interval mapping of quantitative trait loci, using sib pairs
    • Fulker, D.W., Cherny, S.S. & Cardon, L.R. Multipoint interval mapping of quantitative trait loci, using sib pairs. Am. J. Hum. Genet. 56, 1224-1233 (1995).
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 1224-1233
    • Fulker, D.W.1    Cherny, S.S.2    Cardon, L.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.