A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

Nature Genetics

Volumn 15, Issue 3, 1997, Pages 273-276

  Comuzzie, Anthony G ^a   Hixson, James E ^a   Almasy, Laura ^a   Mitchell, Braxton D ^a   Mahaney, Michael C ^a   Dyer, Thomas D ^a   Stern, Michael P ^b   MacCluer, Jean W ^a   Blangero, John ^a  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^b Univ of Texas Health Science Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; LEPTIN;

ADIPOCYTE; ADULT; AGED; ARTICLE; BODY FAT; CHROMOSOME 2; FEMALE; GENETIC LINKAGE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PEDIGREE ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE TRAIT;

EID: 0031017322     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0397-273     Document Type: Article

References (41)

1. Hamilton, B.S., Paglia, D., Kwan, A.Y.M. & Deitel, M. Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med. 9, 953-956 (1995).
2. Lönnqvist, F., Arner, P., Nordfors, L. & Schalling, M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med. 1, 950-953 (1995).
3. Masuzaki, H. et al. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44, 855-858 (1995).
4. Klein, S., Coppack, W., Mohamed-Ali, V. & Landt, M. Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45, 984-987 (1996).
5. Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R. & Burn, P. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546-549 (1995).
6. Halaas, J.L. et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546 (1995).
7. Pelleymounter, M.A. et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543 (1995).
8. Maffei, M. et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med. 1, 1155-1161 (1995).
9. Considine, R.V. et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Eng. J. Med. 334, 292-325 (1996).
10. Frisancho, A.R. Anthropometric Standards for the Assessment of Growth and Nutritional Status. (University of Michigan Press, Ann Arbor, 1990).
11. Hazuda, H.P., Mitchell, B.D., Haffner, S.M. & Stern, M.P. Obesity in Mexican American subgroups: findings from the San Antonio Heart study. Am. J. Clin. Nutr. 53, 1529s-1534s (1991).
12. Comuzzie, A.G. et al. Major gene with sex-specific effects influences fat mass in Mexican Americans. Genet. Epidemiol. 12, 475-488 (1995).
13. Hasstedt, S.J., Ramirez, M.E., Kuida, H. & Williams R.R. Recessive inheritance of a relative fat pattern. Am. J. Hum. Genet. 45, 917-925 (1989).
14. Price, R.A., Ness, R. & Laskarzewski, P. Common major gene inheritance of extreme overweight. Hum. Biol. 62, 747-765 (1990).
15. Rice, T., Borecki I.B., Bouchard, C. & Rao, D.C. Segregation analysis of fat mass and other body composition measures derived from underwater weighing. Am. J. Hum. Genet. 52, 967-973 (1993).
16. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994).
17. Clemént, K. et al. Indication for linkage of the human OB gene region with extreme obesity. Diabetes 45, 687-690 (1996).
18. Reed, D.R. et al. Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 45, 691-694 (1996).
19. Duggirala, R. et al. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. Am. J. Hum. Genet. 59, 694-703 (1996).
20. Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241-247 (1995).
21. Bray, G.A. & York, D. A. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol. Rev. 59, 719-809 (1979).
22. Hautanen, A. & Adlercreutz, H. Altered adrenocorticotropin and cortisol secretion in abdominal obesity: implications for the insulin resistance syndrome. J. Intern. Med. 234, 461-469 (1993).
23. De Vos, P., Saladin, R., Auwerx, J. & Staels, B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J. Biol. Chem. 270, 15958-15961 (1995).
24. Murakami, T., Iida, M. & Shima, K. Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem. Biophys. Res. Comm. 214, 1260-1267 (1995).
25. Warner, J.P., Leek, J.P., Intody, S., Markham, A.F. & Bonthron, D.T. Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization. Mammalian Genome 6, 532-536 (1995).
26. 3-adrenergic receptor and increased capacity to gain weight in patients with morbid obesity. JAMA. 333, 352-354 (1995).
27. Bottini, E. et al. Enzyme polymorphism and clinical variability of diseases: study of acid phosphatase locus 1 (ACP1) in obese subjects. Hum Biol. 62, 403-411 (1990).
28. Pouliot, M.-C. et al. ApoB-100 gene EcoRI polymorphism: Relations to plasma lipoprotein changes associated with abdominal visceral obesity. Arterioscler. Thromb. 14, 527-533 (1994).
29. Rajput-Williams, J. et al. Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels, and increased risk of coronary heart disease. Lancet 2, 1442-1445 (1988).
30. Saha, N., Tay, J.S.H., Heng, C.K., & Humphries, S.E. DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy Indians in Singapore. Clin. Genet. 44, 113-120 (1993).
31. Mahaney, M.C. et al. Plasma HDL cholesterol, triglycerides, and adiposity: A quantitative genetic test of the conjoint trait hypothesis in the San Antonio family heart study. Circulation 92, 3240-3248 (1995).
32. Mitchell, B.D. et al. Genetic analysis of the IRS: Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures. Arterioscler. Thromb. Vasc. Biol. 16, 281-288 (1996).
33. Mitchell, B.D. et al. A comparison of three methods for assessing Amerindian admixture in Mexican Americans. Ethnicity Dis. 3, 22-31 (1993).
34. Ma, Z. et al. Analysis of human plasma leptin by radioimmunoassay. Clin. Chem. J. 42, 942-946 (1996).
35. Amos, C.I. Robust variance-components approach for assessing genetic linkage in pedigrees. Am. J. Hum. Genet. 54, 535-543 (1994)
36. Hopper, J.L. & Mathews, J.D. Extensions to multivariate normal models for pedigree analysis. Ann. Hum. Genet 46, 373-383 (1982).
37. Blangero, J. & Almasy, L.A. SOLAR: Sequential Oligogenic Linkage Analysis Routines. Population Genetics Laboratory Technical Report No. 6, Southwest Foundation for Biomedical Research, San Antonio, Texas (1996).
38. Lange, K., Weeks, D. & Boehnke, M. Programs for pedigree analysis: Mendel, Fisher, and dGene. Genet. Epidemiol. 5, 471-472 (1988).
39. Davis, S., Schoeder, M., Goldin, L.R. & Weeks, D.E. Nonparametric simulation-based statistics for detecting linkage in general pedigrees. Am. J. Hum. Genet. 58, 867-880 (1996).
40. Fulker, D.W., Cherny, S.S. & Cardon, L.R. Multipoint interval mapping of quantitative trait loci, using sib pairs. Am. J. Hum. Genet. 56, 1224-1233 (1995).
41. Green, P., Falls, K. & Crooks, S. Documentation for CRI-MAP. Version 2.4. Department of Genetics, School of Medicine, Washington University, St. Louis (1990).