p53-dependent cell death/apoptosis is required for a productive adenovirus infection

Nature Medicine

Volumn 4, Issue 9, 1998, Pages 1068-1072

  Hall, Anthony R ^a   Dix, Brett R ^a   O'Carroll, Simon J ^a   Braithwaite, Antony W ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADENOVIRUS; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL COUNT; CELL DESTRUCTION; CELL TRANSFORMATION; DELETION MUTANT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS INFECTION; VIRUS REPLICATION;

ADENOVIRUSES, HUMAN; APOPTOSIS; CELL LINE, TRANSFORMED; CYTOPATHOGENIC EFFECT, VIRAL; HELA CELLS; HUMANS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

ADENOVIRIDAE; ONYX; PAPOVAVIRIDAE;

EID: 0031697770     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/2057     Document Type: Article

References (29)

1. Sarnow, P., Ho, Y.S., Williams, J. & Levine, A.J. Adenovirus Elb-58kDa tumor antigen and SV40 large T antigen are physically associated with the same 54kDa protein in transformed cells. Cell 28, 387-394 (1982).
2. Yew, P.R. & Berk, A.J. Inhibition of p53 transactivation required for transformation by adenovirus early 1 b protein. Nature 357, 82-85 (1992).
3. Braithwaite, A.W., Blair, G.E., Nelson, C.C., McGovern, J. & Bellett, A.J.D. Adenovirus Elb-58kDa antigen binds to p53 during infection of rodent cells: evidence for an N-terminal binding site on p53. Oncogene 6, 781-787 (1991).
4. Grand, R.J.A., Grant, M.L. & Gallimore, P.H. Enhanced expression of p53 in human cells infected with mutant adenoviruses. Virology 203, 229-240 (1994).
5. Ridgway, P.J., Hall, A.R., Myers, C.J. & Braithwaite, A.W. p53/E1b58kDa complex regulates adenovirus replication. Virology 237, 404-413 (1997).
6. Bischoff, J.R. et al. An adenovirus mutant that replicates selectively in p53-deficient tumor cells. Science 274, 373-376 (1996).
7. Heise, C. et al. Onyx-015, an E1b gene-attenuated adenovirus, causes tumor -specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nature Med. 3, 639-645 (1997).
8. Graham, F.L., Smiley, J., Russell, W.C. & Nairn, R. Characterization of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36, 59-72 (1977).
9. Scheffner, M., Munger, K., Byrne, J.C. & Howley, P.M. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc. Natl. Acad. Sci. USA. 88, 5523-5527 (1991).
10. Ory, K., LeGros, Y., Auguin, C. & Soussi, T. Analysis of the most representative tumor-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation. EMBO J. 13, 3496-3504 (1994).
11. Philipson, L. & Lindberg, U. in Comprehensive Virology Vol. 3 (eds. Fraenkel-Conrat, H. & Wagner, R.R.) 143-227 (Plenum, New York, 1973).
12. Debbas, M. & White, E. Wild-type p53 mediates apoptosis by Ela, which is inhibited by Elb. Genes Dev. 7, 546-554 (1993).
13. Sharma, S., Schwarte-Waldhoff, I., Oberhuber, H. & Schafer, R. Functional interaction of wild-type and mutant p53 transfected into human tumor cell lines carrying activated RAS genes. Mol. Cell. Biol. 12, 5581-5592 (1993).
14. Slichenmyer, W.J., Nelson, W.G., Slebos, R.J. & Kastan, M.B. Loss of p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res. 53, 4164-4168 (1993).
15. Anderson, M.J., Casey, G., Fasching, C.L. & Stanbridge, E.J. Evidence that wildtype TP53, and not genes on either chromosome 1 or 11, controls the tumorigenic phenotype of the human fibrosarcoma HT1080. Genes, Chromosomes Cancer 9, 266-281 (1994).
16. Evdokiou, A. Tumor-suppressive activity of the growth arrest-specific gene, GAS1. Ph.D. thesis, The University of Adelaide (1997).
17. Dobner, T., Horikoshi, N., Rubenwolf, S. & Shenk, T. Blockage by Adenovirus E4ORF6 of transcriptional activation by the p53 tumor suppressor. Science 272, 1470-1473 (1996).
18. Marcellus, R.C. et al. Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis. J. Virol. 70, 6207-6215 (1996).
19. Lehman, T.A. et al. p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res. 51, 4090-4096 (1991).
20. Masuda, H., Miller, C., Koeffler, P.H., Battifora, H. & Cline, M.J. Rearrangement of the p53 gene in human osteogenic sarcoma. Proc. Natl. Acad. Sci. USA. 84, 7716-7719 (1987).
21. ink4 in human cancer. Proc. Natl. Acad. Sci. USA. 91, 11045-11049 (1994).
22. Romano, J.W. et al. Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line. Oncogene 4, 1483-1488 (1989).
23. ink and telomerase in immortalisation of human cells. Oncogene 11, 971-976 (1995).
24. Ullrich, S.J. et al. Phosphorylation at Ser-1 5 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild type p53. Proc. Natl. Acad. Sci. USA 90, 5954-5958 (1993).
25. Spruck III, C.H. et al. p16 gene in uncultured tumors. Nature 370, 183-184 (1994).
26. ink expression and telomere length during spontaneous immortalization of Li-Fraumeni Syndrome Fibroblasts. Mol Cell. Biol. 15, 4745-4753 (1995).
27. Pilder, S., Moore, M., Logan, J. & Shenk, T. The adenovirus Elb-58kDa transforming polypeptide modulates transport or cytoplasmic stabilization of viral host cell mRNAs. Mol. Cell. Biol. 6, 470-476 (1986).
28. Barker, D.D. & Berk, A.J. Adenovirus proteins from both E1b reading frames are required for transformation of rodent cells by viral infection and DNA transfection. Virology 56, 107-121 (1987).
29. Precious, B & Russell, W.C. in Virology: A Practical Approach (ed. Mahy, B.W.J.) 193-205 (IRL, Oxford, England, 1985).