메뉴 건너뛰기




Volumn 181, Issue 2, 1999, Pages 231-239

The p53 pathway and apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

EID: 0032876814     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199911)181:2<231::AID-JCP5>3.0.CO;2-L     Document Type: Review
Times cited : (206)

References (111)
  • 1
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 Protein Family: Arbiters of Cell Survival
    • Adams JM, Cory S. The Bcl-2 Protein Family: arbiters of Cell Survival. 1998. Science 281:322-325.
    • (1998) Science , vol.281 , pp. 322-325
    • Adams, J.M.1    Cory, S.2
  • 3
    • 0032575714 scopus 로고    scopus 로고
    • Death Receptors: Signaling and modulation
    • Ashkenazi A Dixit VM. 1998. Death Receptors: signaling and modulation. Science, 281:1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 8
    • 0029669929 scopus 로고    scopus 로고
    • T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53
    • Brady HJ, Salomons GS, Bobeldijk RC, Berns AJ. 1996. T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53. EMBO J 15:1221-1230.
    • (1996) EMBO J , vol.15 , pp. 1221-1230
    • Brady, H.J.1    Salomons, G.S.2    Bobeldijk, R.C.3    Berns, A.J.4
  • 12
    • 0028070989 scopus 로고
    • P53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles C, Helmberg A, Karin M. 1994. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370:220-223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 13
    • 0028171182 scopus 로고
    • The p53-dependent G1 cell cycle checkpoint pathway and ataxiatelangiectasia
    • Canman CE., Wolff AC, Chen CY, Fornace AJJ, Kastan MB. 1994. The p53-dependent G1 cell cycle checkpoint pathway and ataxiatelangiectasia. Cancer Res 54:5054-5058.
    • (1994) Cancer Res , vol.54 , pp. 5054-5058
    • Canman, C.E.1    Wolff, A.C.2    Chen, C.Y.3    Fornace, A.J.J.4    Kastan, M.B.5
  • 14
    • 0028958705 scopus 로고
    • Growth factor modulation of p53-mediated growth arrest versus apoptosis
    • Canman CE, Gilmer TM, Coutts SB, Kastan MB. 1995. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev 9:600-611.
    • (1995) Genes Dev , vol.9 , pp. 600-611
    • Canman, C.E.1    Gilmer, T.M.2    Coutts, S.B.3    Kastan, M.B.4
  • 16
    • 0028222955 scopus 로고
    • Bcl-2 blocks p53-dependent apoptosis
    • Chiou SK, Rao L, White E. 1994. Bcl-2 blocks p53-dependent apoptosis. Mol Cell Biol 4:2556-25563.
    • (1994) Mol Cell Biol , vol.4 , pp. 2556-25563
    • Chiou, S.K.1    Rao, L.2    White, E.3
  • 17
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho Y, Gorina S, Jeffrey PD, Pavletich NP. 1994. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265:346-355.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 19
    • 0026731894 scopus 로고
    • Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents
    • Collins MK, Marvel J, Malde P, Lopez-Rivas A. 1992. Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. J Exp Med 176:1043-1051.
    • (1992) J Exp Med , vol.176 , pp. 1043-1051
    • Collins, M.K.1    Marvel, J.2    Malde, P.3    Lopez-Rivas, A.4
  • 21
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/Waf1 undergo normal development, but are defective in G1 checkpoint control
    • Deng C, Zhang P, Harper JW, Elledge SJ, and Leder P. 1995. Mice lacking p21CIP1/Waf1 undergo normal development, but are defective in G1 checkpoint control. Cell 82:675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 23
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • Di Leonardo A, Linke SP, Clarkin K, Wahl GM. 1994. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev 8:2540-2551.
    • (1994) Genes Dev , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 27
    • 0031987277 scopus 로고    scopus 로고
    • Regulation of p53 downstream genes
    • El-Deiry WS. 1998. Regulation of p53 downstream genes. Seminars in Cancer Biol 8:345-357.
    • (1998) Seminars in Cancer Biol , vol.8 , pp. 345-357
    • El-Deiry, W.S.1
  • 28
    • 0032575705 scopus 로고    scopus 로고
    • A matter of life and cell death
    • Evan G, Littlewood T. 1998. A matter of life and cell death. Science 281:317-321
    • (1998) Science , vol.281 , pp. 317-321
    • Evan, G.1    Littlewood, T.2
  • 29
    • 0025853776 scopus 로고
    • Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
    • Fakharzadeh SS, Trusko SP, George DL. 1991. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J 10:1565-1569.
    • (1991) EMBO J , vol.10 , pp. 1565-1569
    • Fakharzadeh, S.S.1    Trusko, S.P.2    George, D.L.3
  • 31
    • 0345369731 scopus 로고    scopus 로고
    • Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain
    • Froesch BA, Aime-Sempe C, Leber B, Andrews, D and Reed JC. 1999. Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain. JBC 274:6469-6475.
    • (1999) JBC , vol.274 , pp. 6469-6475
    • Froesch, B.A.1    Aime-Sempe, C.2    Leber, B.3    Andrews, D.4    Reed, J.C.5
  • 32
    • 0030871457 scopus 로고    scopus 로고
    • p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32 beta
    • Fuchs EJ, McKenna KA, Bedi A. 1997. p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32 beta. Cancer Res 57:2550-2554.
    • (1997) Cancer Res , vol.57 , pp. 2550-2554
    • Fuchs, E.J.1    McKenna, K.A.2    Bedi, A.3
  • 33
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia AJ, Kastan MB. 1998. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 12:2973-2983.
    • (1998) Genes Dev , vol.12 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 34
    • 0029823623 scopus 로고    scopus 로고
    • Relationship of sequence-specific transactivation and p53-regulated apoptosis in interleukin 3-dependent hematopoietic cells
    • Gottlieb E, Lindner S, Oren M. 1996. Relationship of sequence-specific transactivation and p53-regulated apoptosis in interleukin 3-dependent hematopoietic cells. Cell Growth Diff 3:301-310.
    • (1996) Cell Growth Diff , vol.3 , pp. 301-310
    • Gottlieb, E.1    Lindner, S.2    Oren, M.3
  • 35
    • 0032127463 scopus 로고    scopus 로고
    • p53 facilitates pRb cleavage in IL-3-deprived cells: Novel pro-apoptotic activity of p53
    • Gottlieb E, Oren M. 1998. p53 facilitates pRb cleavage in IL-3-deprived cells: novel pro-apoptotic activity of p53. EMBO J 17:3587-3596.
    • (1998) EMBO J , vol.17 , pp. 3587-3596
    • Gottlieb, E.1    Oren, M.2
  • 36
    • 0030996361 scopus 로고    scopus 로고
    • Synergistic activation of transcription by CBP and p53
    • Gu W, Shi X-L, Roeder RG. 1997. Synergistic activation of transcription by CBP and p53. Nature 387:819-822.
    • (1997) Nature , vol.387 , pp. 819-822
    • Gu, W.1    Shi, X.-L.2    Roeder, R.G.3
  • 37
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by transactivation-deflcient p53
    • Haupt Y, Rowan S, Shaulian E, Vousden K, Oren M. 1995. Induction of apoptosis in HeLa cells by transactivation-deflcient p53. Genes Dev 9:2170-2183.
    • (1995) Genes Dev , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.4    Oren, M.5
  • 38
    • 0029985647 scopus 로고    scopus 로고
    • Cell type specific inhibition of p53-mediated apoptosis by mdm2
    • Haupt T, Barak Y, Oren M. 1996. Cell type specific inhibition of p53-mediated apoptosis by mdm2. EMBO J 15:1596-1606.
    • (1996) EMBO J , vol.15 , pp. 1596-1606
    • Haupt, T.1    Barak, Y.2    Oren, M.3
  • 39
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 41
    • 0032524070 scopus 로고    scopus 로고
    • Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
    • Herzog K-H, Chong MJ Kapsetaki M, Morgan JI, Mckinnon PJ. 1998. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 280:1089-1091.
    • (1998) Science , vol.280 , pp. 1089-1091
    • Herzog, K.-H.1    Chong, M.J.2    Kapsetaki, M.3    Morgan, J.I.4    Mckinnon, P.J.5
  • 44
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda R, Tanaka H, Yasuda H. 1997. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420:25-27.
    • (1997) FEBS Lett , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 45
    • 0028227260 scopus 로고
    • Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
    • Howes KA, Ransom N, Papermaster DS, Lasudry JG, Albert DM, Windle JJ. 1994. Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes Dev 8:1300-1310.
    • (1994) Genes Dev , vol.8 , pp. 1300-1310
    • Howes, K.A.1    Ransom, N.2    Papermaster, D.S.3    Lasudry, J.G.4    Albert, D.M.5    Windle, J.J.6
  • 46
    • 0027250493 scopus 로고
    • Activation of the cryptic DNA binding function of mutant forms of p53
    • Hupp TR, Meek DW, Midgley CA, Lane DP. 1993. Activation of the cryptic DNA binding function of mutant forms of p53. Nucleic Acids Res 21:3167-3174.
    • (1993) Nucleic Acids Res , vol.21 , pp. 3167-3174
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 47
    • 0028845158 scopus 로고
    • Small peptides activate the latent sequence-specific DNA binding function of p53
    • Hupp TR, Sparks A, Lane DP. 1995. Small peptides activate the latent sequence-specific DNA binding function of p53. Cell 83:237-245.
    • (1995) Cell , vol.83 , pp. 237-245
    • Hupp, T.R.1    Sparks, A.2    Lane, D.P.3
  • 48
    • 0030802364 scopus 로고    scopus 로고
    • A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis
    • Israeli D, Tessler E, Haupt Y, Elkeles A, Wilder S, Amson R, Telerman A, Oren M. 1997. A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis. EMBO J 16:4384-4392.
    • (1997) EMBO J , vol.16 , pp. 4384-4392
    • Israeli, D.1    Tessler, E.2    Haupt, Y.3    Elkeles, A.4    Wilder, S.5    Amson, R.6    Telerman, A.7    Oren, M.8
  • 49
    • 0029055808 scopus 로고
    • Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the C-terminus
    • Jayaraman L, Prives C. 1995. Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the C-terminus. Cell 81:1021-1029.
    • (1995) Cell , vol.81 , pp. 1021-1029
    • Jayaraman, L.1    Prives, C.2
  • 50
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones SN, Roe AE, Donehower LA, Bradley A. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378:206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 57
  • 58
    • 0026656853 scopus 로고
    • Wild-type p53 is a cell cycle checkpoint determinant following irradiation
    • Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB. 1992. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. PNAS 89:7491-7495.
    • (1992) PNAS , vol.89 , pp. 7491-7495
    • Kuerbitz, S.J.1    Plunkett, B.S.2    Walsh, W.V.3    Kastan, M.B.4
  • 59
    • 0029013273 scopus 로고
    • p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
    • Lee S, Elenbass B, Levine A, Griffith J. 1995. p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell 81:1013-1020.
    • (1995) Cell , vol.81 , pp. 1013-1020
    • Lee, S.1    Elenbass, B.2    Levine, A.3    Griffith, J.4
  • 60
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
    • Lees-Miller, SP Sakaguchi K, Ullrich S, Appella E, Anderson CW. 1992. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol 12:5041-5049.
    • (1992) Mol Cell Biol , vol.12 , pp. 5041-5049
    • Lees-Miller, S.P.1    Sakaguchi, K.2    Ullrich, S.3    Appella, E.4    Anderson, C.W.5
  • 61
    • 0027319521 scopus 로고
    • P53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847-852.
    • (1993) Nature , vol.362 , pp. 847-852
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 63
    • 0028020522 scopus 로고
    • Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis
    • Marin MC, Hsu B, Meyn RE, Donehower LA, el-Naggar AK, McDonnel TJ. 1994.. Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis. Oncogene 9:3107-3112.
    • (1994) Oncogene , vol.9 , pp. 3107-3112
    • Marin, M.C.1    Hsu, B.2    Meyn, R.E.3    Donehower, L.A.4    El-Naggar, A.K.5    McDonnel, T.J.6
  • 64
    • 0028978120 scopus 로고
    • Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation
    • Mayr GA, Reed M, Wang P, Wang Y, Schwedes JF, Tegtmeyer P. 1995. Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation. Cancer Res 55:2410-2417.
    • (1995) Cancer Res , vol.55 , pp. 2410-2417
    • Mayr, G.A.1    Reed, M.2    Wang, P.3    Wang, Y.4    Schwedes, J.F.5    Tegtmeyer, P.6
  • 65
    • 0030938089 scopus 로고    scopus 로고
    • Bas-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
    • McCurrach ME, Connor TMF, Knudson CM, Korsmeyer SJ, Lowe SW. 1997. Bas-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. PNAS 94: 2345-2349.
    • (1997) PNAS , vol.94 , pp. 2345-2349
    • McCurrach, M.E.1    Connor, T.M.F.2    Knudson, C.M.3    Korsmeyer, S.J.4    Lowe, S.W.5
  • 66
    • 0031971228 scopus 로고    scopus 로고
    • Multisite phosphorylation and the integration of stress signals at p53
    • Meek DW. 1998. Multisite phosphorylation and the integration of stress signals at p53. Cell Signal 10(3):159-166.
    • (1998) Cell Signal , vol.10 , Issue.3 , pp. 159-166
    • Meek, D.W.1
  • 67
    • 0030825813 scopus 로고    scopus 로고
    • p53 protein stability in tumor cells is not determined by mutation but is dependent on Mdm2 binding
    • Midgley CA, Lane DP. 1997. p53 protein stability in tumor cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene 15:1179-1189.
    • (1997) Oncogene , vol.15 , pp. 1179-1189
    • Midgley, C.A.1    Lane, D.P.2
  • 68
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC. 1995. tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 69
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivaton
    • Momand J, Zambetti GP, Olson DC, Geoge DL, Levine AJ. 1992. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivaton. Cell 69:1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    Geoge, D.L.4    Levine, A.J.5
  • 70
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca Luna R, Wagner DS, Lozano G. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378:203-206.
    • (1995) Nature , vol.378 , pp. 203-206
    • Montes De Oca Luna, R.1    Wagner, D.S.2    Lozano, G.3
  • 71
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata S. 1997. Apoptosis by death factor. Cell 88:355-365.
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 72
    • 0344389027 scopus 로고    scopus 로고
    • Caspases: The proteases of the apoptotic pathway
    • Nunez G, Benedict MA, Hu Y, Inohara N. 1998. Caspases: the proteases of the apoptotic pathway. Oncogene 17:3237-3245.
    • (1998) Oncogene , vol.17 , pp. 3237-3245
    • Nunez, G.1    Benedict, M.A.2    Hu, Y.3    Inohara, N.4
  • 73
  • 76
    • 0032504784 scopus 로고    scopus 로고
    • p19ARF links the tumour suppressor p53 to Ras
    • Palmero I, Pantoja C, Serrano M. 1998. p19ARF links the tumour suppressor p53 to Ras. Nature 395:125-126.
    • (1998) Nature , vol.395 , pp. 125-126
    • Palmero, I.1    Pantoja, C.2    Serrano, M.3
  • 81
    • 0029587551 scopus 로고
    • Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle DE, Zindy F, Ashmun RA, Sherr CJ. 1995. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83:993-1000.
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 82
    • 0030972216 scopus 로고    scopus 로고
    • Insulin like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta 1 on programmed cell death through a p53- And IGF-independent mechanism
    • Rajah R, Valentinis B, Cohen P. 1997. Insulin like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta 1 on programmed cell death through a p53- and IGF-independent mechanism. JBC 272:12181-12188.
    • (1997) JBC , vol.272 , pp. 12181-12188
    • Rajah, R.1    Valentinis, B.2    Cohen, P.3
  • 83
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell cycle arrest function in a human tumour derived p53 mutant
    • Rowan S, Ludwig RL, Haupt Y, Bates S, Lu X, Oren M, Vousden KH. 1996. Specific loss of apoptotic but not cell cycle arrest function in a human tumour derived p53 mutant. EMBO J. 15:827-838.
    • (1996) EMBO J. , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3    Bates, S.4    Lu, X.5    Oren, M.6    Vousden, K.H.7
  • 84
    • 0031806708 scopus 로고    scopus 로고
    • Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest
    • Ryan KM, Vousden KH. 1998. Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest. MCB 18:3692-3698.
    • (1998) MCB , vol.18 , pp. 3692-3698
    • Ryan, K.M.1    Vousden, K.H.2
  • 86
    • 0030798557 scopus 로고    scopus 로고
    • The polyproline region of p53 is required to activate apoptosis but not growth arrest
    • Sakamuro D, Sabbatini P, White E, Prendergast GC. 1997. The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene 15: 887-898.
    • (1997) Oncogene , vol.15 , pp. 887-898
    • Sakamuro, D.1    Sabbatini, P.2    White, E.3    Prendergast, G.C.4
  • 87
    • 0030726461 scopus 로고    scopus 로고
    • Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins
    • Samuelson AV, Lowe SW. 1997. Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins. PNAS 22:12094-12099.
    • (1997) PNAS , vol.22 , pp. 12094-12099
    • Samuelson, A.V.1    Lowe, S.W.2
  • 88
    • 0030961889 scopus 로고    scopus 로고
    • Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from p53 C-terminal domain
    • Selivanova G, Iotsova V, Okan I, Fritsche M, Storm M, Groner B, Crafstorm RC, Wilman KG. 1997. Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from p53 C-terminal domain. Nat Med 3:632-638.
    • (1997) Nat Med , vol.3 , pp. 632-638
    • Selivanova, G.1    Iotsova, V.2    Okan, I.3    Fritsche, M.4    Storm, M.5    Groner, B.6    Crafstorm, R.C.7    Wilman, K.G.8
  • 89
    • 0032522463 scopus 로고    scopus 로고
    • p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha
    • Sheikh MS, Burns TF, Huang Y, Wu GS, Amundson S, Brooks KS, Fornace AJ Jr, El-Deiry WS. 1998. p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha. Cancer Res 58:1593-1598.
    • (1998) Cancer Res , vol.58 , pp. 1593-1598
    • Sheikh, M.S.1    Burns, T.F.2    Huang, Y.3    Wu, G.S.4    Amundson, S.5    Brooks, K.S.6    Fornace A.J., Jr.7    El-Deiry, W.S.8
  • 90
    • 0032191393 scopus 로고    scopus 로고
    • Tumor surveillance via the ARF-p53 pathway
    • Sherr CJ. 1998. Tumor surveillance via the ARF-p53 pathway. Genes Dev 12:2984-2991.
    • (1998) Genes Dev , vol.12 , pp. 2984-2991
    • Sherr, C.J.1
  • 91
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh S-Y, Ikeda M, Taya Y, Prives C. 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.-Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 94
    • 0032545222 scopus 로고    scopus 로고
    • P53-Independent Role of MDM2 in TGF-B1 Resistance
    • Sun P, Dong P, Dai K, Hannon GJ, Beach D. 1998. P53-Independent Role of MDM2 in TGF-B1 Resistance. Science 282:2270-2272.
    • (1998) Science , vol.282 , pp. 2270-2272
    • Sun, P.1    Dong, P.2    Dai, K.3    Hannon, G.J.4    Beach, D.5
  • 95
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry NA, Lazebnik Y. 1998. Caspases: enemies within. Science 281:312-316.
    • (1998) Science , vol.281 , pp. 312-316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 96
    • 0030860911 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: A dual mechanism
    • Thut CJ, Goodrich JA, Tjian R. 1997. Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes Dev 11:1974-1986.
    • (1997) Genes Dev , vol.11 , pp. 1974-1986
    • Thut, C.J.1    Goodrich, J.A.2    Tjian, R.3
  • 98
    • 0032159103 scopus 로고    scopus 로고
    • Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
    • Tsai KY, Hu Y, Macleod KF, Crowley D, Yamasaki L, Jacks T. 1998. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell 3:293-304.
    • (1998) Mol Cell , vol.3 , pp. 293-304
    • Tsai, K.Y.1    Hu, Y.2    Macleod, K.F.3    Crowley, D.4    Yamasaki, L.5    Jacks, T.6
  • 99
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein B, Kinzler KW. 1992. p53 function and dysfunction. Cell 70:523-526.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 100
    • 0030448650 scopus 로고    scopus 로고
    • Identification of a novel p53 functional domain that is necessary for efficient growth suppression
    • Walker KK, Levine AJ. 1996. Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci USA 93:15335-15340.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15335-15340
    • Walker, K.K.1    Levine, A.J.2
  • 101
    • 0027441217 scopus 로고
    • Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma cell line
    • Wang Y, Szekely L, Okan I, Klein G, Wiman KG. 1993. Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma cell line. Oncogene 12:3427-3431
    • (1993) Oncogene , vol.12 , pp. 3427-3431
    • Wang, Y.1    Szekely, L.2    Okan, I.3    Klein, G.4    Wiman, K.G.5
  • 102
    • 0031840253 scopus 로고    scopus 로고
    • ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
    • Waterman MJF, Stavridi ES, Waterman JLF, Halazonetis TD. 1998. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nature Genet 19:175-178.
    • (1998) Nature Genet , vol.19 , pp. 175-178
    • Waterman, M.J.F.1    Stavridi, E.S.2    Waterman, J.L.F.3    Halazonetis, T.D.4
  • 103
    • 0030879563 scopus 로고    scopus 로고
    • atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
    • Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P. 1997. atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet 16:397-401.
    • (1997) Nat Genet , vol.16 , pp. 397-401
    • Westphal, C.H.1    Rowan, S.2    Schmaltz, C.3    Elson, A.4    Fisher, D.E.5    Leder, P.6
  • 104
    • 0032514485 scopus 로고    scopus 로고
    • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
    • Woo RA, McLure KG, Lees-Miller SP, Rancourt DE, Lee PWK. 1998. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature 394:700-704.
    • (1998) Nature , vol.394 , pp. 700-704
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.K.5
  • 106
    • 0029821651 scopus 로고    scopus 로고
    • Dual roles of ATM in the cellular response to radiation and in cell growth control
    • Xu Y, Baltimore D. 1996. Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev, 10:2401-2410.
    • (1996) Genes Dev , vol.10 , pp. 2401-2410
    • Xu, Y.1    Baltimore, D.2
  • 109
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y, Xiong Y, Yarbrough WG. 1998. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92:725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 110
    • 0033529121 scopus 로고    scopus 로고
    • Association with Cdc2 and inhibition of Cdc2/ Cyclin B1 kinase activity by the p53-regulated protein Gadd45
    • Zhan Q, Antinore MJ, Wang XW, Carrier F, Smith ML, Harris CC, Fornace AJ, Jr. 1999. Association with Cdc2 and inhibition of Cdc2/ Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 18:2892-2900.
    • (1999) Oncogene , vol.18 , pp. 2892-2900
    • Zhan, Q.1    Antinore, M.J.2    Wang, X.W.3    Carrier, F.4    Smith, M.L.5    Harris, C.C.6    Fornace A.J., Jr.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.