Neutralization of interferon-γ in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease

Immunology

Volumn 104, Issue 1, 2001, Pages 92-98

  Bullen, Denise V R ^a   Darwiche, Rima ^a   Metcalf, Donald ^a   Handman, Emanuela ^a   Alexander, Warren S ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; HERMES ANTIGEN; NEUTRALIZING ANTIBODY; R4 6A2; SUPPRESSOR OF CYTOKINE SIGNALLING 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL POPULATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; DRUG EFFECT; EOSINOPHILIA; FATALITY; IMMUNOREGULATION; INFLAMMATORY DISEASE; LEUKOCYTE COUNT; LIVER; LIVER DISEASE; LIVER TOXICITY; LUNG; LYMPH NODE; LYMPHOCYTE DEPLETION; LYMPHOCYTIC INFILTRATION; MOUSE; NEUTROPHILIA; NEWBORN; NONHUMAN; PANCREAS; PRIORITY JOURNAL; SKELETAL MUSCLE; SKIN; SPLEEN; T LYMPHOCYTE; THROMBOCYTOSIS;

ANIMALS; ANIMALS, NEWBORN; BETA-GALACTOSIDASE; CARRIER PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; FATTY LIVER; HEPATITIS, ANIMAL; INFLAMMATION; INTERFERON TYPE II; LYMPHOCYTE COUNT; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; REPRESSOR PROTEINS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 0034792866     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01294.x     Document Type: Article

References (10)

1. A family of cytokine-inducible inhibitors of signalling
2. Structure and function of a new STAT-induced STAT inhibitor
3. A new protein containing an SH2 domain that inhibits JAK kinases
4. SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase
5. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
6. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
7. Lethality of interferon preparations for newborn mice
8. Progressive glomerulonephritis in mice treated with interferon preparations at birth
9. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
10. The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-γ and lacking the SOCS-1 gene