-
1
-
-
0030765924
-
Jaks, STATs, cytokine signal transduction, and immunoregulation: Are we there yet?
-
O'Shea, J. J. (1997) Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? Immunity. 7, 1-11.
-
(1997)
Immunity
, vol.7
, pp. 1-11
-
-
O'Shea, J.J.1
-
2
-
-
0031805248
-
JAK/STAT signaling by cytokine receptors
-
Liu, K. D., Gaffen, S. L., and Goldsmith, M. A. (1998) JAK/STAT signaling by cytokine receptors. Curr. Opin. Immunol. 10, 271-278.
-
(1998)
Curr. Opin. Immunol.
, vol.10
, pp. 271-278
-
-
Liu, K.D.1
Gaffen, S.L.2
Goldsmith, M.A.3
-
3
-
-
0031931647
-
Structural and mechanistic aspects of Janus kinases: How the two-faced god wields a double-edged sword
-
Duhé, R. J. and Farrar, W. L. (1998) Structural and mechanistic aspects of Janus kinases: How the two-faced god wields a double-edged sword. J. Interferon Cytokine Res. 18, 1-15.
-
(1998)
J. Interferon Cytokine Res.
, vol.18
, pp. 1-15
-
-
Duhé, R.J.1
Farrar, W.L.2
-
4
-
-
0032168152
-
Interleukin-6-type cytokine signalling through the gp130/ Jak/STAT pathway
-
Heinrich, P. C., Behrmann, I., Muller-Newen, G., Schaper, F., and Graeve, L. (1998) Interleukin-6-type cytokine signalling through the gp130/ Jak/STAT pathway. Biochem. J. 334, 297-314.
-
(1998)
Biochem. J.
, vol.334
, pp. 297-314
-
-
Heinrich, P.C.1
Behrmann, I.2
Muller-Newen, G.3
Schaper, F.4
Graeve, L.5
-
5
-
-
0031788331
-
Regulation of angiotensin II-induced JAK2 tyrosine phosphorylation: Roles of SHP-1 and SHP-2
-
Marrero, M. B., Venema, V. J., Ju, H., Eaton, D. C., and Venema, R. C. (1998) Regulation of angiotensin II-induced JAK2 tyrosine phosphorylation: roles of SHP-1 and SHP-2. Am. J. Physiol 275, C1216-C1223.
-
(1998)
Am. J. Physiol
, vol.275
-
-
Marrero, M.B.1
Venema, V.J.2
Ju, H.3
Eaton, D.C.4
Venema, R.C.5
-
6
-
-
2642641315
-
The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor
-
Mellado, M., Rodriguez-Frade, J. M., Aragay, A., del Real, G., Martin, A. M., Vila-Coro, A. J., et al. (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J. Immunol. 161, 805-813.
-
(1998)
J. Immunol.
, vol.161
, pp. 805-813
-
-
Mellado, M.1
Rodriguez-Frade, J.M.2
Aragay, A.3
Del Real, G.4
Martin, A.M.5
Vila-Coro, A.J.6
-
7
-
-
0032076183
-
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
-
Rodig, S. J., Meraz, M. A., White, J. M., Lampe, P. A., Riley, J. K., Arthur, C. D., et al. (1998) Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93, 373-383.
-
(1998)
Cell
, vol.93
, pp. 373-383
-
-
Rodig, S.J.1
Meraz, M.A.2
White, J.M.3
Lampe, P.A.4
Riley, J.K.5
Arthur, C.D.6
-
8
-
-
18244432009
-
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
-
Neubauer, H., Cumano, A., Muller, M., Wu, H., Huffstadt, U., and Pfeffer, K. (1998) Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93, 397-409.
-
(1998)
Cell
, vol.93
, pp. 397-409
-
-
Neubauer, H.1
Cumano, A.2
Muller, M.3
Wu, H.4
Huffstadt, U.5
Pfeffer, K.6
-
9
-
-
0032076542
-
Jak2 is essential for signaling through a variety of cytokine receptors
-
Parganas, E., Wang, D., Stravopodis, D., Topham, D. J., Marine, J. C., Teglund, S., et al. (1998) Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93, 385-395.
-
(1998)
Cell
, vol.93
, pp. 385-395
-
-
Parganas, E.1
Wang, D.2
Stravopodis, D.3
Topham, D.J.4
Marine, J.C.5
Teglund, S.6
-
10
-
-
0028840706
-
Defective lymphoid development in mice lacking Jak3
-
Nosaka, T., van Deursen, J. M., Tripp, R. A., Thierfelder, W. E., Witthuhn, B. A., McMickle, A. P., et al. (1995) Defective lymphoid development in mice lacking Jak3. Science 270, 800-802.
-
(1995)
Science
, vol.270
, pp. 800-802
-
-
Nosaka, T.1
Van Deursen, J.M.2
Tripp, R.A.3
Thierfelder, W.E.4
Witthuhn, B.A.5
McMickle, A.P.6
-
11
-
-
0029550822
-
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
-
Park, S. Y., Saijo, K., Takahashi, T., Osawa, M., Arase, H., Hirayama, N., et al. (1995) Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 3, 771-782.
-
(1995)
Immunity
, vol.3
, pp. 771-782
-
-
Park, S.Y.1
Saijo, K.2
Takahashi, T.3
Osawa, M.4
Arase, H.5
Hirayama, N.6
-
12
-
-
0028799457
-
Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
-
Thomis, D. C., Gurniak, C. B., Tivol, E., Sharpe, A. H., and Berg, L. J. (1995) Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270, 794-797.
-
(1995)
Science
, vol.270
, pp. 794-797
-
-
Thomis, D.C.1
Gurniak, C.B.2
Tivol, E.3
Sharpe, A.H.4
Berg, L.J.5
-
13
-
-
0033696404
-
Partial impairment of cytokine responses in Tyk2-deficient mice
-
12a. Karaghiosoff, M., Neubauer, H., Lassnig, C., et al. (2000) Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 13, 549-560.
-
(2000)
Immunity
, vol.13
, pp. 549-560
-
-
Karaghiosoff, M.1
Neubauer, H.2
Lassnig, C.3
-
14
-
-
0033711641
-
Tyk2 plays a restricted role in IFN-α signaling, although it is required for IL-12-mediated T-cell function
-
12b. Shimoda, K., Kato, K., Aoki, K., et al. (2000) Tyk2 plays a restricted role in IFN-α signaling, although it is required for IL-12-mediated T-cell function. Immunity 13, 561-571.
-
(2000)
Immunity
, vol.13
, pp. 561-571
-
-
Shimoda, K.1
Kato, K.2
Aoki, K.3
-
15
-
-
0026332810
-
Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule
-
Cunningham, B. C., Ultsch, M., de Vos, A. M., Mulkerrin, M. G., Clauser, K. R., and Wells, J. A. (1991) Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 254, 821-825.
-
(1991)
Science
, vol.254
, pp. 821-825
-
-
Cunningham, B.C.1
Ultsch, M.2
De Vos, A.M.3
Mulkerrin, M.G.4
Clauser, K.R.5
Wells, J.A.6
-
16
-
-
0026598960
-
Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
-
De Vos, A. M., Ultsch, M., and Kossiakoff, A. A. (1992) Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255, 306-312.
-
(1992)
Science
, vol.255
, pp. 306-312
-
-
De Vos, A.M.1
Ultsch, M.2
Kossiakoff, A.A.3
-
17
-
-
0033548259
-
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
-
Livnah, O., Stura, E. A., Middleton, S. A., Johnson, D. L., Jolliffe, L. K., and Wilson, I. A. (1999) Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283, 987-990.
-
(1999)
Science
, vol.283
, pp. 987-990
-
-
Livnah, O.1
Stura, E.A.2
Middleton, S.A.3
Johnson, D.L.4
Jolliffe, L.K.5
Wilson, I.A.6
-
18
-
-
0033548048
-
Erythropoietin receptor activation by a ligand-induced conformation change
-
Remy, I., Wilson, I. A., and Michnick, S. W. (1999) Erythropoietin receptor activation by a ligand-induced conformation change. Science 283, 990-993.
-
(1999)
Science
, vol.283
, pp. 990-993
-
-
Remy, I.1
Wilson, I.A.2
Michnick, S.W.3
-
19
-
-
0029786754
-
Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase
-
Gauzzi, M. C , Velazquez, L., McKendry, R., Mogensen, K. E., Fellous, M., and Pellegrini, S. (1996) Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J. Biol. Chem. 271, 20,494-20,500.
-
(1996)
J. Biol. Chem.
, vol.271
-
-
Gauzzi, M.C.1
Velazquez, L.2
McKendry, R.3
Mogensen, K.E.4
Fellous, M.5
Pellegrini, S.6
-
21
-
-
0031444188
-
Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity
-
Zhou, Y. J., Hanson, E. P., Chen, Y. Q., Magnuson, K., Chen, M., Swann, P. G., et al. (1997) Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity. Proc. Natl. Acad. Sci. USA 94, 13,850-13,855.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
-
-
Zhou, Y.J.1
Hanson, E.P.2
Chen, Y.Q.3
Magnuson, K.4
Chen, M.5
Swann, P.G.6
-
22
-
-
0027429591
-
Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformation
-
Zheng, J., Knighton, D. R., Xuong, N. H., Taylor, S. S., Sowadski, J. M., and Ten Eyck, L. F. (1993) Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformation. Protein Sci. 2, 1559-1573.
-
(1993)
Protein Sci.
, vol.2
, pp. 1559-1573
-
-
Zheng, J.1
Knighton, D.R.2
Xuong, N.H.3
Taylor, S.S.4
Sowadski, J.M.5
Ten Eyck, L.F.6
-
23
-
-
0028898390
-
Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase
-
Adams, J. A., McGlone, M. L., Gibson, R., and Taylor, S. S. (1995) Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase. Biochemistry 34, 2447-2454.
-
(1995)
Biochemistry
, vol.34
, pp. 2447-2454
-
-
Adams, J.A.1
McGlone, M.L.2
Gibson, R.3
Taylor, S.S.4
-
24
-
-
0030598848
-
Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
-
Mohammadi, M., Schlessinger, J., and Hubbard, S. R. (1996) Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Cell 86, 577-587.
-
(1996)
Cell
, vol.86
, pp. 577-587
-
-
Mohammadi, M.1
Schlessinger, J.2
Hubbard, S.R.3
-
25
-
-
0030766163
-
Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
-
Hubbard, S. R. (1997) Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J. 16, 5572-5581.
-
(1997)
EMBO J.
, vol.16
, pp. 5572-5581
-
-
Hubbard, S.R.1
-
26
-
-
0032493859
-
Switching signals on or off by receptor dimerization
-
Weiss, A. and Schlessinger, J. (1998) Switching signals on or off by receptor dimerization. Cell 94, 277-280.
-
(1998)
Cell
, vol.94
, pp. 277-280
-
-
Weiss, A.1
Schlessinger, J.2
-
27
-
-
0030836517
-
Kinase-deficient forms of Jak1 and Tyk2 inhibit interferon alpha signaling in a dominant manner
-
Krishnan, K., Pine, R., and Krolewski, J. J. (1997) Kinase-deficient forms of Jak1 and Tyk2 inhibit interferon alpha signaling in a dominant manner. Eur. J. Biochem. 247, 298-305.
-
(1997)
Eur. J. Biochem.
, vol.247
, pp. 298-305
-
-
Krishnan, K.1
Pine, R.2
Krolewski, J.J.3
-
28
-
-
0030062769
-
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state
-
Briscoe, J., Rogers, N. C., Witthuhn, B. A., Watling, D., Harpur, A. G., Wilks, A. F., et al. (1996) Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state. EMBO J. 15, 799-809.
-
(1996)
EMBO J.
, vol.15
, pp. 799-809
-
-
Briscoe, J.1
Rogers, N.C.2
Witthuhn, B.A.3
Watling, D.4
Harpur, A.G.5
Wilks, A.F.6
-
29
-
-
0032981804
-
Differential substrate recognition capabilities of Janus family protein kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery
-
Witthuhn, B. A., Williams, M. D., Kerawalla, H., and Uckun, F. M. (1999) Differential substrate recognition capabilities of Janus family protein kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery. Leuk. Lymphoma 32, 289-297.
-
(1999)
Leuk. Lymphoma
, vol.32
, pp. 289-297
-
-
Witthuhn, B.A.1
Williams, M.D.2
Kerawalla, H.3
Uckun, F.M.4
-
30
-
-
0025145585
-
Protein kinases. Regulation by autoinhibitory domains
-
Soderling, T. R. (1990) Protein kinases. Regulation by autoinhibitory domains. J. Biol. Chem. 265, 1823-1826.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 1823-1826
-
-
Soderling, T.R.1
-
31
-
-
0029993727
-
Active and inactive protein kinases: Structural basis for regulation
-
Johnson, L. N., Noble, M. E., and Owen, D. J. (1996) Active and inactive protein kinases: structural basis for regulation. Cell 85, 149-158.
-
(1996)
Cell
, vol.85
, pp. 149-158
-
-
Johnson, L.N.1
Noble, M.E.2
Owen, D.J.3
-
32
-
-
0032511022
-
Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation
-
Dennis, P. B., Pullen, N., Pearson, R. B., Kozma, S. C., and Thomas, G. (1998) Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation. J. Biol. Chem. 273, 14,845-14,852.
-
(1998)
J. Biol. Chem.
, vol.273
-
-
Dennis, P.B.1
Pullen, N.2
Pearson, R.B.3
Kozma, S.C.4
Thomas, G.5
-
33
-
-
0026526799
-
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues
-
Smith, M. K., Colbran, R. J., Brickey, D. A., and Soderling, T. R. (1992) Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues. J. Biol. Chem. 267, 1761-1768.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 1761-1768
-
-
Smith, M.K.1
Colbran, R.J.2
Brickey, D.A.3
Soderling, T.R.4
-
34
-
-
0027250467
-
Isolation of an autoinhibitory region from the regulatory beta-subunit of phosphorylase kinase
-
Sanchez, V. E. and Carlson, G. M. (1993) Isolation of an autoinhibitory region from the regulatory beta-subunit of phosphorylase kinase. J. Biol. Chem. 268, 17,889-17,895.
-
(1993)
J. Biol. Chem.
, vol.268
-
-
Sanchez, V.E.1
Carlson, G.M.2
-
35
-
-
0029871290
-
Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I
-
Goldberg, J., Nairn, A. C., and Kuriyan, J. (1996) Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I. Cell 84, 875-887.
-
(1996)
Cell
, vol.84
, pp. 875-887
-
-
Goldberg, J.1
Nairn, A.C.2
Kuriyan, J.3
-
36
-
-
0028351418
-
Crystallization and preliminary X-ray analysis of the auto-inhibited twitchin kinase
-
Hu, S. H., Lei, J. Y, Wilce, M. C., Valenzuela, M. R., Benian, G. M., Parker, M. W., and Kemp, B. E. (1994) Crystallization and preliminary X-ray analysis of the auto-inhibited twitchin kinase. J. Mol. Biol. 236, 1259-1261.
-
(1994)
J. Mol. Biol.
, vol.236
, pp. 1259-1261
-
-
Hu, S.H.1
Lei, J.Y.2
Wilce, M.C.3
Valenzuela, M.R.4
Benian, G.M.5
Parker, M.W.6
Kemp, B.E.7
-
37
-
-
0028287635
-
Insights into autoregulation from the crystal structure of twitchin kinase
-
Hu, S. H., Parker, M. W., Lei, J. Y., Wilce, M. C., Benian, G. M., and Kemp, B. E. (1994) Insights into autoregulation from the crystal structure of twitchin kinase. Nature 369, 581-584.
-
(1994)
Nature
, vol.369
, pp. 581-584
-
-
Hu, S.H.1
Parker, M.W.2
Lei, J.Y.3
Wilce, M.C.4
Benian, G.M.5
Kemp, B.E.6
-
38
-
-
0031017533
-
Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways
-
Luo, H., Rose, P., Barber, D., Hanratty, W. P., Lee, S., Roberts, T. M., D'Andrea, A. D., and Dearolf, C. R. (1997) Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol. Cell Biol. 17, 1562-1571.
-
(1997)
Mol. Cell Biol.
, vol.17
, pp. 1562-1571
-
-
Luo, H.1
Rose, P.2
Barber, D.3
Hanratty, W.P.4
Lee, S.5
Roberts, T.M.6
D'Andrea, A.D.7
Dearolf, C.R.8
-
39
-
-
0029086236
-
Characterization of active and inactive forms of the JAK2 protein-tyrosine kinase produced via the baculovirus expression vector system
-
Duhé, R. J. and Farrar, W. L. (1995) Characterization of active and inactive forms of the JAK2 protein-tyrosine kinase produced via the baculovirus expression vector system. J. Biol. Chem. 270, 23,084-23,089.
-
(1995)
J. Biol. Chem.
, vol.270
-
-
Duhé, R.J.1
Farrar, W.L.2
-
40
-
-
0029670224
-
tyk2, an interferon-α inducible tyrosine kinase, suppresses the transformed phenotype of Daudi cells
-
tyk2, an interferon-α inducible tyrosine kinase, suppresses the transformed phenotype of Daudi cells. Leukemia 10, 543-551.
-
(1996)
Leukemia
, vol.10
, pp. 543-551
-
-
Davis, E.1
Krishnan, K.2
Yan, H.3
Newcomb, E.W.4
Krolewski, J.J.5
-
41
-
-
0030905167
-
Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos
-
Conway, G., Margoliath, A., Wong-Madden, S., Roberts, R. J., and Gilbert, W. (1997) Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos. Proc. Natl. Acad. Sci. USA 94, 3082-3087.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3082-3087
-
-
Conway, G.1
Margoliath, A.2
Wong-Madden, S.3
Roberts, R.J.4
Gilbert, W.5
-
42
-
-
0028134741
-
Dominant negative effects of a carboxy-truncated Jak2 mutant on Epo- induced proliferation and Jak2 activation
-
Zhuang, H., Patel, S. V., He, T. C., Niu, Z., and Wojchowski, D. M. (1994) Dominant negative effects of a carboxy-truncated Jak2 mutant on Epo- induced proliferation and Jak2 activation. Biochem. Biophys. Res. Commun. 204, 278-283.
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.204
, pp. 278-283
-
-
Zhuang, H.1
Patel, S.V.2
He, T.C.3
Niu, Z.4
Wojchowski, D.M.5
-
43
-
-
0028074204
-
Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2
-
Zhuang, H., Patel, S. V., He, T. C., Sonsteby, S. K., Niu, Z., and Wojchowski, D. M. (1994). Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2. J. Biol. Chem. 269, 21,411-21,414.
-
(1994)
J. Biol. Chem.
, vol.269
-
-
Zhuang, H.1
Patel, S.V.2
He, T.C.3
Sonsteby, S.K.4
Niu, Z.5
Wojchowski, D.M.6
-
44
-
-
0345575181
-
Cytokines and STAT signaling
-
Schindler, C. and Strehlow, I. (2000) Cytokines and STAT signaling. Adv. Pharmacol. 47, 113-74.
-
(2000)
Adv. Pharmacol.
, vol.47
, pp. 113-174
-
-
Schindler, C.1
Strehlow, I.2
-
45
-
-
0032577678
-
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
-
Chen, X., Vinkemeier, U., Zhao, Y., Jeruzalmi, D., Darnell, J. E., Jr., and Kuriyan, J. (1998) Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93, 827-839.
-
(1998)
Cell
, vol.93
, pp. 827-839
-
-
Chen, X.1
Vinkemeier, U.2
Zhao, Y.3
Jeruzalmi, D.4
Darnell Jr., J.E.5
Kuriyan, J.6
-
46
-
-
0032499801
-
Three-dimensional structure of the Stat3beta homodimer bound to DNA
-
Becker, S., Groner, B., and Muller, C. W. (1998) Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 394, 145-151.
-
(1998)
Nature
, vol.394
, pp. 145-151
-
-
Becker, S.1
Groner, B.2
Muller, C.W.3
-
47
-
-
0032934156
-
Functional roles of STAT family proteins: Lessons from knockout mice
-
Akira, S. (1999) Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 17, 138-146.
-
(1999)
Stem Cells
, vol.17
, pp. 138-146
-
-
Akira, S.1
-
48
-
-
0034515268
-
Immune response in Stat2 knockout mice
-
Park, C., Li, S., Cha, E., and Schindler, C. (2000) Immune response in Stat2 knockout mice. Immunity, 13, 795-804.
-
(2000)
Immunity
, vol.13
, pp. 795-804
-
-
Park, C.1
Li, S.2
Cha, E.3
Schindler, C.4
-
49
-
-
0027403374
-
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
-
Noguchi, M., Yi, H., Rosenblatt, H. M., Filipovich, A. H., Adelstein, S., Modi, W. S., McBride, O. W., and Leonard, W. J. (1993) Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73, 147-157.
-
(1993)
Cell
, vol.73
, pp. 147-157
-
-
Noguchi, M.1
Yi, H.2
Rosenblatt, H.M.3
Filipovich, A.H.4
Adelstein, S.5
Modi, W.S.6
McBride, O.W.7
Leonard, W.J.8
-
50
-
-
0028857954
-
Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development
-
Russell, S. M., Tayebi, N., Nakajima, H., Riedy, M. C., Roberts, J. L., Aman, M. J., et al. (1995) Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270, 797-800.
-
(1995)
Science
, vol.270
, pp. 797-800
-
-
Russell, S.M.1
Tayebi, N.2
Nakajima, H.3
Riedy, M.C.4
Roberts, J.L.5
Aman, M.J.6
-
51
-
-
0029164841
-
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
-
Macchi, P., Villa, A., Giliani, S., Sacco, M. G., Frattini, A., Porta, F., et al. (1995) Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 377, 65-68.
-
(1995)
Nature
, vol.377
, pp. 65-68
-
-
Macchi, P.1
Villa, A.2
Giliani, S.3
Sacco, M.G.4
Frattini, A.5
Porta, F.6
-
52
-
-
0033559793
-
Autosomal SCID caused by a point mutation in the N-terminus of Jak3: Mapping of the Jak3-receptor interaction domain
-
Cacalano, N. A., Migone, T. S., Bazan, F., Hanson, E. P., Chen, M., Candotti, R, O'Shea, J. J., and Johnston, J. A. (1999) Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain. EMBO J. 18, 1549-1558.
-
(1999)
EMBO J.
, vol.18
, pp. 1549-1558
-
-
Cacalano, N.A.1
Migone, T.S.2
Bazan, F.3
Hanson, E.P.4
Chen, M.5
Candotti, R.6
O'Shea, J.J.7
Johnston, J.A.8
-
53
-
-
0033066308
-
Prenatal diagnosis of JAK3 deficient SCID
-
Schumacher, R. R, Mella, P., Lalatta, R, Fiorini, M., Giliani, S., Villa, A., Candotti, F., and Notarangelo, L. D. (1999) Prenatal diagnosis of JAK3 deficient SCID. Prenat. Diagn. 19, 653-656.
-
(1999)
Prenat. Diagn.
, vol.19
, pp. 653-656
-
-
Schumacher, R.R.1
Mella, P.2
Lalatta, R.3
Fiorini, M.4
Giliani, S.5
Villa, A.6
Candotti, F.7
Notarangelo, L.D.8
-
54
-
-
0029896604
-
In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction
-
Candotti, F., Oakes, S. A., Johnston, J. A., Notarangelo, L. D., O'Shea, J. J., and Blaese, R. M. (1996) In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction. J. Exp. Med. 183, 2687-2692.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 2687-2692
-
-
Candotti, F.1
Oakes, S.A.2
Johnston, J.A.3
Notarangelo, L.D.4
O'Shea, J.J.5
Blaese, R.M.6
-
55
-
-
0031890632
-
Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer
-
Bunting, K. D., Sangster, M. Y., Ihle, J. N., and Sorrentino, B. P. (1998) Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Nat. Med. 4, 58-64.
-
(1998)
Nat. Med.
, vol.4
, pp. 58-64
-
-
Bunting, K.D.1
Sangster, M.Y.2
Ihle, J.N.3
Sorrentino, B.P.4
-
56
-
-
0033524390
-
Virus-specific immunity after gene therapy in a murine model of severe combined immunodeficiency
-
Bunting, K. D., Flynn, K. J., Riberdy, J. M., Doherty, P. C., and Sorrentino, B. P. (1999) Virus-specific immunity after gene therapy in a murine model of severe combined immunodeficiency. Proc. Natl. Acad. Sci. USA 96, 232-237.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 232-237
-
-
Bunting, K.D.1
Flynn, K.J.2
Riberdy, J.M.3
Doherty, P.C.4
Sorrentino, B.P.5
-
57
-
-
0029006158
-
Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2
-
Zhuang, H., Niu, Z., He, T. C., Patel, S. V., and Wojchowski, D. M. (1995) Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2. J. Biol. Chem. 270, 14,500-14,504.
-
(1995)
J. Biol. Chem.
, vol.270
-
-
Zhuang, H.1
Niu, Z.2
He, T.C.3
Patel, S.V.4
Wojchowski, D.M.5
-
58
-
-
0033554631
-
The Human papilloma virus (HPV)-IS E6 oncoprotein physically associates with tyk2 and impairs jak-STAT activation by interferon-alpha
-
Li, S., Labrecque, S., Gauzzi, M. C., Cuddihy, A. R., Wong, A. H., Pellegrini, S., Matlashewski, G. J., and Koromilas, A. E. (1999) The Human papilloma virus (HPV)-IS E6 oncoprotein physically associates with tyk2 and impairs jak-STAT activation by interferon-alpha. Oncogene 18, 5727-5737.
-
(1999)
Oncogene
, vol.18
, pp. 5727-5737
-
-
Li, S.1
Labrecque, S.2
Gauzzi, M.C.3
Cuddihy, A.R.4
Wong, A.H.5
Pellegrini, S.6
Matlashewski, G.J.7
Koromilas, A.E.8
-
59
-
-
0032473555
-
Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway
-
Miller, D. M., Rahill, B. M., Boss, J. M., Lairmore, M. D., Durbin, J. E., Waldman, J. W., and Sedmak, D. D. (1998) Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. J. Exp. Med. 187, 675-683.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 675-683
-
-
Miller, D.M.1
Rahill, B.M.2
Boss, J.M.3
Lairmore, M.D.4
Durbin, J.E.5
Waldman, J.W.6
Sedmak, D.D.7
-
60
-
-
0031867451
-
Protein kinase A-mediated inhibition of gamma interferon-induced tyrosine phosphorylation of Janus kinases and latent cytoplasmic transcription factors in human monocytes by Ehrlichia chaffeensis
-
Lee, E. H. and Rikihisa, Y. (1998) Protein kinase A-mediated inhibition of gamma interferon-induced tyrosine phosphorylation of Janus kinases and latent cytoplasmic transcription factors in human monocytes by Ehrlichia chaffeensis. Infect. Immun. 66, 2514-2520.
-
(1998)
Infect. Immun.
, vol.66
, pp. 2514-2520
-
-
Lee, E.H.1
Rikihisa, Y.2
-
61
-
-
0029965272
-
Activation of protein kinase a inhibits interferon induction of the Jak/Stat pathway in U266 cells
-
David, M., Petricoin, E., III, and Larner, A. C. (1996) Activation of protein kinase A inhibits interferon induction of the Jak/Stat pathway in U266 cells. J. Biol. Chem. 271, 4585-4588.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4585-4588
-
-
David, M.1
Petricoin III, E.2
Larner, A.C.3
-
62
-
-
0028827229
-
Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: Selective inhibition of signaling through Janus kinases and Stat1
-
Nandan, D. and Reiner, N. E. (1995) Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1. Infect. Immun. 63, 4495-4500.
-
(1995)
Infect. Immun.
, vol.63
, pp. 4495-4500
-
-
Nandan, D.1
Reiner, N.E.2
-
63
-
-
0032744175
-
Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation
-
Blanchette, J , Racette, N., Faure, R., Siminovitch, K. A., and Olivier, M. (1999) Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation. Eur. J. Immunol. 29, 3737-3744.
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 3737-3744
-
-
Blanchette, J.1
Racette, N.2
Faure, R.3
Siminovitch, K.A.4
Olivier, M.5
-
64
-
-
0032954255
-
One hundred years of cancer immunotherapy: A critical appraisal
-
Ben Efraim, S. (1999) One hundred years of cancer immunotherapy: a critical appraisal. Tumor Biol. 20, 1-24.
-
(1999)
Tumor Biol.
, vol.20
, pp. 1-24
-
-
Ben Efraim, S.1
-
65
-
-
0033103021
-
A new era for cancer immunotherapy based on the genes that encode cancer antigens
-
Rosenberg, S. A. (1999) A new era for cancer immunotherapy based on the genes that encode cancer antigens. Immunity 10, 281-287.
-
(1999)
Immunity
, vol.10
, pp. 281-287
-
-
Rosenberg, S.A.1
-
66
-
-
0031571785
-
Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signaling: Role of soluble products from human renal cell carcinomas
-
Kolenko, V., Wang, Q., Riedy, M. C., O'Shea, J., Ritz, J., Cathcart, M. K., et al. (1997) Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signaling: role of soluble products from human renal cell carcinomas. J. Immunol. 159, 3057-3067.
-
(1997)
J. Immunol.
, vol.159
, pp. 3057-3067
-
-
Kolenko, V.1
Wang, Q.2
Riedy, M.C.3
O'Shea, J.4
Ritz, J.5
Cathcart, M.K.6
-
67
-
-
0033121116
-
Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: Impact on interleukin-2 receptor signaling pathway
-
Kolenko, V., Rayman, P., Roy, B., Cathcart, M. K., O'Shea, J., Tubbs, R., et al. (1999) Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: impact on interleukin-2 receptor signaling pathway. Blood 93, 2308-2318.
-
(1999)
Blood
, vol.93
, pp. 2308-2318
-
-
Kolenko, V.1
Rayman, P.2
Roy, B.3
Cathcart, M.K.4
O'Shea, J.5
Tubbs, R.6
-
68
-
-
13344295097
-
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
-
Meydan, N., Grunberger, T., Dadi, H., Shahar, M., Arpaia, E., Lapidot, Z., et al. (1996) Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379, 645-648.
-
(1996)
Nature
, vol.379
, pp. 645-648
-
-
Meydan, N.1
Grunberger, T.2
Dadi, H.3
Shahar, M.4
Arpaia, E.5
Lapidot, Z.6
-
69
-
-
15444339209
-
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
-
Lacronique, V., Boureux, A., Valle, V. D., Poirel, H., Quang, C. T., Mauchauffe, M., et al. (1997) A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278, 1309-1312.
-
(1997)
Science
, vol.278
, pp. 1309-1312
-
-
Lacronique, V.1
Boureux, A.2
Valle, V.D.3
Poirel, H.4
Quang, C.T.5
Mauchauffe, M.6
-
70
-
-
0030852328
-
Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
-
Peeters, P., Raynaud, S. D., Cools, J., Wlodarska, I., Grosgeorge, J., Philip, P., et al. (1997) Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90, 2535-2540.
-
(1997)
Blood
, vol.90
, pp. 2535-2540
-
-
Peeters, P.1
Raynaud, S.D.2
Cools, J.3
Wlodarska, I.4
Grosgeorge, J.5
Philip, P.6
-
71
-
-
0344517071
-
Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling
-
Ho, J. M., Beattie, B. K., Squire, J. A., Frank, D. A., and Barber, D. L. (1999) Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling. Blood 93, 4354-4364.
-
(1999)
Blood
, vol.93
, pp. 4354-4364
-
-
Ho, J.M.1
Beattie, B.K.2
Squire, J.A.3
Frank, D.A.4
Barber, D.L.5
-
72
-
-
0032530972
-
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
-
Schwaller, J., Frantsve, J., Aster, J., Williams, I. R., Tomasson, M. H., Ross, T. S., (1998) Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. EMBO J. 17, 5321-5333.
-
(1998)
EMBO J.
, vol.17
, pp. 5321-5333
-
-
Schwaller, J.1
Frantsve, J.2
Aster, J.3
Williams, I.R.4
Tomasson, M.H.5
Ross, T.S.6
-
73
-
-
0029834676
-
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome
-
Zhang, Q., Nowak, I., Vonderheid, E. C., Rook, A. H., Kadin, M. E., Nowell, P. C., Shaw, L. M., and Wasik, M. A. (1996) Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc. Natl. Acad. Sci. USA 93, 9148-9153.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9148-9153
-
-
Zhang, Q.1
Nowak, I.2
Vonderheid, E.C.3
Rook, A.H.4
Kadin, M.E.5
Nowell, P.C.6
Shaw, L.M.7
Wasik, M.A.8
-
74
-
-
0033120870
-
Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines
-
Liu, R. Y., Fan, C., Garcia, R., Jove, R., and Zuckerman, K. S. (1999) Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines. Blood 93, 2369-2379.
-
(1999)
Blood
, vol.93
, pp. 2369-2379
-
-
Liu, R.Y.1
Fan, C.2
Garcia, R.3
Jove, R.4
Zuckerman, K.S.5
-
75
-
-
0029031668
-
Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects
-
Harrison, D. A., Binari, R., Nahreini, T. S., Gilman, M., and Perrimon, N. (1995) Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J. 14, 2857-2865.
-
(1995)
EMBO J.
, vol.14
, pp. 2857-2865
-
-
Harrison, D.A.1
Binari, R.2
Nahreini, T.S.3
Gilman, M.4
Perrimon, N.5
-
76
-
-
0031587038
-
Microinjected cDNA encoding JAK2 protein-tyrosine kinase induces DNA synthesis in NIH 3T3 cells
-
Smith, M. R., Duhé, R. J., Liu, Y., and Farrar, W. L. (1997) Microinjected cDNA encoding JAK2 protein-tyrosine kinase induces DNA synthesis in NIH 3T3 cells. FEBS Lett. 408, 327-330.
-
(1997)
FEBS Lett.
, vol.408
, pp. 327-330
-
-
Smith, M.R.1
Duhé, R.J.2
Liu, Y.3
Farrar, W.L.4
-
77
-
-
0032473935
-
Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation
-
Chaturvedi, P., Reddy, M. V., and Reddy, E. P. (1998) Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation. Oncogene 16, 1749-1758.
-
(1998)
Oncogene
, vol.16
, pp. 1749-1758
-
-
Chaturvedi, P.1
Reddy, M.V.2
Reddy, E.P.3
-
78
-
-
0031018486
-
Constitutive activation of JAK1 in Src-transformed cells
-
Campbell, G. S., Yu, C.-L., Jove, R., and Carter-Su, C. (1997) Constitutive activation of JAK1 in Src-transformed cells. J. Biol. Chem. 272, 2591-2594.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 2591-2594
-
-
Campbell, G.S.1
Yu, C.-L.2
Jove, R.3
Carter-Su, C.4
-
79
-
-
0031935185
-
Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line
-
Murakami, Y., Nakano, S., Niho, Y., Hamasaki, N., and Izuhara, K. (1998) Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line. J. Cell Physiol 175, 220-228.
-
(1998)
J. Cell Physiol
, vol.175
, pp. 220-228
-
-
Murakami, Y.1
Nakano, S.2
Niho, Y.3
Hamasaki, N.4
Izuhara, K.5
-
80
-
-
0033546367
-
The angiotensin II-dependent association of Jak2 and c-Src requires the N-terminus of Jak2 and the SH2 domain of c-Src
-
Sayeski, P. P., Ali, M. S., Hawks, K., Frank, S. J., and Bernstein, K. E. (1999) The angiotensin II-dependent association of Jak2 and c-Src requires the N-terminus of Jak2 and the SH2 domain of c-Src. Circ. Res. 84, 1332-1338.
-
(1999)
Circ. Res.
, vol.84
, pp. 1332-1338
-
-
Sayeski, P.P.1
Ali, M.S.2
Hawks, K.3
Frank, S.J.4
Bernstein, K.E.5
-
81
-
-
0031306869
-
Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase
-
Yu, C. L., Jove, R., and Burakoff, S. J. (1997) Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase. J. Immunol. 159, 5206-5210.
-
(1997)
J. Immunol.
, vol.159
, pp. 5206-5210
-
-
Yu, C.L.1
Jove, R.2
Burakoff, S.J.3
-
82
-
-
0028817880
-
Jak-STAT signaling induced by the v-abl oncogene
-
Danial, N. N., Pernis, A., and Rothman, P. B. (1995) Jak-STAT signaling induced by the v-abl oncogene. Science 269, 1875-1877.
-
(1995)
Science
, vol.269
, pp. 1875-1877
-
-
Danial, N.N.1
Pernis, A.2
Rothman, P.B.3
-
83
-
-
0029810923
-
Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
-
Shuai, K., Halpern, J., ten Hoeve, J., Rao, X., and Sawyers, C. L. (1996) Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 13, 247-254.
-
(1996)
Oncogene
, vol.13
, pp. 247-254
-
-
Shuai, K.1
Halpern, J.2
Ten Hoeve, J.3
Rao, X.4
Sawyers, C.L.5
-
84
-
-
0029791664
-
Unique signal transduction of Eyk: Constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase
-
Zong, C., Yan, R., August, A., Darnell, J. E., Jr., and Hanafusa, H. (1996) Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. EMBO J. 15, 4515-4525.
-
(1996)
EMBO J.
, vol.15
, pp. 4515-4525
-
-
Zong, C.1
Yan, R.2
August, A.3
Darnell Jr., J.E.4
Hanafusa, H.5
-
85
-
-
0029005549
-
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-1
-
Migone, T. S., Lin, J. X., Cereseto, A., Mulloy, J. C., O'Shea, J. J., Franchini, G., and Leonard, W. J. (1995) Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-1. Science 269, 79-81.
-
(1995)
Science
, vol.269
, pp. 79-81
-
-
Migone, T.S.1
Lin, J.X.2
Cereseto, A.3
Mulloy, J.C.4
O'Shea, J.J.5
Franchini, G.6
Leonard, W.J.7
-
86
-
-
0029128045
-
Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells
-
Xu, X., Kang, S. H., Heidenreich, O., Okerholm, M., O'Shea, J. J., and Nerenberg, M. I. (1995) Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells. J. Clin. Invest 96, 1548-1555.
-
(1995)
J. Clin. Invest
, vol.96
, pp. 1548-1555
-
-
Xu, X.1
Kang, S.H.2
Heidenreich, O.3
Okerholm, M.4
O'Shea, J.J.5
Nerenberg, M.I.6
-
87
-
-
0032895421
-
Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia
-
Zhang, Q., Lee, B., Korecka, M., Li, G., Weyland, C., Eck, S., et al. (1999) Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia. Leuk. Res. 23, 373-384.
-
(1999)
Leuk. Res.
, vol.23
, pp. 373-384
-
-
Zhang, Q.1
Lee, B.2
Korecka, M.3
Li, G.4
Weyland, C.5
Eck, S.6
-
88
-
-
13144276369
-
Proliferation of adult T cell leukemia/ lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
-
Takemoto, S., Mulloy, J. C., Cereseto, A., Migone, T. S., Patel, B. K., Matsuoka, M., et al. (1997) Proliferation of adult T cell leukemia/ lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. Proc. Natl. Acad. Sci. USA 94, 13,897-13,902.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 13897-13902
-
-
Takemoto, S.1
Mulloy, J.C.2
Cereseto, A.3
Migone, T.S.4
Patel, B.K.5
Matsuoka, M.6
-
89
-
-
0032584235
-
Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T- lymphotropic virus type I-transformed T cells
-
Migone, T. S., Cacalano, N. A., Taylor, N., Yi, T., Waldmann, T. A., and Johnston, J. A. (1998) Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T- lymphotropic virus type I-transformed T cells. Proc. Natl. Acad. Sci. USA 95, 3845-3850.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3845-3850
-
-
Migone, T.S.1
Cacalano, N.A.2
Taylor, N.3
Yi, T.4
Waldmann, T.A.5
Johnston, J.A.6
-
90
-
-
0031561791
-
Comparison of IL-13- and IL-4-induced signaling in EBV-immortalized human B cells
-
Murata, T. and Puri, R. K. (1997) Comparison of IL-13- and IL-4-induced signaling in EBV-immortalized human B cells. Cell Immunol. 175, 33-40.
-
(1997)
Cell Immunol.
, vol.175
, pp. 33-40
-
-
Murata, T.1
Puri, R.K.2
-
91
-
-
0033153426
-
Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins
-
Gires, O., Kohlhuber, E, Kilger, E., Baumann, M., Kieser, A., Kaiser, C., et al. (1999) Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins. EMBO J. 18, 3064-3073.
-
(1999)
EMBO J.
, vol.18
, pp. 3064-3073
-
-
Gires, O.1
Kohlhuber, E.2
Kilger, E.3
Baumann, M.4
Kieser, A.5
Kaiser, C.6
-
92
-
-
0032566516
-
HBx protein of hepatitis B virus activates Jak1-STAT signaling
-
Lee, Y. H. and Yun, Y. (1998) HBx protein of hepatitis B virus activates Jak1-STAT signaling. J. Biol. Chem. 273, 25,510-25,515.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25510-25515
-
-
Lee, Y.H.1
Yun, Y.2
-
93
-
-
0028586107
-
Rapid activation of the interferon-gamma signal transduction pathway by inhibitors of tyrosine phosphatases
-
Lamb, P., Haslam, J., Kessler, L., Seidel, H. M., Stein, R. B., and Rosen, J. (1994) Rapid activation of the interferon-gamma signal transduction pathway by inhibitors of tyrosine phosphatases. J. Interferon Res. 14, 365-373.
-
(1994)
J. Interferon Res.
, vol.14
, pp. 365-373
-
-
Lamb, P.1
Haslam, J.2
Kessler, L.3
Seidel, H.M.4
Stein, R.B.5
Rosen, J.6
-
94
-
-
0030795790
-
Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1
-
Haque, S. J., Wu, Q., Kammer, W., Friedrich, K., Smith, J. M., Kerr, I. M., Stark, G. R., and Williams, B. R. (1997) Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1. Proc. Natl. Acad. Sci. USA 94, 8563-8568.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 8563-8568
-
-
Haque, S.J.1
Wu, Q.2
Kammer, W.3
Friedrich, K.4
Smith, J.M.5
Kerr, I.M.6
Stark, G.R.7
Williams, B.R.8
-
95
-
-
0028956353
-
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
-
Klingmüller, U., Lorenz, U., Cantley, L. C., Neel, B. G., and Lodish, H. F. (1995) Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80, 729-738.
-
(1995)
Cell
, vol.80
, pp. 729-738
-
-
Klingmüller, U.1
Lorenz, U.2
Cantley, L.C.3
Neel, B.G.4
Lodish, H.F.5
-
96
-
-
0029973560
-
Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1
-
Jiao, H., Berrada, K., Yang, W., Tabrizi, M., Platanias, L. C., and Yi, T. (1996) Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol. Cell Biol. 16, 6985-6992.
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 6985-6992
-
-
Jiao, H.1
Berrada, K.2
Yang, W.3
Tabrizi, M.4
Platanias, L.C.5
Yi, T.6
-
97
-
-
0028931604
-
Choice of STATs and other substrates specified by modular tyrosine- based motifs in cytokine receptors
-
Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E., Jr., and Yancopoulos, G. D. (1995) Choice of STATs and other substrates specified by modular tyrosine- based motifs in cytokine receptors. Science 267, 1349-1353.
-
(1995)
Science
, vol.267
, pp. 1349-1353
-
-
Stahl, N.1
Farruggella, T.J.2
Boulton, T.G.3
Zhong, Z.4
Darnell Jr., J.E.5
Yancopoulos, G.D.6
-
98
-
-
0029128365
-
Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase
-
Yetter, A., Uddin, S., Krolewski, J. J., Jiao, H., Yi, T., and Platanias, L. C. (1995) Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase. J. Biol. Chem. 270, 18,179-18,182.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18179-18182
-
-
Yetter, A.1
Uddin, S.2
Krolewski, J.J.3
Jiao, H.4
Yi, T.5
Platanias, L.C.6
-
99
-
-
0028972719
-
Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1
-
David, M., Chen, H. E., Goelz, S., Larner, A. C., and Neel, B. G. (1995) Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol. Cell Biol. 15, 7050-7058.
-
(1995)
Mol. Cell Biol.
, vol.15
, pp. 7050-7058
-
-
David, M.1
Chen, H.E.2
Goelz, S.3
Larner, A.C.4
Neel, B.G.5
-
100
-
-
0032545279
-
Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4-and IL-13-dependent signal transduction
-
Haque, S. J., Harbor, P., Tabrizi, M., Yi, T., and Williams, B. R. (1998) Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4-and IL-13-dependent signal transduction. J. Biol. Chem. 273, 33,893-33,896.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33893-33896
-
-
Haque, S.J.1
Harbor, P.2
Tabrizi, M.3
Yi, T.4
Williams, B.R.5
-
101
-
-
0031933076
-
Reduced Tyk2/SHP-1 interaction and lack of SHP-1 mutation in a kindred of familial hemophagocytic lymphohistiocytosis
-
Tabrizi, M., Yang, W., Jiao, H., DeVries, E. M., Platanias, L. C., Arico, M., and Yi, T. (1998) Reduced Tyk2/SHP-1 interaction and lack of SHP-1 mutation in a kindred of familial hemophagocytic lymphohistiocytosis. Leukemia 12, 203-206.
-
(1998)
Leukemia
, vol.12
, pp. 203-206
-
-
Tabrizi, M.1
Yang, W.2
Jiao, H.3
DeVries, E.M.4
Platanias, L.C.5
Arico, M.6
Yi, T.7
-
102
-
-
0030878257
-
Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase
-
Ram, P. A. and Waxman, D. J. (1997) Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase. J. Biol. Chem. 272, 17,694-17,702.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17694-17702
-
-
Ram, P.A.1
Waxman, D.J.2
-
103
-
-
0029844028
-
Constitutive nuclear localization of Janus kinases 1 and 2
-
Lobie, P. E., Ronsin, B., Silvennoinen, O., Haldosen, L. A., Norstedt, G., and Morel, G. (1996) Constitutive nuclear localization of Janus kinases 1 and 2. Endocrinology 137, 4037-4045.
-
(1996)
Endocrinology
, vol.137
, pp. 4037-4045
-
-
Lobie, P.E.1
Ronsin, B.2
Silvennoinen, O.3
Haldosen, L.A.4
Norstedt, G.5
Morel, G.6
-
104
-
-
0032743225
-
Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor
-
Bousquet, C., Susini, C., and Melmed, S. (1999) Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor. J. Clin. Invest 104, 1277-1285.
-
(1999)
J. Clin. Invest
, vol.104
, pp. 1277-1285
-
-
Bousquet, C.1
Susini, C.2
Melmed, S.3
-
105
-
-
0033023679
-
SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 are dramatically increased at the protein level in neutrophils from patients with severe congenital neutropenia (Kostmann's syndrome)
-
Tidow, N., Kasper, B., and Welte, K. (1999) SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 are dramatically increased at the protein level in neutrophils from patients with severe congenital neutropenia (Kostmann's syndrome). Exp. Hematol. 27, 1038-1045.
-
(1999)
Exp. Hematol.
, vol.27
, pp. 1038-1045
-
-
Tidow, N.1
Kasper, B.2
Welte, K.3
-
106
-
-
0028789906
-
The protein tyrosine kinase JAK2 is activated in neutrophils from patients with severe congenital neutropenia
-
Raupich, P., Kasper, B., Tidow, N., and Welte, K. (1995) The protein tyrosine kinase JAK2 is activated in neutrophils from patients with severe congenital neutropenia. Blood 86, 4500-4505.
-
(1995)
Blood
, vol.86
, pp. 4500-4505
-
-
Raupich, P.1
Kasper, B.2
Tidow, N.3
Welte, K.4
-
107
-
-
0032230241
-
Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription
-
Berchtold, S , Volarevic, S., Moriggl, R., Mercep, M., and Groner, B. (1998) Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription. Mol. Endocrinol. 12, 556-567.
-
(1998)
Mol. Endocrinol.
, vol.12
, pp. 556-567
-
-
Berchtold, S.1
Volarevic, S.2
Moriggl, R.3
Mercep, M.4
Groner, B.5
-
108
-
-
0032523416
-
Involvement of SHP-2 in multiple aspects of IL-2 signaling: Evidence for a positive regulatory role
-
Gadina, M., Stancato, L. M., Bacon, C. M., Larner, A. C., and O'Shea, J. J. (1998) Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role. J. Immunol 160, 4657-4661.
-
(1998)
J. Immunol
, vol.160
, pp. 4657-4661
-
-
Gadina, M.1
Stancato, L.M.2
Bacon, C.M.3
Larner, A.C.4
O'Shea, J.J.5
-
109
-
-
0030297324
-
SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates
-
Maegawa, H., Kashiwagi, A., Fujita, T., Ugi, S., Hasegawa, M., Obata, T., et al. (1996) SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates. Biochem. Biophys. Res. Commun. 228, 122-127.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.228
, pp. 122-127
-
-
Maegawa, H.1
Kashiwagi, A.2
Fujita, T.3
Ugi, S.4
Hasegawa, M.5
Obata, T.6
-
110
-
-
0031033714
-
Molecular characterization of specific-interactions between SHP-2 phosphatase and JAK tyrosine kinases
-
Yin, T., Shen, R., Feng, G. S., and Yang, Y. C. (1997) Molecular characterization of specific-interactions between SHP-2 phosphatase and JAK tyrosine kinases. J. Biol. Chem. 272, 1032-1037.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 1032-1037
-
-
Yin, T.1
Shen, R.2
Feng, G.S.3
Yang, Y.C.4
-
111
-
-
0032980574
-
Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway
-
You, M., Yu, D. H., and Feng, G. S. (1999) Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol. Cell Biol. 19, 2416-2424.
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 2416-2424
-
-
You, M.1
Yu, D.H.2
Feng, G.S.3
-
112
-
-
0033578334
-
Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction
-
Li, C. and Friedman, J. M. (1999) Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc. Natl. Acad. Sci. USA 96, 9677-9682.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 9677-9682
-
-
Li, C.1
Friedman, J.M.2
-
113
-
-
0031800490
-
The SOCS proteins: A new family of negative regulators of signal transduction
-
Nicholson, S. E. and Hilton, D. J. (1998) The SOCS proteins: a new family of negative regulators of signal transduction. J. Leukoc. Biol. 63, 665-668.
-
(1998)
J. Leukoc. Biol.
, vol.63
, pp. 665-668
-
-
Nicholson, S.E.1
Hilton, D.J.2
-
114
-
-
0031731175
-
SOCS: Suppressors of cytokine signalling
-
Starr, R. and Hilton, D. J. (1998) SOCS: suppressors of cytokine signalling. Int. J. Biochem. Cell Biol. 30, 1081-1085.
-
(1998)
Int. J. Biochem. Cell Biol.
, vol.30
, pp. 1081-1085
-
-
Starr, R.1
Hilton, D.J.2
-
115
-
-
0032836015
-
Suppressors of cytokine signaling (SOCS): Negative regulators of signal transduction
-
Alexander, W. S., Starr, R., Metcalf, D., Nicholson, S. E., Farley, A., Elefanty, A. G., et al. (1999) Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction. J. Leukoc. Biol. 66, 588-592.
-
(1999)
J. Leukoc. Biol.
, vol.66
, pp. 588-592
-
-
Alexander, W.S.1
Starr, R.2
Metcalf, D.3
Nicholson, S.E.4
Farley, A.5
Elefanty, A.G.6
-
116
-
-
0032751388
-
The SOCS-1 story
-
Metcalf, D. (1999) The SOCS-1 story. Exp. Hematol. 27, 1715-1723.
-
(1999)
Exp. Hematol.
, vol.27
, pp. 1715-1723
-
-
Metcalf, D.1
-
117
-
-
0032759325
-
The CIS/SOCS proteins: A family of cytokine-inducible regulators of signaling
-
Gisselbrecht, S. (1999) The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling. Eur. Cytokine Netw. 10, 463-470.
-
(1999)
Eur. Cytokine Netw.
, vol.10
, pp. 463-470
-
-
Gisselbrecht, S.1
-
118
-
-
0029014206
-
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
-
Yoshimura, A., Ohkubo, T., Kiguchi, T., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Hara, T., and Miyajima, A. (1995) A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14, 2816-2826.
-
(1995)
EMBO J.
, vol.14
, pp. 2816-2826
-
-
Yoshimura, A.1
Ohkubo, T.2
Kiguchi, T.3
Jenkins, N.A.4
Gilbert, D.J.5
Copeland, N.G.6
Hara, T.7
Miyajima, A.8
-
119
-
-
0030956715
-
CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
-
Matsumoto, A., Masuhara, M., Mitsui, K., Yokouchi, M., Ohtsubo, M., Misawa, H., Miyajima, A., and Yoshimura, A. (1997) CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89, 3148-3154.
-
(1997)
Blood
, vol.89
, pp. 3148-3154
-
-
Matsumoto, A.1
Masuhara, M.2
Mitsui, K.3
Yokouchi, M.4
Ohtsubo, M.5
Misawa, H.6
Miyajima, A.7
Yoshimura, A.8
-
120
-
-
0030839112
-
A new protein containing an SH2 domain that inhibits JAK kinases
-
Endo, T. A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., et al. (1997) A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387, 921-924.
-
(1997)
Nature
, vol.387
, pp. 921-924
-
-
Endo, T.A.1
Masuhara, M.2
Yokouchi, M.3
Suzuki, R.4
Sakamoto, H.5
Mitsui, K.6
-
121
-
-
0030755934
-
Structure and function of a new STAT-induced STAT inhibitor
-
Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., et al. (1997) Structure and function of a new STAT-induced STAT inhibitor. Nature 387, 924-929.
-
(1997)
Nature
, vol.387
, pp. 924-929
-
-
Naka, T.1
Narazaki, M.2
Hirata, M.3
Matsumoto, T.4
Minamoto, S.5
Aono, A.6
-
122
-
-
0030792590
-
A family of cytokine-inducible inhibitors of signalling
-
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J., Rayner, J. R., Jenkins, B. J., et al. (1997) A family of cytokine-inducible inhibitors of signalling. Nature 387, 917-921.
-
(1997)
Nature
, vol.387
, pp. 917-921
-
-
Starr, R.1
Willson, T.A.2
Viney, E.M.3
Murray, L.J.4
Rayner, J.R.5
Jenkins, B.J.6
-
123
-
-
0031581086
-
Cloning and characterization of novel CIS family genes
-
Masuhara, M., Sakamoto, H., Matsumoto, A., Suzuki, R., Yasukawa, H., Mitsui, K., et al. (1997) Cloning and characterization of novel CIS family genes. Biochem. Biophys. Res. Commun. 239, 439-446.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.239
, pp. 439-446
-
-
Masuhara, M.1
Sakamoto, H.2
Matsumoto, A.3
Suzuki, R.4
Yasukawa, H.5
Mitsui, K.6
-
124
-
-
0031559588
-
Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
-
Minamoto, S., Ikegame, K., Ueno, K., Narazaki, M., Naka, T., Yamamoto, H., et al. (1997) Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem. Biophys. Res. Commun. 237, 79-83.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.237
, pp. 79-83
-
-
Minamoto, S.1
Ikegame, K.2
Ueno, K.3
Narazaki, M.4
Naka, T.5
Yamamoto, H.6
-
125
-
-
13144258732
-
Twenty proteins containing a C-terminal SOCS box form five structural classes
-
Hilton, D. J., Richardson, R. T., Alexander, W. S., Viney, E. M., Willson, T. A., Sprigg, N. S., et al. (1998) Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA 95, 114-119.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 114-119
-
-
Hilton, D.J.1
Richardson, R.T.2
Alexander, W.S.3
Viney, E.M.4
Willson, T.A.5
Sprigg, N.S.6
-
126
-
-
0032564463
-
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
-
Starr, R., Metcalf, D., Elefanty, A. G., Brysha, M., Willson, T. A., Nicola, N. A., Hilton, D. J., and Alexander, W. S. (1998) Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. USA 95, 14,395-14,399.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 14395-14399
-
-
Starr, R.1
Metcalf, D.2
Elefanty, A.G.3
Brysha, M.4
Willson, T.A.5
Nicola, N.A.6
Hilton, D.J.7
Alexander, W.S.8
-
127
-
-
13044276245
-
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
-
Naka, T., Matsumoto, T., Narazaki, M., Fujimoto, M., Morita, Y., Ohsawa, Y., et al. (1998) Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc. Natl. Acad. Sci. USA 95, 15,577-15,582.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15577-15582
-
-
Naka, T.1
Matsumoto, T.2
Narazaki, M.3
Fujimoto, M.4
Morita, Y.5
Ohsawa, Y.6
-
128
-
-
0033520326
-
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
-
Alexander, W. S., Starr, R., Fenner, J. E., Scott, C. L., Handman, E., Sprigg, N. S., et al. (1999) SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98, 597-608.
-
(1999)
Cell
, vol.98
, pp. 597-608
-
-
Alexander, W.S.1
Starr, R.2
Fenner, J.E.3
Scott, C.L.4
Handman, E.5
Sprigg, N.S.6
-
129
-
-
0033520467
-
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
-
Marine, J. C., Topham, D. J., McKay, C., Wang, D., Parganas, E., Stravopodis, D., Yoshimura, A., and Ihle, J. N. (1999) SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98, 609-616.
-
(1999)
Cell
, vol.98
, pp. 609-616
-
-
Marine, J.C.1
Topham, D.J.2
McKay, C.3
Wang, D.4
Parganas, E.5
Stravopodis, D.6
Yoshimura, A.7
Ihle, J.N.8
-
130
-
-
18744427668
-
Bone marrow and thymus expression of interferon-gamma results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies
-
Young, H. A., Klinman, D. M., Reynolds, D. A., Grzegorzewski, K. J., Nii, A., Ward, J. M., et al. (1997) Bone marrow and thymus expression of interferon-gamma results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies. Blood 89, 583-595.
-
(1997)
Blood
, vol.89
, pp. 583-595
-
-
Young, H.A.1
Klinman, D.M.2
Reynolds, D.A.3
Grzegorzewski, K.J.4
Nii, A.5
Ward, J.M.6
-
131
-
-
20244389693
-
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
-
Yasukawa, H., Misawa, H., Sakamoto, H., Masuhara, M., Sasaki, A., Wakioka, T., et al. (1999) The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18, 1309-1320.
-
(1999)
EMBO J.
, vol.18
, pp. 1309-1320
-
-
Yasukawa, H.1
Misawa, H.2
Sakamoto, H.3
Masuhara, M.4
Sasaki, A.5
Wakioka, T.6
-
132
-
-
0032573161
-
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling
-
Narazaki, M., Fujimoto, M., Matsumoto, T., Morita, Y., Saito, H., Kajita, T., et al. (1998) Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling. Proc. Natl. Acad. Sci. USA 95, 13,130-13,134.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13130-13134
-
-
Narazaki, M.1
Fujimoto, M.2
Matsumoto, T.3
Morita, Y.4
Saito, H.5
Kajita, T.6
-
133
-
-
0033555258
-
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
-
Nicholson, S. E., Willson, T. A., Farley, A., Starr, R., Zhang, J. G., Baca, M., et al. (1999) Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18, 375-385.
-
(1999)
EMBO J.
, vol.18
, pp. 375-385
-
-
Nicholson, S.E.1
Willson, T.A.2
Farley, A.3
Starr, R.4
Zhang, J.G.5
Baca, M.6
-
134
-
-
0030869426
-
SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase
-
Ohya, K., Kajigaya, S., Yamashita, Y., Miyazato, A., Hatake, K., Miura, Y., et al. (1997) SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. J. Biol. Chem. 272, 27,178-27,182.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 27178-27182
-
-
Ohya, K.1
Kajigaya, S.2
Yamashita, Y.3
Miyazato, A.4
Hatake, K.5
Miura, Y.6
-
135
-
-
0033558088
-
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation
-
De Sepulveda, P., Okkenhaug, K., Rose, J. L., Hawley, R. G., Dubreuil, P., and Rottapel, R. (1999) Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 18, 904-915.
-
(1999)
EMBO J.
, vol.18
, pp. 904-915
-
-
De Sepulveda, P.1
Okkenhaug, K.2
Rose, J.L.3
Hawley, R.G.4
Dubreuil, P.5
Rottapel, R.6
-
136
-
-
0032170490
-
A janus kinase inhibitor, JAB, is an interferon-γ-inducible gene and confers resistance to interferons
-
Sakamoto, H., Yasukawa, H., Masuhara, M., Tanimura, S., Sasaki, A., Yuge, K., et al. (1998) A janus kinase inhibitor, JAB, is an interferon-γ-inducible gene and confers resistance to interferons. Blood 92, 1668-1676.
-
(1998)
Blood
, vol.92
, pp. 1668-1676
-
-
Sakamoto, H.1
Yasukawa, H.2
Masuhara, M.3
Tanimura, S.4
Sasaki, A.5
Yuge, K.6
-
137
-
-
0033016764
-
Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons
-
Dickensheets, H. L. and Donnelly, R. P. (1999) Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons. J. Leukoc. Biol. 65, 307-312.
-
(1999)
J. Leukoc. Biol.
, vol.65
, pp. 307-312
-
-
Dickensheets, H.L.1
Donnelly, R.P.2
-
138
-
-
0033120880
-
SOCS-1 is a potent inhibitor of IL-4 signal transduction
-
Losman, J. A., Chen, X. P., Hilton, D., and Rothman, P. (1999) SOCS-1 is a potent inhibitor of IL-4 signal transduction. J. Immunol. 162, 3770-3774.
-
(1999)
J. Immunol.
, vol.162
, pp. 3770-3774
-
-
Losman, J.A.1
Chen, X.P.2
Hilton, D.3
Rothman, P.4
-
139
-
-
0033120515
-
Repression of IL-4-induced gene expression by IFN-gamma requires Stat1 activation
-
Venkataraman, C., Leung, S., Salvekar, A., Mano, H., and Schindler, U. (1999) Repression of IL-4-induced gene expression by IFN-gamma requires Stat1 activation. J. Immunol. 162, 4053-4061.
-
(1999)
J. Immunol.
, vol.162
, pp. 4053-4061
-
-
Venkataraman, C.1
Leung, S.2
Salvekar, A.3
Mano, H.4
Schindler, U.5
-
140
-
-
0032850616
-
Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression
-
Dickensheets, H. L., Venkataraman, C., Schindler, U., and Donnelly, R. P. (1999) Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. Proc. Natl Acad. Sci. USA 96, 10,800-10,805.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 10800-10805
-
-
Dickensheets, H.L.1
Venkataraman, C.2
Schindler, U.3
Donnelly, R.P.4
-
141
-
-
0032014178
-
Identification of SOCS-3 as a potential mediator of central leptin resistance
-
Bjørbaek, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., and Flier, J. S. (1998) Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 1, 619-625.
-
(1998)
Mol. Cell
, vol.1
, pp. 619-625
-
-
Bjørbaek, C.1
Elmquist, J.K.2
Frantz, J.D.3
Shoelson, S.E.4
Flier, J.S.5
-
142
-
-
0033001325
-
Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues
-
Emilsson, V., Arch, J. R., de Groot, R. P., Lister, C. A., and Cawthorne, M. A. (1999) Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues. FEBS Lett. 455, 170-174.
-
(1999)
FEBS Lett.
, vol.455
, pp. 170-174
-
-
Emilsson, V.1
Arch, J.R.2
De Groot, R.P.3
Lister, C.A.4
Cawthorne, M.A.5
-
143
-
-
0033569730
-
The role of SOCS-3 in leptin signaling and leptin resistance
-
Bjørbaek, C., EI Haschimi, K., Frantz, J. D., and Flier, J. S. (1999) The role of SOCS-3 in leptin signaling and leptin resistance. J. Biol. Chem. 274, 30,059-30,065.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30059-30065
-
-
Bjørbaek, C.1
EI Haschimi, K.2
Frantz, J.D.3
Flier, J.S.4
-
144
-
-
0033324777
-
Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor
-
Bjørbaek, C., Elmquist, J. K., EI Haschimi, K., Kelly, J., Ahima, R. S., Hileman, S., and Flier, J. S. (1999) Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. Endocrinology 140, 2035-2043.
-
(1999)
Endocrinology
, vol.140
, pp. 2035-2043
-
-
Bjørbaek, C.1
Elmquist, J.K.2
EI Haschimi, K.3
Kelly, J.4
Ahima, R.S.5
Hileman, S.6
Flier, J.S.7
-
145
-
-
0032230273
-
Pituitary corticotroph SOCS-3: Novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion
-
Auernhammer, C. J., Chesnokova, V., Bousquet, C., and Melmed, S. (1998) Pituitary corticotroph SOCS-3: novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion. Mol. Endocrinol. 12, 954-961.
-
(1998)
Mol. Endocrinol.
, vol.12
, pp. 954-961
-
-
Auernhammer, C.J.1
Chesnokova, V.2
Bousquet, C.3
Melmed, S.4
-
146
-
-
0033054062
-
Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: Evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis
-
Auernhammer, C. J. and Melmed, S. (1999) Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis. Endocrinology 140, 1559-1566.
-
(1999)
Endocrinology
, vol.140
, pp. 1559-1566
-
-
Auernhammer, C.J.1
Melmed, S.2
-
147
-
-
0031915126
-
Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling
-
Adams, T. E., Hansen, J. A., Starr, R., Nicola, N. A., Hilton, D. J., and Billestrup, N. (1998) Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273, 1285-1287.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1285-1287
-
-
Adams, T.E.1
Hansen, J.A.2
Starr, R.3
Nicola, N.A.4
Hilton, D.J.5
Billestrup, N.6
-
148
-
-
0033544899
-
SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
-
Ram, P. A. and Waxman, D. J. (1999) SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J. Biol. Chem. 274, 35,553-35,561.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 35553-35561
-
-
Ram, P.A.1
Waxman, D.J.2
-
149
-
-
0344655657
-
Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction
-
Favre, H., Benhamou, A., Finidori, J., Kelly, P. A., and Edery, M. (1999) Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction. FEBS Lett. 453, 63-66.
-
(1999)
FEBS Lett.
, vol.453
, pp. 63-66
-
-
Favre, H.1
Benhamou, A.2
Finidori, J.3
Kelly, P.A.4
Edery, M.5
-
150
-
-
0033197958
-
Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma
-
Stoiber, D., Kovarik, P., Cohney, S., Johnston, J. A., Steinlein, P., and Decker, T. (1999) Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma. J. Immunol. 163, 2640-2647.
-
(1999)
J. Immunol.
, vol.163
, pp. 2640-2647
-
-
Stoiber, D.1
Kovarik, P.2
Cohney, S.3
Johnston, J.A.4
Steinlein, P.5
Decker, T.6
-
151
-
-
0033104946
-
Interleukin-10 inhibits expression of both interferon α and interferon-γ-induced genes by supressing tyrosine phosphorylation of STAT1
-
Ito, S., Ansari, P., Sakatsume, M., Dickensheets, H., Vazquez, N., Donnelly, R. P., Larner, A. C., and Finbloom, D. S. (1999) Interleukin-10 inhibits expression of both interferon α and interferon-γ-induced genes by supressing tyrosine phosphorylation of STAT1. Blood 93, 1456-1463.
-
(1999)
Blood
, vol.93
, pp. 1456-1463
-
-
Ito, S.1
Ansari, P.2
Sakatsume, M.3
Dickensheets, H.4
Vazquez, N.5
Donnelly, R.P.6
Larner, A.C.7
Finbloom, D.S.8
-
152
-
-
13044290651
-
Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: Evidence for an IL-10-induced pathway that is independent of STAT protein activation
-
Cassatella, M. A., Gasperini, S., Bovolenta, C., Calzetti, F., Vollebregt, M., Scapini, P., et al. (1999) Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation. Blood 94, 2880-2889.
-
(1999)
Blood
, vol.94
, pp. 2880-2889
-
-
Cassatella, M.A.1
Gasperini, S.2
Bovolenta, C.3
Calzetti, F.4
Vollebregt, M.5
Scapini, P.6
-
153
-
-
0033037268
-
SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
-
Cohney, S. J., Sanden, D., Cacalano, N. A., Yoshimura, A., Mui, A., Migone, T. S., and Johnston, J. A. (1999) SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell Biol. 19, 4980-4988.
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 4980-4988
-
-
Cohney, S.J.1
Sanden, D.2
Cacalano, N.A.3
Yoshimura, A.4
Mui, A.5
Migone, T.S.6
Johnston, J.A.7
-
154
-
-
0033520389
-
SOCS3 is essential in the regulation of fetal liver erythropoiesis
-
Marine, J. C., McKay, C., Wang, D., Topham, D. J., Parganas, E.,
-
(1999)
Cell
, vol.98
, pp. 617-627
-
-
Marine, J.C.1
McKay, C.2
Wang, D.3
Topham, D.J.4
Parganas, E.5
Nakajima, H.6
-
155
-
-
0032508617
-
Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor
-
Dey, B. R., Spence, S. L., Nissley, P., and Furlanetto, R. W. (1998) Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. J. Biol. Chem. 273, 24,095-24,101.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 24095-24101
-
-
Dey, B.R.1
Spence, S.L.2
Nissley, P.3
Furlanetto, R.W.4
-
156
-
-
0032567353
-
The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
-
Song, M. M. and Shuai, K. (1998) The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J. Biol. Chem. 273, 35,056-35,062.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35056-35062
-
-
Song, M.M.1
Shuai, K.2
-
157
-
-
0030983549
-
Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
-
Yu, C. L. and Burakoff, S. J. (1997) Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation. J. Biol. Chem. 272, 14,017-14,020.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14017-14020
-
-
Yu, C.L.1
Burakoff, S.J.2
-
158
-
-
0032955406
-
Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation
-
Gebert, C. A., Park, S. H., and Waxman, D. J. (1999) Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation. Mol. Endocrinol. 13, 213-227.
-
(1999)
Mol. Endocrinol.
, vol.13
, pp. 213-227
-
-
Gebert, C.A.1
Park, S.H.2
Waxman, D.J.3
-
159
-
-
0032894684
-
Termination of growth hormone pulse-induced STAT5b signaling
-
Gebert, C. A., Park, S. H., and Waxman, D. J. (1999) Termination of growth hormone pulse-induced STAT5b signaling. Mol. Endocrinol. 13, 38-56.
-
(1999)
Mol. Endocrinol.
, vol.13
, pp. 38-56
-
-
Gebert, C.A.1
Park, S.H.2
Waxman, D.J.3
-
160
-
-
0032080245
-
Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors
-
Callus, B. A. and Mathey-Prevot, B. (1998) Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors. Blood 91, 3182-3192.
-
(1998)
Blood
, vol.91
, pp. 3182-3192
-
-
Callus, B.A.1
Mathey-Prevot, B.2
-
161
-
-
0032561322
-
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation
-
Verdier, F. Chrétien, S., Muller, O., Vrlet, P., Yoshimura, A., Gisselbrecht, S., Lacombe, C., and Mayeux, P. (1998) Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. J. Biol. Chem. 273, 28,185-28,190.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 28185-28190
-
-
Verdier, F.1
Chrétien, S.2
Muller, O.3
Vrlet, P.4
Yoshimura, A.5
Gisselbrecht, S.6
Lacombe, C.7
Mayeux, P.8
-
162
-
-
0032535364
-
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
-
Kamura, T., Sato, S., Haque, D., Liu, L., Kaelin, W. G., Jr., Conaway, R. C., and Conaway, J. W. (1998) The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 12, 3872-3881.
-
(1998)
Genes Dev.
, vol.12
, pp. 3872-3881
-
-
Kamura, T.1
Sato, S.2
Haque, D.3
Liu, L.4
Kaelin Jr., W.G.5
Conaway, R.C.6
Conaway, J.W.7
-
163
-
-
13044263097
-
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
-
Zhang, J. -G., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., et al. (1999) The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA 96, 2071-2076.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2071-2076
-
-
Zhang, J.G.1
Farley, A.2
Nicholson, S.E.3
Willson, T.A.4
Zugaro, L.M.5
Simpson, R.J.6
-
164
-
-
0030812414
-
Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosporylated upon B cell receptor stimulation
-
Yokouchi, M., Suzuki, R., Masuhara, M., Komiya, S., Inoue, A., and Yoshimura, A. (1997) Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosporylated upon B cell receptor stimulation. Oncogene 15, 7-15.
-
(1997)
Oncogene
, vol.15
, pp. 7-15
-
-
Yokouchi, M.1
Suzuki, R.2
Masuhara, M.3
Komiya, S.4
Inoue, A.5
Yoshimura, A.6
-
165
-
-
0033056041
-
APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl
-
Wakioka, T., Sasaki, A., Mitsui, K., Yokouchi, M., Inoue, A., Komiya, S., and Yoshimura, A. (1999) APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. Leukemia 13, 760-767.
-
(1999)
Leukemia
, vol.13
, pp. 760-767
-
-
Wakioka, T.1
Sasaki, A.2
Mitsui, K.3
Yokouchi, M.4
Inoue, A.5
Komiya, S.6
Yoshimura, A.7
-
166
-
-
0030613545
-
Identification of SH2-Bβ as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling
-
Rui, L., Mathews, L. S., Hotta, K., Gustafson, T. A., and Carter-Su, C. (1997) Identification of SH2-Bβ as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling. Mol. Cell. Biol. 17, 6633-6644.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 6633-6644
-
-
Rui, L.1
Mathews, L.S.2
Hotta, K.3
Gustafson, T.A.4
Carter-Su, C.5
-
167
-
-
0033594812
-
Identification of SH2-Bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2
-
Rui, L. and Carter-Su, C. (1999) Identification of SH2-Bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2. Proc. Natl. Acad. Sci. USA 96, 7172-7177.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7172-7177
-
-
Rui, L.1
Carter-Su, C.2
-
168
-
-
0031180973
-
TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes
-
Bright, J. J., Kerr, L. D., and Sriram, S. (1997) TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes. J. Immunol. 159, 175-183.
-
(1997)
J. Immunol.
, vol.159
, pp. 175-183
-
-
Bright, J.J.1
Kerr, L.D.2
Sriram, S.3
-
169
-
-
0032529220
-
TGF-beta inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes
-
Bright, J. J. and Sriram, S. (1998) TGF-beta inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes. J. Immunol. 161, 1772-1777.
-
(1998)
J. Immunol.
, vol.161
, pp. 1772-1777
-
-
Bright, J.J.1
Sriram, S.2
-
170
-
-
0033106371
-
TGF-beta does not inhibit IL-12-and IL-2-induced activation of Janus kinases and STATs
-
Sudarshan, C., Galon, J., Zhou, Y., and O'Shea, J. J. (1999) TGF-beta does not inhibit IL-12-and IL-2-induced activation of Janus kinases and STATs. J. Immunol. 162, 2974-2981.
-
(1999)
J. Immunol.
, vol.162
, pp. 2974-2981
-
-
Sudarshan, C.1
Galon, J.2
Zhou, Y.3
O'Shea, J.J.4
-
171
-
-
0031171607
-
Molecular role of TGF-beta, secreted from a new type of CD4+ suppressor T cell, NY4.2, in the prevention of autoimmune IDDM in NOD mice
-
Han, H. S., Jun, H. S., Utsugi, T., and Yoon, J. W. (1997) Molecular role of TGF-beta, secreted from a new type of CD4+ suppressor T cell, NY4.2, in the prevention of autoimmune IDDM in NOD mice. J. Autoimmun. 10, 299-307.
-
(1997)
J. Autoimmun.
, vol.10
, pp. 299-307
-
-
Han, H.S.1
Jun, H.S.2
Utsugi, T.3
Yoon, J.W.4
-
172
-
-
0033104705
-
Downregulation of interleukin-12 (IL-12) responsiveness in human T cells by transforming growth factor-beta: Relationship with IL-12 signaling
-
Pardoux, C., Ma, X., Gobert, S., Pellegrini, S., Mayeux, P., Gay, F., Trinchieri, G., and Chouaib, S. (1999) Downregulation of interleukin-12 (IL-12) responsiveness in human T cells by transforming growth factor-beta: relationship with IL-12 signaling. Blood 93, 1448-1455.
-
(1999)
Blood
, vol.93
, pp. 1448-1455
-
-
Pardoux, C.1
Ma, X.2
Gobert, S.3
Pellegrini, S.4
Mayeux, P.5
Gay, F.6
Trinchieri, G.7
Chouaib, S.8
-
173
-
-
0028881246
-
Mechanism of inhibition of eosinophil activation by transforming growth factor-beta. Inhibition of Lyn, MAP, Jak2 kinases and STAT1 nuclear factor
-
Pazdrak, K., Justement, L., and Alam, R. (1995) Mechanism of inhibition of eosinophil activation by transforming growth factor-beta. Inhibition of Lyn, MAP, Jak2 kinases and STAT1 nuclear factor. J. Immunol. 155, 4454-4458.
-
(1995)
J. Immunol.
, vol.155
, pp. 4454-4458
-
-
Pazdrak, K.1
Justement, L.2
Alam, R.3
-
174
-
-
0031065145
-
TGF-beta attenuates the class II transactivator and reveals an accessory pathway of IFN-gamma action
-
Nandan, D. and Reiner, N. E. (1997) TGF-beta attenuates the class II transactivator and reveals an accessory pathway of IFN-gamma action. J. Immunol. 158, 1095-1101.
-
(1997)
J. Immunol.
, vol.158
, pp. 1095-1101
-
-
Nandan, D.1
Reiner, N.E.2
-
175
-
-
0028983551
-
TGF-beta suppression of IFN-gamma-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-gamma enhanced factor X expression
-
Panek, R. B., Lee, Y. J., and Benveniste, E. N. (1995) TGF-beta suppression of IFN-gamma-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-gamma enhanced factor X expression. J. Immunol. 154, 610-619.
-
(1995)
J. Immunol.
, vol.154
, pp. 610-619
-
-
Panek, R.B.1
Lee, Y.J.2
Benveniste, E.N.3
-
176
-
-
0031914374
-
Nitric oxide and thiol redox regulation of Janus kinase activity
-
Duhé, R. J., Evans, G. A., Erwin, R. A., Kirken, R. A., Cox, G. W., and Farrar, W. L. (1998) Nitric oxide and thiol redox regulation of Janus kinase activity. Proc. Natl. Acad. Sci. USA 95, 126-131.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 126-131
-
-
Duhé, R.J.1
Evans, G.A.2
Erwin, R.A.3
Kirken, R.A.4
Cox, G.W.5
Farrar, W.L.6
-
177
-
-
0032526629
-
Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway
-
Bingisser, R. M., Tilbrook, P. A., Holt, P. G., and Kees, U. R. (1998) Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. J. Immunol. 160, 5729-5734.
-
(1998)
J. Immunol.
, vol.160
, pp. 5729-5734
-
-
Bingisser, R.M.1
Tilbrook, P.A.2
Holt, P.G.3
Kees, U.R.4
-
178
-
-
0025753367
-
Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway
-
Mills, C. D. (1991) Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway. J. Immunol. 146, 2719-2723.
-
(1991)
J. Immunol.
, vol.146
, pp. 2719-2723
-
-
Mills, C.D.1
-
179
-
-
0025942326
-
Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway
-
Albina, J. E., Abate, J. A., and Henry, W. L., Jr. (1991) Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway. J. Immunol. 147, 144-148.
-
(1991)
J. Immunol.
, vol.147
, pp. 144-148
-
-
Albina, J.E.1
Abate, J.A.2
Henry Jr., W.L.3
-
180
-
-
0028328352
-
Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells
-
Taylor-Robinson, A. W., Liew, F. Y., Severn, A., Xu, D., McSorley, S. J., Garside, P., Padron, J., and Phillips, R. S. (1994) Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur. J. Immunol. 24, 980-984.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 980-984
-
-
Taylor-Robinson, A.W.1
Liew, F.Y.2
Severn, A.3
Xu, D.4
McSorley, S.J.5
Garside, P.6
Padron, J.7
Phillips, R.S.8
-
181
-
-
0028316846
-
Nitric oxide involvement in tumor-induced immunosuppression
-
Lejeune, P., Lagadec, P., Onier, N., Pinard, D., Ohshima, H., and Jeannin, J. F. (1994) Nitric oxide involvement in tumor-induced immunosuppression. J. Immunol. 152, 5077-5083.
-
(1994)
J. Immunol.
, vol.152
, pp. 5077-5083
-
-
Lejeune, P.1
Lagadec, P.2
Onier, N.3
Pinard, D.4
Ohshima, H.5
Jeannin, J.F.6
-
182
-
-
0026501661
-
Lymphocyte transformation and thiol compounds: The role of ADF/thioredoxin as an endogenous reducing agent
-
Yamauchi, A., Masutani, H., Tagaya, Y., Wakasugi, N., Mitsui, A., Nakamura, H., et al. (1992) Lymphocyte transformation and thiol compounds: the role of ADF/thioredoxin as an endogenous reducing agent. Mol. Immunol. 29, 263-270.
-
(1992)
Mol. Immunol.
, vol.29
, pp. 263-270
-
-
Yamauchi, A.1
Masutani, H.2
Tagaya, Y.3
Wakasugi, N.4
Mitsui, A.5
Nakamura, H.6
-
183
-
-
0028318891
-
Thiol-mediated redox regulation of lymphocyte proliferation. Possible involvement of adult T cell leukemia-derived factor and glutathione in transferrin receptor expression
-
Iwata, S., Hori, T., Sato, N., Ueda-Taniguchi, Y., Yamabe, T., Nakamura, H., Masutani, H., and Yodoi, J. (1994) Thiol-mediated redox regulation of lymphocyte proliferation. Possible involvement of adult T cell leukemia-derived factor and glutathione in transferrin receptor expression. J. Immunol. 152, 5633-5642.
-
(1994)
J. Immunol.
, vol.152
, pp. 5633-5642
-
-
Iwata, S.1
Hori, T.2
Sato, N.3
Ueda-Taniguchi, Y.4
Yamabe, T.5
Nakamura, H.6
Masutani, H.7
Yodoi, J.8
-
184
-
-
0027487310
-
Requirement of thiol compounds as reducing agents for IL-2-mediated induction of LAK activity and proliferation of human NK cells
-
Yamauchi, A. and Bloom, E. T. (1993) Requirement of thiol compounds as reducing agents for IL-2-mediated induction of LAK activity and proliferation of human NK cells. J. Immunol. 151, 5535-5544.
-
(1993)
J. Immunol.
, vol.151
, pp. 5535-5544
-
-
Yamauchi, A.1
Bloom, E.T.2
-
185
-
-
0033580837
-
Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes
-
Carballo, M., Conde, M., El Bekay, R., Martin-Nieto, J., Camacho, M. J., Monteseirin, J., et al. (1999) Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J. Biol. Chem. 274, 17,580-17,586.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17580-17586
-
-
Carballo, M.1
Conde, M.2
El Bekay, R.3
Martin-Nieto, J.4
Camacho, M.J.5
Monteseirin, J.6
-
186
-
-
0032416113
-
Activation of the JAK-STAT pathway by reactive oxygen species
-
Simon, A. R., Rai, U., Fanburg, B. L., and Cochran, B. H. (1998) Activation of the JAK-STAT pathway by reactive oxygen species. Am. J. Physiol 275, C1640-C1652.
-
(1998)
Am. J. Physiol
, vol.275
-
-
Simon, A.R.1
Rai, U.2
Fanburg, B.L.3
Cochran, B.H.4
-
187
-
-
0030296632
-
Structure and function of the protein tyrosine phosphatases
-
Fauman, E. B. and Saper, M. A. (1996) Structure and function of the protein tyrosine phosphatases. Trends Biochem. Sci. 21, 413-417.
-
(1996)
Trends Biochem. Sci.
, vol.21
, pp. 413-417
-
-
Fauman, E.B.1
Saper, M.A.2
-
188
-
-
0032562586
-
Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography
-
Pannifer, A. D., Flint, A. J., Tonks, N. K., and Barford, D. (1998) Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography. J. Biol. Chem. 273, 10,454-10,462.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10454-10462
-
-
Pannifer, A.D.1
Flint, A.J.2
Tonks, N.K.3
Barford, D.4
-
189
-
-
0033597766
-
Fyn and JAK2 mediate Ras activation by reactive oxygen species
-
Abe, J. and Berk, B. C. (1999) Fyn and JAK2 mediate Ras activation by reactive oxygen species. J. Biol. Chem. 274, 21,003-21,010.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21003-21010
-
-
Abe, J.1
Berk, B.C.2
-
190
-
-
0025730414
-
Peroxynitrite oxidation of sulfhydryls. the cytotoxic potential of superoxide and nitric oxide
-
Radi, R., Beckman, J. S., Bush, K. M., and Freeman, B. A. (1991) Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 266, 4244-4250.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 4244-4250
-
-
Radi, R.1
Beckman, J.S.2
Bush, K.M.3
Freeman, B.A.4
-
191
-
-
0028968949
-
Tyrosine kinase inhibition: An approach to drug development
-
Levitzki, A. and Gazit, A. (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267, 1782-1788.
-
(1995)
Science
, vol.267
, pp. 1782-1788
-
-
Levitzki, A.1
Gazit, A.2
-
192
-
-
0031887743
-
Protein kinase inhibitors: The tyrosine-specific protein kinases
-
Lawrence, D. S. and Niu, J. (1998) Protein kinase inhibitors: the tyrosine-specific protein kinases. Pharmacol. Ther. 77, 81-114.
-
(1998)
Pharmacol. Ther.
, vol.77
, pp. 81-114
-
-
Lawrence, D.S.1
Niu, J.2
-
193
-
-
0029083427
-
Inhibition of protein phosphorylation modulates expression of the Jak family protein tyrosine kinases
-
Fiorucci, G., Percario, Z. A., Marcolin, C., Coccia, E. M., Affabris, E., and Romeo, G. (1995) Inhibition of protein phosphorylation modulates expression of the Jak family protein tyrosine kinases. J. Virol. 69, 5833-5837.
-
(1995)
J. Virol.
, vol.69
, pp. 5833-5837
-
-
Fiorucci, G.1
Percario, Z.A.2
Marcolin, C.3
Coccia, E.M.4
Affabris, E.5
Romeo, G.6
-
194
-
-
0031179645
-
The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms
-
Elder, R. T., Xu, X., Williams, J. W., Gong, H., Finnegan, A., and Chong, A. S. (1997) The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms. J. Immunol. 159, 22-27.
-
(1997)
J. Immunol.
, vol.159
, pp. 22-27
-
-
Elder, R.T.1
Xu, X.2
Williams, J.W.3
Gong, H.4
Finnegan, A.5
Chong, A.S.6
-
195
-
-
0032519992
-
Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production
-
Siemasko, K., Chong, A. S., Jack, H. M., Gong, H., Williams, J. W., and Finnegan, A. (1998) Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. J. Immunol. 160, 1581-1588.
-
(1998)
J. Immunol.
, vol.160
, pp. 1581-1588
-
-
Siemasko, K.1
Chong, A.S.2
Jack, H.M.3
Gong, H.4
Williams, J.W.5
Finnegan, A.6
-
196
-
-
0031898875
-
Suppression of proliferation and phosphorylation of Jak3 and STAT5 in malignant T-cell lymphoma cells by derivatives of octylamino-undecyl-dimethylxanthine
-
Wasik, M. A., Nowak, I., Zhang, Q., and Shaw, L. M. (1998) Suppression of proliferation and phosphorylation of Jak3 and STAT5 in malignant T-cell lymphoma cells by derivatives of octylamino-undecyl-dimethylxanthine. Leuk. Lymphoma 28, 551-560.
-
(1998)
Leuk. Lymphoma
, vol.28
, pp. 551-560
-
-
Wasik, M.A.1
Nowak, I.2
Zhang, Q.3
Shaw, L.M.4
-
197
-
-
0027198702
-
Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins
-
Osherov, N., Gazit, A., Gilon, C., and Levitzki, A. (1993) Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins. J. Biol. Chem. 268, 11,134-11,142.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 11134-11142
-
-
Osherov, N.1
Gazit, A.2
Gilon, C.3
Levitzki, A.4
-
198
-
-
0029134065
-
JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3′ kinase
-
Sharfe, N., Dadi, H. K., and Roifman, C. M. (1995) JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3′ kinase. Blood 86, 2077-2085.
-
(1995)
Blood
, vol.86
, pp. 2077-2085
-
-
Sharfe, N.1
Dadi, H.K.2
Roifman, C.M.3
-
200
-
-
0032934674
-
Involvement of JAK2, but not PI 3-kinase/Akt and MAP kinase pathways, in anti-apoptotic signals of GM-CSF in human eosinophils
-
Miike, S., Nakao, A., Hiraguri, M., Kurasawa, K., Saito, Y., and Iwamoto, I. (1999) Involvement of JAK2, but not PI 3-kinase/Akt and MAP kinase pathways, in anti-apoptotic signals of GM-CSF in human eosinophils. J. Leukoc. Biol. 65, 700-706.
-
(1999)
J. Leukoc. Biol.
, vol.65
, pp. 700-706
-
-
Miike, S.1
Nakao, A.2
Hiraguri, M.3
Kurasawa, K.4
Saito, Y.5
Iwamoto, I.6
-
201
-
-
0031472685
-
Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils
-
Simon, H. -U., Yousefi, S., Dibbert, B., LeviSchaffer, F., and Blaser, K. (1997) Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils. Eur. J. Immunol. 27, 3536-3539.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 3536-3539
-
-
Simon, H.U.1
Yousefi, S.2
Dibbert, B.3
Levischaffer, F.4
Blaser, K.5
-
202
-
-
2042503119
-
Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells
-
Kirken, R. A., Erwin, R. A., Taub, D., Murphy, W. J., Behbod, F., Wang, L., Pericle, F., and Farrar, W. L. (1999) Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells. J. Leukoc. Biol. 65, 891-899.
-
(1999)
J. Leukoc. Biol.
, vol.65
, pp. 891-899
-
-
Kirken, R.A.1
Erwin, R.A.2
Taub, D.3
Murphy, W.J.4
Behbod, F.5
Wang, L.6
Pericle, F.7
Farrar, W.L.8
-
203
-
-
0001123864
-
JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response
-
Wang, L. H., Kirken, R. A., Erwin, R. A., Yu, C. R., and Farrar, W. L. (1999) JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. J. Immunol. 162, 3897-3904.
-
(1999)
J. Immunol.
, vol.162
, pp. 3897-3904
-
-
Wang, L.H.1
Kirken, R.A.2
Erwin, R.A.3
Yu, C.R.4
Farrar, W.L.5
-
204
-
-
0033563170
-
Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis
-
Bright, J. J., Du, C., and Sriram, S. (1999) Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis. J. Immunol. 162, 6255-6262.
-
(1999)
J. Immunol.
, vol.162
, pp. 6255-6262
-
-
Bright, J.J.1
Du, C.2
Sriram, S.3
-
205
-
-
0030978808
-
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoldes: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines
-
Nielsen, M., Kaltoft, K., Nordahl, M., Röpke, C., Geisler, C., Mustelin, T., et al. (1997) Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoldes: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. Proc. Natl. Acad. Sci. USA 94, 6764-6769.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 6764-6769
-
-
Nielsen, M.1
Kaltoft, K.2
Nordahl, M.3
Röpke, C.4
Geisler, C.5
Mustelin, T.6
-
206
-
-
0031768521
-
Tyrphostin AG490, a tyrosine kinase inhibitor, blocks actively induced experimental autoimmune encephalomyelitis
-
Constantin, G., Brocke, S., Izikson, A., Laudanna, C., and Butcher, E. C. (1998) Tyrphostin AG490, a tyrosine kinase inhibitor, blocks actively induced experimental autoimmune encephalomyelitis. Eur. J. Immunol. 28, 3523-3529.
-
(1998)
Eur. J. Immunol.
, vol.28
, pp. 3523-3529
-
-
Constantin, G.1
Brocke, S.2
Izikson, A.3
Laudanna, C.4
Butcher, E.C.5
-
207
-
-
0033556146
-
Inhibition of experimental autoimmune encephalomyelitis by a tyrosine kinase inhibitor
-
Constantin, G., Laudanna, C., Brocke, S., and Butcher, E. C. (1999) Inhibition of experimental autoimmune encephalomyelitis by a tyrosine kinase inhibitor. J. Immunol. 162, 1144-1149.
-
(1999)
J. Immunol.
, vol.162
, pp. 1144-1149
-
-
Constantin, G.1
Laudanna, C.2
Brocke, S.3
Butcher, E.C.4
-
208
-
-
0032504249
-
Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells
-
Goodman, P. A., Niehoff, L. B., and Uckun, F. M. (1998) Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells. J. Biol. Chem. 273, 17742-17748.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 17742-17748
-
-
Goodman, P.A.1
Niehoff, L.B.2
Uckun, F.M.3
-
209
-
-
0033053383
-
Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents
-
Sudbeck, E. A., Liu, X. P., Narla, R. K., Mahajan, S., Ghosh, S., Mao, C., and Uckun, F. M. (1999) Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin. Cancer Res. 5, 1569-1582.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 1569-1582
-
-
Sudbeck, E.A.1
Liu, X.P.2
Narla, R.K.3
Mahajan, S.4
Ghosh, S.5
Mao, C.6
Uckun, F.M.7
-
210
-
-
0344466789
-
In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 4-(4′hydroxyphenyl)-amino-6,7-dimethoxyquinazoline
-
Uckun, F. M., Ek, O., Liu, X. P., and Chen, C. L. (1999) In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4′hydroxyphenyl)-amino-6,7-dimethoxyquinazoline. Clin. Cancer Res. 5, 2954-2962.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 2954-2962
-
-
Uckun, F.M.1
Ek, O.2
Liu, X.P.3
Chen, C.L.4
-
211
-
-
0033590987
-
Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions
-
Malaviya, R. and Uckun, F. M. (1999) Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions. Biochem. Biophys. Res. Commun. 257, 807-813.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.257
, pp. 807-813
-
-
Malaviya, R.1
Uckun, F.M.2
-
212
-
-
0033578618
-
Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis
-
Malaviya, R., Zhu, D., Dibirdik, I., and Uckun, F. M. (1999) Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis. J. Biol. Chem. 274, 27,028-27,038.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 27028-27038
-
-
Malaviya, R.1
Zhu, D.2
Dibirdik, I.3
Uckun, F.M.4
|