Dbl family guanine nucleotide exchange factors

Trends in Biochemical Sciences

Volumn 26, Issue 12, 2001, Pages 724-732

  Zheng, Yi ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; INOSITOL PHOSPHATE; PLECKSTRIN; PROTEIN KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

AUTOREGULATION; BIOCHEMISTRY; CATALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETICS; GENOME; GROWTH; HUMAN; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; EVOLUTION, MOLECULAR; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0035668525     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(01)01973-9     Document Type: Review

References (65)

1. Dbl family proteins
2. The Dbl family of oncogenes
3. Rho GTPases and signaling networks
4. Rho GTPases and the actin cytoskeleton
5. The sequence of the human genome
6. The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating
7. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
8. Unc-73 activates the Rac GTPase and is required for cell and growth cone migrations in C elegans
9. Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers
10. Trio combines with Dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
11. Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding
12. The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension
13. Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos
14. Regulatory and signaling properties of the Vav family
15. Isolation and characterization of the faciogenital dysplasia (Arskog-Scott syndrome) gene: A putative Rho/Rac guanine nucleotide exchange factor
16. Mutation in ARHGEF6, encoding a guanine nucleotide exchange factor for the Rho GTPases, in patients with X-linked mental retardation
17. The Dbl-homology domain of BCR is not a simple spacer in p210Bcr-Abl of the Philadelphia chromosome
18. Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho
19. Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA
20. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia
21. The PH superfold: A structural scaffold for multiple functions
22. Human Ect2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis
23. Identification of Rho GTPase-dependent sites in the DH domain of oncogenic Dbl that are required for transformation
24. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation
25. Dependence of Dbl and Dbs transformation on MEK and NF-κB activation
26. Activation of G1 progression, JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1
27. αPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms
28. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
29. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos
30. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
31. Autoinhibition mechanism of proto-Dbl
32. Ras-specific exchange factor GRF: Oligomerization through its Dbl homology domain and calcium-dependent activation of Raf
33. Oligomerization of DH domain is essential for Dbl-induced transformation
34. Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1
35. Identification of potential mechanisms for regulation of p115RhoGEF through analysis of endogenous and mutant forms of the exchange factor
36. Direct stimulation of the guanine nucleotide exchange activity of p115RhoGEF by Gα13
37. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins
38. Association of the proto-oncogene product Dbl with G protein βγ subunits
39. Activation of RhoA by association of Gα(13) with Dbl
40. Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signaling proteins
41. The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways
42. EPS8 and E3B1 transduce signals from Ras to Rac
43. Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding
44. Modulation of oncogenic Dbl activity by phosphoinositol phosphate binding to PH domain
45. Phosphorylation of the Cdc42 exchange factor Cdc24 by the PAK-like kinase Cla4 may regulate polarized growth in yeast
46. The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin
47. Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase
48. Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl
49. Asef, a link between the tumor suppressor APC and G-protein signaling
50. Functional interaction between the cytoplasmic leucine-zpper domain of HIV-1 gp41 and p115RhoGEF
51. CD44 interaction with Tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
52. Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration
53. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin
54. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
55. Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc4p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc42p
56. GEFs: Structural basis for their activation of small GTP-binding proteins
57. NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio
58. Crystal structure of the Dbl and pleckstrin homology domains from the human son of sevenless protein
59. Structure and mutagenesis of the Dbl homology domain
60. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
61. 2+ cofactor in guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTPases
62. Trp56 of Rac1 specifies interaction with a subset of guanine nucleotide exchange factors
63. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins
64. S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells
65. Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10