Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N

Biochemical and Biophysical Research Communications

Volumn 274, Issue 3, 2000, Pages 825-830

  Hamaguchi, Tetsuya ^a   Ito, Masaaki ^a   Feng, Jianhua ^a   Seko, Tetsuya ^a   Koyama, Mutsumi ^a   Machida, Hirofumi ^a   Takase, Koujiro ^a   Amano, Mutsuki ^b   Kaibuchi, Kozo ^b   Hartshorne, David J ^c   Nakano, Takeshi ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Ca2+ sensitization; CPI 17; Myosin phosphatase; PKN; Rho; Smooth muscle

Indexed keywords

ENZYME; ENZYME INHIBITOR; MYOSIN PHOSPHATASE; PROTEIN CPI 17; PROTEIN KINASE N; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENSITIZATION; SMOOTH MUSCLE CONTRACTION;

ANIMALIA;

EID: 0034637032     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3225     Document Type: Article

References (37)

1. Signal transduction and regulation in smooth muscle
2. Biochemistry of the contractile process in smooth muscle
3. Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction
4. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
5. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPase in mammalian cells
6. Myosin light chain phosphatase: Subunit composition, interactions, and regulation
7. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
8. Inhibitory phosphorylation site for Rho-associated kinase on the smooth muscle myosin phosphatase
9. Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle
10. 2+-sensitization of smooth muscle
11. Rho-associated kinase of chicken gizzard smooth muscle
12. 2+-sensitizing effect of protein kinase C on vascular smooth muscle: Inhibition of myosin light chain phosphatase
13. 2+ sensitization in smooth muscle
14. Possible involvement of the novel CPI-17 protein in protein kinase C signal transduction of rabbit arterial smooth muscle
15. A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization
16. Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: Its specific localization in smooth muscle
17. 2+ sensitization through inhibition of myosin phosphatase in rabbit trachea
18. Agonist trigger G protein-mediated activation of the CPI-17 in-hibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility
19. A novel protein kinase with leucine zipper-like sequences: Its catalytic domain is highly homologous to that of protein kinase C
20. Activation of PKN, a novel 120-kDa protein kinase with leucine zipper-like sequences, by unsaturated fatty acids and by limited proteolysis
21. Protein kinase N (PKN) and PKN-related protein Rhophilin as targets of small GTPase Rho
22. Identification of a putative target for Rho as the serine-threonine kinase protein kinasee N
23. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase
24. Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN
25. Selective purification of the 20,000-Da light chains of smooth muscle myosin
26. 2+ on the conformation and enzymatic activity of smooth muscle myosin
27. Smooth muscle myosin light chain kinase
28. Interaction and properties of smooth muscle myosin phosphatase
29. Cleavage of structure proteins during the assembly of the head of bacteriophage T4
30. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
31. A novel phosphoprotein inhibitor of type-1 phosphatase holoenzymes
32. Identification of trimeric myosin phosphatase (PPIM) as a target for a novel PKC-potentiated protein phosphatase-1 inhibitor protein (CPI17) in porcine aorta smooth muscle
33. Purification and characterization of a fatty acid-activated protein kinase (PKN) from rat testis
34. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
35. 2+ sensitization of myosin phosphorylation and force in guinea-pig ileum
36. The COOH terminus of Rho-kinase negatively regulates Rho-kinase activity
37. Pharmacological properties of Y-27632, a specific inhibitor of Rho-associated kinases