Modulation of amyloid precursor protein processing by compounds with various mechanisms of action: Detection by liquid phase electrochemiluminescent system

Journal of Neuroscience Methods

Volumn 82, Issue 2, 1998, Pages 159-166

  Khorkova, Olga E ^a   Pate, Kirti ^a   Heroux, Jeffrey ^b   Sahasrabudhe, Sudhir ^a  

^a CNS Dis Grp and Biotech Res Grp   (United States)

^b IGEN Inc   (United States)

Author keywords

AEBSF; Alzheimer's disease; Ammonium chloride; Amyloid peptide; Brefeldin A; Chloroquine; Electrochemiluminescent detection; Methylamine

Indexed keywords

AMMONIUM ACETATE; AMMONIUM CHLORIDE; AMYLOID PRECURSOR PROTEIN; BREFELDIN A; CHLOROQUINE; LEUPEPTIN; METHYLAMINE; MONOCLONAL ANTIBODY; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTEINASE INHIBITOR; SYNTHETIC PEPTIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMOLUMINESCENCE; CHO CELL; DEGENERATIVE DISEASE; ELECTROCHEMICAL ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GOLGI COMPLEX; GUINEA PIG; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; SENILE PLAQUE;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CHEMILUMINESCENT MEASUREMENTS; CHO CELLS; CRICETINAE; ELECTROCHEMISTRY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GUINEA PIGS; MALE; TRANSFECTION;

EID: 0032145289     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0270(98)00053-3     Document Type: Article

References (17)

1. Blackburn G.F., Shah H.P., Kenten J.H., Leland J., Kamin R.A., Link J., Peterman J., Powell M.J., Shah A., Talley D.B., Tyagi S.K., Wilkins E., Wu T., Massey R.J. Electrochemiluminescent detection for development of immunoassays and DNA probe assays for clinical diagnostics. Clin Chem. 37:1995;1534-1539.
2. Checler F. Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J Neurochem. 65:1995;1431-1444.
3. Citron M., Diehl T.S., Capell A., Haass C., Teplow D.B., Selkoe D.J. Inhibition of amyloid β protein production in neural cells by the serine protease inhibitor AEBSF. Cell. 17:1996;171-179.
4. Deaver D.R. A new non-isotopic detection system for immunoassays. Nature. 377:1995;758-760.
5. Haass C., Michael G., Schlossmacher M.G., Hung A.Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B.L., Lieberburg I., Koo E.H., Schenk D., Teplow D.B., Selkoe D.J. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature. 359:1992;322-325.
6. Haass C., Hung A.Y., Schlossmacher M.G., Teplow D.B., Selkoe D.J. β-Amyloid peptide and 3-kDa fragment are derived by distinct cellular mechanisms. J Biol Chem. 268:1993;3021-3024.
7. Higaki J., Quon D., Zhong Z., Cordell B. Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism. Neuron. 14:1995;651-659.
8. Kenten J.H., Gudibande S., Link J., Wiley J.J., Curfman B., Major E.O., Massey R.J. Improved electrochemiluminescent label for DNA probe assays: rapid quantitation assay of HIV-1 polymerase chain reaction products. Clin Chem. 38:1992;873-879.
9. Knops J., Suomensaari S., Lee M., McConlogue L., Seubert P., Sinha S. Cell-type and amyloid precursor protein-type specific inhibition of Aβ release by bafilomycin A1, a selective inhibitor of vacuolar ATPases. J Biol Chem. 270:1995;2419-2422.
10. Koo E.H., Squazzo S.L. Evidence that production and release of amyloid β-protein involves the endocytic pathway. J Biol Chem. 269:1994;17386-17389.
11. Sahasrabudhe S.R., Spruyt M.A., Muenkel H.A., Blume A.J., Vitek M.P., Jacobsen S.J. Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells. J Biol Chem. 267:1992;25602-25608.
12. Selkoe D.J. Normal and abnormal biology of the β-amyloid precursor protein. Annu Rev Neurosci. 17:1994;489-517.
13. Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher M., Whaley J., Swindlehurst C., McCormack R., Wolfert R., Selkoe D.J., Lieberburg I., Schenk D. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature. 359:1992;325-327.
14. Shoji M., Golde T.E., Ghiso J., Cheung T.T., Estus S., Shaffer L.M., Cai X., McKay D.M., Tintner R., Frangione B., Younkin S.G. Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science. 258:1992;126-129.
15. Tartakoff A. Perturbation of vesicular trafficking with the carboxylic ionophore monensin. Cell. 32:1983;1026-1028.
16. Yang H., Leland J.K., Yost D., Massey R.J. Electrochemiluminescence: a new diagnostic and research tool. Biotechnology. 12:1994;193-194.
17. Yankner B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 16:1996;921-932.