Platelet-derived growth factor activates protein kinase Cε through redundant and independent signaling pathways involving phospholipase Cγ or phosphatidylinositol 3-kinase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 1, 1996, Pages 151-155

  Moriya, Shigeharu ^a,b   Kazlauskas, Andrius ^c   Akimoto, Kazunori ^a   Hirai, Syu Ichi ^a   Mizuno, Keiko ^a   Takenawa, Tadaomi ^d   Fukui, Yasuhisa ^e   Watanabe, Yutaka ^d   Ozaki, Shoichiro ^d   Ohno, Shigeo ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

^e EHIME UNIVERSITY   (Japan)

Author keywords

diacylglycerol; phorbol 12 tetradecanoate 13 acetate response element; phosphatidylinositol 3,4,5 trisphosphate; signal transduction; translocation

Indexed keywords

DIACYLGLYCEROL; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POLYPHOSPHOINOSITIDE; PROTEIN KINASE C; WORTMANNIN;

ARTICLE; CELL MEMBRANE; CELL STRAIN HEPG2; CYTOSOL; ENZYME ACTIVATION; ENZYME BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL COMPARTMENTATION; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION; HUMANS; ISOENZYMES; PEPTIDES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE C; PROTEIN KINASE C-EPSILON; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 9044253707     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.1.151     Document Type: Article

References (34)

1. Takai, Y., Kishimoto, A., Kikkawa, U., Mori, T. & Nishizuka, Y. (1979) Biochem. Biophys. Res. Commun. 91, 1218-1224.
2. Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U. & Nishiuka, Y. (1982) J. Biol. Chem. 257, 7847-7851.
3. Nishizuka, Y. (1984) Nature (London) 308, 693-698.
4. Nishizuka, Y. (1995) FASEB J. 9, 484-496.
5. Divecha, N. & Irvine, R. F. (1995) Cell 80, 269-278.
6. Kapellaer, R. & Cantley, L. C. (1994) BioEssays 16, 565-576.
7. Ha, K.-S. & Exton, J. H. (1993) J. Biol. Chem. 268, 10534-10539.
8. Akita, Y., Ohno, S., Yajima, Y. & Suzuki, K. (1990) Biochem. Biophys. Res. Commun. 172, 184-189.
9. Ohno, S., Mizuno, K., Adachi, Y., Hata, A., Akita, Y., Akimoto, K., Osada, S., Hirai, S. & Suuki, K. (1994) J. Biol. Chem. 269, 17495-17501.
10. Fantil, W. J., Johnson, D. E. & Williams, L. T. (1993) Annu. Rev. Biochem. 62, 453-481.
11. Kumjian, D. A., Wahl, M. I., Rhee, S. G. & Daniel, T. O. (1989) Proc. Natl. Acad. Sci. USA 86, 8232-8236.
12. Coughlin, S. R., Escobedo, J. A. & Williams, L. T. (1989) Science 243, 1191-1194.
13. Valius, M. & Kazlauskas, K. (1993) Cell 73, 321-334.
14. Ohno, S., Akita, Y., Konno, Y., Imajoh, S. & Suzuki, K. (1988) Cell 53, 731-741.
15. Watanabe, Y., Hirofuji, H. & Ozaki, S. (1994) Tetrahedron Lett. 35, 123-124.
16. Mizuno, K., Kubo, K., Saido, T. C., Akita, Y., Osada, S., Kuroki, T., Ohno, S. & Suzuki, K. (1991) Eur. J. Biochem. 202, 931-940.
17. Dekker, L. V. & Parker, P. J. (1994) Trends Biochem. Sci. 19, 73-77.
18. Hata, A., Akita, Y., Suzuki, K. & Ohno, S. (1993) J. Biol. Chem. 268, 9122-9129.
19. Olivier, A. R. & Parker, P. J. (1994) J. Biol. Chem. 269, 2758-2763.
20. Nishimura, R., Li, W., Kashishian, A., Mondino, A., Zhou, M., Cooper, J. & Schlessinger, J. (1993) Mol. Cell. Biol. 13, 6889-6896.
21. Thelen, M., Wymann, M. P. & Langen, H. (1994) Proc. Natl. Acad. Sci. USA 91, 4960-4964.
22. Okada, T., Sakuma, L., Fukui, Y., Hazeki, O. & Ui, M. (1994) J. Biol. Chem. 269, 3563-3567.
23. Yano, H., Nakanishi, S., Kimura, K., Hanai, N., Saitoh, Y., Fukui, Y., Nonomura, Y. & Matsuda, Y. (1993) J. Biol. Chem. 268, 25846-25856.
24. Nakanishi, H., Brewer, K. A. & Exton, J. H. (1993) J. Biol. Chem. 268, 13-16.
25. Toker, A., Meyer, M., Reddy, K. K., Falck, J. R., Aneja, R., Aneja, S., Parra, A., Burns, D. J., Ballas, L. & Cantley, L. C. (1994) J. Biol. Chem. 269, 32358-32368.
26. Singh, S. S., Chauhan, A., Brockerhoff, H. & Chauhan, V. P. S. (1993) Biochem. Biophys. Res. Commun. 195, 104-112.
27. Konno, Y., Ohno, S., Akita, Y., Kawasaki, H. & Suzuki, K. (1989) J. Biochem. 106, 673-678.
28. Yeo, E. J., Kazlauskas, A. & Exton, J. H. (1994) J. Biol. Chem. 269, 27823-27826.
29. Nishizuka, Y. (1992) Science 258, 607-614.
30. Nakanishi, H. & Exton, J. H. (1992) J. Biol. Chem. 267, 16347-16354.
31. Akimoto, K., Mizuno, K., Osada, S., Hirai, S., Tanuma, S., Suzuki, K. & Ohno, S. (1994) J. Biol. Chem. 269, 12677-12683.
32. Quest, A. F. G., Bardes, E. S. G. & Bell, R. M. (1994) J. Biol. Chem. 269, 2953-2960.
33. Ono, Y., Fujii, T., Igarashi, K., Kuno, T., Tanaka, C., Kikkawa, U. & Nishizuka, Y. (1989) Proc. Natl. Acad. Sci. USA 86, 4868-4871.
34. Akimoto, K., Moriya, S., Kimura, K., Fukui, Y., Osada, S., Mizunu, K., Hirai, S., Kazlauskas, A. & Ohno, S., EMBO J., in press.