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Volumn 95, Issue 7, 2000, Pages 2378-2385

HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DOXORUBICIN; GLYCOPROTEIN P; GRANZYME B; HEXAMETHYLENEBISACETAMIDE; PERFORIN; PROTEIN BCL 2; TUMOR NECROSIS FACTOR; VINCRISTINE;

EID: 0034176015     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.7.2378.007k10_2378_2385     Document Type: Article
Times cited : (90)

References (47)
  • 1
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman M, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem. 1993;62:385.
    • (1993) Annu Rev Biochem , vol.62 , pp. 385
    • Gottesman, M.1    Pastan, I.2
  • 2
    • 0026621245 scopus 로고
    • ABC transporters: From microorganisms to man
    • Higgins CF. ABC transporters: from microorganisms to man. Annu Rev Cell Biol. 1992;8:67.
    • (1992) Annu Rev Cell Biol , vol.8 , pp. 67
    • Higgins, C.F.1
  • 3
    • 0027458116 scopus 로고
    • ATP-dependent transport systems in bacteria and humans: Relevance to cystic fibrosis and multidrug resistance
    • Doige CA, Ames FG. ATP-dependent transport systems in bacteria and humans: relevance to cystic fibrosis and multidrug resistance. Annu Rev Microbiol. 1993;47:291.
    • (1993) Annu Rev Microbiol , vol.47 , pp. 291
    • Doige, C.A.1    Ames, F.G.2
  • 4
    • 0032499771 scopus 로고    scopus 로고
    • The drug efflux protein, P-glycoprotein, additionally protects drug-resistant cells from multiple forms of caspase-dependent apoptosis
    • Smyth MJ, Krasovskis E, Sutton VR, Johnstone RW. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant cells from multiple forms of caspase-dependent apoptosis. Proc Natl Acad Sci U S A. 1998;95:7024.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7024
    • Smyth, M.J.1    Krasovskis, E.2    Sutton, V.R.3    Johnstone, R.W.4
  • 5
    • 0032950954 scopus 로고    scopus 로고
    • P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death
    • Johnstone RW, Cretney E, Smyth MJ. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood. 1999;93:1075.
    • (1999) Blood , vol.93 , pp. 1075
    • Johnstone, R.W.1    Cretney, E.2    Smyth, M.J.3
  • 7
    • 0030011398 scopus 로고    scopus 로고
    • Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
    • Boldin MP, Goncharov TM, Goltsev YV, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 1996;85:803.
    • (1996) Cell , vol.85 , pp. 803
    • Boldin, M.P.1    Goncharov, T.M.2    Goltsev, Y.V.3    Wallach, D.4
  • 8
    • 15844412409 scopus 로고    scopus 로고
    • FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/ APO-1) death-inducing signaling complex
    • Muzio M, Chinnaiyan AM, Kischkel FC, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/ APO-1) death-inducing signaling complex. Cell. 1996;85:872.
    • (1996) Cell , vol.85 , pp. 872
    • Muzio, M.1    Chinnaiyan, A.M.2    Kischkel, F.C.3
  • 9
    • 0029905073 scopus 로고    scopus 로고
    • Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
    • Srinivasula SM, Ahmad M, Fernades-Alnemri T, Litwack G, Alnemri ES. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci U S A. 1996;93:14,486.
    • (1996) Proc Natl Acad Sci U S A , vol.93
    • Srinivasula, S.M.1    Ahmad, M.2    Fernades-Alnemri, T.3    Litwack, G.4    Alnemri, E.S.5
  • 10
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 1996;86:147.
    • (1996) Cell , vol.86 , pp. 147
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 11
    • 0031037897 scopus 로고    scopus 로고
    • The release of cylochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cylochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 1997;275:1132.
    • (1997) Science , vol.275 , pp. 1132
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 12
    • 0030782177 scopus 로고    scopus 로고
    • Cytochrome c: Can't live with it - Can't live without it
    • Reed JC. Cytochrome c: can't live with it - can't live without it. Cell. 1997;91:559.
    • (1997) Cell , vol.91 , pp. 559
    • Reed, J.C.1
  • 13
    • 0033521741 scopus 로고    scopus 로고
    • Molecular characterization of mitochondrial apoptosis-inducing factor
    • Susin SA, Lorenzo HK, Zamzami N, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 1999;397:441.
    • (1999) Nature , vol.397 , pp. 441
    • Susin, S.A.1    Lorenzo, H.K.2    Zamzami, N.3
  • 14
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/ caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/ caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91:479.
    • (1997) Cell , vol.91 , pp. 479
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3
  • 15
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 1997;90: 405.
    • (1997) Cell , vol.90 , pp. 405
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 16
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li H, Zhu H, Xu C, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1997;94:491.
    • (1997) Cell , vol.94 , pp. 491
    • Li, H.1    Zhu, H.2    Xu, C.3    Yuan, J.4
  • 17
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 1997;94:481.
    • (1997) Cell , vol.94 , pp. 481
    • Luo, X.1    Budihardjo, I.2    Zou, H.3    Slaughter, C.4    Wang, X.5
  • 18
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science. 1997;275:1129.
    • (1997) Science , vol.275 , pp. 1129
    • Yang, J.1    Liu, X.2    Bhalla, K.3
  • 19
    • 0032561352 scopus 로고    scopus 로고
    • Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent
    • Trapani JA, Jans DA, Jans PJ, Smyth MJ, Browne KA, Sutton VR. Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent. J Biol Chem. 1997;273: 27934.
    • (1997) J Biol Chem , vol.273 , pp. 27934
    • Trapani, J.A.1    Jans, D.A.2    Jans, P.J.3    Smyth, M.J.4    Browne, K.A.5    Sutton, V.R.6
  • 20
    • 0032193209 scopus 로고    scopus 로고
    • Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes
    • Deas O, Dumont C, MacFarlane M, et al. Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes. J Immunol. 1997;161:3375.
    • (1997) J Immunol , vol.161 , pp. 3375
    • Deas, O.1    Dumont, C.2    MacFarlane, M.3
  • 21
    • 0032472329 scopus 로고    scopus 로고
    • Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
    • Bossy-Wetzel E, Newmeyer DD, Green DR. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 1998; 17:37.
    • (1998) EMBO J , vol.17 , pp. 37
    • Bossy-Wetzel, E.1    Newmeyer, D.D.2    Green, D.R.3
  • 22
    • 0032545372 scopus 로고    scopus 로고
    • Bcl-2 prevents caspase-independent cell death
    • Okuno S, Shimizu S, Ito T, et al. Bcl-2 prevents caspase-independent cell death. J Biol Chem. 1998;273:34,272.
    • (1998) J Biol Chem , vol.273
    • Okuno, S.1    Shimizu, S.2    Ito, T.3
  • 23
    • 0031570536 scopus 로고    scopus 로고
    • Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes
    • Sutton VR, Vaux OL, Trapani JA. Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes. J Immunol. 1997;158:783.
    • (1997) J Immunol , vol.158 , pp. 783
    • Sutton, V.R.1    Vaux, O.L.2    Trapani, J.A.3
  • 24
    • 0030745314 scopus 로고    scopus 로고
    • Two cytodifferentiation agent-induced pathways, differentiation and apoptosis, are distinguished by the expression of human papillomavirus 16 E7 in human bladder carcinoma cells
    • Richon VM, Russo P, Venta-Perez G, Cordon-Cardo C, Rifkind RA, Marks PA. Two cytodifferentiation agent-induced pathways, differentiation and apoptosis, are distinguished by the expression of human papillomavirus 16 E7 in human bladder carcinoma cells. Cancer Res. 1997;57: 2789.
    • (1997) Cancer Res , vol.57 , pp. 2789
    • Richon, V.M.1    Russo, P.2    Venta-Perez, G.3    Cordon-Cardo, C.4    Rifkind, R.A.5    Marks, P.A.6
  • 25
    • 0028116705 scopus 로고
    • Inducing differentiation of transformed cells with hybrid polar compounds: A cell cycle-dependent process
    • Marks PA, Richon VM, Kiyokawa H, Rifkind RA. Inducing differentiation of transformed cells with hybrid polar compounds: a cell cycle-dependent process. Proc Natl Acad Sci U S A. 1994;91:10,251.
    • (1994) Proc Natl Acad Sci U S A , vol.91
    • Marks, P.A.1    Richon, V.M.2    Kiyokawa, H.3    Rifkind, R.A.4
  • 26
    • 0026446246 scopus 로고
    • Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: A phase II clinical trial with a differentiation-inducing agent
    • Andreef M, Stone R, Michaeli J, et al. Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation-inducing agent. Blood. 1992;80:2604.
    • (1992) Blood , vol.80 , pp. 2604
    • Andreef, M.1    Stone, R.2    Michaeli, J.3
  • 27
    • 0028080878 scopus 로고
    • Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells
    • Kiyokawa H, Richon VM, Ritkind RA, Marks PA. Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells. Mol Cell Biol. 1994;11:7195.
    • (1994) Mol Cell Biol , vol.11 , pp. 7195
    • Kiyokawa, H.1    Richon, V.M.2    Ritkind, R.A.3    Marks, P.A.4
  • 28
    • 0032005979 scopus 로고    scopus 로고
    • Differentiation inducers modulate cytokine signaling pathways in a murine erythroleukemia cell line
    • Yamashita T, Wakao H, Miyajima A, Asano S. Differentiation inducers modulate cytokine signaling pathways in a murine erythroleukemia cell line. Cancer Res. 1998;58:556.
    • (1998) Cancer Res , vol.58 , pp. 556
    • Yamashita, T.1    Wakao, H.2    Miyajima, A.3    Asano, S.4
  • 29
    • 0031892734 scopus 로고    scopus 로고
    • Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cells
    • Siegel DS, Zhang X, Feinman R, et al. Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cells. Proc Natl Acad Sci U S A. 1998;95:162.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 162
    • Siegel, D.S.1    Zhang, X.2    Feinman, R.3
  • 30
    • 0028356225 scopus 로고
    • Cellular and karyotypic characterization of two doxorubicin resistant cell lines isolated from the same parental human leukemia cell line
    • Zalcberg JR, Hu XF, Wall DM, et al. Cellular and karyotypic characterization of two doxorubicin resistant cell lines isolated from the same parental human leukemia cell line. Int J Cancer. 1994; 57:522.
    • (1994) Int J Cancer , vol.57 , pp. 522
    • Zalcberg, J.R.1    Hu, X.F.2    Wall, D.M.3
  • 31
    • 0024208685 scopus 로고
    • Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline
    • Broggini M, Grandi M, Ubezio P, Geroni C, Giuliani FC, D'Incalci M. Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline. Biochem Pharmacol. 1988;37:4423.
    • (1988) Biochem Pharmacol , vol.37 , pp. 4423
    • Broggini, M.1    Grandi, M.2    Ubezio, P.3    Geroni, C.4    Giuliani, F.C.5    D'Incalci, M.6
  • 32
    • 0030670626 scopus 로고    scopus 로고
    • Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis
    • Herr I, Wilhelm D, Bohler T, Angel P, Debatin K-M. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 1997;16:6200.
    • (1997) EMBO J , vol.16 , pp. 6200
    • Herr, I.1    Wilhelm, D.2    Bohler, T.3    Angel, P.4    Debatin, K.-M.5
  • 33
    • 0031847334 scopus 로고    scopus 로고
    • Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction
    • Trapani JA, Jans P, Smyth MJ, et al. Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction. Cell Death Diff. 1998;5: 488.
    • (1998) Cell Death Diff , vol.5 , pp. 488
    • Trapani, J.A.1    Jans, P.2    Smyth, M.J.3
  • 34
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248.
    • (1976) Anal Biochem , vol.72 , pp. 248
    • Bradford, M.M.1
  • 35
    • 0033521626 scopus 로고    scopus 로고
    • Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis
    • MacDonald G, Shi L, Vande Velde C, Lieberman J, Greenberg AH. Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis. J Exp Med. 1999;189:131.
    • (1999) J Exp Med , vol.189 , pp. 131
    • MacDonald, G.1    Shi, L.2    Vande Velde, C.3    Lieberman, J.4    Greenberg, A.H.5
  • 36
    • 0029125701 scopus 로고
    • Protease activation during apoptosis: Death by a thousand cuts?
    • Martin SJ, Green DR. Protease activation during apoptosis: death by a thousand cuts? Cell. 1995; 82:349.
    • (1995) Cell , vol.82 , pp. 349
    • Martin, S.J.1    Green, D.R.2
  • 37
    • 0017061205 scopus 로고
    • The sensitivity of chromatin from thymuses and spleens of irradiated mice to alkaline solutions
    • Skalka M, Matyasova J, Cejkova M. The sensitivity of chromatin from thymuses and spleens of irradiated mice to alkaline solutions. FEBS Lett. 1976;72:271.
    • (1976) FEBS Lett , vol.72 , pp. 271
    • Skalka, M.1    Matyasova, J.2    Cejkova, M.3
  • 38
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 1980;284:555.
    • (1980) Nature , vol.284 , pp. 555
    • Wyllie, A.H.1
  • 40
    • 0032498630 scopus 로고    scopus 로고
    • E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk
    • Lavoie JN, Nguyen M, Marcellus RC, Branton PE, Shore GC. E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk. J Cell Biol. 1998;140:637.
    • (1998) J Cell Biol , vol.140 , pp. 637
    • Lavoie, J.N.1    Nguyen, M.2    Marcellus, R.C.3    Branton, P.E.4    Shore, G.C.5
  • 41
    • 0030863670 scopus 로고    scopus 로고
    • Requirement for the GD3 ganglioside in CD95- and ceramide-induced apoptosis
    • De Maria R, Lenti L, Malisan F, et al. Requirement for the GD3 ganglioside in CD95- and ceramide-induced apoptosis. Science. 1997;277:1652.
    • (1997) Science , vol.277 , pp. 1652
    • De Maria, R.1    Lenti, L.2    Malisan, F.3
  • 42
    • 0030797727 scopus 로고    scopus 로고
    • Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
    • Miller TM, Moulder KL, Knudson CM, et al. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol. 1997;139:205.
    • (1997) J Cell Biol , vol.139 , pp. 205
    • Miller, T.M.1    Moulder, K.L.2    Knudson, C.M.3
  • 43
    • 0032546795 scopus 로고    scopus 로고
    • Caspase-3 is required for α-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis
    • Janicke RU, Ng P, Sprengart ML, Porter AG. Caspase-3 is required for α-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. J Biol Chem. 1998;275:15,540.
    • (1998) J Biol Chem , vol.275
    • Janicke, R.U.1    Ng, P.2    Sprengart, M.L.3    Porter, A.G.4
  • 44
    • 0030806351 scopus 로고    scopus 로고
    • Comparison of apoptosis in wild-type and Fas-resistant cells: Chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions
    • Eischen CM, Kottke TJ, Martins LM, et al. Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions. Blood. 1997;90:935.
    • (1997) Blood , vol.90 , pp. 935
    • Eischen, C.M.1    Kottke, T.J.2    Martins, L.M.3
  • 45
    • 0032533599 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53
    • Byrd JC, Shinn C, Waselenko JK, et al. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. Blood. 1998;92:3804.
    • (1998) Blood , vol.92 , pp. 3804
    • Byrd, J.C.1    Shinn, C.2    Waselenko, J.K.3
  • 46
    • 0032588672 scopus 로고    scopus 로고
    • Bcl-XL induction during terminal differentiation of friend erythroleukemia cells correlates with delay in apoptosis and loss of proliferative capacity but not haemoglobinization
    • Hafid-Medheb K, Poindessous-Jazat V, Augery-Bourget Y, Hanania N, Robert-Lezenes J. Bcl-XL induction during terminal differentiation of friend erythroleukemia cells correlates with delay in apoptosis and loss of proliferative capacity but not haemoglobinization. Cell Death Differ. 1999;6: 166.
    • (1999) Cell Death Differ , vol.6 , pp. 166
    • Hafid-Medheb, K.1    Poindessous-Jazat, V.2    Augery-Bourget, Y.3    Hanania, N.4    Robert-Lezenes, J.5
  • 47
    • 1542588471 scopus 로고    scopus 로고
    • Second generation hybrid polar compounds are potent inducers of transformed cell differentiation
    • Richon VM, Webb Y, Merger R, et al. Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc Natl Acad Sci U S A. 1996;93:5705.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 5705
    • Richon, V.M.1    Webb, Y.2    Merger, R.3


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