Nutrients and their role in host resistance to infection

Journal of Leukocyte Biology

Volumn 71, Issue 1, 2002, Pages 16-32

  Field, Catherine J ^a   Johnson, Ian R ^a   Schley, Patricia D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Arginine; Ascorbic acid; Docosahexaenoic acid; Eicosapentaenoic acid; Glutamine; Iron; Nucleotides; Vitamin A; Vitamin E; Zinc

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; FATTY ACID; GLUTAMINE; IRON; NUCLEOTIDE; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; RETINOL; SELENIUM; ZINC;

CLINICAL TRIAL; DIET; HOST RESISTANCE; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNE STATUS; IMMUNOCOMPETENCE; IMMUNOCOMPETENT CELL; INFECTION RESISTANCE; INFECTION SENSITIVITY; NONHUMAN; NUTRITIONAL STATUS; PREVALENCE; PRIORITY JOURNAL; PROTEIN CALORIE MALNUTRITION; PUBLIC HEALTH; REVIEW;

ANIMALS; ASCORBIC ACID; DIET; DIETARY FATS, UNSATURATED; HUMANS; IMMUNITY, NATURAL; NUCLEOTIDES; TRACE ELEMENTS; VITAMIN A; VITAMIN E;

EID: 0036141210     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (224)

1. Cellular immunity in semistarved states in hospitalized adults
2. Nutrients and immune responses
3. Protein, calories, and immune defenses
4. Omega-3 fatty acids as cancer chemopreventive agents
5. Modulation of immune function by dietary fatty acids
6. Modulation of inflammation and cytokine production by dietary (n-3) fatty acids
7. Dietary fatty acids and lymphocyte functions
8. Effect of (n-3) polyunsaturated fatty acids on cytokine production and their biologic function
9. Dietary fatty acids and the immune system
10. Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network
11. Dietary fish oil and the severity of symptoms in patients with systemic lupus erythematosus
12. Omega-3 fatty acid supplementation in clinical and experimental lupus nephritis
13. Essential fatty acids: Molecular and cellular basis of their anti-cancer action and clinical implications
14. Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: A randomized control trial
15. Suppression of growth by dietary fish oil of human breast carcinomas maintained in three different strains of immune-deficient mice
16. R3230AC rat mammary tumor and dietary long-chain (n-3) fatty acids change immune cell composition and function during mitogen activation
17. Reduced splenocyte metabolism and immune function in rats implanted with the Morris Hepatoma 7777
18. Tumor-induced immune dysfunction
19. Very low dietary intake of n-3 fatty acids affects the immune function of healthy elderly people
20. Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men
21. Effects of purified dietary n-3 ethyl esters on murine T lymphocyte function
22. Inhibition of natural killer cell activity by dietary lipids
23. The effect of increasing levels of dietary fish oil rich in eicosapentaenoic and docosahexaenoic acids on lymphocyte phospholipid fatty acid composition and cell-mediated immunity in the mouse
24. The ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation and vitamin E status in aged dogs
25. Dietary long-chain (n-3) fatty acids facilitate immune cell activation in sedentary, but not exercise-trained rats
26. Immunologic effects of National Cholesterol Education Panel Step-2 diets with and without fish-derived n-3 fatty acid enrichment
27. Immunologic effects of marine- and plant-derived n-3 polyunsaturated fatty acids in nonhuman primates
28. Modulation of rat and human lymphocyte function by n-6 and n-3 polyunsaturated fatty acids and acetylsalicylic acid
29. Lower proportion of CD45R0(+) cells and deficient interleukin-10 production by formula-fed infants, compared with human-fed, is corrected with supplementation of long-chain polyunsaturated fatty acids
30. Fatty acids and immune responses - A new perspective in searching for clues to mechanism
31. Lipids and the immune response
32. 2 production but have different effects on lymphocyte functions and cell-mediated immunity
33. Essential fatty acids and the immune response
34. Modulatory influence of unsaturated fatty acids on the biology of tumour necrosis factor-α
35. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function
36. Purified dietary n-3 polyunsaturated fatty acids alter diacylglycerol mass and molecular species composition in concanavalin A-stimulated murine splenocytes
37. The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters
38. Effects of the fatty acid composition of phosphatidylserine and diacylglycerol on the in vitro activity of protein kinase C from rat spleen: Influences of (n-3) and (n-6) polyunsaturated fatty acids
39. Dietary fish oil appears to prevent the activation of phospholipase C-gamma in lymphocytes
40. Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids
41. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor α
42. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
43. An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer
44. Fish oil modulates macrophage P44/P42 mitogen-activated protein kinase activity induced by lipopolysaccharide
45. Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-alpha
46. Very long chain n-3 and n-6 polyunsaturated fatty acids inhibit proliferation of human T-lymphocytes in vitro
47. Influence of antioxidant vitamins on fatty acid inhibition of lymphocyte proliferation
48. Vitamin A deficiency results in a priming environment conducive for Th1 cell development
49. Multiple functions of vitamin A
50. Vitamin A status: Relationship to immunity and the antibody response
51. The role of vitamin A and related retinoids in immune function
52. Vitamin A, infection, and immune function
53. Vitamin A supplementation and child mortality
54. Effects of vitamin A-deprivation on hamster tracheal epithelium. A quantitative morphologic study
55. In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function
56. Infant mortality and maternal vitamin A deficiency during human immunodeficiency virus infection
57. Innate immunity, gut integrity, and vitamin A in Gambian and Indian infants
58. Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil
59. Vitamin A supplementation fails to reduce incidence of acute respiratory illness and diarrhea in preschool-age Indonesian children
60. Potential interventions for the prevention of childhood pneumonia in developing countries: A meta-analysis of data from field trials to assess the impact of vitamin A supplementation on pneumonia morbidity and mortality
61. Increased mortality associated with vitamin A deficiency during human immunodeficiency virus type 1 infection
62. Vitamin A deficiency and maternal-infant transmissions of HIV in two metropolitan areas in the United States
63. Overview of the potential role of vitamin A in mother-to-child transmission of HIV-1
64. Antigen-specific immune response impairment in the chick as influenced by dietary vitamin A
65. Decreased resistance and immune response to Escherichia coli infection in chicks with low or high intakes of vitamin A
66. Impaired T lymphocyte immune response in vitamin A depleted rats and chicks
67. The effect of varying dietary concentrations of vitamin A on immune response in the turkey
68. Vitamin A deficiency has different effects on immunoglobulin A production and transport during influenza A infection in BALB/c mice
69. Characterization of a helper T lymphocyte defect in vitamin A-deficient mice
70. Vitamin A deficiency alters rat neutrophil function
71. The effect of varying levels of dietary vitamin A on immune response in the chick
72. The direct involvement of vitamin A in glycosyl transfer reactions of mammalian membranes
73. Retinoic acid promotes proliferation and induces expression of retinoic acid receptor-alpha gene in murine T lymphocytes
74. Retinoic acid receptor-alpha gene expression is modulated by dietary vitamin A and by retinoic acid in chicken T lymphocytes
75. Abnormal regulation of IFN-gamma secretion in vitamin A deficiency
76. Modulation of interleukin production by ascorbic acid
77. Ascorbic acid is a potent inhibitor of various forms of T cell apoptosis
78. Ascorbic acid and the common cold. Evaluation of its efficacy and toxicity
79. Vitamin C and common cold incidence: A review of studies with subjects under heavy physical stress
80. Immune function in aged women is improved by ingestion of vitamins C and E
81. Vitamin C and the genesis of autoimmune disease and allergy
82. Enhancement of natural killer cell activity and T and B cell function by buffered vitamin C in patients exposed to toxic chemicals: The role of protein kinase-C
83. The influence of ascorbic acid on selected parameters of cell immunity in guinea pigs exposed to cadmium
84. New evidence for antioxidant properties of vitamin C
85. Effect of vitamin C supplementation on chromosome damage, apoptosis and necrosis ex vivo
86. Sustained levels of ascorbic acid are toxic and immunosuppressive for human T cells
87. The influence of phagocytic stimuli on the expression of HLA-DR antigens: Role of reactive oxygen intermediates
88. 2-induced DNA damage in human lymphocytes
89. Vitamin E: Introduction to biochemistry and health benefits
90. Vitamin C and cellular immune functions. Protection against hypochlorous acid-mediated inactivation of glyceraldehyde-3-phosphate dehydrogenase and ATP generation in human leukocytes as a possible mechanism of ascorbate-mediated immunostimulation
91. The role of vitamin E and selenium on arachidonic acid oxidation by way of the 5-lipoxygenase pathway
92. Vitamin E, immune response, and disease resistance
93. Vitamin E status and immune function
94. Vitamin E and immunity
95. Recent developments in vitamin E and immune response
96. Vitamin E and immune response in the aged
97. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects
98. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial
99. Long-term feeding of high vitamin E diet improves the decreased mitogen response of the rat splenic lymphocytes with aging
100. Vitamin E supplementation improves cell-mediated immunity and oxidative stress of Asian men and women
101. Vitamin-E supplements and their effect on vitamin-E status in blood and genetic damage rate in peripheral blood lymphocytes
102. Vitamin E is an important factor in T cell differentiation in thymus of F344 rats
103. Vitamin E enhances T cell differentiation through increased epithelial cell function in rat thymus
104. Pretreatment of young pigs with vitamin E attenuates the elevation in plasma interleukin-6 and cortisol caused by a challenge dose of lipopolysaccharide
105. Effect of vitamin E supplementation on leukocyte function
106. Humoral immune response impairment following excess vitamin E nutrition in the chick and turkey
107. Selenoorganic compounds and the therapy of hydroperoxide-linked pathological conditions
108. Selenium: An essential element for immune function
109. Regulation of cellular immune responses by selenium
110. Effect of selenium on the expression of high affinity interleukin 2 receptors
111. Selenium and immune cell functions. I. Effect on lymphocyte proliferation and production of interleukin 1 and interleukin 2
112. Seleniun and immune cell functions. II. Effect on lymphocyte-mediated cytotoxicity
113. Increased neutrophil adherence and adhesion molecule mRNA expression in endothelial cells during selenium deficiency
114. Supplementation with selenium and human immune cell functions. I. Effect on lymphocyte proliferation and interleukin 2 receptor expression
115. Supplementation with selenium and human immune cell functions. II. Effect on cvtotoxic lymphocytes and natural killer cells
116. Supplementation with selenium restores age-related decline in immune cell function
117. Selenium and interleukins in persons infected with human immunodeficiency virus type 1
118. Nutritionally induced oxidative stress: Effect on viral disease
119. Host nutritional selenium status as a driving force for influenza virus mutations
120. Incorporation of fatty acids by concanavalin A-stimulated lymphocytes and the effect on fatty acid composition and membrane fluidity
121. Selenium and immune function
122. Iron biology in immune function, muscle metabolism and neuronal functioning
123. Iron and its relation to immunity and infectious disease
124. Cellular and molecular aspects of iron and immune function
125. Iron deficiency alters the progression of mitogen-treated murine splenic lymphocytes through the cell cycle
126. Modulation of transferrin synthesis, transferrin receptor expression, iNOS expression and NO production in mouse macrophages by cytokines, either alone or in combination
127. Effects of iron overload on the immune system
128. The role of iron and iron binding proteins in lymphocyte physiology and pathology
129. Lymphocyte proliferation is controlled by both iron availability and regulation of iron uptake pathways
130. Maternal-iron-deficiency effects on peritoneal macrophage and peritoneal natural-killer-cell cytotoxicity in rat pups
131. Iron depletion: A defense against intracellular infection and neoplasia
132. Iron and infection
133. Elevated iron status increases bacterial invasion and survival and alters cytokine/chemokine mRNA expression in Caco-2 human intestinal cells
134. Effect of daily iron supplementation on iron status, cell-mediated immunity, and incidence of infections in 6-36 month old Togolese children
135. Mechanism of high susceptibility of iron-overloaded mouse to Vibrio vulnificus infection
136. The role of iron in cancer
137. Overnutrition and immune responses
138. The dynamic link between the integrity of the immune system and zinc status
139. Zinc and immunity
140. Zinc deficiency and immune function
141. Serum thymulin in human zinc deficiency
142. A reappraisal of the role of zinc in life and death decisions of cells
143. Zinc and immune function: The biological basis of altered resistance to infection
144. Effects of zinc deficiency on Th1 and Th2 cytokine shifts
145. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial
146. Effect of treatment with zinc gluconate or zinc acetate on experimental and natural colds
147. Zinc gluconate lozenges for treating the common cold in children: A randomized controlled trial
148. Zinc and the common cold: A meta-analysis revisited
149. Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD)
150. Zinc supplementation in young children with acute diarrhea in India
151. Zinc supplementation reduces the incidence of persistent diarrhea and dysentery among low socioeconomic children in India
152. Randomised controlled trial of zinc supplementation in malnourished Bangladeshi children with acute diarrhoea
153. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: Pooled analysis of randomized controlled trials
154. Impact of zinc supplementation on persistent diarrhoea in malnourished Bangladeshi children
155. Impact of zinc supplementation on subsequent growth and morbidity in Bangladeshi children with acute diarrhoea
156. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: A double-blind, controlled trial
157. Effect of zinc supplementation on cell-mediated immunity and lymphocyte subsets in preschool children
158. The role of corticosterone in the loss in immune function in the zinc-deficient A/J mouse
159. Delayed type hypersensitivity in zinc deficient adult mice: Impairment and restoration of responsivity to dinitrofluorobenzene
160. Interference in the development of a secondary immune response in mice by zinc deprivation: Persistence of effects
161. Alteration of the immune and nutritional status of mice by synergy between zinc deficiency and infection with Trypanosoma cruzi
162. Effect of maternal dietary zinc on growth and mitogenic responsiveness in suckling mice
163. Alteration of antibody-mediated responses of suckling mice to T-cell-dependent and independent antigens by maternal marginal zinc deficiency: Restoration of responsivity by nutritional repletion
164. Changes in the levels of marker expression by mononuclear phagocytes in zinc-deficient mice
165. Changes in the regulation of lymphopoiesis and myelopoiesis in the zinc deficient mouse
166. Possible roles for zinc in destruction of Trypanosoma cruzi by toxic oxygen metabolites produced by mononuclear phagocytes
167. Zinc requirement for macrophage function: Effect of zinc deficiency on uptake and killing of a protozoan parasite
168. Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans
169. Zinc deficiency affects cell cycle and deoxythymidmic kinase (TK) gene expression in HUT-78 cell
170. Decreased natural killer cell activity in zinc deficient subjects with sickle cell disease
171. Depletion of cells of the B lineage in the bone marrow of zinc-deficient mice
172. Variance in the resistance of murine early bone marrow B cells to a deficiency in zinc
173. Preferential induction of apoptosis in mouse CD4+CD8+ alpha beta TCRloCD3 epsilon lo thymocytes by zinc
174. Glucocorticoid activation of a calcium dependent endonuclease in thymocyte nuclei leads to cell death
175. Dietary sources of nucleotides - From breast milk to weaning
176. Nucleotide actions on humoral immune responses
177. Symposium: Dietary nucleotides: A recently demonstrated requirement for cellular development and immune function
178. Role of nucleotides in intestinal development and repair: Implications for infant nutrition
179. Dietary nucleotides: Cellular immune, intestinal and hepatic system effects
180. The role of dietary sources of nucleotides in immune function: A review
181. Dietary nucleotides can up-regulate antigen-specific Th1 immune responses and suppress antigen-specific IgE responses in mice
182. Dietary ribonucleotides modulate type 1 and type 2 T-helper cell responses against ovalbumin in young BALB/cJ mice
183. Dietary nucleosides and nucleotides reduce Cryptosporidium parvum infection in dexamethasone immunosuppressed adult mice
184. Effects of dietary nucleotides on serum antibody and splenic cytokine production in mice
185. Dietary nucleotide effects upon murine natural killer cell activity and macrophage activation
186. The role of nucleotides in adult nutrition
187. The biochemistry and physiology of nucleotides
188. Glutamine and arginine: Immunonutrients for improved health
189. Monounsaturated fats and immune function
190. Linoleic acid and the immune response
191. Dose-dependent effects of dietary γ-linolenic acid on rat spleen lymphocyte functions
192. Conjugated linoleic acid: Implications for human health
193. The fermentable fiber content of the diet alters the function and composition of canine gut associated lymphoid tissue
194. Micronutrients and innate immunity
195. Folate status and the immune system
196. Immunomodulation by vitamin B12: Augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment
197. Vitamin B6 and immune competence
198. Paracrine role of calcitriol in the immune system and skin creates new therapeutic possibilities for vitamin D analogs
199. Vitamin D deficiency suppresses cell-mediated immunity in vivo
200. Roles of trace metals in the maturation, activation and effector functions of immune cells
201. Copper and immunity
202. Alcohol and infection
203. Increased susceptibility of experimental animals to infectious organisms as a consequence of ethanol consumption
204. Ethanol and cytokine secretion
205. Increased vitamin E intake restores fish-oil-induced suppressed blastogenesis of mitogen-stimulated T lymphocytes
206. Snppression of human T-cell growth in vitro by cis-unsaturated fatty acids: Relationship to free radicals and lipid peroxidation
207. Dietary (n-3) polyunsaturated fatty acids suppress murine lymphoproliferation, interleukin-2 secretion, and the formation of diacylglycerol and ceramide
208. Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes
209. Fish oil enhances macrophage tumor necrosis factor-alpha mRNA expression at the transcriptional level
210. Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils
211. Increasing the dietary (n-3) to (n-6) polyunsaturated fatty acid ratio increases tumor necrosis factor production by murine resident peritoneal macrophages without an effect on elicited peritoneal macrophages
212. Interleukin-1 and tumor necrosis factor synthesis by mouse peritoneal macrophages is enhanced by dietary n-3 polyunsaturated fatty acids
213. Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils
214. Maintenance of epithelial cell differentiation: The mode of action of vitamin A
215. Gap junction proliferation in retinoic acid-treated human basal cell carcinoma
216. Vitamin A deficiency exacerbates murine Lyme arthritis
217. Effect of vitamin E supplementation on immune responsiveness of the aged
218. Supplementation with selenium augments the functions of natural killer and lymphokine-activated killer cells
219. Restricted expression of mitogen-induced high affinity IL-2 receptors in aging mice
220. Hypothesis: Iron chelation plays a vital role in neutrophilic inflammation
221. Zinc reversibly inhibits steroid binding to murine glucocorticoid receptor
222. Functional capacity of the residual lymphocytes from zinc-deficient adult mice