Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD)

American Journal of Hematology

Volumn 61, Issue 3, 1999, Pages 194-202

  Prasad, Ananda S ^a,c   Beck, Frances W J ^a   Kaplan, Joseph ^a   Chandrasekar, Pranatharthi H ^a   Ortega, Jesus ^a   Fitzgerald, James T ^b   Swerdlow, Paul ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c DETROIT RECEIVING HOSPITAL   (United States)

Author keywords

Infection; Sickle cell disease; Zinc

Indexed keywords

INTERLEUKIN 2; PLACEBO; ZINC ACETATE;

ARTICLE; BACTERIAL INFECTION; CELL FUNCTION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET SUPPLEMENTATION; ESCHERICHIA COLI; FEMALE; HELPER CELL; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; INCIDENCE; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; SICKLE CELL ANEMIA; STAPHYLOCOCCUS; STREPTOCOCCUS; URINARY TRACT INFECTION; ZINC DEFICIENCY;

ADMINISTRATION, ORAL; ADULT; ANEMIA, SICKLE CELL; COMMUNICABLE DISEASES; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; GRANULOCYTES; HEMATOCRIT; HEMOGLOBINS; HUMANS; INCIDENCE; INTERLEUKIN-2; LYMPHOCYTES; MIDDLE AGED; TIME FACTORS; ZINC;

EID: 0032990335     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8652(199907)61:3<194::AID-AJH6>3.0.CO;2-C     Document Type: Article

References (36)

1. Prasad AS, Schoomaker EB, Ortega J, Brewer GJ, Oberleas D, Oelshlegel FJ. Zinc deficiency in sickle cell disease. Clin Chem 1975; 21:582-587.
2. Yuzbasiyan-Gurkan VA, Brewer GJ, Vander AJ, Guenther MJ, Prasad AS. Net renal tubular reabsorption of zinc in healthy man and impaired handling in sickle cell anemia. Am J Hematol 1989;31:3187-3190.
3. Prasad AS, Cossack ZT. Zinc supplementation and growth in sickle cell disease. Ann Intern Med 1984;100:367-371.
4. Prasad AS, Abbasi AA, Rabbani P, DuMouchelle E: Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects. Am J Hematol 1981;10:119-127.
5. Warth JA, Prasad AS, Zwas F, Frank RN. Abnormal dark adaptation in sickle cell anemia. J Lab Clin Med 1981;98:189-194.
6. Prasad AS, Rabbani P, Warth JA. Effect of zinc on hyperammonemia in sickle cell anemia subjects. Am J Hematol 1979;7:323-327.
7. Tapazoglou E, Prasad AS, Hill G, Brewer GJ, Kaplan J. Decreased natural killer cell activity in patients with zinc deficiency with sickle cell disease. J Lab Clin Med 1985;105:19-22.
8. Ballester OF, Abdallah JM, Prasad AS. Impaired IgM antibody responses to an influenza virus vaccine in adults with sickle cell anemia. Am J Hematol 1985;20:409-412.
9. Ballester OF, Abdallah JM, Prasad AS. Lymphocyte subpopulation abnormalities in sickle cell anemia. Am J Hematol 1986;21:23-27.
10. Prasad AS, Meftah S, Abdallah J, Kaplan J, Brewer GJ, Bach JF, Dardenne M. Serum thymulin in human zinc deficiency. J Clin Invest 1988;82:1202-1210.
11. Beck FWJ, Kaplan J, Fine N, Handscheu W, Prasad AS. Decreased expression of CD73 (Ecto-5′-nucleotidase) in the CD8+ subset is associated with zinc deficiency in humans. J Lab Clin Med 1997;130: 147-156.
12. Phebus CK, Maciak BJ, Gloninger MF, Paul HS. Zinc status of children with sickle cell disease: Relationship to poor growth. Am J Hematol 1998;29:67-73.
13. Niell HB, Leach BE, Kraus AP. Zinc metabolism in sickle cell anemia. JAMA 1979;242:2686-2687.
14. Karayalcin G, Lanzkowsky P, Kazai AB. Zinc deficiency in children with sickle cell disease. Am J Pediatr Hematol Oncol 1979;1:283-284.
15. Russell MO, Finan A, Moskowitz SR, Elmer MA, Gill FM. Nutrition and poor growth in pre-adolescent children with sickling disorders. Pediatr Res 1981;15:586.
16. Daeschner CW, Matusik MC, Carpentieri U, Haggard ME. Zinc and growth in patients with sickle cell disease. J Pediatr 1981;98:778-780.
17. Barrett-Conner E. Bacterial infection and sickle cell anemia. Medicine 1971;50:97-112.
18. Hook EW, Campbell CG, Weens HS, Cooper GR. Salmonella osteomyelitis in patients with sickle cell anemia. N Engl J Med 1957;257: 403-407.
19. Onwubalili JK. Sickle cell disease and infection. J Infect 1983;7:2-20.
20. Buchanan GR. Infection. In Sickle Cell Disease. Embury SH, Hebbel RP, Mohandas N, Steinberg MH, editors. New York: Raven Press; 1994. pp. 567-588.
21. Shulman ST, Barlett J, Clyde WA, Ayoub EM. The unusual severity of mycoplasma pneumonia in children with sickle cell disease. N Engl J Med 1972;287:164.
22. Sergeant GR, Sergeant BE, Thomas PW, Anderson MJ, Patou G, Pattison JR: Human parvo-virus infection in homozygous sickle cell disease. Lancet 1993;341:1237-1240.
23. Hardy RE, Cummings C, Thomas F, Harrison D. Cryptococcal pneumonia in a patient with sickle cell disease. Chest 1986;89:892-895.
24. Haddad JD, John JF, Pappas AA: Cytomegalovirus pneumonia in sickle cell disease. Chest 86:265-266, 1984.
25. Meftah S, Prasad AS, Lee D, Brewer GJ. Ecto 5′ nucleotidase (5′NT) as a sensitive indicator of human zinc deficiency. J Lab Clin Med 1991;118:309-319.
26. Wang H, Prasad AS, DuMouchelle E. Zinc in platelets, lymphocytes, and granulocytes by flameless atomic absorption spectrophotometry (AAS). J Micro Nutr Anal 1989;5:181-190.
27. Prasad AS, Miale A Jr., Farid Z, Sandstead H, Schulert A. Zinc metabolism in patients with syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism and hypogonadism. J Lab Clin Med 1963; 61:537-549.
28. Prasad AS: Clinical spectrum of human zinc deficiency. In Prasad AS. Biochemistry of zinc. New York: Plenum; 1993. pp. 219-258.
29. Beck FWJ, Prasad AS, Kaplan J, Fitzgerald JT, Brewer GJ. Changes in cytokine production and T-cell subpopulations in experimentally induced zinc deficient humans. Am J Physiol 1997;272:E1002-E1007.
30. Ballester OF, Prasad AS. Anergy, zinc deficiency and decreased nucleoside phosphorylase activity in patients with sickle cell anemia. Ann Intern Med 1983;98:180-182.
31. Shankar AH, Prasad AS. Zinc and immune function: The biological basis of altered resistance to infection. Am J Clin Nutr 1998;68(suppl): 4475-635.
32. Schnog JB, Lard LR, Rojer RA, Vander Dijs FPL, Muskiet FAJ, Duits AJ. New concepts in assessing sickle cell disease severity. Am J Hematol 1996;58:61-66.
33. Smolinski PA, Offermann MK, Eckman JR, Wick TM. Double-stranded RNA induces sickle erythrocyte adherence to endothelium: A potential role for viral infection in vaso-occlusive pain episodes in sickle cell anemia. Blood 1995;85:2945-2950.
34. Hebbel RP, Vercellotti GM. The endothelial biology of sickle cell disease. J Lab Clin Med 1997;129:288-293.
35. Solovey A, Gui L, Key NS, Hebbel RP. Tissue factor expression by endothelial cells in sickle cell anemia. J Clin Invest 1998;101:1899-1904.
36. Brewer GJ, Brewer LF, Prasad AS. Suppression of irreversible sickled erythrocytes by zinc therapy in sickle cell anemia. J Lab Clin Med 1977;90:549-554.