Reduced splenocyte metabolism and immune function in rats implanted with the Morris Hepatoma 7777

Metabolism: Clinical and Experimental

Volumn 45, Issue 7, 1996, Pages 848-855

  Shewchuk, Leann D ^a   Baracos, Vickie E ^a   Field, Catherine J ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARBON DIOXIDE; GLUCOSE; GLUTAMINE; LACTIC ACID; PYRUVIC ACID;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; GLUCOSE METABOLISM; IMMUNE RESPONSE; LIVER CELL CARCINOMA; MALE; MITOGENESIS; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; TUMOR GROWTH; TUMOR IMMUNOLOGY;

EID: 0029975372     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90158-4     Document Type: Article

References (39)

1. Morris HP: Studies on the development, biochemistry, and biology of experimental hepatomas. Adv Cancer Res 9:227-302, 1965
2. Robins RA: T-cell responses at the host:tumor interface. Biochim Biophys Acta 865:289-305, 1986
3. Heberman RB: Possible role of natural killer cells and other effector cells in immune surveillance against cancer. J Invest Dermatol 83:1378-1408, 1984
4. Woodruff MFA: The cytolytic and regulatory role of natural killer cells in experimental neoplasia. Biochim Biophys Acta 865:43-57, 1986
5. Newsholme EA, Newsholme P, Curi R: The role of the citric acid cycle in cells of the immune system and its importance in sepsis, trauma and burns. Biochem Soc Symp 54:145-161, 1987
6. Ardawi MSM, Newsholme EA: Metabolism in lymphocytes and its importance in the immune response. Essays Biochem 21:1-44, 1985
7. Wu G, Field CJ, Marliss EB: Enhanced glutamine and glucose metabolism in cultured rat splenocytes stimulated by phorbol myristate acetate plus ionomycin. Metabolism 41:982-988, 1992
8. Field CJ, Chayoth R, Montambault M, et al: Enhanced 2-deoxy-D-glucose uptake and metabolism in splenocytes from diabetic and diabetes-prone BB rats. J Biol Chem 266:3675-3681, 1991
9. Park KGM, Heys SD, McNurlan MA, et al: Lymphocyte protein synthesis in vivo: A measure of activation. Clin Sci 86:671-675, 1994
10. Kafkewitz D, Bendich A: Enzyme-induced asparagine and glutamine depletion and immune system function. Am J Clin Nutr 37:1025-1030, 1983
11. Jacobs DB, Lee T-P, Jung CY, et al: Mechanism of mitogen-induced stimulation of glucose transport in human peripheral blood mononuclear cells. J Clin Invest 83:437-443, 1989
12. Le Bricon T, Cynober L, Field CJ, et al: Supplemental nutrition with ornithine α-ketoglutarate in rats with cancerassociated cachexia: Surgical treatment of the tumor improves efficacy of nutritional support. J Nutr 125:2999-3010, 1995
13. Medina MA, Sánchez-Jiménez F, Marquez J, et al: Relevance of glutamine metabolism to tumor cell growth. Mol Cell Biochem 113:1-15, 1992
14. Sauer LA, Dauchy RT: Ketone body, glucose, lactic acid, and amino acid utilization by tumors in vivo in fasted rats. Cancer Res 43:3497-3503, 1983
15. Horst HJ: L-(+)-Lactate: Determination with lactic dehydrogenase and DPN, in Bergmeyer HU (ed): Methods of Enzymatic Analysis. Weinheim, Germany, Verlag Chemie, 1974, pp 266-270
16. Czok R, Lamprecht W: Pyruvate, phosphoenolpyruvate and D-glycerate-2-phosphate, in Bergmeyer HU (ed): Methods of Enzymatic Analysis. Weinheim, Germany, Verlag Chemie, 1974, pp 1446-1451
17. Jones BN, Gilligan JP: O-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids. J Chromatogr 266:471-482, 1983
18. Steele RGD, Torrie JH: Principles and Procedures of Statistics (ed 2). New York, NY, McGraw-Hill, 1980
19. Fidler IJ : Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines. Science 208:1469-1471, 1980
20. Kritchevsky D: Influence of caloric restriction and exercise on tumorigenesis in rats. Proc Soc Exp Biol Med 193:35-38, 1990
21. Corman LC: Effect of specific nutrients on the immune response. Selected clinical applications. Med Clin North Am 69:759-791, 1988
22. Balducci L, Hardy C: Cancer and malnutrition - A critical interaction: A review. Am J Hematol 18:91-103, 1985
23. Carver JD: Dietary nucleotides: Cellular immune, intestinal and hepatic system effects. J Nutr 124:144S-148S, 1994
24. Van Buren C, Kulkarni AD, Rudolph FB: The role of nucleotides in adult nutrition. J Nutr 124:160S-164S, 1994
25. Britten V, Robins RA, Baldwin RW: In vitro activation of natural killer-like cytotoxicity by specifically in vivo primed T-helper lymphocytes in the rat. Immunology 52:31-39, 1984
26. Kawamura I, Moldawer LL, Keenan RA, et al: Altered amino acid kinetics in rats with progressive tumor growth. Cancer Res 42:824-829, 1982
27. Fields LA, Wolman SL, Cheema-Dhadli S, et al: Regulation of energy metabolism in Morris hepatoma 7777 and 7800. Cancer Res 41:2762-2766, 1981
28. Weber G, Lui MS: Molecular targets of anti-glutamine therapy with Acivicin in cancer cells, in Haussinger D (ed): Glutamine Metabolism in Mammalian Tissues. Berlin, Germany, Springer-Verlag, 1984, pp 278-291
29. Linder-Horowitz M, Knox WE, Morris HP: Glutaminase activities and growth rates of rat hepatomas. Cancer Res 29:1195-1199, 1969
30. Fischer JF, Chance WT: Total parenteral nutrition, glutamine, and tumor growth. JPEN 14:86S-89S, 1990
31. Strelkov AB, Fields AL, Baracos VE: Effects of systemic inhibition of prostaglandin production on protein metabolism in tumor-bearing rats. Am J Physiol 26:C261-C269, 1989
32. González-Mateos F, Gómez M-E, Garcia-Salguero L, et al: Inhibition of glycolysis by amino acids in ascites tumor cells. J Biol Chem 268:7809-7817, 1993
33. Lavietes BB, Regan DH, Demopoulos HB: Glutamate oxidation of 6C3HED lymphoma: Effects of L-asparaginase on sensitive and resistant lines. Proc Natl Acad Sci USA 71:3993-3997, 1974
34. Marquez J, Matés JM, Quesada AR, et al: Altered ornithine metabolism in tumor-bearing mice. Life Sci 45:1877-1884, 1989
35. 31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells. Biochim Biophys Acta 1051:131-137, 1990
36. Klimberg VS, Pappas AA, Nwokedi E, et al: Effect of supplemental dietary glutamine on methotrexate concentrations in tumors. Arch Surg 127:1317-1320, 1992
37. Wu G, Field CJ, Marliss EB: Glucose and glutamine metabolism in rat macrophages: Enhanced glycolysis and unaltered glutaminolysis in spontaneously diabetic BB rats. Biochim Biophys Acta 1115:116-173, 1991
38. Hanna N: The role of natural killer cells in the control of tumor growth and metastasis. Biochim Biophys Acta 780:213-226, 1985
39. Shewchuk LD, Baracos VE, Field CJ: Dietary L-glutamine does not modify lymphocyte metabolism and function in exercise-trained rats. Sports Exer Sci Med (in press)