Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 1241-1246

  Khair El Din, Tarik ^b   Sicher, Stanley C ^b   Vazquez, Miguel A ^b   Chung, Gary W ^b   Stallworth, Kerry A ^b   Kitamura, Kenichiro ^b   Miller, R Tyler ^b   Lu, Christopher Y ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; DOCOSAHEXAENOIC ACID; FISH OIL; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; INFECTION SENSITIVITY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; RNA TRANSCRIPTION; TRANSCRIPTION REGULATION;

ADULT; ANIMALS; CELL LINE; DOCOSAHEXAENOIC ACIDS; ENZYME INDUCTION; FATTY ACIDS, OMEGA-3; FETUS; FISH OILS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INFANT, NEWBORN; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C3H; NITRIC OXIDE SYNTHASE; RATS; SERUM ALBUMIN; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0029994936     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.1241     Document Type: Article

References (34)

1. Lu, C.Y., and E.R. Unanue. 1985. Macrophage ontogeny: implications for host defence, T Lymphocyte differentiation, and the acquisition of self-tolerance. Clin. Immunol. Allergy. 5:253-269.
2. Redline, R.W., and C.Y. Lu. 1987. Role of local immunosuppression in murine fetoplacental listeriosis. J. Clin. Invest. 79:1234-1241.
3. Lu, C.Y., and E.R. Unanue. 1982. Ontogeny of murine macrophages: functions related to antigen presentation. Infect. Immun. 36:169-175.
4. Snyder, D.S., C.Y. Lu, and E.R. Unanue. 1982. Control of macrophage Ia expression in neonatal mice: role of splenic suppressor cell. J. Immunol. 128:1458-1465.
5. Delorme, J., C. Benassayag, N. Christeff, G. Vallette, L. Savu, and E. Nunez. 1984. Age-dependent responses of the serum non-esterified fatty acids to adrenalectomy and ovariectomy in developing rats. Biochim. Biophys. Acta. 792:6-10.
6. Neuringer, M., M.E. Connor, C. Van Petten, and L. Barstad. 1984. Dietary Omega-3 fatty acid deficiency and visual loss in infant Rhesus monkeys. J. Clin. Invest. 73:272-276.
7. Dustin, L.B., R. Soberman, C.M. Shea, and C.Y. Lu. 1990. Docosahexaenoic acid, a constituent of rodent fetal serum and fish oil diets, inhibits acquisition of macrophage tumoricidal function. J. Immunol. 144:4888-4897.
8. Salem, N.J., H.Y. Kim, and J.A. Yergey. 1986. 15, Docosahexaenoic acid: membrane function and metabolism. In Health effects of polyunsaturated fatty acids in seafoods. A.P. Simopoulos, R.R. Kifer, and R.E. Martin, editors. Academic Press, Orlando, FL. 263-318,
9. Nathan, C., and Q.W. Xie. 1994. Nitric oxide synthases: roles, tolls, and controls. Cell. 78:915-918.
10. Nathan, C.F., and J.B.J. Hibbs. 1991. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol. 3:65-70.
11. Stuehr, D.J., S.S. Gross, I. Sakuma, R. Levi, and C.F. Nathan. 1989. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. J. Exp. Med. 169:1011-1020.
12. Chen, R.F. 1967. Removal of fatty acids from serum albumin by charcoal treatment. J. Biol. Chem. 242:173-181.
13. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal. Biochem. 162:156-159.
14. Lyons, C.R., G.J. Orloff, and J.M. Cunningham. 1992. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J. Biol. Chem. 267:6370-6374.
15. Danielson, P.E., S. Forss-Petter, M.A. Brow, L. Calavetta, J. Douglass, R.J. Milner, and J.G. Sutcliffe. 1988. p1B15: a cDNA clone of the rat mRNA encoding cyclophilin. DNA (NY). 7: 261-267.
16. Yanato, K., Z. El-Hajjaoui, and H.P. Koeffler. 1989. Regulation of levels of IL-1 mRNA in human fibroblasts. J. Cell. Physiol. 139:610-616.
17. Fort, P., L. Marty, M. Piechaczyk, S. El Sabrouty, C. Cani, P. Jeanteur, and J.M. Blanchard. 1985. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res. 13:1431-1442.
18. Xie, Q.W., R. Whisnant, and C. Nathan. 1993. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J. Exp. Med. 177:1779-1784.
19. Hsia, J.C., T.T. Wong, C.E. Trimble, and H.F. Deutsch. 1987. 15, An in vitro model of placental transfer of polyunsaturated fatty acids - the albumin-AFP exchange system. In Biological activities of Alpha 1-fetoprotein. Vol. 1. G.J. Mizejewski and H.I. Jacobson, editors. CRC Press, Boca Raton, FL. 205-212.
20. Crandall, B.F. 1981. Alpha-fetoprotein: a review. CRC Rev. Clin. Lab. Sci. 15:127-185.
21. Savu, L., C. Benassayag, G. Vallette, N. Christeff, and E. Nunez. 1981. Mouse alpha-1-fetoprotein and albumin: a comparison of their binding properties with estrogen and fatty acid ligands. J. Biol. Chem. 256:9414-9418.
22. Lu, C.Y., P.S. Changelian, and E.R. Unanue. 1984. Alpha-fetoprotein inhibits macrophage expression of Ia antigens. J. Immunol. 132:1722-1727.
23. Parmelee, D.C., M.A. Evenson, and H.F. Deutsch. 1978. The presence of fatty acids in human alpha-fetoprotein. J. Biol. Chem. 253:2114-2119.
24. Khair-El-Din, T.A., S.C. Sicher, M.A. Vazquez, W.J. Wright, and C.Y. Lu. 1995. Docosahexaenoic acid, a major constituent of fetal serum and fish oil diets, inhibits IFN gamma induced Ia-expression by murine macrophages in vitro. J. Immunol. 154:1296-1306.
25. Leu, R.W., N.R. Leu, B.J. Shannon, and D.J. Fast. 1991. IFN-gamma differentially modulates the susceptibility of L1210 and P815 tumor targets for macrophage-mediated cytotoxicity: role of macrophage-target interaction coupled to nitric oxide-generation, but independent of tumor necrosis factor production. J. Immunol. 147:1816-1822.
26. Hubbard, N.E., D. Lim, S.D. Somers, and K.L. Erickson 1993. Effects of in vitro exposure to arachidonic acid on TNF-alpha production by murine periotneal macrophages. J Leuko. Biol. 54:105-110.
27. Lu, C.Y., R.W. Redline, L.B. Dustin, D.B. McKay, C.M. Shea. 1991. 11, Inhibition of macrophage and T-lymphocyte functions in the placenta and decidua during listeriosis; implications for tolerance of the fetoplacental allograft. In Molecular and cellular immunobiology of the maternal fetal interface. T.G. Wegmann, T.J.I. Gill, and E. Nisbet-Brown, editors. Oxford University Press, NY. 141-167.
28. Crainie, M., A. Semeluk, K.C. Lee, and T.G. Wegmann. 1989. Regulation of constitutive and lymphokine induced Ia expression by murine alpha-fetoprotein. Cell. Immunol. 118: 41-52.
29. Simopoulos, A.P. 1991. Omega-3 fatty acids in health and disease and in growth and development. Am. J. Clin. Nutr 54:38-63.
30. Robinson, D.R., L.L. Xu, S.G. Tateno, M., and R.B. Colvin. 1993. Suppression of autoimmune disease by dietary n-3 fatty acids. J. Lipid. Res. 34:1435-1444.
31. Kelley, V.E., A. Ferretti, S. Izui, and T.B. Strom. 1985. A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites and suppresses lupus in MRL-lpr mice. J. Immunol. 134:1914-1919.
32. Prickett, J.D., D.R. Robinson, and A.D. Steinberg. 1981. Dietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB X NZW mice. J. Clin. Invest. 68:556-559.
33. Leslie, C.A., W.A. Gonnerman, M.D. Ullman, K.C. Hayes, C. Franzblau, and E.S. Cathcart. 1985. Dietary fish oil modulates macrophage fatty acids and decreases arthritis susceptibility in mice. J. Exp. Med. 162:1336-1349.
34. Van der Heide, J.J.H., H.J.G. Bilo, J.M. Donker, J.M. Wilmink, and A.M. Tegzess. 1993. Effect of dietary fish oil on renal function and rejection in cyclosporine-treated recipients of renal transplants. N. Engl. J. Med. 329:769-773.