Elevated iron status increases bacterial invasion and survival and alters cytokine/chemokine mRNA expression in Caco-2 human intestinal cells

Journal of Nutrition

Volumn 131, Issue 5, 2001, Pages 1452-1458

  Foster, S L ^a   Richardson, S H ^a   Failla, M L ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Caco 2 human intestinal cells; Chemokines; Cytokines; Infection; Iron; Transforming growth factor 1

Indexed keywords

CHEMOKINE; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 8; IRON; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIAL INFECTION; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOKINE RELEASE; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; INTESTINE CELL; MUCOSA INFLAMMATION; SURVIVAL;

BACTERIA (MICROORGANISMS); ENTERITIDIS; MAMMALIA; SALMONELLA ENTERITIDIS;

EID: 0035003106     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.5.1452     Document Type: Article

References (47)

1. Overview and mechanisms of iron regulation
2. Iron absorption
3. Regulation of iron absorption: Proteins involved in duodenal mucosal uptake and transport
4. Iron absorption and pyrexia
5. Absorption of radioactive iron in patients with fever and with anemia of varied etiology
6. The anemia of infection: Hypoferremia, hypercupremia and alterations in porphyrin metabolism in patients
7. Cellular iron metabolism in health and disease
8. Iron withholding: A defense against infection and neoplasia
9. Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron
10. Role of iron in intracellular growth of Trypanosoma cruzi
11. Plasmodium falciparum: Inhibition of in vitro growth by desferrioxamine
12. Interferon-gamma-activated primary enterocytes inhibit Toxoplasma gondii replication: A role for intracellular iron
13. Inflammation and mucosal cytokine production
14. Epithelial cells as sensors for microbial infection
15. The intestinal epithelial cell: Immunological aspects
16. Differentiation-associated antimicrobial functions in human colon adenocarcinoma cell lines
17. Iron deficiency and interleukin-1 production by rat leukocytes
18. Increased in vitro tumour necrosis factor-alpha production in iron deficiency anemia
19. Iron overload alters innate and T helper cell responses to Candida albicans in mice
20. Differential regulation of human alveolar macrophage-derived interleukin-1beta and tumor necrosis factor-alpha by iron
21. TGF-beta and collagen-alpha 1 (I) gene expression are increased in hepatic acinar zone 1 of rats with iron overload
22. Inositol phosphates inhibit uptake and transport of iron and zinc by a human intestinal cell line
23. A fine structure genetic and chemical study of the enzyme alkaline phosphatase of E. coli. I. Purification and characterization of alkaline phosphatase
24. Penetration of human intestinal epithelial cells by Salmonella: Molecular cloning and expression of Salmonella typhi invasion determinants in Escherichia coli
25. Osmolarity and growth phase overlap in regulation of Salmonella typhi adherence to and invasion of human intestinal cells
26. Caco-2 cell line: A system for studying intestinal iron transport across epithelial cell monolayers
27. Ascorbate offsets the inhibitory effect of inositol phosphates or iron uptake and transport by Caco-2 cells
28. Quantitation of selected intracellular and secreted hydrolases of macrophages
29. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
30. Transferrin-iron and proinflammatory cytokines influence iron status and apical iron transport efficiency of Caco-2 intestinal cell line
31. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion
32. Caco-2 cell ferritin formation predicts nonradiolabeled food iron availability in an in vitro digestion/Caco-2 cell culture model
33. Transforming growth factor beta (TGF-beta) in inflammation: A cause and a cure
34. Differential cytokine expression by human intestinal epithelial cell lines: Regulated expression of interleukin 8
35. Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells
36. IL-1 alpha is constitutively expressed in the rat intestinal epithelial cell line IEC-6
37. Synthesis and regulation of accessory/proinflammatory cytokines by intestinal epithelial cells
38. Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1
39. Interleukin 1 administration in mice produces hypoferremia despite neutropenia
40. Up-regulation of tumour necrosis factor-alpha receptors on monocytes by desferrioxamine
41. Suppression of TNF-alpha gene expression by hemin: Implications for the role of iron homeostasis in host inflammatory responses
42. Electron microscope studies of experimental Salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium
43. Pathogenesis of salmonellosis: Studies of fluid secretion, mucosal invasion, and morphologic reaction in the rabbit ileum
44. Salmonella interactions with polarized human intestinal Caco-2 epithelial cells
45. Development of an in vitro model for study of non-O1 Vibrio cholerae virulence using Caco-2 cells
46. Characterization of interactions of enteropathogenic Escherichia coli O127:H6 with mammalian cells in vitro
47. Expression of receptors for enterotoxigenic Escherichia coli during enterocytic differentiation of human polarized intestinal epithelial cells in culture