Multiple levels of Notch signal regulation (review)

Molecular Membrane Biology

Volumn 19, Issue 1, 2002, Pages 27-38

  Baron, M ^a   Aslam, H ^a   Flasza, M ^a   Fostier, M ^a   Higgs, J E ^a   Mazaleyrat, S L ^a   Wilkin, M B ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Covalent modification; Notch; Proteolysis; Trafficking; Ubiquitination

Indexed keywords

NOTCH RECEPTOR; PROTEIN DELTEX; PROTEIN FRINGE; PROTEIN NRARP; PROTEIN SEL 10; UNCLASSIFIED DRUG; WNT1 PROTEIN;

ACETYLATION; CELL FATE; CHROMATIN; DEACETYLATION; DROSOPHILA; ENDOCYTOSIS; GENE EXPRESSION; GENE TRANSLOCATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SPATIAL ORIENTATION;

ANIMALS; CALCIUM-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOCYTOSIS; GLYCOPROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; N-ACETYLGLUCOSAMINYLTRANSFERASES; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; UBIQUITIN; VERTEBRATES;

INVERTEBRATA; MAMMALIA; VERTEBRATA;

EID: 0036117680     PISSN: 09687688     EISSN: None     Source Type: Journal    
DOI: 10.1080/09687680110112929     Document Type: Review

References (135)

1. The WWE domain: A common interaction module in protein ubiquitination and ADP ribosylation
2. Notch signaling: Cell fate control and signal integration in development
3. Interaction between Wingless and Notch signaling pathways mediated by dishevelled
4. Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity
5. The R8-photoreceptor equivalence group in Drosophila: Fate choice precedes regulated Delta transcription and is independent of Notch gene dose
6. The Notch 3 intracellular domain represses Notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters
7. The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
8. Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch
9. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
10. Notch signalling in Drosophila: Three ways to use a pathway
11. Repression by Notch is required before Wingless signalling during muscle progenitor cell development in Drosophila
12. Wingless modulates the effects of dominant negative Notch molecules in the developing wing of Drosophila
13. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
14. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
15. Ligand-induced signaling in the absence of Furin processing of Notch1
16. A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein
17. Wnt signaling: A common theme in animal development
18. The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase
19. Notch is required for wingless signaling in the epidermis of Drosophila
20. Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila
21. Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
22. The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe
23. Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing
24. Modifications of Notch function by Abruptex mutations in Drosophila melanogaster
25. Notch signalling mediates segmentation of the Drosophila leg
26. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch Intracellular domain
27. Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway
28. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
29. Structural conservation of Notch receptors and ligands
30. Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc
31. The Suppressor of hairless protein participates in Notch receptor signaling
32. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye
33. Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of Notch signaling
34. Dissecting the mechanisms of Suppressor of hairless function
35. A role for Abl in Notch signalling
36. A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster
37. Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch
38. Functional interaction between SEL-10, a F-box protein, and the nuclear form of activated Notch1 receptor
39. Quality control in the secretory pathway
40. The ubiquitin system
41. Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signaling
42. Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing
43. sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
44. Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis
45. The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
46. Cis-Interactions between Delta and Notch modulate neurogenic signalling in Drosophila
47. Signalling downstream of activated mammalian Notch
48. Cutting edge: Protective effects of Notch-1 on TCR-induced apoptosis
49. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
50. Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus
51. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
52. An intrinsic dominant negative activity of Serrate that is modulated during wing development in Drosophila
53. Two different activities of Suppressor of Hairless during wing development in Drosophila
54. Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: Members of the Notch signalling pathway in Drosophila
55. Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development
56. Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development
57. Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain
58. Functional interaction between the mouse Notch1 intracellular region and histone acetyltransferases PCAF and GCN5
59. Neuralized functions cell-autonomously to regulate a subset of Notch-dependent processes during adult Drosophila development
60. Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development
61. Nrarp is a novel intracellular component of the Notch signaling pathway
62. Structural requirements for Notch signalling with Delta and Serrate during the development and patterning of the wing disc of Drosophila
63. Notch signaling targets the Wingless responsiveness of a Ubx visceral mesoderm enhancer in Drosophila
64. Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos
65. The Scabrous protein can act as an extracellular antagonist of Notch signaling in the Drosophila wing
66. Sorting in the endosomal system in yeast and animal cells
67. Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye
68. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
69. The Notch1 receptor is cleaved constitutively by a furin-like convertase
70. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
71. Human deltex is a conserved regulator of Notch signalling
72. Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
73. Wnt signaling: Moving in a new direction
74. The dynamin family of mechanoenzymes: Pinching in new places
75. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
76. Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila
77. Fringe is a glycosyltransferase that modifies Notch
78. Repression by Suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo
79. Notch signaling: From the outside in
80. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
81. The Notch signalling regulator Fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD
82. The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
83. Notch inhibition of E47 supports the existence of a novel signaling pathway
84. Fringe modulates Notch-ligand interactions
85. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
86. Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila
87. Mastermind is a putative activator for Notch
88. LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway
89. Notch around the clock
90. Scabrous complexes with Notch to mediate boundary formation
91. The developmental role of warthog, the Notch modifier encoding Drab6
92. Processing of the Notch ligand Delta by the metalloprotease Kuzbanian
93. Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase
94. Calcium depletion dissociates and activates heterodimeric Notch receptors
95. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor
96. Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis
97. Positive and negative signals between interacting cells for establishing neural fate
98. Ubiquitination and endocytosis of plasma membrane proteins: Role of Nedd4/Rsp5p family of ubiquitin-protein ligases
99. Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila
100. Wingless refines its own expression domain on the Drosophila wing margin
101. Numb is an endocytic protein
102. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
103. Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal notum
104. Dominant-negative mutation in the beta2 and beta6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage
105. Requirement for dynamin during Notch signaling in Drosophila neurogenesis
106. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
107. Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype
108. Numb antagonizes Notch signaling to specify sibling neuron cell fates
109. SNARE-dependent signaling at the Drosophila wing margin
110. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins
111. Nuclear access and action of Notch in vivo
112. Presenilin is required for activity and nuclear access of Notch in Drosophila
113. Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila
114. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
115. Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila
116. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)
117. The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription
118. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
119. Immobilization of Notch ligand, Delta-1, is required for induction of Notch signaling
120. Human Notch-1 inhibits NF-κB activity in the nucleus through a direct interaction involving a novel domain
121. p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans
122. Notch and Wingless regulate expression of cuticle patterning genes
123. Notch responds differently to Delta and Wingless in cultured Drosophila cells
124. Analysis of Notch lacking the carboxyl terminus identified in Drosophila embryos
125. Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats
126. Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin
127. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
128. deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster
129. The involvement of the Notch locus in Drosophila oogenesis
130. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
131. Neutralized functions as an E3 ubiquitin ligase during Drosophila development
132. Neuralized functions cell autonomously to regulate Drosophila sense organ development
133. An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila
134. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchlC to facilitate NotchlC function
135. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation