The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity

Mechanisms of Development

Volumn 104, Issue 1-2, 2001, Pages 3-20

  Beatus, Paul ^a   Lundkvist, Johan ^a   Öberg, Camilla ^a   Pedersen, Kia ^a   Lendahl, Urban ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

CADASIL; PCAF; RBP J ; SKIP; Suppressor of Hairless

Indexed keywords

ANKYRIN; DNA BINDING PROTEIN; NOTCH RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENETIC REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; REPRESSOR GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANKYRINS; BINDING, COMPETITIVE; BLOTTING, WESTERN; CELLS, CULTURED; CLONING, MOLECULAR; COS CELLS; DNA; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE DELETION; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; LUCIFERASES; MEMBRANE PROTEINS; MICE; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0034968027     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(01)00373-2     Document Type: Article

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3. Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription
4. The Notch 3 intracellular domain represses Notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters
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34. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jk/Su(H)
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36. The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis
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40. Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless