The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation

Journal of Clinical Investigation

Volumn 100, Issue 2, 1997, Pages 398-403

  Stein, Daniel T ^a   Stevenson, Brent E ^a   Chester, Michael W ^a   Basit, Majid ^a   Daniels, Murphy B ^a   Turley, Stephen D ^a   McGarry, J Denis ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Hyperinsulinemia; Hyperlipidemia; Insulin secretion; Saturated fatty acids; Unsaturated fatty acids

Indexed keywords

FATTY ACID; INSULIN; LINOLEIC ACID; OCTANOIC ACID; OLEIC ACID; PALMITIC ACID; PALMITOLEIC ACID; STEARIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FAT INTAKE; FATTY ACID BLOOD LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERLIPIDEMIA; INSULIN RELEASE; LIPID COMPOSITION; MALE; NONHUMAN; PANCREAS PERFUSION; PRIORITY JOURNAL; RAT;

EID: 0030876806     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119546     Document Type: Article

References (28)

1. Greenough, W.B., S.R. Crespin, and D. Steinberg. 1967. Hypoglycemia and hyperinsulinaemiain response to raised free-fatty acid levels. Lancet. ii: 1334-1336.
2. Seyffert, W.A., Jr., and L.L. Madison. 1967. Physiologic effects of metabolic fuels on carbohydrate metabolism. I. Acute effect of elevation of plasma free fatty acids on hepatic glucose output, peripheral glucose utilization, serum insulin, and plasma glucagon levels. Diabetes. 16:765-776.
3. Crespin, S.R., W.B. Greenough, and D. Steinberg. 1973. Stimulation of insulin secretion by long-chain free fatty acids. A direct pancreatic effect. J. Clin. Invest. 52:1979-1984.
4. Balasse, E.O., and H.A. Ooms. 1973. Role of plasma free fatty acids in the control of insulin secretion in man. Diabetologia. 9:145-151.
5. Tamarit-Rodriguez, J., E. Vara, and J. Tamarit. 1984. Starvation induced changes of palmitate metabolism and insulin secretion in isolated rat islets stimulated by glucose. Biochem. J. 221:317-324.
6. Boden, G., X. Chen, J. Rosner, and M. Barton. 1995. Effects of a 48h fat infusion on insulin secretion and glucose utilization. Diabetes. 44:1239-1242.
7. Stein, D.T., V. Esser, B. Stevenson, K.E. Lane, J.H. Whiteside, M.B. Daniels, S. Chen, and J.D. McGarry. 1996. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J. Clin. Invest. 97: 2728-2735.
8. Chen, S., A. Ogawa, M. Ohneda, R.H. Unger, D.W. Foster, and J.D. McGarry. 1994. More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic β-cell signaling. Diabetes. 43: 878-883.
9. Hamilton, J.G., and K. Comai. 1988. Rapid separation of neutral lipids, free fatty acids and polar lipids using prepacked silica sep-pak columns. Lipids. 23:1146-1149.
10. Malaisse, W.J., F. Malaisse-Lagae, and P.H. Wright. 1967. Effect of fasting upon insulin secretion in the rat. Am. J. Physiol. 213:843-848.
11. Grey, N.J., S. Goldring, and D.M. Kipnis. 1970. The effect of fasting, diet, and actinomycin D on insulin secretion in the rat. J. Clin. Invest. 49:881-889.
12. Burch, P.T., M.D. Trus, D.K. Berner, A. Leontire, K.C. Zawalich, and F.M. Matschinsky. 1981. Adaptation of glycolytic enzymes: glucose use and insulin release in rat pancreatic islets during fasting and refeeding. Diabetes. 30: 923-928.
13. Alstrup, K.K., S. Gregersen, and K. Hermansen. 1996. Differential effects of cis and trans falty acids on insulin release from isolated mouse islets of Langerhans. Diabetologia. 39:A113.
14. Richieri, G.V., and A.M. Kleinfeld. 1995. Unbound free fatty acid levels in human serum. J. Lipid Res. 36:229-239.
15. Opara, E.C., M. Garfinkel, V.S. Hubbard, W.M. Burch, and O.E. Akwari. 1994. Effect of fatty acids on insulin release: role of chain length and degree of unsaturation. Am. J. Physiol. 266:E635-E639.
16. Prentki, M., S. Vischer, M.C. Glennon, R. Regazzi, J.T. Deeney, and B.E. Corkey. 1992. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J. Biol. Chem. 267:5802-5810.
17. Berne, C. 1975. The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies. Biochem. J. 152:661-666.
18. Warnotte, C., P. Gilon, M. Nenquin, and J.C. Henquin. 1994. Mechanisms of the stimulation of insulin release by saturated fatty acids: a study of palmitate effects in mouse β-cells. Diabetes. 43:703-711.
19. Grundy, S.M., and M.A. Denke. 1990. Dietary influences on serum lipids and lipoproteins. J. Lipid Res. 31:1149-1172.
20. Maron, D.J., J.M. Fair, and W.L. Haskell. 1991. Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford coronary risk intervention project investigators and staff. Circulation. 84:2020-2027.
21. Mayer, E.J., B. Newman, C.P. Quesenberry, Jr., and J.V. Selby. 1993. Usual dietary fat intake and insulin concentrations in healthy women twins. Diabetes Care. 16:1459-1469.
22. Parker, D.R., S.T. Weiss, R. Troisi, P.A. Cassano, P.S. Vokonas, and L. Landsberg. 1993. Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the normative aging study. Am. J. Clin. Nutr. 58:129-136.
23. Hannah, J.S., and B.V. Howard. 1994. Dietary fats, insulin resistance, and diabetes. J. Cardiovasc. Risk. 1:31-37.
24. McGarry, J.D. 1994. Disordered metabolism in diabetes: have we underemphasized the fat component? J. Cell. Biochem. 55 (Suppl.):29-38.
25. Rasmussen, O., F.F. Lauszus, C. Christiansen, C. Thomsen, and K. Hermansen. 1996. Differential effects of saturated and monounsaturated fat on blood glucose and insulin responses in subjects with non-insulin-dependent diabetes mellitus. Am. J. Clin. Nutr. 63:249-253.
26. Lee, Y., H. Hiroshi, M. Ohneda, J.H. Johnson, J.D. McGarry, and R.H. Unger. 1994. β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc. Natl. Acad. Sci. USA. 91:10878-10882.
27. Zhou, Y.P., and V.E. Grill. 1995. Long term exposure to fatty acids and ketones inhibits β-cell function in human pancreatic islets of Langerhans. J. Clin. Endocrinol. Metab. 80:1584-1590.
28. Paolisso, G., A. Gambardella, L. Amato, R. Tortoriello, A. D'Amore, M. Varricchio, and F. D'Onofrio. 1995. Opposite effects of short-and long-term fatty acid infusion on insulin secretion in healthy subjects. Diabetologia. 38: 1295-1299.