메뉴 건너뛰기




Volumn 43, Issue 5, 2000, Pages 533-549

New insights into sympathetic regulation of glucose and fat metabolism

Author keywords

Adrenergic; Diabetes; Glucose; Leptin; Obesity; Sympathetic

Indexed keywords

ADRENALIN; BETA 3 ADRENERGIC RECEPTOR; GLUCOSE; INSULIN; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN RECEPTOR; NORADRENALIN; SEROTONIN 2C RECEPTOR;

EID: 0034077279     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051341     Document Type: Review
Times cited : (444)

References (125)
  • 1
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • 1. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763-770
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 2
    • 0031623306 scopus 로고    scopus 로고
    • The Mona Lisa hypothesis in the time of leptin
    • 2. Bray GA, York DA (1998) The Mona Lisa hypothesis in the time of leptin. Recent Prog Horm Res 53: 95-118
    • (1998) Recent Prog Horm Res , vol.53 , pp. 95-118
    • Bray, G.A.1    York, D.A.2
  • 4
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • 4. Saladin R, De Vos P, Guerre-Millo M et al. (1995) Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3
  • 5
    • 0030883332 scopus 로고    scopus 로고
    • Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects
    • 5. Biden G, Chen X, Kolaczynski JW, Polansky M (1997) Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J Clin Invest 100: 1107-1113
    • (1997) J Clin Invest , vol.100 , pp. 1107-1113
    • Biden, G.1    Chen, X.2    Kolaczynski, J.W.3    Polansky, M.4
  • 6
    • 0030928781 scopus 로고    scopus 로고
    • Insulin stimulates both leptin secretion and production by rat white adipose tissue
    • 6. Barr VA, Malide D, Zarnowski MJ, Talor SI, Cushman SW (1997) Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology 138: 4463-4472
    • (1997) Endocrinology , vol.138 , pp. 4463-4472
    • Barr, V.A.1    Malide, D.2    Zarnowski, M.J.3    Talor, S.I.4    Cushman, S.W.5
  • 7
    • 0030015246 scopus 로고    scopus 로고
    • Activation of β3 adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice
    • 7. Mantzoros CS, Qu D, Frederich RC et al. (1996) Activation of β3 adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes 45: 909-914
    • (1996) Diabetes , vol.45 , pp. 909-914
    • Mantzoros, C.S.1    Qu, D.2    Frederich, R.C.3
  • 8
    • 0033060430 scopus 로고    scopus 로고
    • Obesity: Autonomic circuits versus feeding
    • 8. Nonogaki K (1999) Obesity: autonomic circuits versus feeding. Nat Med 5: 742-743
    • (1999) Nat Med , vol.5 , pp. 742-743
    • Nonogaki, K.1
  • 9
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • 9. Ahima RS, Prabakaran D, Mantzoros C et al. (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1    Prabakaran, D.2    Mantzoros, C.3
  • 10
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • 10. Chehab FF, Lim ME, Lu R (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 12: 318-320
    • (1996) Nat Genet , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 11
    • 16944364768 scopus 로고    scopus 로고
    • Human leptin levels are pulsatile and inversely related to pituitary-adrenal function
    • 11. Licinio J, Mantzoros C, Negrao AB et al. (1997) Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 3: 575-579
    • (1997) Nat Med , vol.3 , pp. 575-579
    • Licinio, J.1    Mantzoros, C.2    Negrao, A.B.3
  • 12
    • 0031832836 scopus 로고    scopus 로고
    • The interaction between leptin and the hypothalamic-pituitary-thyroid axis
    • 12. Orban Z, Bornstein SR, Chrousos GP (1998) The interaction between leptin and the hypothalamic-pituitary-thyroid axis. Horm Metab Res 30: 231-235
    • (1998) Horm Metab Res , vol.30 , pp. 231-235
    • Orban, Z.1    Bornstein, S.R.2    Chrousos, G.P.3
  • 13
    • 0026728836 scopus 로고
    • Nervous control of liver metabolism and hemodynamics
    • 13. Gardemann A, Puschel GP, Jungermann K (1992) Nervous control of liver metabolism and hemodynamics. Eur J Biochem 207: 399-411
    • (1992) Eur J Biochem , vol.207 , pp. 399-411
    • Gardemann, A.1    Puschel, G.P.2    Jungermann, K.3
  • 14
    • 0029930979 scopus 로고    scopus 로고
    • Innervation of the liver and glucoregulation: Role of the hypothalamus and autonomic nerves
    • 14. Shimazu T (1996) Innervation of the liver and glucoregulation: role of the hypothalamus and autonomic nerves. Nutrition 12: 65-66
    • (1996) Nutrition , vol.12 , pp. 65-66
    • Shimazu, T.1
  • 15
    • 0032718323 scopus 로고    scopus 로고
    • Microanatomy of the human liver-exploring the hidden interfaces
    • 15. Saxena R, Theise ND, Crawford JM (1999) Microanatomy of the human liver-exploring the hidden interfaces. Hepatology 30: 1339-1346
    • (1999) Hepatology , vol.30 , pp. 1339-1346
    • Saxena, R.1    Theise, N.D.2    Crawford, J.M.3
  • 16
    • 0001186102 scopus 로고
    • Catecholamines and adrenal medulla
    • Wilson JD, Foster DW (eds) W. B. Saunders, Philadelphia
    • 16. Landsberg L, Young JB (1992) Catecholamines and adrenal medulla. In: Wilson JD, Foster DW (eds) Williams textbook of Endocrinology, 8th edn. W. B. Saunders, Philadelphia, pp 621-706
    • (1992) Williams Textbook of Endocrinology, 8th Edn. , pp. 621-706
    • Landsberg, L.1    Young, J.B.2
  • 17
    • 0031765344 scopus 로고    scopus 로고
    • Innervation of mammalian white adipose tissue: Implications for the regulation of total body fat
    • 17. Bartness TJ, Bamshad M (1998) Innervation of mammalian white adipose tissue: implications for the regulation of total body fat. Am J Physiol 275: R1399-R1411
    • (1998) Am J Physiol , vol.275
    • Bartness, T.J.1    Bamshad, M.2
  • 18
    • 0031557093 scopus 로고    scopus 로고
    • Role of central neural mechanisms in the regulation of hepatic glucose metabolism
    • 18. Nonogaki K, Iguchi A (1997) Role of central neural mechanisms in the regulation of hepatic glucose metabolism. Life Sci 60: 797-807
    • (1997) Life Sci , vol.60 , pp. 797-807
    • Nonogaki, K.1    Iguchi, A.2
  • 19
    • 0030743860 scopus 로고    scopus 로고
    • Stress, acute hyperglycemia and hyperlipidemia: Role of autonomic nervous system and cytokines
    • 19. Nonogaki K, Iguchi A (1997) Stress, acute hyperglycemia and hyperlipidemia: role of autonomic nervous system and cytokines. Trends Endocrinol Metab 8: 192-197
    • (1997) Trends Endocrinol Metab , vol.8 , pp. 192-197
    • Nonogaki, K.1    Iguchi, A.2
  • 20
    • 0024405046 scopus 로고
    • Vagally mediated insulin secretion by stimulation of brain cholinergic neurons with neostigmine in bilateral adrenalectomized rats
    • 20. Gotoh M, Iguchi A, Yatomi A et al. (1989) Vagally mediated insulin secretion by stimulation of brain cholinergic neurons with neostigmine in bilateral adrenalectomized rats. Brain Res 493: 97-102
    • (1989) Brain Res , vol.493 , pp. 97-102
    • Gotoh, M.1    Iguchi, A.2    Yatomi, A.3
  • 21
    • 0030865881 scopus 로고    scopus 로고
    • Regulation of glucose homeostasis in humans with denervated livers
    • 21. Perseghin G, Regalia E, Battezzati A et al. (1997) Regulation of glucose homeostasis in humans with denervated livers. J Clin Invest 100: 931-941
    • (1997) J Clin Invest , vol.100 , pp. 931-941
    • Perseghin, G.1    Regalia, E.2    Battezzati, A.3
  • 22
    • 0031911333 scopus 로고    scopus 로고
    • Effect of a selective rise in sinusoidal norepinephrine on HPG is due to an increase in glycogenolysis
    • 22. Chu C, Sindelar DK, Neal DW, Allen EJ, Donahue EP, Cherrington AD (1998) Effect of a selective rise in sinusoidal norepinephrine on HPG is due to an increase in glycogenolysis. Am J Physiol 274: E162-E171
    • (1998) Am J Physiol , vol.274
    • Chu, C.1    Sindelar, D.K.2    Neal, D.W.3    Allen, E.J.4    Donahue, E.P.5    Cherrington, A.D.6
  • 23
    • 0030662238 scopus 로고    scopus 로고
    • Role of epinephrine and norepinephrine in the metabolic response to stress hormone infusion in the conscious dog
    • 23. McGuinness OP, Shau V, Benson EM et al. (1997) Role of epinephrine and norepinephrine in the metabolic response to stress hormone infusion in the conscious dog. Am J Physiol 273: E674-E681
    • (1997) Am J Physiol , vol.273
    • McGuinness, O.P.1    Shau, V.2    Benson, E.M.3
  • 24
    • 0025942149 scopus 로고
    • Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats
    • 24. Sudo M, Minokoshi Y, Shimazu T (1991) Ventromedial hypothalamic Stimulation enhances peripheral glucose uptake in anesthetized rats. Am J Physiol 261: E298-E303
    • (1991) Am J Physiol , vol.261
    • Sudo, M.1    Minokoshi, Y.2    Shimazu, T.3
  • 25
    • 0028200927 scopus 로고
    • Regulatory mechanism of the ventromedial hypothalamus in enhancing glucose uptake in skeletal muscles
    • 25. Minokoshi Y, Okano Y, Shimazu T (1994) Regulatory mechanism of the ventromedial hypothalamus in enhancing glucose uptake in skeletal muscles. Brain Res 649: 343-347
    • (1994) Brain Res , vol.649 , pp. 343-347
    • Minokoshi, Y.1    Okano, Y.2    Shimazu, T.3
  • 26
    • 0028954723 scopus 로고
    • Neural control of glucose uptake by skeletal muscle after central administration of NMDA
    • 26. Lang CH, Ajmal M, Baillie AGS (1995) Neural control of glucose uptake by skeletal muscle after central administration of NMDA. Am J Physiol 268: R492-R497
    • (1995) Am J Physiol , vol.268
    • Lang, C.H.1    Ajmal, M.2    Baillie, A.G.S.3
  • 27
    • 0027787792 scopus 로고
    • Effect of a β3-adrenergic agonist, BRL35135A, on glucose uptake in rat skeletal muscle in vivo and in vitro
    • 27. Abe H, Minokoshi Y, Shimazu T (1993) Effect of a β3-adrenergic agonist, BRL35135A, on glucose uptake in rat skeletal muscle in vivo and in vitro. J Endocrinol 139: 479-486
    • (1993) J Endocrinol , vol.139 , pp. 479-486
    • Abe, H.1    Minokoshi, Y.2    Shimazu, T.3
  • 28
    • 0029670070 scopus 로고    scopus 로고
    • Biophagic effects of the β-adrenoceptor agonist, BRL 37344, on glucose utilization in rat isolated skeletal muscle
    • 28. Liu YL, Cawthorne MA, Stock MJ (1996) Biophagic effects of the β-adrenoceptor agonist, BRL 37344, on glucose utilization in rat isolated skeletal muscle. Brit J Pharmacol 117: 1355-1361
    • (1996) Brit J Pharmacol , vol.117 , pp. 1355-1361
    • Liu, Y.L.1    Cawthorne, M.A.2    Stock, M.J.3
  • 29
    • 0026575134 scopus 로고
    • Acute and chronic signals controlling glucose transport in muscle
    • 29. Klip A, Marette A (1992) Acute and chronic signals controlling glucose transport in muscle. J Cell Biochem 48: 51-60
    • (1992) J Cell Biochem , vol.48 , pp. 51-60
    • Klip, A.1    Marette, A.2
  • 30
    • 0031183274 scopus 로고    scopus 로고
    • The β3-adrenergic agonist BRL37344 increases glucose transport into L6 myocytes through a mechanism different from that of insulin
    • 30. Tanishita T, Shimazu Y, Minokoshi Y, Shimazu T (1997) The β3-adrenergic agonist BRL37344 increases glucose transport into L6 myocytes through a mechanism different from that of insulin. J Biochem (Tokyo) 122: 90-95
    • (1997) J Biochem (Tokyo) , vol.122 , pp. 90-95
    • Tanishita, T.1    Shimazu, Y.2    Minokoshi, Y.3    Shimazu, T.4
  • 31
    • 0026325126 scopus 로고
    • Molecular cloning and expression of the rat β3-adrenergic receptor
    • 31. Granneman JG, Lahners KN, Chaudhry A (1991) Molecular cloning and expression of the rat β3-adrenergic receptor. Mol Pharmacol 40: 895-899
    • (1991) Mol Pharmacol , vol.40 , pp. 895-899
    • Granneman, J.G.1    Lahners, K.N.2    Chaudhry, A.3
  • 32
    • 0027246267 scopus 로고
    • Molecular cloning of a human β3-adrenergic receptor cDNA
    • 32. Lelias JM, Kaghad M, Rodriguez M et al. (1993) Molecular cloning of a human β3-adrenergic receptor cDNA. FEBS Lett 324: 127-130
    • (1993) FEBS Lett , vol.324 , pp. 127-130
    • Lelias, J.M.1    Kaghad, M.2    Rodriguez, M.3
  • 33
    • 0026343747 scopus 로고
    • An adipose tissue-specific β-adrenergic receptor
    • 33. Muzzin P, Revelli JP, Kuhne F et al. (1991) An adipose tissue-specific β-adrenergic receptor. J Biol Chem 266: 24053-24058
    • (1991) J Biol Chem , vol.266 , pp. 24053-24058
    • Muzzin, P.1    Revelli, J.P.2    Kuhne, F.3
  • 34
    • 0027392074 scopus 로고
    • Tissue distribution of β3-adrenergic receptor mRNA in man
    • 34. Krief A, Lonnquist F, Raimbault S et al. (1993) Tissue distribution of β3-adrenergic receptor mRNA in man. J Clin Invest 91: 344-349
    • (1993) J Clin Invest , vol.91 , pp. 344-349
    • Krief, A.1    Lonnquist, F.2    Raimbault, S.3
  • 35
    • 0030803534 scopus 로고    scopus 로고
    • CL-316,243, a β3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats
    • 35. De Souza CJ, Hirshman MF, Horton ES (1997) CL-316,243, a β3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats. Diabetes 46: 1257-1263
    • (1997) Diabetes , vol.46 , pp. 1257-1263
    • De Souza, C.J.1    Hirshman, M.F.2    Horton, E.S.3
  • 36
    • 0026793421 scopus 로고
    • Epinephrine administration stimulates GLUT4 translocation but reduces glucose transport in muscle
    • 36. Bonen A, Megeney LA, McCarthy SC, McDermott JC, Tan MH (1992) Epinephrine administration stimulates GLUT4 translocation but reduces glucose transport in muscle. Biochem Biophys Res Commun 187: 685-691
    • (1992) Biochem Biophys Res Commun , vol.187 , pp. 685-691
    • Bonen, A.1    Megeney, L.A.2    McCarthy, S.C.3    McDermott, J.C.4    Tan, M.H.5
  • 37
    • 0031980299 scopus 로고    scopus 로고
    • Epinephrine translocates GLUT-4 but inhibits insulin-stimulated glucose transport in rat muscle
    • 37. Han X-X, Bonen A (1998) Epinephrine translocates GLUT-4 but inhibits insulin-stimulated glucose transport in rat muscle. Am J Physiol 274: E700-E707
    • (1998) Am J Physiol , vol.274
    • Han, X.-X.1    Bonen, A.2
  • 38
    • 0031910907 scopus 로고    scopus 로고
    • Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans
    • 38. Laurent D, Petersen KF, Russell RR, Cline GW, Shulman GI (1998) Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans. Am J Physiol 274: E130-E138
    • (1998) Am J Physiol , vol.274
    • Laurent, D.1    Petersen, K.F.2    Russell, R.R.3    Cline, G.W.4    Shulman, G.I.5
  • 39
    • 0030657562 scopus 로고    scopus 로고
    • Regulation of glucose transporter GLUT-4 and hexokinase II gene transcription by insulin and epinephrine
    • 39. Jones JP, Dohm L (1997) Regulation of glucose transporter GLUT-4 and hexokinase II gene transcription by insulin and epinephrine. Am J Physiol 273: E682-E687
    • (1997) Am J Physiol , vol.273
    • Jones, J.P.1    Dohm, L.2
  • 40
    • 0028325983 scopus 로고
    • Chronic norepinephrine infusion stimulates glucose uptake in white and brown adipose tissues
    • 40. Liu X, Perusse F, Bukowiecki LJ (1994) Chronic norepinephrine infusion stimulates glucose uptake in white and brown adipose tissues. Am J Physiol 266: R914-R920
    • (1994) Am J Physiol , vol.266
    • Liu, X.1    Perusse, F.2    Bukowiecki, L.J.3
  • 41
    • 0031802989 scopus 로고    scopus 로고
    • Mechanisms of the antidiabetic effects of the β3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats
    • 41. Kiu X, Perusse F, Bukowiecki LJ (1998) Mechanisms of the antidiabetic effects of the β3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats. Am J Physiol 274: R1212-R1219
    • (1998) Am J Physiol , vol.274
    • Kiu, X.1    Perusse, F.2    Bukowiecki, L.J.3
  • 42
    • 0028567278 scopus 로고
    • Isoproterenol inhibits cyclic AMP-mediated but not insulin-mediated translocation of the Glut-4 glucose transporter isoform
    • 42. Macaulay SL, Kelada ASM, Proietto J (1994) Isoproterenol inhibits cyclic AMP-mediated but not insulin-mediated translocation of the Glut-4 glucose transporter isoform. Mol Cell Biochem 141: 27-33
    • (1994) Mol Cell Biochem , vol.141 , pp. 27-33
    • Macaulay, S.L.1    Kelada, A.S.M.2    Proietto, J.3
  • 43
    • 0029916707 scopus 로고    scopus 로고
    • Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanisms different from that of insulin
    • 43. Shimizu Y, Kielar D, Minokoshi Y, Shimazu T (1996) Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanisms different from that of insulin. Biochem J 314: 485-490
    • (1996) Biochem J , vol.314 , pp. 485-490
    • Shimizu, Y.1    Kielar, D.2    Minokoshi, Y.3    Shimazu, T.4
  • 44
    • 0028972839 scopus 로고
    • Fat cell α2-adrenocpetors: The regulation of fat cell function and lipolysis
    • 44. Lafontan M, Berlan M (1995) Fat cell α2-adrenocpetors: the regulation of fat cell function and lipolysis. Endocr Rev 1: 716-738
    • (1995) Endocr Rev , vol.1 , pp. 716-738
    • Lafontan, M.1    Berlan, M.2
  • 45
    • 0028809386 scopus 로고
    • Regulation of lipoprotein lipase translation by epinephrine in3T3-L1 cells importance of the 3 ′ untranslated region
    • 45. Yurht A, Davis RC, Ong JM, Ranganathan G, Kern PA (1995) Regulation of lipoprotein lipase translation by epinephrine in3T3-L1 cells importance of the 3 ′ untranslated region. J Clin Invest 96: 2438-2444
    • (1995) J Clin Invest , vol.96 , pp. 2438-2444
    • Yurht, A.1    Davis, R.C.2    Ong, J.M.3    Ranganathan, G.4    Kern, P.A.5
  • 46
    • 0031045726 scopus 로고    scopus 로고
    • Adrenergic stimulation of lipoprotein lipase gene expression in rat brown adipocytes differentiated in culture: Mediation via β3-and α1-adrenergic receptors
    • 46. Kuusela P, Rehnmark S, Jacobsson A, Cannon B, Nedergaard J (1997) Adrenergic stimulation of lipoprotein lipase gene expression in rat brown adipocytes differentiated in culture: mediation via β3-and α1-adrenergic receptors. Biochem J 321: 759-767
    • (1997) Biochem J , vol.321 , pp. 759-767
    • Kuusela, P.1    Rehnmark, S.2    Jacobsson, A.3    Cannon, B.4    Nedergaard, J.5
  • 47
    • 0028224485 scopus 로고
    • Effect of CL-316, 243, a thermogenic β3-agonist, on energy balance and brown and white adipose tissues in rat
    • 47. Himms-Hagen J, Cui J, Danforth E Jr et al. (1994) Effect of CL-316, 243, a thermogenic β3-agonist, on energy balance and brown and white adipose tissues in rat. Am J Physiol 266: R1371-R1382
    • (1994) Am J Physiol , vol.266
    • Himms-Hagen, J.1    Cui, J.2    Danforth E., Jr.3
  • 49
    • 0032553418 scopus 로고    scopus 로고
    • Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes
    • 49. Liu L, Karkanias GB, Morales JC et al. (1998) Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. J Biol Chem 47: 31160-31167
    • (1998) J Biol Chem , vol.47 , pp. 31160-31167
    • Liu, L.1    Karkanias, G.B.2    Morales, J.C.3
  • 50
    • 0344327138 scopus 로고    scopus 로고
    • Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucosae uptake in ob/ob mice
    • 50. Burcelin R, Kamohara S, Li J, Tannenbaum GS, Charron MJ, Friedman JM (1999) Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucosae uptake in ob/ob mice. Diabetes 48: 1264-1269
    • (1999) Diabetes , vol.48 , pp. 1264-1269
    • Burcelin, R.1    Kamohara, S.2    Li, J.3    Tannenbaum, G.S.4    Charron, M.J.5    Friedman, J.M.6
  • 51
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • 51. Cohen B, Novick D, Rubinstein M (1996) Modulation of insulin activities by leptin. Science 274: 1185-1188
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3
  • 52
    • 0032934279 scopus 로고    scopus 로고
    • Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver
    • 52. Nemecz M, Preinneger K, Englisch R et al. (1999) Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology 29: 166-172
    • (1999) Hepatology , vol.29 , pp. 166-172
    • Nemecz, M.1    Preinneger, K.2    Englisch, R.3
  • 53
    • 0030895726 scopus 로고    scopus 로고
    • Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for PI-3-kinase-mediated effect
    • 53. Berti L, Kellerer M, Capp E, Haring HU (1997) Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for PI-3-kinase-mediated effect. Diabetologia 40: 606-609
    • (1997) Diabetologia , vol.40 , pp. 606-609
    • Berti, L.1    Kellerer, M.2    Capp, E.3    Haring, H.U.4
  • 54
    • 0032913312 scopus 로고    scopus 로고
    • Leptin enhances glycogen storage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulin
    • 54. Aiston S, Agius L (1999) Leptin enhances glycogen storage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulin. Diabetes 48: 15-20
    • (1999) Diabetes , vol.48 , pp. 15-20
    • Aiston, S.1    Agius, L.2
  • 56
    • 0032971214 scopus 로고    scopus 로고
    • Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats
    • 56. Minokoshi Y, Shahidul M, Shimazu T (1999) Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats. Diabetes 48: 287-291
    • (1999) Diabetes , vol.48 , pp. 287-291
    • Minokoshi, Y.1    Shahidul, M.2    Shimazu, T.3
  • 57
    • 0032830174 scopus 로고    scopus 로고
    • Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats
    • 57. Haque MS, Minokoshi Y, Hamai M, Iwai M, Horiuchi M, Shimazu T (1999) Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats. Diabetes 48: 1706-1712
    • (1999) Diabetes , vol.48 , pp. 1706-1712
    • Haque, M.S.1    Minokoshi, Y.2    Hamai, M.3    Iwai, M.4    Horiuchi, M.5    Shimazu, T.6
  • 58
    • 0033306791 scopus 로고    scopus 로고
    • Differential effects of leptin in regulation of tissue glucose utilization in vivo
    • 58. Wang J-L, Chinookoswong N, Scully S, QI M, Shi Z-G (1999) Differential effects of leptin in regulation of tissue glucose utilization in vivo. Endocrinology 140: 2117-2124
    • (1999) Endocrinology , vol.140 , pp. 2117-2124
    • Wang, J.-L.1    Chinookoswong, N.2    Scully, S.3    Qi, M.4    Shi, Z.-G.5
  • 59
    • 0033305464 scopus 로고    scopus 로고
    • Effects of intravenously infused leptin on insulin sensitivity and on the expression of uncoupling proteins in brown adipose tissue
    • 59. Rouru J, Cusin I, Zakrzewska KE, Jeanrenaud B, Rohner-Jeanrenaud F (1999) Effects of intravenously infused leptin on insulin sensitivity and on the expression of uncoupling proteins in brown adipose tissue. Endocrinology 140: 3688-3692
    • (1999) Endocrinology , vol.140 , pp. 3688-3692
    • Rouru, J.1    Cusin, I.2    Zakrzewska, K.E.3    Jeanrenaud, B.4    Rohner-Jeanrenaud, F.5
  • 61
    • 0033037727 scopus 로고    scopus 로고
    • Leptin restores euglycemic and normalizes glucose turnover in insulin-deficient diabetes in the rat
    • 61. Chinookoswong N, Wang J-L, Shi Z-Q (1999) Leptin restores euglycemic and normalizes glucose turnover in insulin-deficient diabetes in the rat. Diabetes 48: 1487-1492
    • (1999) Diabetes , vol.48 , pp. 1487-1492
    • Chinookoswong, N.1    Wang, J.-L.2    Shi, Z.-Q.3
  • 63
    • 0040381066 scopus 로고    scopus 로고
    • Leptin impairs metabolic actions of insulin in isolated rat adipocytes
    • 63. Muller G, Ertl J, Gerl M, Preibisch G (1997) Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 272: 10585-10593
    • (1997) J Biol Chem , vol.272 , pp. 10585-10593
    • Muller, G.1    Ertl, J.2    Gerl, M.3    Preibisch, G.4
  • 64
    • 0031010408 scopus 로고    scopus 로고
    • Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
    • 64. Fei H, Okano HJ, Li C et al. (1997) Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci USA 94: 7001-7005
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7001-7005
    • Fei, H.1    Okano, H.J.2    Li, C.3
  • 65
    • 0030898516 scopus 로고    scopus 로고
    • Direct antidiabetic effect of leptin through triglyceride depletion of tissues
    • 65. Shimabukuro M, Koyama K, Chen G et al. (1997) Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94: 4637-4641
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4637-4641
    • Shimabukuro, M.1    Koyama, K.2    Chen, G.3
  • 66
    • 0031467631 scopus 로고    scopus 로고
    • Direct effects of leptin on brown and white adipose tissue
    • 66. Siegrist-Kaiser CA, Pauli V, Juge-Aubry CE et al. (1997) Direct effects of leptin on brown and white adipose tissue. J Clin Invest 100: 2858-2863
    • (1997) J Clin Invest , vol.100 , pp. 2858-2863
    • Siegrist-Kaiser, C.A.1    Pauli, V.2    Juge-Aubry, C.E.3
  • 67
    • 0031587418 scopus 로고    scopus 로고
    • In vitro lipolytic effect of leptin on mouse adipocytes: Evidence for a possible autocrine/paracrine role of leptin
    • 67. Fruhbeck G, Aguado M, Martinez JA (1997) In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. Biochem Biophys Res Commun 240: 590-594
    • (1997) Biochem Biophys Res Commun , vol.240 , pp. 590-594
    • Fruhbeck, G.1    Aguado, M.2    Martinez, J.A.3
  • 69
    • 85011486581 scopus 로고    scopus 로고
    • A leptin dose-response study in obese (ob/ob) mice and lean (+/?) mice
    • 69. Harris RBS, Zhou J, Redmann SM Jr et al. (1998) A leptin dose-response study in obese (ob/ob) mice and lean (+/?) mice. Endocrinology 139: 8-19
    • (1998) Endocrinology , vol.139 , pp. 8-19
    • Harris, R.B.S.1    Zhou, J.2    Redmann S.M., Jr.3
  • 71
    • 0030759687 scopus 로고    scopus 로고
    • Leptin increases uncoupling protein expression and energy expenditure
    • 71. Scarpace PJ, Matheny M, Pollock BH, Tumer N (1997) Leptin increases uncoupling protein expression and energy expenditure. Am J Phsyiol 273: E226-E230
    • (1997) Am J Phsyiol , vol.273
    • Scarpace, P.J.1    Matheny, M.2    Pollock, B.H.3    Tumer, N.4
  • 72
    • 0031821693 scopus 로고    scopus 로고
    • Leptin induction of UCP1 gene expression is dependent on sympathetic innervation
    • 72. Scarpace PJ, Matheny M (1998) Leptin induction of UCP1 gene expression is dependent on sympathetic innervation. Am J Physiol 275: E259-E264
    • (1998) Am J Physiol , vol.275
    • Scarpace, P.J.1    Matheny, M.2
  • 74
    • 0030885584 scopus 로고    scopus 로고
    • CNS sites involved in sympathetic and parasympathetic control of the pancreas: A viral tracing study
    • 74. Jansen ASP, Loewy HAD (1997) CNS sites involved in sympathetic and parasympathetic control of the pancreas: a viral tracing study. Brain Res 766: 29-38
    • (1997) Brain Res , vol.766 , pp. 29-38
    • Jansen, A.S.P.1    Loewy, H.A.D.2
  • 75
    • 0033036199 scopus 로고    scopus 로고
    • CNS origins of the sympathetic nervous system outflow to brown adipose tissue
    • 75. Bamshad M, Song CK, Bartness TJ (1999) CNS origins of the sympathetic nervous system outflow to brown adipose tissue. Am J Physiol 276: R1569-R1578
    • (1999) Am J Physiol , vol.276
    • Bamshad, M.1    Song, C.K.2    Bartness, T.J.3
  • 76
    • 0031843809 scopus 로고    scopus 로고
    • Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue
    • 76. Bamshad M, Aoki VT, Adkison MG, Warren WS, Bartness TJ (1998) Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue. Am J Physiol 275: R291-R299
    • (1998) Am J Physiol , vol.275
    • Bamshad, M.1    Aoki, V.T.2    Adkison, M.G.3    Warren, W.S.4    Bartness, T.J.5
  • 77
    • 0032518022 scopus 로고    scopus 로고
    • Protective and damaging effects of stress mediators
    • 77. McEwen BS (1998) Protective and damaging effects of stress mediators. N Engl J Med 338:171-179
    • (1998) N Engl J Med , vol.338 , pp. 171-179
    • McEwen, B.S.1
  • 78
    • 0033304765 scopus 로고    scopus 로고
    • Estrogen actions in the central nervous system
    • 78. McEwen BS (1999) Estrogen actions in the central nervous system. Endocr Rev 20: 279-307
    • (1999) Endocr Rev , vol.20 , pp. 279-307
    • McEwen, B.S.1
  • 79
    • 0033304886 scopus 로고    scopus 로고
    • The molecular and neuroanatomical basis for estrogen effects in the central nervous system
    • 79. McEwen BS (1999) The molecular and neuroanatomical basis for estrogen effects in the central nervous system. J Clin Endocrinol Metab 84:1790-1797
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1790-1797
    • McEwen, B.S.1
  • 80
    • 0031979756 scopus 로고    scopus 로고
    • Acute estradiol and progesterone administration reduced cardiovascular and catecholamine responses to mental stress in menopausal women
    • 80. Del Rio G, Velardo A, Menozzi R et al. (1998) Acute estradiol and progesterone administration reduced cardiovascular and catecholamine responses to mental stress in menopausal women. Neuroendocrinology 67: 269-274
    • (1998) Neuroendocrinology , vol.67 , pp. 269-274
    • Del Rio, G.1    Velardo, A.2    Menozzi, R.3
  • 81
    • 0033019914 scopus 로고    scopus 로고
    • Centrally mediated effect of 17β-estradiol on parasympathetic tone in male rats
    • 81. Saleh TM, Connell BJ (1999) Centrally mediated effect of 17β-estradiol on parasympathetic tone in male rats. Am J Physiol 276: R474-R481
    • (1999) Am J Physiol , vol.276
    • Saleh, T.M.1    Connell, B.J.2
  • 82
    • 0032833029 scopus 로고    scopus 로고
    • Sympathetic activation of leptin via the ventromedial hypothalamus. Leptin-induced increase in catecholamine secretion
    • 82. Satoh N, Ogawa Y, Katsuura G et al. (1999) Sympathetic activation of leptin via the ventromedial hypothalamus. Leptin-induced increase in catecholamine secretion. Diabetes 48: 1787-1793
    • (1999) Diabetes , vol.48 , pp. 1787-1793
    • Satoh, N.1    Ogawa, Y.2    Katsuura, G.3
  • 83
    • 0030831040 scopus 로고    scopus 로고
    • Chronic central neuropeptide Y infusion in normal rats: Status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinemia
    • 83. Sainsbury A, Rohner-Jeanrenaud F, Cusin I et al. (1997) Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinemia. Diabetologia 40: 1269-1277
    • (1997) Diabetologia , vol.40 , pp. 1269-1277
    • Sainsbury, A.1    Rohner-Jeanrenaud, F.2    Cusin, I.3
  • 84
    • 0033573760 scopus 로고    scopus 로고
    • Disruption in neuropeptide Y and leptin signaling in obese ventromedial hypothalamic-lesioned rats
    • 84. Dube MG, Xu B, Kalra PS, Sninsky CA, Kalra SP (1999) Disruption in neuropeptide Y and leptin signaling in obese ventromedial hypothalamic-lesioned rats. Brain Res 816: 38-46
    • (1999) Brain Res , vol.816 , pp. 38-46
    • Dube, M.G.1    Xu, B.2    Kalra, P.S.3    Sninsky, C.A.4    Kalra, S.P.5
  • 85
    • 8044227781 scopus 로고    scopus 로고
    • Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: Evidence for loss of its satiety effect in VMH-lesioned rats
    • 85. Satoh N, Ogawa Y, Katsuura G et al. (1997) Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: evidence for loss of its satiety effect in VMH-lesioned rats. Endocrinology 138: 947-954
    • (1997) Endocrinology , vol.138 , pp. 947-954
    • Satoh, N.1    Ogawa, Y.2    Katsuura, G.3
  • 86
    • 0030599148 scopus 로고    scopus 로고
    • Injection with gold thioglucose impairs sensitivity to glucose: Evidence that glucose-responsive neurons are important for long-term regulation of body weight
    • 86. Bergen HT, Monkman N, Mobbs CV (1996) Injection with gold thioglucose impairs sensitivity to glucose: evidence that glucose-responsive neurons are important for long-term regulation of body weight. Brain Res 734: 332-336
    • (1996) Brain Res , vol.734 , pp. 332-336
    • Bergen, H.T.1    Monkman, N.2    Mobbs, C.V.3
  • 87
    • 0029827180 scopus 로고    scopus 로고
    • Effects of glold thioglucose on neuropeptide Y messenger RNA levels in the mouse hypothalamus
    • 87. Marks JL, Waite K, Cameron-Smith D, Blair SC, Cooney GJ (1996) Effects of glold thioglucose on neuropeptide Y messenger RNA levels in the mouse hypothalamus. Am J Physiol 270: R1208-R1214
    • (1996) Am J Physiol , vol.270
    • Marks, J.L.1    Waite, K.2    Cameron-Smith, D.3    Blair, S.C.4    Cooney, G.J.5
  • 88
    • 0031766722 scopus 로고    scopus 로고
    • Hyperphagia and weight gain after gold-thioglucose:realtion to hypothalamic neuropeptide Y and proopiomelanocortin
    • 88. Bergen HT, Mizuno TM, Taylor J, Mobbs CV (1998) Hyperphagia and weight gain after gold-thioglucose:realtion to hypothalamic neuropeptide Y and proopiomelanocortin. Endocrinology 139: 4483-4488
    • (1998) Endocrinology , vol.139 , pp. 4483-4488
    • Bergen, H.T.1    Mizuno, T.M.2    Taylor, J.3    Mobbs, C.V.4
  • 89
    • 0033304973 scopus 로고    scopus 로고
    • Hypothalamic obesity: Multiple routes mediated by loss of function in medial cell groups
    • 89. Choi S, Dallman MF (1999) Hypothalamic obesity: multiple routes mediated by loss of function in medial cell groups. Endocrinology 140: 4081-4088
    • (1999) Endocrinology , vol.140 , pp. 4081-4088
    • Choi, S.1    Dallman, M.F.2
  • 90
    • 0033305564 scopus 로고    scopus 로고
    • Rats with hypothalamic obesity are insensitive to central leptin injections
    • 90. Choi S, Sparks R, Clay M, Dallman MF (1999) Rats with hypothalamic obesity are insensitive to central leptin injections. Endocrinology 140: 4426-4433
    • (1999) Endocrinology , vol.140 , pp. 4426-4433
    • Choi, S.1    Sparks, R.2    Clay, M.3    Dallman, M.F.4
  • 91
    • 0030894709 scopus 로고    scopus 로고
    • Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome
    • 91. Kesterson RA, Huszar D, Lynch CA, Simerly RB, Cone RD (1997) Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Mol Endocrinol 11: 630-637
    • (1997) Mol Endocrinol , vol.11 , pp. 630-637
    • Kesterson, R.A.1    Huszar, D.2    Lynch, C.A.3    Simerly, R.B.4    Cone, R.D.5
  • 92
    • 0031888157 scopus 로고    scopus 로고
    • Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin
    • 92. Mizuno TM, Kleopoulos SP, Bergen HT, Roberts JL, Priest CA, Mobbs CV (1997) Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47: 294-297
    • (1997) Diabetes , vol.47 , pp. 294-297
    • Mizuno, T.M.1    Kleopoulos, S.P.2    Bergen, H.T.3    Roberts, J.L.4    Priest, C.A.5    Mobbs, C.V.6
  • 93
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • 93. Schwartz MW, Seeley RJ, Woods SC et al. (1997) Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46: 2119-2123
    • (1997) Diabetes , vol.46 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3
  • 94
    • 0031963436 scopus 로고    scopus 로고
    • Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
    • 94. Hakansson M-L, Brown H, Ghilardi N, Skoda RC, Meister B (1998) Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci 18: 559-572
    • (1998) J Neurosci , vol.18 , pp. 559-572
    • Hakansson, M.-L.1    Brown, H.2    Ghilardi, N.3    Skoda, R.C.4    Meister, B.5
  • 95
    • 0032899719 scopus 로고    scopus 로고
    • Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    • 95. Haynes WG, Morgan DA, Djalai A, Sivitz WI, Mark AL (1999) Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 33: 542-547
    • (1999) Hypertension , vol.33 , pp. 542-547
    • Haynes, W.G.1    Morgan, D.A.2    Djalai, A.3    Sivitz, W.I.4    Mark, A.L.5
  • 96
    • 0028112970 scopus 로고
    • Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor
    • 96. Lu D, Willard D, Patel IR et al. (1994) Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor. Nature 371: 799-802
    • (1994) Nature , vol.371 , pp. 799-802
    • Lu, D.1    Willard, D.2    Patel, I.R.3
  • 97
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • 97. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD (1994) Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8: 1298-1308
    • (1994) Mol Endocrinol , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 98
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • 98. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD (1997) Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385: 165-168
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 99
    • 0030678119 scopus 로고    scopus 로고
    • Independent and additive effects of central POMC and leptin pathways on murine obesity
    • 99. Boston BA, Blaydon KM, Varnerin J, Cone RD (1997) Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 278: 1641-1644
    • (1997) Science , vol.278 , pp. 1641-1644
    • Boston, B.A.1    Blaydon, K.M.2    Varnerin, J.3    Cone, R.D.4
  • 100
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • 100. Huszar D, Lynch CA, Fairchild-Huntress V et al. (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88: 131-141
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3
  • 101
    • 0032900284 scopus 로고    scopus 로고
    • Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
    • 101. Marsh DJ, Hollopeter G, Huszar D et al. (1999) Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21: 119-122
    • (1999) Nat Genet , vol.21 , pp. 119-122
    • Marsh, D.J.1    Hollopeter, G.2    Huszar, D.3
  • 102
    • 0027456428 scopus 로고
    • Physiolpharmacological interactions between stress hormones and central serotonergic systems
    • 102. Chaouloff F (1993) Physiolpharmacological interactions between stress hormones and central serotonergic systems. Brain Res Brain Res Rev 18: 1-32
    • (1993) Brain Res Brain Res Rev , vol.18 , pp. 1-32
    • Chaouloff, F.1
  • 103
    • 0028870515 scopus 로고
    • Functional assesment of the 5-HT1A-, 1B-, 2A/2C-, and 3-receptor subtypes on food intake and metabolic rate in rats
    • 103. Boetoo S, Richard D (1995) Functional assesment of the 5-HT1A-, 1B-, 2A/2C-, and 3-receptor subtypes on food intake and metabolic rate in rats. Am J Physiol 37: R14-R20
    • (1995) Am J Physiol , vol.37
    • Boetoo, S.1    Richard, D.2
  • 104
    • 0030594561 scopus 로고    scopus 로고
    • Effects of the 5-HT2c/2B receptor agonist 1-(3-chlorophenyl) piperazine on plasma glucose level of rats
    • 104. Sugimoto Y, Yamada J, Yoshikawa T, Horisaka K (1996) Effects of the 5-HT2c/2B receptor agonist 1-(3-chlorophenyl) piperazine on plasma glucose level of rats. Eur J Pharmacol 307: 75-80
    • (1996) Eur J Pharmacol , vol.307 , pp. 75-80
    • Sugimoto, Y.1    Yamada, J.2    Yoshikawa, T.3    Horisaka, K.4
  • 105
    • 0028909857 scopus 로고
    • Eating disorder and epilepsy in mice lacking 5-HT2c receptors
    • 105. Tecott LH, Sunn LM, Akana SF et al. (1995) Eating disorder and epilepsy in mice lacking 5-HT2c receptors. Nature 374: 542-546
    • (1995) Nature , vol.374 , pp. 542-546
    • Tecott, L.H.1    Sunn, L.M.2    Akana, S.F.3
  • 106
    • 0031721271 scopus 로고    scopus 로고
    • Leptin-independent hyperphagia and type 2 diabetes in mice mutated serotonin 5-HT2c receptor gene
    • 106. Nonogaki K, Strack AM, Dallman MF, Tecott LH (1998) Leptin-independent hyperphagia and type 2 diabetes in mice mutated serotonin 5-HT2c receptor gene. Nat Med 4: 1152-1156
    • (1998) Nat Med , vol.4 , pp. 1152-1156
    • Nonogaki, K.1    Strack, A.M.2    Dallman, M.F.3    Tecott, L.H.4
  • 107
    • 0028985633 scopus 로고
    • Comparative localiztion of serotonin 1A,1C and 2 receptor subtype mRNAs in rat brain
    • 107. Wright DE, Seroogy KB, Lundgren KH, Davis BM, Jennes L (1995) Comparative localiztion of serotonin 1A,1C and 2 receptor subtype mRNAs in rat brain. J Comp Neurol 351: 357-373
    • (1995) J Comp Neurol , vol.351 , pp. 357-373
    • Wright, D.E.1    Seroogy, K.B.2    Lundgren, K.H.3    Davis, B.M.4    Jennes, L.5
  • 108
    • 0028838836 scopus 로고
    • Targeted disruption of the β3-adrenergic receptor gene
    • 108. Susulic VS, Frederich RC, Iwaitts J et al. (1995) Targeted disruption of the β3-adrenergic receptor gene. J Biol Chem 270: 29483-29492
    • (1995) J Biol Chem , vol.270 , pp. 29483-29492
    • Susulic, V.S.1    Frederich, R.C.2    Iwaitts, J.3
  • 109
    • 0028281432 scopus 로고
    • Impaired expression and functional activity of the β3 and β1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice
    • 109. Collins S, Daniel KW, Rohlfs EM, Ramkumar V, Taylor IL, Gettys TE (1994) Impaired expression and functional activity of the β3 and β1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Mol Endocrinol 8: 518-527
    • (1994) Mol Endocrinol , vol.8 , pp. 518-527
    • Collins, S.1    Daniel, K.W.2    Rohlfs, E.M.3    Ramkumar, V.4    Taylor, I.L.5    Gettys, T.E.6
  • 110
    • 0030884477 scopus 로고    scopus 로고
    • Targeted gene disruption reveals a leptin-independent role for the mouse β3-adrenoceptor in the regulation of body composition
    • 110. Revelli J-P, Preitner F, Samec S et al. (1997) Targeted gene disruption reveals a leptin-independent role for the mouse β3-adrenoceptor in the regulation of body composition. J Clin Invest 100: 1098-11106
    • (1997) J Clin Invest , vol.100 , pp. 1098-11106
    • Revelli, J.-P.1    Preitner, F.2    Samec, S.3
  • 111
    • 1842409029 scopus 로고    scopus 로고
    • Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
    • 111. Enerback S, Jacobsson A, Simpson EM et al. (1997) Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387: 90-99
    • (1997) Nature , vol.387 , pp. 90-99
    • Enerback, S.1    Jacobsson, A.2    Simpson, E.M.3
  • 112
    • 0033151806 scopus 로고    scopus 로고
    • The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes
    • 112. Strosberg AD, Issad T (1999) The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes. Trends Pharmacol Sci 20: 227-230
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 227-230
    • Strosberg, A.D.1    Issad, T.2
  • 113
    • 0033010326 scopus 로고    scopus 로고
    • Identification and functional analysis of novel human melanocortin-4 receptor varients
    • 113. Gu W, Tu Z, Kleyn PW, Kissebah A et al. (1999) Identification and functional analysis of novel human melanocortin-4 receptor varients. Diabetes 48: 635-639
    • (1999) Diabetes , vol.48 , pp. 635-639
    • Gu, W.1    Tu, Z.2    Kleyn, P.W.3    Kissebah, A.4
  • 114
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • 114. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19: 155-157
    • (1998) Nat Genet , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 115
    • 0029084088 scopus 로고
    • Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the β3-adrenergic receptor gene
    • 115. Walston J, Siver K, Boagardus C et al. (1995) Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the β3-adrenergic receptor gene. N Engl J Med 333: 343-347
    • (1995) N Engl J Med , vol.333 , pp. 343-347
    • Walston, J.1    Siver, K.2    Boagardus, C.3
  • 116
    • 0028978913 scopus 로고
    • Association of a polymorphism in the β3-adrenergic receptor gene with features of the insulin resistance syndrome in Finns
    • 116. Widen E, Letto M, Kanninen T, Walston J, Shuldiner AR, Groop LC (1995) Association of a polymorphism in the β3-adrenergic receptor gene with features of the insulin resistance syndrome in Finns. N Engl J Med 333: 348-351
    • (1995) N Engl J Med , vol.333 , pp. 348-351
    • Widen, E.1    Letto, M.2    Kanninen, T.3    Walston, J.4    Shuldiner, A.R.5    Groop, L.C.6
  • 117
    • 0028978910 scopus 로고
    • Genetic variation in the β3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity
    • 117. Clement K, Vaisse C, Manning BSJ et al. (1995) Genetic variation in the β3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 333: 352-354
    • (1995) N Engl J Med , vol.333 , pp. 352-354
    • Clement, K.1    Vaisse, C.2    Manning, B.S.J.3
  • 118
    • 0028856750 scopus 로고
    • Mutation of β3-adrenergic receptor gene and response to treatment of obesity
    • 118. Yoshida T, Sakane N, Umekawa T, Sakai Y, Takahashi T, Kondo M (1995) Mutation of β3-adrenergic receptor gene and response to treatment of obesity. Lancet 46: 1433-1434
    • (1995) Lancet , vol.46 , pp. 1433-1434
    • Yoshida, T.1    Sakane, N.2    Umekawa, T.3    Sakai, Y.4    Takahashi, T.5    Kondo, M.6
  • 119
    • 0030731084 scopus 로고    scopus 로고
    • Effects of Trp64Arg mutation in the β3-adrenergci receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients
    • 119. Sakane N, Yoshida T, Umekawa T, Kogure A, Takakura Y, Kondo M (1997) Effects of Trp64Arg mutation in the β3-adrenergci receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients. Diabetes Care 20: 1887-1890
    • (1997) Diabetes Care , vol.20 , pp. 1887-1890
    • Sakane, N.1    Yoshida, T.2    Umekawa, T.3    Kogure, A.4    Takakura, Y.5    Kondo, M.6
  • 120
    • 0028970525 scopus 로고
    • A mutation in the β3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects
    • 120. Kadowaki H, Kosaka K, Yamada N et al. (1995) A mutation in the β3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects. Biochem Biophys Res Commun 215: 555-560
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 555-560
    • Kadowaki, H.1    Kosaka, K.2    Yamada, N.3
  • 121
    • 0031787748 scopus 로고    scopus 로고
    • Meta-analysis of the association of Trp64Arg polymorphism of β3-adrenergic receptor gene with body mass index
    • 121. Fujisawa T, Ikegami H, Kawaguchi Y, Ogihara T (1998) Meta-analysis of the association of Trp64Arg polymorphism of β3-adrenergic receptor gene with body mass index. J Clin Endocrinol Metabo 83: 2441-2444
    • (1998) J Clin Endocrinol Metabo , vol.83 , pp. 2441-2444
    • Fujisawa, T.1    Ikegami, H.2    Kawaguchi, Y.3    Ogihara, T.4
  • 122
    • 0032589914 scopus 로고    scopus 로고
    • Trp64Arg mutation of β3-adrenoceptor gene deteriorates lipolysis induced by β3-adrenoceptor agonist in human omental adipocytes
    • 122. Umekawa T, Yoshida T, Sakane N, Kogure A, Kondo M, Honjyo H (1999) Trp64Arg mutation of β3-adrenoceptor gene deteriorates lipolysis induced by β3-adrenoceptor agonist in human omental adipocytes. Diabetes 48: 117-120
    • (1999) Diabetes , vol.48 , pp. 117-120
    • Umekawa, T.1    Yoshida, T.2    Sakane, N.3    Kogure, A.4    Kondo, M.5    Honjyo, H.6
  • 123
    • 0033037181 scopus 로고    scopus 로고
    • Adrenoceptor genes in human obesity
    • 123. Arner P, Hoffstedt J (1999) Adrenoceptor genes in human obesity. J Intern Med 245: 667-672
    • (1999) J Intern Med , vol.245 , pp. 667-672
    • Arner, P.1    Hoffstedt, J.2
  • 124
    • 0031661901 scopus 로고    scopus 로고
    • Increase in insulin action and fat oxidation after treatment with CL316,243, a highly selective β3-adrenoceptor agonist in humans
    • 124. Weyer C, Tataranni PA, Snitker S, Danforth E Jr, Ravussin E (1998) Increase in insulin action and fat oxidation after treatment with CL316,243, a highly selective β3-adrenoceptor agonist in humans. Diabetes 47: 1555-1561
    • (1998) Diabetes , vol.47 , pp. 1555-1561
    • Weyer, C.1    Tataranni, P.A.2    Snitker, S.3    Danforth E., Jr.4    Ravussin, E.5
  • 125
    • 0031436966 scopus 로고    scopus 로고
    • Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associated with altered adipocyte beta-2 adrenoceptor function
    • 125. Large V, Hellstrom L, Reynisdottir S et al. (1997) Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associated with altered adipocyte beta-2 adrenoceptor function. J Clin Invest 100: 3005-3013
    • (1997) J Clin Invest , vol.100 , pp. 3005-3013
    • Large, V.1    Hellstrom, L.2    Reynisdottir, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.