Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in β-cells

Diabetes

Volumn 48, Issue 1, 1999, Pages 228-232

  Mulder, Hindrik ^a   Holst, Lena Stenson ^a   Svensson, Håkan ^a   Degerman, Eva ^a   Sundler, Frank ^a   Ahrén, Bo ^a   Rorsman, Patrik ^a   Holm, Cecilia ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HORMONE SENSITIVE LIPASE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; HORMONE SENSITIVITY; HYDROLYSIS; IMMUNOCYTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STIMULUS SECRETION COUPLING;

EID: 0032933607     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.1.228     Document Type: Article

References (27)

1. Unger RH: Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications. Diabetes 44:863-870, 1995
2. Boden G: Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10, 1997
3. Sako Y, Grill VE: A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127:1580-1589, 1990
4. Elks ML: Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release. Endocrinology 133:208-214, 1993
5. Milburn JL Jr, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, BeltrandelRio H, Newgard CB, Johnson JH, Unger RH: Pancreatic beta cells in obesity: evidence for induction of functional, morphological, and metabolic abnormalities by increased long-chain fatty acids. J Biol Chem 270:1295-1299, 1995
6. Prentki M, Corkey BE: Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283, 1996
7. Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M: A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells. J Biol Chem 264:21608-21612, 1989
8. Koyama K, Chen G, Wang M-Y, Lee Y, Shimabukuro M, Newgard CB, Unger RH: β-Cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. Diabetes 48:1276-1280, 1997
9. Langin D, Holm C, Lafontan M: Adipocyte hormone-sensitive lipase: a major regulator of lipid metabolism. Proc Nutr Soc 55:93-109, 1996
10. Björklund A, Yaney G, McGarry JD, Weir G: Fatty acids and beta-cell function. Diabetologia 40 (Suppl. 3):B21-B26, 1997
11. Wijkander J, Stenson Holst L, Rahn T, Resjö S, Castan I, Manganiello V, Belfrage P, Degerman E: Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate: membrane translocation in response to peroxovanadate. J Biol Chem 272:21520-21526, 1997
12. Holm C, Kirchgessner TG, Svenson KL, Fredrikson G, Nilsson S, Miller CG, Shivery JE, Heinzmann C, Sparkes RS, Mohandas T, Belfrage P, Schotz MC: Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3. Science 241:1503-1506, 1988
13. Langin D, Laurell H, Stenson Holst L, Belfrage P, Holm C: Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium. Proc Natl Acad Sci U S A 90:4897-4901, 1993
14. Stenson Holst L, Langin D, Mulder H, Laurell H, Grober J, Bergh A, Mohrenweiser HW, Edgren G, Holm C: Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase. Genomics 36:441-447, 1996
15. Grober J, Laurell H, Blaise R, Fabry B, Schaak S, Holm C, Langin D: Characterization of the promoter of human adipocyte hormone-sensitive lipase. Biochem J 2:453-461, 1997
16. Mulder H, Lindh AC, Sundler F: Islet amyloid polypeptide gene expression in the endocrine pancreas of the rat: a combined in situ hybridization and immunocytochemical study. Cell Tissue Res 274:467-474, 1993
17. Österlund T, Danielsson B, Degerman E, Contreras JA, Edgren G, Davis RC, Schotz MC, Holm C: Domain-structure analysis of recombinant rat hormone-sensitive lipase. Biochem J 2:411-420, 1996
18. Persaud SJ: Protein kinase C signalling in pancreatic beta-cells: cellular and molecular approaches. Digestion 2:86-92, 1997
19. Chen S, Ogawa A, Ohneda M, Unger RH, Foster DW, McGarry JD: More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic β-cell signaling. Diabetes 43:878-883, 1994
20. Shimabukuro M, Ohneda M, Lee Y, Unger RH: Role of nitric oxide in obesity-induced beta cell disease. J Clin Invest 100:290-295, 1997
21. Brun T, Assimacopoulos-Jeannet F, Corkey BE, Prentki M: Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic β-cell line INS-1. Diabetes 46:393-400, 1997
22. Larsson O, Deeney JT, Bränström R, Berggren PO, Corkey BE: Activation of the ATP-sensitive K+ channel by long chain acyl-CoA: a role in modulation of pancreatic beta-cell glucose sensitivity. J Biol Chem 271:10623-10626, 1996
23. Antinozzi PA, Segall L, Prentki M, McGarry JD, Newgard CB: Molecular and pharmacological perturbtion of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. J Biol Chem 273:16146-16154, 1998
24. Zhang S, Kim KH: Essential role of acetyl-CoA carboxylase in the glucose-induced insulin secretion in a pancreatic beta-cell line. Cell Signal 10:35-42, 1998
25. Gromada J, Holst JJ, Rorsman P: Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1. Pflügers Arch 435:583-594, 1998
26. Zhao AZ, Zhao H, Teague J, Fujimoto W, Beavo JA: Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B. Proc Natl Acad Sci U S A 94:3223-3228, 1997
27. Stenson Holst L, Mulder H, Manganiello V, Sundler F, Ahrén B, Holm C, Degerman E: Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I. Biochem. Biophys Res Commun 250:181-186, 1998