Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with Type II diabetes

Diabetologia

Volumn 44, Issue 7, 2001, Pages 824-833

  Levin, K ^a   Daa Schroeder, H ^a   Alford, F P ^a   Beck Nielsen, H ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Electron microscopy; Glycogen; Insulin sensitivity; Intramyocellular; Skeletal muscle; Triglyceride; Type II diabetes

Indexed keywords

FAT; GLUCOSE; GLYCOGEN; INSULIN; TRIACYLGLYCEROL;

ADULT; AEROBIC METABOLISM; ARTICLE; CALORIMETRY; CELL VOLUME; CLAMP; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; INSULIN METABOLISM; INSULIN SENSITIVITY; LIPID STORAGE; MALE; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; SKELETAL MUSCLE;

ADIPOCYTES; BLOOD GLUCOSE; CALORIMETRY, INDIRECT; CHOLESTEROL; CHOLESTEROL, HDL; DIABETES MELLITUS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FATTY ACIDS, NONESTERIFIED; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; GLYCOGEN; HUMANS; HYPERINSULINISM; INSULIN RESISTANCE; LIPID METABOLISM; MIDDLE AGED; MUSCLE, SKELETAL; OBESITY; TRIGLYCERIDES;

EID: 0034945787     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250100545     Document Type: Article

References (61)

1. Role of insulin resistance in human disease. Banting lecture
2. Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic diseases?
3. A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM
4. Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study
5. What if Minkowski had been ageusic? An alternative angle on diabetes
6. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
7. Effects of lipid on basal carbohydrate metabolism in normal men
8. Impairment of glucose disposal by infusion of triglycerides in humans: Role of glycemia
9. Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus
10. Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus
11. A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat
12. Metabolic effects of troglitazone in NIDDM patients
13. Triglyceride uptake in muscles in rats
14. Influence of body fat distribution on free fatty acid metabolism in obesity
15. Skeletal muscle triglyceride levels are inversely related to insulin action
16. Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
17. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
18. Increasing intramyocellular triglyceride stores are associated with impaired glucose tolerance and NIDDM
19. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
20. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: A 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
21. Effects of arterial versus venous sampling on analysis of glucose kinetics in man
22. Labelled glucose infusate technique in clamp studies. Is precise matching of glucose specific activity important?
23. Calculation of substrate oxidation rates in vivo from gaseous exchange
24. Effect of hyperinsulinemia on urea pool size and substrate oxidation rates
25. Influence of glucose loading and of injected insulin on hepatic glucose output
26. Impact of variable insulinemia and glycemia on in vivo glycolysis and glucose storage in dogs
27. Quantitation of glycolysis and skeletal muscle glycogen synthesis in humans
28. Assessment of insulin sensitivity in vivo
29. Insulinopenia and hyperglycemia influence the in vivo partitioning of GE and SI
30. Assessment of fat-free mass using bioelectrical impedance measurements of the human body
31. Intracellular defects in glucose metabolism in obese patients with NIDDM
32. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis
33. Two-site time-resolved immunofluorometric assay of human insulin
34. Design of the oxygen and substrate pathways. I. Model and strategy to test symmorphosis in a network structure
35. Insulin resistance, but normal basal rates of glucose production in patients with newly diagnosed mild diabetes mellitus
36. Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM
37. Assessment of hepatic insulin action in obese type 2 diabetic patients
38. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without Type II (non-insulin-dependent) diabetes mellitus
39. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
40. Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin-dependent) diabetes mellitus
41. Splanchnic and muscle metabolism during exercise in NIDDM patients
42. Correlation between muscle glycogen synthase activity and in vivo insulin action in man
43. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus
44. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
45. New insights into the role and mechanism of glycogen synthase activation by insulin
46. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
47. Glycogen
48. Defects of insulin action and skeletal muscle glucose metabolism in growth hormone-deficient adults persist after 24 months of recombinant human growth hormone therapy
49. Differential regulation of intracellular glucose metabolism by glucose and insulin in human muscle
50. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria
51. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
52. Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653
53. Mechanism of free fatty acid-induced insulin resistance in humans
54. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
55. Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men
56. In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy
57. Muscle triglyceride utilization during exercise: Effect of training
58. Endurance training in humans: Aerobic capacity and structure of skeletal muscle
59. Design of the oxygen and substrate pathways. VI. structural basis of intracellular substrate supply to mitochondria in muscle cells